Application of Metafor Package in R Software_Chinese Journal of Evidence-Based Medicine

Authors：

DONG Shengjie ¹ , ZENG Xiantao ² ,  GUO Yi ^3,4

1. Department of Orthopaedic, The First Affiliated Hospital of Soochow University, Suzhou 215006, China;2. Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China;3. Department of Epidemiology, School of Public Health, Wuhan University, Wuhan 430071, China;4. State Key Laboratory of Virology, Wuhan University, Wuhan 430071, China;

Corresponding author：

GUO Yi, Email: guoyi@whu.edu.cn

Keywords：

R software; Metafor package; Meta-analysis

DOI：

10.7507/1672-2531.20120178

Video：

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R software is a free and powerful statistical tool, including Metafor, Meta as well as Rmeta packages, all of which could conduct meta-analysis. Metafor package provides functions for meta-analyses which include analysis of continuous and categorical data, meta-regression, cumulative meta-analysis as well as test for funnel plot asymmetry. The package can also draw various plots, such as forest plot, funnel plot, radial plot and so forth. Mixed-effects models (involving single or multiple categorical and/or continuous moderates) can only be fitted with Metafor packages. Advanced methods for testing model coefficients and confidence intervals are also implemented only in this package. This article introduces detailed operation steps of Metafor package for meta-analysis using cases.

Citation： DONG Shengjie,ZENG Xiantao,GUO Yi. Application of Metafor Package in R Software. Chinese Journal of Evidence-Based Medicine, 2012, 12(9): 1141-1147. doi: 10.7507/1672-2531.20120178 Copy

1.	曾宪涛, 冷卫东, 郭毅, 等. Meta分析系列之一: Meta分析的类型. 中国循证心血管医学杂志, 2012, 4(1): 3-5.
2.	蒋文瀚, 陈炳为, 郑建光, 等. R语言meta包在Meta分析中的应用. 循证医学, 2011, 11(5): 305-309.
3.	Colditz GA, Brewer TF, Berkey CS, et al. Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. JAMA, 1994, 271(9): 698-702.
4.	Knapp G, Hartung J. Improved tests for a random effects meta-regression with a single covariate. Stat Med, 2003, 22(17): 2693-2710.
5.	Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
6.	Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
7.	Mielke PW, Berry KJ. Permutation methods: a distance function approach (2nd. edition). Springer-Verlag, New York, Inc, 2007.
8.	Follmann DA, Proschan MA. Valid inference in random effects meta-analysis. Biometrics, 1999, 55(3): 732-737.
9.	曾宪涛, Joey S.W. Kwong, 田国祥, 等. Meta分析系列之二: Meta分析的软件. 中国循证心血管医学杂志, 2012, 4(2): 89-91.
10.	曾宪涛, 冷卫东, 李胜, 等. 如何正确理解及使用GRADE系统. 中国循证医学杂志, 2011, 11(9): 985-990.
11.	曾宪涛, 田国祥, 牛玉明, 等. GRADEprofiler软件的使用简介. 中国循证心血管医学杂志, 2011, 3(5): 390-392.

1. 曾宪涛, 冷卫东, 郭毅, 等. Meta分析系列之一: Meta分析的类型. 中国循证心血管医学杂志, 2012, 4(1): 3-5.
2. 蒋文瀚, 陈炳为, 郑建光, 等. R语言meta包在Meta分析中的应用. 循证医学, 2011, 11(5): 305-309.
3. Colditz GA, Brewer TF, Berkey CS, et al. Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. JAMA, 1994, 271(9): 698-702.
4. Knapp G, Hartung J. Improved tests for a random effects meta-regression with a single covariate. Stat Med, 2003, 22(17): 2693-2710.
5. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
6. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
7. Mielke PW, Berry KJ. Permutation methods: a distance function approach (2nd. edition). Springer-Verlag, New York, Inc, 2007.
8. Follmann DA, Proschan MA. Valid inference in random effects meta-analysis. Biometrics, 1999, 55(3): 732-737.
9. 曾宪涛, Joey S.W. Kwong, 田国祥, 等. Meta分析系列之二: Meta分析的软件. 中国循证心血管医学杂志, 2012, 4(2): 89-91.
10. 曾宪涛, 冷卫东, 李胜, 等. 如何正确理解及使用GRADE系统. 中国循证医学杂志, 2011, 11(9): 985-990.
11. 曾宪涛, 田国祥, 牛玉明, 等. GRADEprofiler软件的使用简介. 中国循证心血管医学杂志, 2011, 3(5): 390-392.

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