COX-2 Polymorphism and Susceptibility to Esophageal Cancer: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

TANG Weifeng , SUN Bing , GU Haiyong , DING Guowen ,  CHEN Suocheng

Department of Cardiothoracic Surgery, the People’s Hospital of Jiangsu University, Zhenjiang 212000, China;

Corresponding author：

CHEN Suocheng, Email: chensuocheng@sina.com

Keywords：

COX-2; Esophageal cancer; Gene polymorphism; Case-control study; Meta-analysis

DOI：

10.7507/1672-2531.20110236

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To investigate the relationship between cyclooxygenase-2 (COX-2) gene polymorphism and genetic susceptibility to esophageal cancer.
Methods 　The PubMed and EMbase databases were searched from the date of their establishment to January 1st, 2011 to collect the case-control studies on COX-2 polymorphism and susceptibility to esophageal cancer. For the population genotype distributions of both esophagus cancer group and control group, their odds ratios (ORs) and 95% confidence intervals (CIs) were taken as the effect indexes, either the fixed or random effect model was applied to conducted Meta-analysis in homozygote comparison, dominant and recessive genetic models, and the publication bias was assessed then. All statistical analyses were conducted with Stata11.0 software.
Results　 A total of five case-control studies were included. The results of meta-analyses showed for the COX-2-765G gt;C polymorphism, the CC+GC genotype was associated with the risk of esophageal cancer in a dominant genetic model (CC+GC vs. GG: OR=1.806, 95% CI 1.050 to 3.106); for the COX-2-1195G gt;A polymorphism, the AA genotype was associated with the risk of esophageal cancer in homozygote comparison and recessive genetic models, the AA+GA genotype was associated with the risk of esophageal cancer in a dominant genetic model.
Conclusion　 It is suggested that COX-2 polymorphism may be associated with genetic susceptibility to esophageal cancer.

Citation： TANG Weifeng,SUN Bing,GU Haiyong,DING Guowen,CHEN Suocheng. COX-2 Polymorphism and Susceptibility to Esophageal Cancer: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2011, 11(12): 1391-1394. doi: 10.7507/1672-2531.20110236 Copy

1.	Cao Y, Prescott SM. Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J Cell Physiol, 2002, 190(3): 279-286.
2.	Boonyaphiphat P, Thongsuksai P, Sriplung H, et al. Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Lett, 2002, 186(2): 193-199.
3.	Tsujii M, Kawano S, DuBois RN. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci U S A, 1997, 94(7): 3336-3340.
4.	Leahy KM, Koki AT, Masferrer JL. Role of cyclooxygenases in angiogenesis. Curr Med Chem, 2000, 7(11): 1163-1170.
5.	Sivula A, Buskens CJ, van Rees BP, et al. Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. Int J Cancer, 2005, 116(6): 903-908.
6.	Dixon DA. Regulation of COX-2 expression in human cancers. Prog Exp Tumor Res, 2003, 37: 52-71.
7.	Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. Bmj, 1997, 315(7109): 629-634.
8.	Moons LM, Kuipers EJ, Rygiel AM, et al. COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma. Am J Gastroenterol, 2007, 102(11): 2373-2379.
9.	Biramijamal F, Basatvat S, Hossein-Nezhad A, et al. Association of COX-2 promoter polymorphism with gastrointestinal tract cancer in Iran. Biochem Genet, 2010, 48(11-12): 915-923.
10.	Hu HM, Kuo CH, Lee CH, et al. Polymorphism in COX-2 modifies the inverse association between Helicobacter pylori seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study. BMC Gastroenterol, 2009, 9: 37.
11.	Kristinsson JO, van Westerveld P, te Morsche RH, et al. Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma. World J Gastroenterol, 2009, 15(28): 3493-3497.
12.	Upadhyay R, Jain M, Kumar S, et al. Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma. Mutat Res, 2009, 663(1-2): 52-59.
13.	Zhang X, Miao X, Tan W, et al. Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. Gastroenterology, 2005, 129(2): 565-576.
14.	Guo SW, Thompson EA. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics, 1992, 48(2): 361-372.
15.	Kiritoshi S, Nishikawa T, Sonoda K, et al. Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy. Diabetes, 2003, 52(10): 2570-2577.
16.	Li M, Gao Y, Li C, et al. Association of COX2 functional polymorphisms and the risk of vitiligo in Chinese populations. J Dermatol Sci, 2009, 53(3): 176-181.

1. Cao Y, Prescott SM. Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J Cell Physiol, 2002, 190(3): 279-286.
2. Boonyaphiphat P, Thongsuksai P, Sriplung H, et al. Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Lett, 2002, 186(2): 193-199.
3. Tsujii M, Kawano S, DuBois RN. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci U S A, 1997, 94(7): 3336-3340.
4. Leahy KM, Koki AT, Masferrer JL. Role of cyclooxygenases in angiogenesis. Curr Med Chem, 2000, 7(11): 1163-1170.
5. Sivula A, Buskens CJ, van Rees BP, et al. Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. Int J Cancer, 2005, 116(6): 903-908.
6. Dixon DA. Regulation of COX-2 expression in human cancers. Prog Exp Tumor Res, 2003, 37: 52-71.
7. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. Bmj, 1997, 315(7109): 629-634.
8. Moons LM, Kuipers EJ, Rygiel AM, et al. COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma. Am J Gastroenterol, 2007, 102(11): 2373-2379.
9. Biramijamal F, Basatvat S, Hossein-Nezhad A, et al. Association of COX-2 promoter polymorphism with gastrointestinal tract cancer in Iran. Biochem Genet, 2010, 48(11-12): 915-923.
10. Hu HM, Kuo CH, Lee CH, et al. Polymorphism in COX-2 modifies the inverse association between Helicobacter pylori seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study. BMC Gastroenterol, 2009, 9: 37.
11. Kristinsson JO, van Westerveld P, te Morsche RH, et al. Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma. World J Gastroenterol, 2009, 15(28): 3493-3497.
12. Upadhyay R, Jain M, Kumar S, et al. Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma. Mutat Res, 2009, 663(1-2): 52-59.
13. Zhang X, Miao X, Tan W, et al. Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. Gastroenterology, 2005, 129(2): 565-576.
14. Guo SW, Thompson EA. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics, 1992, 48(2): 361-372.
15. Kiritoshi S, Nishikawa T, Sonoda K, et al. Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy. Diabetes, 2003, 52(10): 2570-2577.
16. Li M, Gao Y, Li C, et al. Association of COX2 functional polymorphisms and the risk of vitiligo in Chinese populations. J Dermatol Sci, 2009, 53(3): 176-181.

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COX-2 Polymorphism and Susceptibility to Esophageal Cancer: A Meta-analysis

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