Objective To review evidences of the relationship between olfactory ensheathing cells (OECs) transplantation and motor functional restitution of spinal cord injury (SCI).
Methods We searched the CBM, CNKI, VIP and PubMed databases for collecting relative studies published from January 1989 to December 2009. Randomized controlled experiments of treating rats SCI with OECs transplantation were included. Quality of included experiments was assessed by Jadad scale, and the available data were abstracted and meta-analyzed with RevMan 4.2 software.
Results A total of 12 randomized controlled experiments were identified. Meta-analysis showed that, OECs group was higher than control group in both BBB score (WMD=1.67, 95%CI 0.99 to 2.36; WMD=3.61, 95%CI 1.97 to 5.26; WMD=6.50, 95%CI 5.76 to 7.24; WMD=4.23, 95%CI 1.19 to 7.28; WMD=1.90, 95%CI 1.22 to 2.58; WMD=3.30, 95%CI 2.63 to 3.97) and MEP latency period (WMD= – 3.98, 95%CI – 5.71 to – 2.25), but there was no statistical significance in SEP latency period or amplitude period (WMD= – 7.13, 95%CI – 16.49 to 2.23; WMD=3.00, 95%CI – 1.12 to 7.11; WMD=1.95, 95%CI – 0.89 to4.78).
Conclusions This meta-analysis based on current experiments suggests that OECs transplantation is superior in motor function restitution after spinal cord injury, but is similar as control group in SEP latency or amplitude.
Citation: CHEN Wei,HE Lina,LI Ang,LIANG Nan. Effect of Olfactory Ensheathing Cells Transplantation for Motor Function Restitution on Spinal Cord Injury of Rats: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2010, 10(10): 1194-1198. doi: 10.7507/1672-2531.20100569 Copy