Correlation between p53 Codon 72 Polymorphism in Peripheral Blood and Keloid in Chinese Population: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

WU Yan ¹ , LIU Jiali ² , CHEN Jing ¹ , SUN Yan ¹ , LI Yuanhong ¹ , GAO XingHua ¹ ,  CHEN HongDuo ¹

1. Department of Dermatology, the First Hospital of China Medical University, Shenyang 110001, China;2. Department of Oncology, the Fourth Hospital of China Medical University, Shenyang 110001, China;

Corresponding author：

CHEN HongDuo, Email: chenhd@cae.cn

Keywords：

p53; Polymorphism; Keloid; Meta-analysis; Chinese population

DOI：

10.7507/1672-2531.20110115

Video：

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Objective 　To clarify the correlation of p53 codon 72 polymorphism in peripheral blood with keloid susceptibility in Chinese population.
Methods 　All the literatures of case-control research on the correlation between p53 codon 72 polymorphism in peripheral blood and keloid in Chinese population were searched in PubMed, EBSCO, CNKI, CBM, and WanFang Data from their establishment to August 2010. Meta-analyses were performed to detect whether there were differences between the keloid group and the control group about the distribution of genotypes of p53 codon 72 in peripheral blood, such as, Pro/Pro vs. Arg/Arg, Pro/Pro vs. Pro/Arg, and alleles Pro vs. Arg.
Results 　Five studies involving 328 keloid patients and 420 patients in the control group were included. The results of meta-analyses showed that the population having the genotype Pro/Pro presented no increased keloid risk compared to that with the genotypes Arg/Arg (OR=2.17, 95%CI 0.86 to 5.47) or Pro/Arg (OR=1.90, 95%CI 0.92 to 3.93), while the allele Pro showed significant association with increased keloid risk compared to the allele Arg (OR=1.86, 95%CI 1.03 to 3.35).
Conclusion 　The allele Pro of p53 codon 72 in peripheral blood of Chinese population is significantly associated with increased keloid risk.

Citation： WU Yan,LIU Jiali,CHEN Jing,SUN Yan,LI Yuanhong,GAO XingHua,CHEN HongDuo. Correlation between p53 Codon 72 Polymorphism in Peripheral Blood and Keloid in Chinese Population: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2011, 11(6): 651-654. doi: 10.7507/1672-2531.20110115 Copy

1.	1 Atiyeh BS, Costagliola M, Hayek SN. Keloid or hypertrophic scar: the controversy: review of the literature. Ann Plast Surg , 2005, 54(6): 676-680.
2.	2 Menezes HL, Jucá MJ, Gomes EG, et al . Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors. Arq Gastroenterol , 2010, 47(2): 141-147.
3.	3 Thomas M, Kalita A, Labrecque S, et al . Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol Cell Biol , 1999, 19(2): 1092-1100.
4.	11 Sakamuro D, Sabbatini P, White E, et al . The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene , 1997, 15(8): 887-898.
5.	12 Walker KK, Levine AJ. Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc Natl Acad Sci U S A , 1996, 93(26): 15335-15340.
6.	13 Matlashewski GJ, Tuck S, Pim D, et al . Primary structure polymorphism at amino acid residue 72 of human p53. Mol Cell Biol , 1987, 7(2): 961-963.
7.	14 Thomas M, Kalita A, Labrecque S, et al . Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol Cell Biol , 1999, 19(2): 1092-1100.
8.	15 Saed GM, Ladin D, Olson J, et al . Analysis of p53 gene mutations in keloids using polymerase chain reaction-based single-strand conformational polymorphism and DNA sequencing. Arch Dermatol , 1998, 134(8): 963-967.
9.	王春梅, 百束比古, 中泽南堂. 增生性瘢痕和瘢痕疙瘩p53基因多态性的分析.中华整形外科杂志, 2005, 21(1): 32-35.
10.	吕雅丽, 李俊枝, 米明仁, 等. CBS基因多态性与中国人缺血性脑卒中关系的Meta分析. 中国循证医学杂志, 2010, 10(6): 674-677.
11.	卓阳. p53、Fas基因多态性与瘢痕疙瘩的相关性研究及基因检测试剂盒的初步构建. 广州: 第一军医大学, 2005.
12.	靳瑾. 瘢痕疙瘩p53基因检测试剂盒的临床应用与评价. 广州: 南方医科大学, 2007.
13.	刘勇. 中国汉族瘢痕疙瘩致病基因初步连锁分析和相关基因多态性的研究. 沈阳: 中国医科大学, 2007.
14.	卓阳, 高建华, 曾兴业, 等. 瘢痕疙瘩p53 基因检测试剂盒的临床应用. 中国美容医学, 2008, 17(5): 694-696.
15.	刘永波. 瘢痕疙瘩成纤维细胞Fas及P53蛋白凋亡缺陷的相关研究. 广州: 南方医科大学, 2008.
16.	严笠, 吕晓岩, 王春梅, 等. p53基因第72密码子多态性与部分中国人瘢痕疙瘩关系的研究. 中华整形外科杂志, 2007, 23(5): 428-430.

