Manganese Superoxide Dismutase Val-9Ala Polymorphism and Breast Cancer Susceptibility: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

SUN Guogui ¹ ,  WANG Yadi ² , WANG Shijie ³ , ZHENG Mingmin ² , CHENG Yunjie ³ , LI Chenglin ³ , CHAI Hong ⁴

1. Department of Chemoradiotherapy, Tangshan People’s Hospital, Tangshan 063000, China; 2. Department of Radiotherapy, the Military General Hospital of Beijing PLA, Beijing 100700, China;3. Department of Radiotherapy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China; 4. Department of Endocrinology, Tangshan Workers Hospital, Tangshan 063000, China;

Corresponding author：

WANG Yadi, Email: yadi_wang@yahoo.cn

Keywords：

Manganese superoxide dismutase; Breast cancer; Gene polymorphism; Tumor susceptibility; Meta-analysis

DOI：

10.7507/1672-2531.20110172

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Objective 　To explore the association between manganese superoxide dismutase (MnSOD) Val-9Ala polymorphism and breast cancer risk and to investigate the interaction with menopausal status by meta-analysis.
Methods 　Such databases as The Cochrane Libtary (Issue1, 2010), Pubmed, CBM, CNKI and WanFang Data were searched from the date of their establishment to October, 2010, and the case-control studies of MnSOD Val-9Ala polymorphism and breast cancer risk were collected according to the inclusion and exclusion criteria. Then the quality of the included trials was assessed and meta-analysis was performed by RevMan 4.2.10 software.
Results 　A total of 14 studies involving 17 842 patients were included. The results of meta-analyses showed no significant relation between MnSOD Val-9Ala polymorphism and the breast cancer susceptibility (Val/Ala vs. Val/Val: OR=1.04, 95%CI 0.93 to 1.17; Ala/Ala vs. Val/Val: OR=1.12, 95%CI 0.95 to 1.33; Ala/Ala vs. Val/Ala+Val/Val: OR=1.06, 95%CI 0.93 to 1.20; Val/Ala+ Ala/Ala vs. Val/Val: OR=1.06, 95%CI 0.94 to 1.10). However, in the subgroup analysis, the breast cancer risk significantly increased for premenopausal women (Val/Ala+Ala/Ala vs. Val/Val: OR=1.15, 95%CI 1.01 to1.31).
Conclusion 　This meta-analysis suggests that the MnSOD Val-9Ala polymorphism is not significantly associated with the breast cancer susceptibility, but it may increase the risk of breast cancer in the presence of menopausal state.

Citation： SUN Guogui,WANG Yadi,WANG Shijie,ZHENG Mingmin,CHENG Yunjie,LI Chenglin,CHAI Hong. Manganese Superoxide Dismutase Val-9Ala Polymorphism and Breast Cancer Susceptibility: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2011, 11(9): 1027-1032. doi: 10.7507/1672-2531.20110172 Copy

