ZHANG Lingli , LI Youping 1 , ZHANG Chuan 2 , HUANG Liang 1 , LIANG Yi 1 , HAN Lu 1,3
  • 1. Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu 610041, China;2. Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China2. School of Pharmacy, Sichuan University, Chengdu 610041, China;
LI Youping, Email: yzmylab@hotmail.com
Children; Clinical guideline; Evidence-based guideline
10.7507/1672-2531.20110166
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Objective 　To investigate and analyze the status of clinical guidelines of children in China, so as to regulate the development of children’s evidence-based clinical guidelines and provide recommendations for children’s clinical guidelines.
Methods 　Names of guidelines, year and institution of publication, methodology of development and reference number were descriptively analyzed. Years of publication and diseases of guidelines were analyzed with statistical graphs. AGREE instrument was used to evaluate the evidence-based guidelines of children.
Results 　a) Of 91 clinical guidelines of children, 62 were translations. Of 29 guidelines ourselves, nine were traditional Chinese medicine guidelines and five (17%) were evidence-based guidelines; b) Guideline on Rational Use of Antibiotics in Acute Respiratory Infections (Probation), the first guideline of children, was published in 1999. Guidelines of children was not published until 2005. Then, the number of guidelines was increasing each year and reached a peak in 2008. Of 13 guidelines in 2008, seven were traditional Chinese medicine guidelines. Guidelines on respiratory diseases were 14 ranked as the top; c) Guidelines on congenital deformity and chromosomal abnormalities, tumor, circulatory system disease, blood disease and western guideline on communicable disease were not formulated in China; and d) Average scores on six domain of five evidence-based guidelines were 84.4%, 37.5%, 74.3%, 90.0%, 22.2%, 46.6%, respectively. Guide on Diagnosis and Treatment of Children Aged 0 to 5 with Acute Fever of Unknown Etiology was bly recommended, Guide on Management of Children with Community-Acquired Pneumonia, Evidence-Based Guide on Diagnosis and Treatment of Children with Common Kidney Disease, Guide on Nutrition Support of Newborn, Guide on Diagnosis and Treatment of Children with Chronic Cough were recommended.
Conclusion 　Clinical guidelines of children in China begin late, develop slowly and are lack of update. A standard on development of guidelines is needed. The government should increase the fund of development, implementation and promotion of guidelines. Recommendations for high-quality guidelines should be included in procedure of medical quality assurance. Compliance of guidelines should be provided by organization which formulatesd the guideline, so as to promote the application of high-quality guidelines.

Citation： ZHANG Lingli,LI Youping,ZHANG Chuan,HUANG Liang,LIANG Yi,HAN Lu. Analysis on Status of Clinical Guidelines and Evaluation on Evidence-Based Guidelines of Children in China. Chinese Journal of Evidence-Based Medicine, 2011, 11(9): 991-999. doi: 10.7507/1672-2531.20110166 Copy

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