Influence of Alcohol Intervention on the Outcome of Rats and Mice with Ischemic Stroke: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

QI Guangwei ¹ , ZHENG Jia ² ,  ZHAO Ruibo ¹

1. Department of Pathology, Basic Medical Science College, Harbin Medical University. Harbin 150081, China;2. Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin 150081, China;

Corresponding author：

ZHAO Ruibo, Email: zhaoruib@sohu.com

Keywords：

Alcohol; Ischemic stroke; Cerebral ischemia; Systematic review; Meta-analysis; Animal experiment

DOI：

10.7507/1672-2531.20130035

Video：

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Objective 　To systematically evaluate the influence of alcohol intervention on the outcome of rats and mice with ischemic stroke.
Methods 　Databases including PubMed, EMbase, BIOSIS and CNKI were electronically searched from establishment dates of databases to June 2012 to retrieve animal experiments on the influence of alcohol intervention on the outcome of rats and mice with ischemic stroke. The relevant studies were identified according to the predefined inclusion and exclusion criteria, the data were extracted, and the quality was evaluated. Then meta-analysis was performed using RevMan 5.1 software.
Results 　Eight studies were included. The results of meta-analysis showed that no significant difference was found between the alcohol intervention group and the control group (MD=−6.98%, 95%CI −20.38% to 6.43%, P=0.31). However, compared with the control group, low dose of acute alcohol intervention (less than 2 g/kg) improved the prognosis of ischemic stroke with a significant difference (MD=−22.83%, 95%CI −38.77% to −6.89%, P=0.005), and highly-concentrated of chronic alcohol intervention worsened the cerebral ischemic damage of rats and mice with a significant difference (MD=24.06%, 95%CI 10.54% to 37.58%, P=0.000 5).
Conclusion 　Low dose of acute alcohol intervention (less than 2 g/kg) could improve the prognosis of rats and mice with ischemic stroke which has the potential neuro-protective effects. However, highly-concentrated chronic alcohol intervention could worsen the cerebral ischemic damage. Due to the limitations of the included studies such as publication bias, the influence of alcohol intervention on the outcome of rats and mice with ischemic stroke could be overestimated.

Citation： QI Guangwei,ZHENG Jia,ZHAO Ruibo. Influence of Alcohol Intervention on the Outcome of Rats and Mice with Ischemic Stroke: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2013, 13(2): 204-209. doi: 10.7507/1672-2531.20130035 Copy

1.	Patra J, Taylor B, Irving H, et al. Alcohol consumption and the risk of morbidity and mortality for different stroke types–a systematic review and meta-analysis. BMC Public Health, 2010, 10: 258.
2.	Macleod MR, O’Collins T, Howells DW, et al. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke, 2004, 35(5):1203-1208.
3.	MacDougall NJ, Muir KW. Hyperglycaemia and infarct size in animal models of middle cerebral artery occlusion: systematic review and meta-analysis. J Cereb Blood Flow Metab, 2011, 31(3): 807-818.
4.	Crews FT, Steck JC, Chandler LJ, et al. Ethanol, stroke, brain damage, and excitotoxicity. Pharmacol Biochem Behav, 1998, 59(4): 981-991.
5.	Zhao H, Mayhan WG, Arrick DM, et al. Dose-related influence of chronic alcohol consumption on cerebral ischemia/reperfusion injury. Alcohol Clin Exp Res, 2011, 35(7): 1265-1269.
6.	Phillis JW, Estevez AY, O’Regan MH. Protective effects of the free radical scavengers, dimethyl sulfoxide and ethanol, in cerebral ischemia in gerbils. Neurosci Lett, 1998, 244(2): 109-111.
7.	Masoero E, Frattini P, Favalli L, et al. Effect of acute alcohol on ischemia-induced glutamate release and brain damage. Alcohol, 2000, 22(3): 173-177.
8.	Strong R, Grotta JC, Aronowski J. Combination of low dose ethanol and caffeine protects brain from damage produced by focal ischemia in rats. Neuropharmacology, 2000, 39(3): 515-522.
9.	Wang F, Wang Y, Geng X, et al. Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. Stroke, 2012, 43(1): 205-210.
10.	Wang Q, Sun AY, Simonyi A, et al. Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS. Free Radic Biol Med, 2007, 43(7): 1048-1060.
11.	Zhao H, Mayhan WG, Arrick DM, et al. Alcohol-induced exacerbation of ischemic brain injury: role of NAD(P)H oxidase. Alcohol Clin Exp Res, 2010, 34(11): 1948-1955.
12.	Mandybur TI, Mendenhall CL. The effects of chronic alcoholism on development of ischemic cerebral infarcts following unilateral carotid artery ligation in gerbils. Alcohol Clin Exp Res, 1983, 7(4): 357-361.
13.	Zhao YJ, Yang GY, Domino EF. Acute ethanol effects on focal cerebral ischemia in nonfasted rats. Alcohol Clin Exp Res, 1997, 21(4): 745-748.
14.	Zhao YJ, Yang GY, Ben-Joseph O, et al. Acute ethanol effects on focal cerebral ischemia in fasted rats. Alcohol Clin Exp Res, 1998, 22(3): 717-722.
15.	Qi SH, Liu Y, Wang WW, et al. Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation. Brain Res, 2009, 1276: 151-158.
16.	Qi SH, Liu Y, Hao LY, et al. Neuroprotection of ethanol against ischemia/reperfusion -induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release. Neuroscience, 2010, 167(4): 1125-1137.
17.	Zeng X, Asmaro K, Ren C, et al. Acute ethanol treatment reduces blood-brain barrier dysfunction following ischemia/reperfusion injury. Brain Res, 2012, 1437: 127-133.
18.	Sena E, van der Worp HB, Howells D, et al. How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci, 2007, 30(9): 433-439.
19.	Macleod MR, O’Collins T, Horky LL, et al. FK506对实验性卒中疗效的系统评价和Meta分析. 中国循证医学杂志, 2006, 6(5): 430-434.

