Diagnosis of Rheumatoid Arthritis by Antifilaggrin Autoantibodies: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Zehao ^1,2 , YI Kang ^1,2 , YANG Rui ³ , TIAN Jinhui ¹ ,  YANG Kehu ¹

1. Evidence-Based Medicine Center, School of Basic Medical Science, Lanzhou University, Lanzhou 730000, China;2. The First Hospital of Lanzhou University, Lanzhou 730000, China;3. The Second People’ s Hospital of Gansu Province, Lanzhou 730000, China;

Corresponding author：

YANG Kehu, Email: Yangkh2006@163.com

Keywords：

Antifilaggrin autoantibodies; Rheumatoid arthritis; Diagnostic study; Meta-analysis

DOI：

10.7507/1672-2531.20120168

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To evaluate diagnostic value of antifilaggrin autoantibodies (AFA) for rheumatoid arthritis (RA).
Methods 　A systematic, comprehensive literature search was conducted in PubMed (1966 to 2010.8), The Cochrane Library (issue 8, 2010), EMbase (1974 to 2010.8), CBM (1978 to 2010.8), CNKI (1994 to 2010.8), VIP (1989 to 2010.8) and Chinese Medical Association of Digital Periodicals (1997 to 2010.8). The diagnosis studies on AFA versus the standards of American College of Rheumatology for RA were included. QUADAS items were used to evaluate the quality of the included studies. Meta-disc software (version 1.4) was used to analyze data. Sensitivity (SEN), specificity (SPE), positive likelihood ratio (+LR), negative likelihood ratio (–LR) and summary receiver operating characteristic curve (SROC) were calculated to assess the diagnostic value of individual diagnostic tests.
Results 　A total of 18 articles were included, involving 6 971 cases of subjects from 7 countries. Results of meta-analysis showed that, compared with the standards of American College of Rheumatology, pooled SEN, SPE, +LR, –LR, and SROC curve of AFA were 0.52 (0.50, 0.54), 0.93 (0.92, 0.94), 7.11 (5.35, 9.45), 0.53 (0.48, 0.60), 13.82 (9.93, 19.24), and 0.834 7, respectively.
Conclusion 　IBT, ELISA detection of AFA are of high efficiency in the diagnosis of RA. However, the antigen from human breast skin is not conducive to clinical application.

Citation： WANG Zehao,YI Kang,YANG Rui,TIAN Jinhui,YANG Kehu. Diagnosis of Rheumatoid Arthritis by Antifilaggrin Autoantibodies: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2012, 12(9): 1076-1082. doi: 10.7507/1672-2531.20120168 Copy