1.	1 Debruin LS, Josephy PD. Perspectives on the chemical etiology of breast cancer. Environ Health Perspect , 2002, 110(suppl1): 119-128.
2.	Knight JA, Onay UV, Wells S, et al . Genetic variants of GPX1 and SOD2 and breast cancer risk at the ontario site of the breast cancer family registry. Cancer Epidemiol Biomarkers Prev , 2004 13(1): 146-149.
3.	Woodson K, Tangrea JA, Lehman TA, et al . Manganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland). Cancer Causes Control , 2003, 14(6): 513-518.
4.	吴晓梅, 时玥, 时景璞, 等. 中国汉族人群脑出血患者血管紧张素转换酶基因插入/缺失多态性的Meta分析. 中国循证医学杂志, 2009, 9(12): 1323-1327.
5.	Ambrosone CB, Freudenheim JL, Thompson PA, et al . Manganese superoxide dismutase (MnSOD) geneticpolymorphisms, dietary antioxidants, and risk of breastcancer. Cancer Res , 1999, 59(3): 602-606.
6.	Mitrunen K, Sillanpaa P, Kataja V, et al . Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk. Carcinogenesis , 2001, 22(5): 827-829.
7.	Egan KM, Thompson PA, Titus-Ernstoff L, et al . MnSOD polymorphism and breast cancer in a population-based case–control study. Cancer Lett , 2003, 199(1): 27-33.
8.	Cai Q, Shu XO, Wen W, et al . Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Breast Cancer Res , 2004, 6(6): 647-655.
9.	Millikan RC, Player J, De Coftret AR, et al . Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites. Breast Cancer Res , 2004, 6(4): 264-274.
10.	Tamimi RM, Hankinson SE, Spiegelman D, et al . Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancer. Cancer Epidemiol Biomarkers Prev , 2004, 13(6): 989-996.
11.	Bergman M, Ahnstrom M, Palmeba CK, et al . Polymorphism in the manganese superoxidedismutase (MnSOD) gene and risk of breast cancer in young women. J Cancer Res Clin Oncol , 2005, 131(7): 439-444.
12.	Cheng TC, Chen ST, Huang CS, et al . Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: A multigenic study on cancer susceptibility. Int J Cancer , 2005, 113(3): 345-353.
13.	Gaudet MM, Gammon MD, Santella RM, et al . MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New York. Cancer Causes Control , 2005, 16(10): 1225-1234.
14.	Kocabas NA, Sardas S, Cholerton S, et al . Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility. Cell Biochem Funct , 2005, 23(1): 73-76.
15.	Slanger TE, Chang-Claude J, Wang-Gohrke S. Manganese superoxide dismutase Ala-9Val polymorphism, environmental modifiers, and risk of breast cancer in a German population. Cancer Causes Control , 2006, 17(8): 1025-1031.
16.	Bica CG. Association of manganese superoxide dismutase gene polymorphism (Ala-9Val) and breastcancer in males and females. J Bras Patol Med Lab , 2007, 43(3): 219-225.
17.	Bica CG. MnSOD Gene polymorphism association with steroid-dependent cancer. Pathol Oncol Res , 2009, 15(1): 19-24.
18.	Eras-Erdogan N, Akbas E, Senli H, et al . Relationship between polymorphism in the manganese superoxide dismutase gene and breast cancer. Mutation Research , 2009, 680(1-2): 7-11.
19.	Trachootham D, Lu W, Ogasawara MA, et al . Redox regulation of cell survival. Antioxid Redox Signal , 2008, 10(8): 1343-1374.
20.	Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol , 2007, 47(N): 143-183.
21.	Sutton A, Khoury H, Prip-Buus C, et al . The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics , 2003, 13(3): 145-157.
22.	Wang LI, Miller DP, Sai Y, et al . Manganese superoxide dismutase alanine- to-valine polymorphism at codon 16 and lung cancer risk. J Natl Cancer Inst , 2001, 93(23): 1818-1821.
23.	程云杰, 王雅棣, 刘青, 等. 超氧化物歧化酶基因的多态性与食管的发生发展关系. 中华肿瘤杂志, 2009, 31(11): 831-835.
24.	Robert CG, Martin MD, Qing L, et al . No apparent association between genetic polymorphisms (–102 C>T) and (–9 T>C) in the human manganese superoxide dismutase gene and gastric cancer. J Surg Res , 2005, 124(1): 92-97.
25.	Lin P, Hsueh YM, Ko JL, et al . Analysis of NQO1, GSTP1, and MnSOD genetic polymorphisms on lung cancer risk in Taiwan. Lung Cancer , 2003, 40(2): 123-129.

