Association of Apolipoprotein E Polymorphism and Alzheimer’s Disease in Chinese Population: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHANG Yaodong , XU Yong , NIE Hongwei , ZHANG Ling , WU Yan

School of Public Health, Soochow University, Suzhou 215123, China;

Corresponding author：

ZHANG Yaodong, Email: childhealth@suda.edu.cn

Keywords：

Apolipoprotein E; Polymorphism; Alzheimer’s disease; Meta-analysis

DOI：

10.7507/1672-2531.20110075

Video：

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Objective 　To evaluate the relationship between genetic polymorphism of ApoE and Alzheimer’s disease in Chinese population.
Methods 　Such databases as PubMed, EBSCO, CNKI, CBM, and WangFang Data were searched from their establishment to December 2010 to collect the literature about the relationship between genetic polymorphism of ApoE and Alzheimer’s disease in Chinese population. RevMan 5.0 was adopted to conduct consistency check and data merging, and to evaluate publication bias.
Results 　ApoEε4 was the risky allele (P lt;0.05) in Chinese population, and its pooled odds ratios and 95%CI was 3.53 (2.49 to 5.00). ApoEε3 was the protective alleles (P lt;0.05) in Chinese population, and its pooled odds ratios and 95%CI was 0.52 (0.40 to 0.68). ApoEε4/ε4, ApoEε4/ε3, and ApoEε4/ε2 were the risky genotypes (all P lt;0.05) in Chinese population, and their pooled odds ratios and 95%CI were 10.17 (4.25 to 24.19), 2.57 (2.04 to 3.25), and 1.94 (1.13 to 3.34), respectively. ApoEε3/ε3 was the protective genotype (P lt;0.05) in Chinese population, and its pooled odds ratios and 95%CI was 0.67 (0.57 to 0.77).
Conclusion 　In Chinese population, some ApoE alleles and genotypes are associated with Alzheimer’s disease.

Citation： ZHANG Yaodong,XU Yong,NIE Hongwei,ZHANG Ling,WU Yan. Association of Apolipoprotein E Polymorphism and Alzheimer’s Disease in Chinese Population: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2011, 11(4): 433-436. doi: 10.7507/1672-2531.20110075 Copy

1.	2 Siest G, Pillot T, Régis-Bailly A, et al . Apolipoprotein E: an important gene and protein to follow in laboratory medicine. Clin Chem , 1995, 41(8 Pt 1): 1068-1086.
2.	黄静. 老年性痴呆患者的症状分析及护理措施. 中国民康医学, 2009, 21(3): 298-299.
3.	Levy-Lahad E, Bird TD. Genetic factors in Alzheimer's disease: a review of recent advances. Ann Neurol , 1996, 40(6): 829-840.
4.	Strittmatter WJ, Saunders AM, Schmechel D, et al . Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A , 1993, 90(5): 1977-1981.
5.	McKhann G, Drachman D, Folstein M, et al . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology , 1984, 34(7): 939-944.
6.	Lichtenstein MJ, Mulrow CD, Elwood PC. Guidelines for reading case-control studies. J Chronic Dis , 1987, 40(9): 893-903.
7.	周伯荣, 胡昔权, 许职强, 等. 载脂蛋白E基因多态性与Alzheimer病. 卒中与神经疾病, 1999, 6(1): 4-6.
8.	周常文, 徐江涛, 何江, 等. 载脂蛋白E基因与阿尔茨海默病的遗传相关性研究. 西北国防医学杂志, 2003, 24(4): 244-246.
9.	毕胜, 张煜, 吴江, 等. 载脂蛋白E基因型与阿尔茨海默病及其血清胆固醇水平的关系. 中国神经免疫学和神经病学杂志, 2002, 9(1): 13-16.
10.	黄绍宽, 陆益强, 陈盛强, 载脂蛋白E基因多态性与Alzheimer病的关系探讨. 现代临床医学生物工程学杂志, 2001, 7(1): 9-11.
11.	麦以成, 罗有年, 顾鸿, 等. 载脂蛋白E基因多态性与Alzheimer病的关联研究. 临床精神医学杂志, 2007, 17(6): 365-366.
12.	贾建平, 张津, 徐敏, 等. 载脂蛋白E基因多态性与散发性阿尔茨海默病的关系. 中华老年医学杂志, 2002, 21(4): 248-250.
13.	陈等, 张俊武, 张振馨, 等. 载脂蛋白E基因多态性与阿尔茨海默病. 遗传学报, 2003, 30(12): 1167-1170.
14.	朱济瑛, 徐文玲, 高颖, 等. Alzheimer病与遗传基因载脂蛋白E的多态性分析. 实用老年医学, 2000, 14(1): 23-25.
15.	杨静芳, 陈彪, 柏华, 等. 载脂蛋白E基因多态性与中国人阿尔茨海默病和颈动脉粥样硬化相关性研究. 基础医学与临床, 2001, 21(1): 40-42.
16.	Corder EH, Saunders AM, Strittmatter WJ, et al . Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science , 1993, 261(5123): 921-923.
17.	Alzheimer's Disease Collaborative Group. Apolipoprotein E genotype and Alzheimer's disease. Lancet , 1993, 342: 737-738.
18.	顾文明, 陈美娟, 高哲石, 等. 阿尔茨海默病载脂蛋白E基因多态性研究. 临床精神医学杂志, 2003, 13: 131-133.
19.	Farrer LA, Cupples LA, Haines JL, et al . Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA , 1997, 278(16):1349-1356.
20.	Rubinsztein DC, Easton DF. Apolipoprotein E genetic variation and Alzheimer's disease. a meta-analysis. Dement Geriatr Cogn Disord , 1999, 10(3): 199-209.

