• Department of Internal Medical Ward, Shanghai Clinical Center for Diabetes, The Sixth People’s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China;
REN Ying, Email: renying@sjtu.edu.cn
Export PDF Favorites Scan Get Citation

Objective  To systematically review the correlation between diabetes and the incidence rate of colorectal cancer, so as to provide objective proof for early screening diabetic patients with colorectal cancer.
Methods  The databases such as MEDLINE and EMbase published from January 1990 to July 2010 were searched to include cohort studies. The meta-analysis including seventeen qualified studies was performed by using the Cochrane Collaboration’s RevMan 4.3 software.
Results  The results of meta-analyses of 17 cohort studies involving 1 690 869 participants indicated that the diabetes patients had a higher incidence rate of colorectal cancer compared with the control group (16.50‰ vs. 10.13‰). The odds ratio (OR) was 1.43, and the 95% confidence interval (CI) was from 1.29 to 1.60. The results were consistent by sex compared with the control group, although the OR for colorectal cancer in diabetes was little higher in males than females (1.47 vs. 1.41).
Conclusion  Diabetes mellitus is a risk factor of inducing colorectal cancer.

Citation: SHAO Qi,REN Ying,ZHAO Cuichun,WANG Hongping. Relationship between Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2011, 11(5): 518-523. doi: 10.7507/1672-2531.20110093 Copy

  • Previous Article

    Association of Myocardial Enzymes’ Changes with Critical Illness Score in Neonatal Infection
  • Next Article

    Expression and Clinical Significance of Cyclooxygenase-2 in Breast Cancer: A Meta-analysis