1. 1 Atiyeh BS, Costagliola M, Hayek SN. Keloid or hypertrophic scar: the controversy: review of the literature. Ann Plast Surg , 2005, 54(6): 676-680.
2. 2 Menezes HL, Jucá MJ, Gomes EG, et al . Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors. Arq Gastroenterol , 2010, 47(2): 141-147.
3. 3 Thomas M, Kalita A, Labrecque S, et al . Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol Cell Biol , 1999, 19(2): 1092-1100.
4. 11 Sakamuro D, Sabbatini P, White E, et al . The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene , 1997, 15(8): 887-898.
5. 12 Walker KK, Levine AJ. Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc Natl Acad Sci U S A , 1996, 93(26): 15335-15340.
6. 13 Matlashewski GJ, Tuck S, Pim D, et al . Primary structure polymorphism at amino acid residue 72 of human p53. Mol Cell Biol , 1987, 7(2): 961-963.
7. 14 Thomas M, Kalita A, Labrecque S, et al . Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol Cell Biol , 1999, 19(2): 1092-1100.
8. 15 Saed GM, Ladin D, Olson J, et al . Analysis of p53 gene mutations in keloids using polymerase chain reaction-based single-strand conformational polymorphism and DNA sequencing. Arch Dermatol , 1998, 134(8): 963-967.
9. 王春梅, 百束比古, 中泽南堂. 增生性瘢痕和瘢痕疙瘩p53基因多态性的分析.中华整形外科杂志, 2005, 21(1): 32-35.
10. 吕雅丽, 李俊枝, 米明仁, 等. CBS基因多态性与中国人缺血性脑卒中关系的Meta分析. 中国循证医学杂志, 2010, 10(6): 674-677.
11. 卓阳. p53、Fas基因多态性与瘢痕疙瘩的相关性研究及基因检测试剂盒的初步构建. 广州: 第一军医大学, 2005.
12. 靳瑾. 瘢痕疙瘩p53基因检测试剂盒的临床应用与评价. 广州: 南方医科大学, 2007.
13. 刘勇. 中国汉族瘢痕疙瘩致病基因初步连锁分析和相关基因多态性的研究. 沈阳: 中国医科大学, 2007.
14. 卓阳, 高建华, 曾兴业, 等. 瘢痕疙瘩p53 基因检测试剂盒的临床应用. 中国美容医学, 2008, 17(5): 694-696.
15. 刘永波. 瘢痕疙瘩成纤维细胞Fas及P53蛋白凋亡缺陷的相关研究. 广州: 南方医科大学, 2008.
16. 严笠, 吕晓岩, 王春梅, 等. p53基因第72密码子多态性与部分中国人瘢痕疙瘩关系的研究. 中华整形外科杂志, 2007, 23(5): 428-430.

Chinese Journal of Evidence-Based Medicine

Correlation between p53 Codon 72 Polymorphism in Peripheral Blood and Keloid in Chinese Population: A Meta-analysis

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