1. 2 Siest G, Pillot T, Régis-Bailly A, et al . Apolipoprotein E: an important gene and protein to follow in laboratory medicine. Clin Chem , 1995, 41(8 Pt 1): 1068-1086.
2. 黄静. 老年性痴呆患者的症状分析及护理措施. 中国民康医学, 2009, 21(3): 298-299.
3. Levy-Lahad E, Bird TD. Genetic factors in Alzheimer's disease: a review of recent advances. Ann Neurol , 1996, 40(6): 829-840.
4. Strittmatter WJ, Saunders AM, Schmechel D, et al . Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A , 1993, 90(5): 1977-1981.
5. McKhann G, Drachman D, Folstein M, et al . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology , 1984, 34(7): 939-944.
6. Lichtenstein MJ, Mulrow CD, Elwood PC. Guidelines for reading case-control studies. J Chronic Dis , 1987, 40(9): 893-903.
7. 周伯荣, 胡昔权, 许职强, 等. 载脂蛋白E基因多态性与Alzheimer病. 卒中与神经疾病, 1999, 6(1): 4-6.
8. 周常文, 徐江涛, 何江, 等. 载脂蛋白E基因与阿尔茨海默病的遗传相关性研究. 西北国防医学杂志, 2003, 24(4): 244-246.
9. 毕胜, 张煜, 吴江, 等. 载脂蛋白E基因型与阿尔茨海默病及其血清胆固醇水平的关系. 中国神经免疫学和神经病学杂志, 2002, 9(1): 13-16.
10. 黄绍宽, 陆益强, 陈盛强, 载脂蛋白E基因多态性与Alzheimer病的关系探讨. 现代临床医学生物工程学杂志, 2001, 7(1): 9-11.
11. 麦以成, 罗有年, 顾鸿, 等. 载脂蛋白E基因多态性与Alzheimer病的关联研究. 临床精神医学杂志, 2007, 17(6): 365-366.
12. 贾建平, 张津, 徐敏, 等. 载脂蛋白E基因多态性与散发性阿尔茨海默病的关系. 中华老年医学杂志, 2002, 21(4): 248-250.
13. 陈等, 张俊武, 张振馨, 等. 载脂蛋白E基因多态性与阿尔茨海默病. 遗传学报, 2003, 30(12): 1167-1170.
14. 朱济瑛, 徐文玲, 高颖, 等. Alzheimer病与遗传基因载脂蛋白E的多态性分析. 实用老年医学, 2000, 14(1): 23-25.
15. 杨静芳, 陈彪, 柏华, 等. 载脂蛋白E基因多态性与中国人阿尔茨海默病和颈动脉粥样硬化相关性研究. 基础医学与临床, 2001, 21(1): 40-42.
16. Corder EH, Saunders AM, Strittmatter WJ, et al . Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science , 1993, 261(5123): 921-923.
17. Alzheimer's Disease Collaborative Group. Apolipoprotein E genotype and Alzheimer's disease. Lancet , 1993, 342: 737-738.
18. 顾文明, 陈美娟, 高哲石, 等. 阿尔茨海默病载脂蛋白E基因多态性研究. 临床精神医学杂志, 2003, 13: 131-133.
19. Farrer LA, Cupples LA, Haines JL, et al . Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA , 1997, 278(16):1349-1356.
20. Rubinsztein DC, Easton DF. Apolipoprotein E genetic variation and Alzheimer's disease. a meta-analysis. Dement Geriatr Cogn Disord , 1999, 10(3): 199-209.

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Association of Apolipoprotein E Polymorphism and Alzheimer’s Disease in Chinese Population: A Meta-analysis

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