• Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China;
YI Zhanmiao, Email: zhanmiao.yi@gmail.com
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Objective  To introduce the evidence-based evaluation on off-label uses at home and abroad, so as to investigate a systematic method of evidence-based evaluation on off-label uses.
Methods  In combination with the domestic and international research literature, a systematic method of evidence-based evaluation on off-label uses was discussed from the following three aspects: sources of evidence, levels of evidence, and recommendation strength.
Results  Sources of evidence included Clinical Pharmacology, DRUGDEX? System, NCCN Drugs  amp; Biologics Compendium and handsearched literature. Levels of evidence and recommendation strength could refer to the 2009 grade system of Oxford Centre for Evidence-Based Medicine, and the strength of recommendations and scientific support of DRUGDEX? System.
Conclusion  A systematic method of evidence-based evaluation on off-label uses is initially established.

Citation: YI Zhanmiao,LIU Fang,ZHAI Suodi. Method of Evidence-Based Evaluation on Off-label Uses. Chinese Journal of Evidence-Based Medicine, 2011, 11(12): 1464-1467. doi: 10.7507/1672-2531.20110247 Copy

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