1.	Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet, 2010, 76(9746): 1094-1108.
2.	Machold KP. Prevention and cure of rheumatoid arthritis: is it possible?. Best Pract Res Clin Rheumatol, 2010, 24(3): 353-361.
3.	Puszczewicz M, Iwaszkiewicz C. Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch Med Sci, 2011, 7(2): 189-194.
4.	Choi SW, Lim MK, Shin DH, et al. Diagnostic performances of anti-cyclic citrullinated peptides antibody and antifilaggrin antibody in Korean patients with rheumatoid arthritis. J Korean Med Sci, 2005, 20(3): 473-478.
5.	Simon M, Girbal E, Sebbag M, et al. The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis. J Clin Invest, 1993, 92(3): 1387-1393.
6.	Suzuki K, Sawada T, Murakami A, et al. High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis. Scand J Rheumatol, 2003, 32(4): 197-204.
7.	Battaglia M, Bucher H, Egger M, et al. The Bayes Library of Diagnostic Studies and Reviews. 2nd edition, 2002.
8.	Whiting P, Rutjes AW, Reitsma JB, et al. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 3: 25.
9.	Vincent C, de Keyser F, Masson-Bessière C, et al. Anti-perinuclear factor compared with the so called "antikeratin" antibodies and antibodies to human epidermis filaggrin, in the diagnosis of arthritides. Ann Rheum Dis, 1999, 58(1): 42-48.
10.	Bas S, Perneger TV, Mikhnevitch E, et al. Association of rheumatoid factors and anti-filaggrin antibodies with severity of erosions in rheumatoid arthritis. Rheumatology (Oxford), 2000, 39(10): 1082-1088.
11.	Choi SW, Lim MK, Shin DH, et al. Diagnostic performances of anti-cyclic citrullinated peptides antibody and antifilaggrin antibody in Korean patients with rheumatoid arthritis. J Korean Med Sci, 2005, 20(3): 473-478.
12.	Dubucquoi S, Solau-Gervais E, Lefranc D, et al. Evaluation of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic diseases. Ann Rheum Dis, 2004, 63(4): 415-419.
13.	Suzuki K, Sawada T, Murakami A, et al. High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis. Scand J Rheumatol, 2003, 32(4): 197-204.
14.	Nogueira L, Sebbag M, Vincent C, et al. Performance of two ELISAs for antifilaggrin autoantibodies, using either affinity purified or deiminated recombinant human filaggrin, in the diagnosis of rheumatoid arthritis. Ann Rheum Dis, 2001, 60(9): 882-887.
15.	Goldbach-Mansky R, Lee J, McCoy A, et al. Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res, 2000, 2(3): 236-243.
16.	Aho K, Palosuo T, Lukka M, et al. Antifilaggrin antibodies in recent-onset arthritis. Scand J Rheumatol, 1999, 28(2): 113-116.
17.	Ferraro-Peyret C, Tebib J, Desbos A, et al. Improvement in diagnosis of rheumatoid arthritis using dual indirect immunofluorescence and immunoblotting assays for antifilaggrin autoantibodies: a retrospective 3 year study. J Rheumatol, 2002, 29(2): 276-281.
18.	张莉芸, 李小峰, 胡学芳, 等. 间接免疫荧光法和免疫印迹法联合检测抗聚角蛋白微丝蛋白抗体对类风湿关节炎的诊断价值. 中华风湿病学杂志, 2004, 8(6): 338-341.
19.	艾脉兴, 冷晓梅, 曾小峰. 检测抗聚丝蛋白抗体在类风湿关节炎诊断中的意义. 基础医学与临床, 2007, 27(9): 1052-1056.
20.	李守勇, 张婷兰. 抗RA54抗体、抗CCP抗体、APF、AFA和RF联合检测诊断类风湿性关节炎的临床价值. 山东医药, 2005, 45(5): 25-25.
21.	刘斌, 曾庆馀. 抗纤聚蛋白抗体检测及其在类风湿关节炎中的意义. 中华风湿病学杂志, 2002, 6(6): 429-432.
22.	张丽卿, 李小峰, 胡学芳, 等. 类风湿关节炎中抗纤聚蛋白抗体意义的探讨. 中华风湿病学杂志, 2006, 10(4): 219-223.
23.	肖镇, 白丽杰, 秦毅强. AFA、抗CCP抗体RF对类风湿关节炎诊断及病情评估的意义. 内蒙古医学院学报, 2005, 27(4): 265-270,278.
24.	张蜀澜, 李永哲, 佟大伟. 抗丝集蛋白抗体谱检测在类风湿性关节炎诊断中的临床意义. 中国医学检验杂志, 2005, 6(3): 177-179.
25.	曹金, 李小峰, 胡学芳, 等. 抗聚角蛋白微丝蛋白抗体在早期类风湿关节炎中的意义. 中华风湿病学杂志, 2005, 9(5): 294-297.
26.	曾小峰, 张丽君. 抗聚角蛋白微丝蛋白抗体的检测在类风湿关节炎诊断中的意义. 中华风湿病学杂志, 2002, 6(3): 157-160.
27.	刘斌. 纤聚蛋白与类风湿性关节炎, 现代诊断与治疗, 2003, 14(5): 294-296.
28.	Forslind K, Vincent C, Serre G, et al. Antifilaggrin autoantibodies in early rheumatoid arthritis. Scand J Rheumatol, 2000, 29(5): 320-322.
29.	赵超, 王雪. 类风湿因子定量检测在类风湿关节炎诊治中的应用. 实用医技杂志, 2005, 12(5): 1345.
30.	Dubucquoi S, Solau-Gervais E, Lefranc D, et al. Evaluation of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic disease. Ann Rheum Dis, 2004, 63(4): 415-419.
31.	Tackmann R, Schuetz G, Hamm B, et al. Quality of the reporting of diagnostic accuracy studies: STARD (Standards for the Reporting of Diagnostic accuracy studies). Rofo, 2010, 182(8): 655-659.

1. Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet, 2010, 76(9746): 1094-1108.
2. Machold KP. Prevention and cure of rheumatoid arthritis: is it possible?. Best Pract Res Clin Rheumatol, 2010, 24(3): 353-361.
3. Puszczewicz M, Iwaszkiewicz C. Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch Med Sci, 2011, 7(2): 189-194.
4. Choi SW, Lim MK, Shin DH, et al. Diagnostic performances of anti-cyclic citrullinated peptides antibody and antifilaggrin antibody in Korean patients with rheumatoid arthritis. J Korean Med Sci, 2005, 20(3): 473-478.
5. Simon M, Girbal E, Sebbag M, et al. The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis. J Clin Invest, 1993, 92(3): 1387-1393.
6. Suzuki K, Sawada T, Murakami A, et al. High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis. Scand J Rheumatol, 2003, 32(4): 197-204.
7. Battaglia M, Bucher H, Egger M, et al. The Bayes Library of Diagnostic Studies and Reviews. 2nd edition, 2002.
8. Whiting P, Rutjes AW, Reitsma JB, et al. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 3: 25.
9. Vincent C, de Keyser F, Masson-Bessière C, et al. Anti-perinuclear factor compared with the so called "antikeratin" antibodies and antibodies to human epidermis filaggrin, in the diagnosis of arthritides. Ann Rheum Dis, 1999, 58(1): 42-48.
10. Bas S, Perneger TV, Mikhnevitch E, et al. Association of rheumatoid factors and anti-filaggrin antibodies with severity of erosions in rheumatoid arthritis. Rheumatology (Oxford), 2000, 39(10): 1082-1088.
11. Choi SW, Lim MK, Shin DH, et al. Diagnostic performances of anti-cyclic citrullinated peptides antibody and antifilaggrin antibody in Korean patients with rheumatoid arthritis. J Korean Med Sci, 2005, 20(3): 473-478.
12. Dubucquoi S, Solau-Gervais E, Lefranc D, et al. Evaluation of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic diseases. Ann Rheum Dis, 2004, 63(4): 415-419.
13. Suzuki K, Sawada T, Murakami A, et al. High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis. Scand J Rheumatol, 2003, 32(4): 197-204.
14. Nogueira L, Sebbag M, Vincent C, et al. Performance of two ELISAs for antifilaggrin autoantibodies, using either affinity purified or deiminated recombinant human filaggrin, in the diagnosis of rheumatoid arthritis. Ann Rheum Dis, 2001, 60(9): 882-887.
15. Goldbach-Mansky R, Lee J, McCoy A, et al. Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res, 2000, 2(3): 236-243.
16. Aho K, Palosuo T, Lukka M, et al. Antifilaggrin antibodies in recent-onset arthritis. Scand J Rheumatol, 1999, 28(2): 113-116.
17. Ferraro-Peyret C, Tebib J, Desbos A, et al. Improvement in diagnosis of rheumatoid arthritis using dual indirect immunofluorescence and immunoblotting assays for antifilaggrin autoantibodies: a retrospective 3 year study. J Rheumatol, 2002, 29(2): 276-281.
18. 张莉芸, 李小峰, 胡学芳, 等. 间接免疫荧光法和免疫印迹法联合检测抗聚角蛋白微丝蛋白抗体对类风湿关节炎的诊断价值. 中华风湿病学杂志, 2004, 8(6): 338-341.
19. 艾脉兴, 冷晓梅, 曾小峰. 检测抗聚丝蛋白抗体在类风湿关节炎诊断中的意义. 基础医学与临床, 2007, 27(9): 1052-1056.
20. 李守勇, 张婷兰. 抗RA54抗体、抗CCP抗体、APF、AFA和RF联合检测诊断类风湿性关节炎的临床价值. 山东医药, 2005, 45(5): 25-25.
21. 刘斌, 曾庆馀. 抗纤聚蛋白抗体检测及其在类风湿关节炎中的意义. 中华风湿病学杂志, 2002, 6(6): 429-432.
22. 张丽卿, 李小峰, 胡学芳, 等. 类风湿关节炎中抗纤聚蛋白抗体意义的探讨. 中华风湿病学杂志, 2006, 10(4): 219-223.
23. 肖镇, 白丽杰, 秦毅强. AFA、抗CCP抗体RF对类风湿关节炎诊断及病情评估的意义. 内蒙古医学院学报, 2005, 27(4): 265-270,278.
24. 张蜀澜, 李永哲, 佟大伟. 抗丝集蛋白抗体谱检测在类风湿性关节炎诊断中的临床意义. 中国医学检验杂志, 2005, 6(3): 177-179.
25. 曹金, 李小峰, 胡学芳, 等. 抗聚角蛋白微丝蛋白抗体在早期类风湿关节炎中的意义. 中华风湿病学杂志, 2005, 9(5): 294-297.
26. 曾小峰, 张丽君. 抗聚角蛋白微丝蛋白抗体的检测在类风湿关节炎诊断中的意义. 中华风湿病学杂志, 2002, 6(3): 157-160.
27. 刘斌. 纤聚蛋白与类风湿性关节炎, 现代诊断与治疗, 2003, 14(5): 294-296.
28. Forslind K, Vincent C, Serre G, et al. Antifilaggrin autoantibodies in early rheumatoid arthritis. Scand J Rheumatol, 2000, 29(5): 320-322.
29. 赵超, 王雪. 类风湿因子定量检测在类风湿关节炎诊治中的应用. 实用医技杂志, 2005, 12(5): 1345.
30. Dubucquoi S, Solau-Gervais E, Lefranc D, et al. Evaluation of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic disease. Ann Rheum Dis, 2004, 63(4): 415-419.
31. Tackmann R, Schuetz G, Hamm B, et al. Quality of the reporting of diagnostic accuracy studies: STARD (Standards for the Reporting of Diagnostic accuracy studies). Rofo, 2010, 182(8): 655-659.

Chinese Journal of Evidence-Based Medicine

Diagnosis of Rheumatoid Arthritis by Antifilaggrin Autoantibodies: A Meta-Analysis

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