1. Patra J, Taylor B, Irving H, et al. Alcohol consumption and the risk of morbidity and mortality for different stroke types–a systematic review and meta-analysis. BMC Public Health, 2010, 10: 258.
2. Macleod MR, O’Collins T, Howells DW, et al. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke, 2004, 35(5):1203-1208.
3. MacDougall NJ, Muir KW. Hyperglycaemia and infarct size in animal models of middle cerebral artery occlusion: systematic review and meta-analysis. J Cereb Blood Flow Metab, 2011, 31(3): 807-818.
4. Crews FT, Steck JC, Chandler LJ, et al. Ethanol, stroke, brain damage, and excitotoxicity. Pharmacol Biochem Behav, 1998, 59(4): 981-991.
5. Zhao H, Mayhan WG, Arrick DM, et al. Dose-related influence of chronic alcohol consumption on cerebral ischemia/reperfusion injury. Alcohol Clin Exp Res, 2011, 35(7): 1265-1269.
6. Phillis JW, Estevez AY, O’Regan MH. Protective effects of the free radical scavengers, dimethyl sulfoxide and ethanol, in cerebral ischemia in gerbils. Neurosci Lett, 1998, 244(2): 109-111.
7. Masoero E, Frattini P, Favalli L, et al. Effect of acute alcohol on ischemia-induced glutamate release and brain damage. Alcohol, 2000, 22(3): 173-177.
8. Strong R, Grotta JC, Aronowski J. Combination of low dose ethanol and caffeine protects brain from damage produced by focal ischemia in rats. Neuropharmacology, 2000, 39(3): 515-522.
9. Wang F, Wang Y, Geng X, et al. Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. Stroke, 2012, 43(1): 205-210.
10. Wang Q, Sun AY, Simonyi A, et al. Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS. Free Radic Biol Med, 2007, 43(7): 1048-1060.
11. Zhao H, Mayhan WG, Arrick DM, et al. Alcohol-induced exacerbation of ischemic brain injury: role of NAD(P)H oxidase. Alcohol Clin Exp Res, 2010, 34(11): 1948-1955.
12. Mandybur TI, Mendenhall CL. The effects of chronic alcoholism on development of ischemic cerebral infarcts following unilateral carotid artery ligation in gerbils. Alcohol Clin Exp Res, 1983, 7(4): 357-361.
13. Zhao YJ, Yang GY, Domino EF. Acute ethanol effects on focal cerebral ischemia in nonfasted rats. Alcohol Clin Exp Res, 1997, 21(4): 745-748.
14. Zhao YJ, Yang GY, Ben-Joseph O, et al. Acute ethanol effects on focal cerebral ischemia in fasted rats. Alcohol Clin Exp Res, 1998, 22(3): 717-722.
15. Qi SH, Liu Y, Wang WW, et al. Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation. Brain Res, 2009, 1276: 151-158.
16. Qi SH, Liu Y, Hao LY, et al. Neuroprotection of ethanol against ischemia/reperfusion -induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release. Neuroscience, 2010, 167(4): 1125-1137.
17. Zeng X, Asmaro K, Ren C, et al. Acute ethanol treatment reduces blood-brain barrier dysfunction following ischemia/reperfusion injury. Brain Res, 2012, 1437: 127-133.
18. Sena E, van der Worp HB, Howells D, et al. How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci, 2007, 30(9): 433-439.
19. Macleod MR, O’Collins T, Horky LL, et al. FK506对实验性卒中疗效的系统评价和Meta分析. 中国循证医学杂志, 2006, 6(5): 430-434.

Chinese Journal of Evidence-Based Medicine

Influence of Alcohol Intervention on the Outcome of Rats and Mice with Ischemic Stroke: A Systematic Review

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