1. 1 Debruin LS, Josephy PD. Perspectives on the chemical etiology of breast cancer. Environ Health Perspect , 2002, 110(suppl1): 119-128.
2. Knight JA, Onay UV, Wells S, et al . Genetic variants of GPX1 and SOD2 and breast cancer risk at the ontario site of the breast cancer family registry. Cancer Epidemiol Biomarkers Prev , 2004 13(1): 146-149.
3. Woodson K, Tangrea JA, Lehman TA, et al . Manganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland). Cancer Causes Control , 2003, 14(6): 513-518.
4. 吴晓梅, 时玥, 时景璞, 等. 中国汉族人群脑出血患者血管紧张素转换酶基因插入/缺失多态性的Meta分析. 中国循证医学杂志, 2009, 9(12): 1323-1327.
5. Ambrosone CB, Freudenheim JL, Thompson PA, et al . Manganese superoxide dismutase (MnSOD) geneticpolymorphisms, dietary antioxidants, and risk of breastcancer. Cancer Res , 1999, 59(3): 602-606.
6. Mitrunen K, Sillanpaa P, Kataja V, et al . Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk. Carcinogenesis , 2001, 22(5): 827-829.
7. Egan KM, Thompson PA, Titus-Ernstoff L, et al . MnSOD polymorphism and breast cancer in a population-based case–control study. Cancer Lett , 2003, 199(1): 27-33.
8. Cai Q, Shu XO, Wen W, et al . Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Breast Cancer Res , 2004, 6(6): 647-655.
9. Millikan RC, Player J, De Coftret AR, et al . Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites. Breast Cancer Res , 2004, 6(4): 264-274.
10. Tamimi RM, Hankinson SE, Spiegelman D, et al . Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancer. Cancer Epidemiol Biomarkers Prev , 2004, 13(6): 989-996.
11. Bergman M, Ahnstrom M, Palmeba CK, et al . Polymorphism in the manganese superoxidedismutase (MnSOD) gene and risk of breast cancer in young women. J Cancer Res Clin Oncol , 2005, 131(7): 439-444.
12. Cheng TC, Chen ST, Huang CS, et al . Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: A multigenic study on cancer susceptibility. Int J Cancer , 2005, 113(3): 345-353.
13. Gaudet MM, Gammon MD, Santella RM, et al . MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New York. Cancer Causes Control , 2005, 16(10): 1225-1234.
14. Kocabas NA, Sardas S, Cholerton S, et al . Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility. Cell Biochem Funct , 2005, 23(1): 73-76.
15. Slanger TE, Chang-Claude J, Wang-Gohrke S. Manganese superoxide dismutase Ala-9Val polymorphism, environmental modifiers, and risk of breast cancer in a German population. Cancer Causes Control , 2006, 17(8): 1025-1031.
16. Bica CG. Association of manganese superoxide dismutase gene polymorphism (Ala-9Val) and breastcancer in males and females. J Bras Patol Med Lab , 2007, 43(3): 219-225.
17. Bica CG. MnSOD Gene polymorphism association with steroid-dependent cancer. Pathol Oncol Res , 2009, 15(1): 19-24.
18. Eras-Erdogan N, Akbas E, Senli H, et al . Relationship between polymorphism in the manganese superoxide dismutase gene and breast cancer. Mutation Research , 2009, 680(1-2): 7-11.
19. Trachootham D, Lu W, Ogasawara MA, et al . Redox regulation of cell survival. Antioxid Redox Signal , 2008, 10(8): 1343-1374.
20. Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol , 2007, 47(N): 143-183.
21. Sutton A, Khoury H, Prip-Buus C, et al . The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics , 2003, 13(3): 145-157.
22. Wang LI, Miller DP, Sai Y, et al . Manganese superoxide dismutase alanine- to-valine polymorphism at codon 16 and lung cancer risk. J Natl Cancer Inst , 2001, 93(23): 1818-1821.
23. 程云杰, 王雅棣, 刘青, 等. 超氧化物歧化酶基因的多态性与食管的发生发展关系. 中华肿瘤杂志, 2009, 31(11): 831-835.
24. Robert CG, Martin MD, Qing L, et al . No apparent association between genetic polymorphisms (–102 C>T) and (–9 T>C) in the human manganese superoxide dismutase gene and gastric cancer. J Surg Res , 2005, 124(1): 92-97.
25. Lin P, Hsueh YM, Ko JL, et al . Analysis of NQO1, GSTP1, and MnSOD genetic polymorphisms on lung cancer risk in Taiwan. Lung Cancer , 2003, 40(2): 123-129.

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Manganese Superoxide Dismutase Val-9Ala Polymorphism and Breast Cancer Susceptibility: A Meta-analysis

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