Soy Foods Intake in Adolescence and the Risk of Breast Cancer: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

ZHAO Yang ¹ , PAN Jianhong ² ,  ZHANG Lili ¹

1. Nursing School of Southern Medical University, Guangzhou 510515, China;2. Department of Biostatistics, Public Health and Tropical Medicine School of Southern Medical University, Guangzhou 510515, China;

Corresponding author：

ZHANG Lili, Email: zhll@fimmu.com

Keywords：

Adolescence; Soy food; Breast cancer; Meta-analysis; Systematic review

DOI：

10.7507/1672-2531.20120089

Video：

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Objective 　To assess the influence of soy foods intake in Adolescence on the female adult’s breast cancer.
Methods 　Literatures about the influence of soy foods intake in Adolescence on the female adult’s breast cancer were retrieved in The Cochrane Library, MEDLINE, EMbase, CNKI, VIP, WanFang Data and CBM from the date of their establishment to August 2011, meanwhile, the references of included papers were also retrieved. The data were extracted according to the inclusion and exclusion criteria by two reviewers independently, the quality of the included studies was assessed according to the Cochrane Newcastle-Ottawa scale and GRAEDprofiler 3.2.2, and meta-analysis was conducted by using Stata 11.0.
Results 　A total of 6 studies involving 6 609 patients and 79 538 controls were included. The results of meta-analyses showed that compared with the non-intake or low intake of soy foods in Adolescence, high soy foods intake in Adolescence was associated with lower risk of breast cancer (OR=0.816, 95%CI 0.670 to 0.993); In the subgroup analysis, soy foods intake in Adolescence was more effective to prevent premenopausal (OR=0.661, 95%CI 0.550 to 0.796) rather than post-menopausal (OR=0.782, 95%CI 0.486 to 1.259) breast cancer; and the effects of soy foods intake in Adolescence were not significantly different between the eastern (OR=0.793, 95%CI 0.569 to 1.105) and western (OR=0.837, 95%CI 0.743 to 0.943) women.
Conclusion 　Soy foods intake in Adolescence may be associated with a small reduction in the risk of adults’ breast cancer, especially for the premenopausal women, though there is no difference between the eastern and western women. However, restricted by quantity and quality of the studies, this conclusion should be confirmed by more studies.

Citation： ZHAO Yang,PAN Jianhong,ZHANG Lili. Soy Foods Intake in Adolescence and the Risk of Breast Cancer: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2012, 12(5): 550-556. doi: 10.7507/1672-2531.20120089 Copy

1.	Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 2006, 24(14): 2137.
2.	Ziegler RG, Hoover RN, Pike MC, et al. Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer I, 1993, 85(22): 1819.
3.	McPherson K, Steel CM, Dixon JM. Breast cancer—epidemiology, risk factors, and genetics. BMJ, 2000, 321(7261): 624.
4.	Hunter DJ, Spiegelman D, Adami HO, et al. Cohort studies of fat intake and the risk of breast cancer—a pooled analysis. New Engl J Med, 1996, 334(6): 356-361.
5.	Messina M, Barnes S. The role of soy products in reducing risk of cancer. J Natl Cancer I, 1991, 83(8): 541.
6.	Trock BJ, Hilakivi-Clarke L, Clarke R. Meta-analysis of soy intake and breast cancer risk. J Natl Cancer Inst, 2006, 98(7): 459-471.
7.	Wu AH, Yu MC, Tseng CC, et al. Epidemiology of soy exposures and breast cancer risk. Brit J Cancer, 2008, 98(1): 9-14.
8.	Dong JY, Qin LQ. Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat, 2011, 125(2): 315-323.
9.	Hooper L, Ryder JJ, Kurzer MS, et al. Effects of soy protein and isoflavones on circulating hormone concentrations in pre-and post-menopausal women: a systematic review and meta-analysis. Hum Reprod Update, 2009, 15(4): 423.
10.	Schedin PJ, Byers T. Adolescent diet and the risk of breast cancer in adulthood: A role for vitamin A? Nutrition, 1997, 13(10): 924-925.
11.	Tyczynski J, Tarkowski W, Parkin DM, et al. Cancer mortality among Polish migrants to Australia. Eur J Cancer, 1994, 30(4): 478-484.
12.	Hilakivi-Clarke L, Onojafe I, et al. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis. Brit J Cancer, 1999, 80(11): 1682-1688.
13.	Murrill WB, Brown NM, Zhang JX, et al. Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis, 1996, 17(7): 1451-1457.
14.	Potischman N, Weiss HA, Swanson CA, et al. Diet during adolescence and risk of breast cancer among young women. J Natl Cancer I, 1998, 90(3): 226-233.
15.	Shu XO, Jin F, Dai Q, et al. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer epidemiology, biomarkers & prevention, 2001, 10(5): 483-488.
16.	Wu AH, Wan P, Hankin J, et al. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis, 2002, 23(9): 1491-1496.
17.	Thanos J, Cotterchio M, Boucher BA, et al. Adolescent dietary phytoestrogen intake and breast cancer risk (Canada). Cancer Causes Control, 2006 , 17(10): 1253-1261.
18.	Korde LA, Wu AH, Fears T, et al. Childhood soy intake and breast cancer risk in Asian American women. Cancer Epidemiol Biomarkers Prev, 2009 , 18(4): 1050-1059.
19.	Lee SA, Shu XO, Li HL, et al. Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women’s Health Study. Am J Clin Nutr, 2009, 89(6): 1920-1926.
20.	Atkins D, Best D, Briss PA. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328(7454): 1490.
21.	Lu LJ, Anderson KE, Grady JJ, et al. Effects of soya consumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction. Cancer Epidem Biomar, 1996, 5(1): 63.

1. Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 2006, 24(14): 2137.
2. Ziegler RG, Hoover RN, Pike MC, et al. Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer I, 1993, 85(22): 1819.
3. McPherson K, Steel CM, Dixon JM. Breast cancer—epidemiology, risk factors, and genetics. BMJ, 2000, 321(7261): 624.
4. Hunter DJ, Spiegelman D, Adami HO, et al. Cohort studies of fat intake and the risk of breast cancer—a pooled analysis. New Engl J Med, 1996, 334(6): 356-361.
5. Messina M, Barnes S. The role of soy products in reducing risk of cancer. J Natl Cancer I, 1991, 83(8): 541.
6. Trock BJ, Hilakivi-Clarke L, Clarke R. Meta-analysis of soy intake and breast cancer risk. J Natl Cancer Inst, 2006, 98(7): 459-471.
7. Wu AH, Yu MC, Tseng CC, et al. Epidemiology of soy exposures and breast cancer risk. Brit J Cancer, 2008, 98(1): 9-14.
8. Dong JY, Qin LQ. Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat, 2011, 125(2): 315-323.
9. Hooper L, Ryder JJ, Kurzer MS, et al. Effects of soy protein and isoflavones on circulating hormone concentrations in pre-and post-menopausal women: a systematic review and meta-analysis. Hum Reprod Update, 2009, 15(4): 423.
10. Schedin PJ, Byers T. Adolescent diet and the risk of breast cancer in adulthood: A role for vitamin A? Nutrition, 1997, 13(10): 924-925.
11. Tyczynski J, Tarkowski W, Parkin DM, et al. Cancer mortality among Polish migrants to Australia. Eur J Cancer, 1994, 30(4): 478-484.
12. Hilakivi-Clarke L, Onojafe I, et al. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis. Brit J Cancer, 1999, 80(11): 1682-1688.
13. Murrill WB, Brown NM, Zhang JX, et al. Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis, 1996, 17(7): 1451-1457.
14. Potischman N, Weiss HA, Swanson CA, et al. Diet during adolescence and risk of breast cancer among young women. J Natl Cancer I, 1998, 90(3): 226-233.
15. Shu XO, Jin F, Dai Q, et al. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer epidemiology, biomarkers & prevention, 2001, 10(5): 483-488.
16. Wu AH, Wan P, Hankin J, et al. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis, 2002, 23(9): 1491-1496.
17. Thanos J, Cotterchio M, Boucher BA, et al. Adolescent dietary phytoestrogen intake and breast cancer risk (Canada). Cancer Causes Control, 2006 , 17(10): 1253-1261.
18. Korde LA, Wu AH, Fears T, et al. Childhood soy intake and breast cancer risk in Asian American women. Cancer Epidemiol Biomarkers Prev, 2009 , 18(4): 1050-1059.
19. Lee SA, Shu XO, Li HL, et al. Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women’s Health Study. Am J Clin Nutr, 2009, 89(6): 1920-1926.
20. Atkins D, Best D, Briss PA. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328(7454): 1490.
21. Lu LJ, Anderson KE, Grady JJ, et al. Effects of soya consumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction. Cancer Epidem Biomar, 1996, 5(1): 63.

Chinese Journal of Evidence-Based Medicine

Soy Foods Intake in Adolescence and the Risk of Breast Cancer: A Systematic Review

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