Objective To analyze the effectiveness of conservative medical treatments for ectopic pregnancy (EP): methotrexate (MTX) + mifepristone + Ectopic Pregnancy II decoction (EP-II) vs. methotrexate + mifepristone.
Methods A total of 95 patients with EP in Shenzhen Shajing Affiliated Hospital of Guangzhou Medical University from January 2009 to January 2011 were randomly divided into two groups: 45 patients in the experimental group were treated with MTX, mifepristone and EP II decoction, while the other 50 patients in the control group were treated with MTX and mifepristone. The effectiveness of the two groups was analyzed with SPSS 13.0 software.
Results There were significant differences in the time of serum β-HCG return to normal (16.13±8.13 ds vs. 22.05±7.15 ds, P lt;0.05), time of EP mass absorption (30.46±7.56 ds vs. 39.99±18.26 ds, P lt;0.05) and tubal patency rate (80% vs. 75%, P lt;0.05) between the two groups. But there were no significant differences in effective rate (95.56%, 43/45 vs. 94%, 47/50, χ2=0.0809, P gt;0.05) and side effects.
Conclusion The combination of methotrexate, mifepristone and EP II decoction for ectopic pregnancy is more effective than mifepristone and methotrexate in coordinately killing the embryo, shortening the time of serum β-HCG return to normal and the time of EP mass absorption, and improving the function of oviducts.
Citation： PEI Haiying,ZHANG Dawei,WU Qinlan,XIAO Gaoxiu,WANG Yanping,ZHANG Jinfeng. Ectopic Pregnance II Decoction Combined with Methotrexate and Mifepristone for Ectopic Pregnancy: A Randomized Controlled Trial. Chinese Journal of Evidence-Based Medicine, 2012, 12(2): 168-172. doi: 10.7507/1672-2531.20120028 Copy