Disease Burden and Quality of Life of Rheumatoid Arthritis in China: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 ZENG Xiaofeng ¹ , ZHU Songlin ² , TAN Aichun ³ , XIE Xiaoping ⁴

1. Department of Rheumatology, Peking Union Medical College Hospital, Beijing 100032, China;2. Hunan Provincial Tumor Hospital, Changsha 410083, China;3. School of Public Health, Central South University, Changsha 410078, China;4. Pfizer China, Beijing 100010, China;

Corresponding author：

ZENG Xiaofeng, Email: xiaofeng.zeng@cstar.org.cn

Keywords：

Rheumatoid arthritis; Disease burden; Morbidity; Quality of life; Systematic review; Meta-analysis

DOI：

10.7507/1672-2531.20130052

Video：

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Objective 　To get known about the disease burden and quality of life (QOL) of rheumatoid arthritis (RA) in China by conducting a systematic review.
Methods 　The observational studies about the disease burden and QOL of RA in China were systematically searched in the following databases: CNKI, CBM, VIP, WanFang Data, MEDLINE/Pub Med, EMbase, and Science Citation Index. The retrieval time was from January 1st, 1990 to July 31st, 2010. According to the inclusion and exclusion criteria, the literature was screened, the data were extracted, and the methodological quality of the included studies was assessed. The morbidity of RA was pooled by adopting generic inverse variance model, the meta-analyses on 8 dimensions of SF-36 life quality score (LQS) was conducted by suing RevMan5.0 software, the weighted mean difference (WMD) was regarded as the indicator of intervention effect, and the impact of studies’ quality on the results was assessed by sensitivity analysis.
Results 　A total of 20 studies with medium quality in general were included. The morbidity of RA was 14.7/100 000. The disability adjusted of life years (DALYs) per capita were 4.92. If excluding the cost resulted from DALY, the overall economic cost was RMB 1 250.45 yuan per capita per year; While considering DALY, the cost was RMB 15 717.91 yuan per capita per year. The average cost of outpatient medications was RMB 8 018±17 238 yuan per capita per year. The weighted morbidity was 0.42% (95%CI 0.39% to 0.45%), and it was higher in female than male (P lt;0.05). There was no secular trend and difference between southern and northern (P gt;0.05), but there were statistical significances in the WMD of 8 dimensions of SF-36 LQS. Sensitivity analyses revealed that the weighted pooled results were stable.
Conclusion 　The epidemiological and economic burden of rheumatoid arthritis are heavier in China, which needs to be concerned by both government and society.

Citation： ZENG Xiaofeng,ZHU Songlin,TAN Aichun,XIE Xiaoping. Disease Burden and Quality of Life of Rheumatoid Arthritis in China: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2013, 13(3): 300-307. doi: 10.7507/1672-2531.20130052 Copy

1.	Alamanos Y, Voulgari PV, Drosos AA. Incidence and Prevalence of rheumatoid arthritis, Based on the 1987 American College of Rheumatology Criteria: A Systematic Review. Seminars in Arthritis and Rheumatism, 2006; 36: 182-188.
2.	胡善联. 疾病负担的研究. 卫生经济学研究, 2005, 5: 22-27.
3.	Burton W, Morrison A, Maclean R, et al. Systematic review of studies of productivity loss due to rheumatoid arthritis. Occupational Medicine, 2006, 56: 18-27.
4.	Cooper NJ. Economic burden of rheumatoid arthritis: a systematic review. Rheumatology, 2000, 39: 28-33.
5.	Boonen A. Socioeconomic consequences of ankylosing spondylitis. Clin Exp Rheumatol, 2002, 20 (28): 23-6.
6.	Chorus AMJ, Miedema HS, Boonen A, et al. Quality of life and work in patients with rheumatoid arthritis and ankylosing spondylitis of working age. Ann Rheum Dis, 2003, 62: 1178-84.
7.	Critchley JA, Capewell S. Mortality risk reduction associated with smoking cessation in patients with coronary heart disease: a systematic review. JAMA, 2003, 290(1): 86-97.
8.	The Cochrane Collaboration. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6, 2006.
9.	Rostom A, Dubé C, Cranney A, et al. Celiac Disease. Evidence Reports/Technology Assessments, No. 104. Rockville (MD): Agency for Healthcare Research and Quality (US), 2004.
10.	Sutton AJ, Abrams KR, Jones DR, et al. Methods for Meta-analysis in medical research. Chichester, England: JohnWiley & Sons, Ltd, 2000.
11.	张凤山, 任潞雪. 我国北方高寒林区风湿病的流行病学调查. 哈尔滨医科大学学报, 1991, 25(1): 25-27.
12.	叶冬青, 倪进发, 郑惠玲, 等. 安徽省淮南市潘集区类风湿性关节炎的流行病学调查. 安徽医科大学学报, 1993, (01): 34-36.
13.	王晓光, 严碧玉. “风湿四病”与虚证发病相关性的流行病学调查. 新中医, 1993, 25(5): 15-17.
14.	张乃峥, K Couo. 关于某些风湿性疾病在中国流行情况的调查. 中华内科杂志, 1995, 34(2): 79-83.
15.	曾庆馀, 黄小弼. 汕头地区风湿病流行病学调查十年小结. 汕头大学医学院学报, 1997. 10(2): 59-62.
16.	薛昭平, 曹华, 丁志勇. 市郊“风湿四病”流行病学调查及地理气候相关性分析. 上海预防医学, 1998, 10(7): 328-329.
17.	张鸿逵, 刘振帆, 苏厚恒. 对山东省农村地区类风湿关节炎与强直性脊柱炎流行病学的调查. 中华风湿病学杂志, 1998, 2(2): 85-87.
18.	万晓芳, 周端求. 湖南省湘乡市风湿四病流行病学抽样调查报告. 中国全科医学, 2000, 3(1): 53-55.
19.	戴生明, 韩星海, 施冶青, 等. 上海市杨浦区常见风湿性疾病的流行病学调查. 现代康复, 2001, (01): 42-43, 51.
20.	白人骁. 我国"风湿四病"流行病学抽样调查. 首届国际中西医结合风湿病学术会议. 2004.
21.	史方. 上海市关节炎疾病负担评价. 上海: 复旦大学, 2005.
22.	叶志中. 深圳市风湿病流行病学调查. 中国误诊学杂志, 2006, 6(4): 786-787.
23.	臧长海. 太原地区常见风湿病流行病学研究. 中国药物与临床, 2007. 7(8): 597-602.
24.	陈勇, 陈志伟, 黄华, 等. SF-36量表用于类风湿关节炎患者生命质量的研究. 苏州大学学报(医学版), 2005, (03): 443-455, 450.
25.	杨帆, 兰光华. 类风湿性关节炎患者病情与生活质量的相关研究. 中国民康医学(上半月), 2006, 18(13): 536-538.
26.	胡绍先, 萧文泽, 孔芳, 等. 三种常见风湿性疾病患者生活质量分析. 中华物理医学与康复杂志, 2007, 29(10): 688-691.
27.	高翌娟. 类风湿性关节炎患者生命质量及相关因素分析. 临床医学, 2009, 29(9): 28-30.
28.	牛红青, 李小峰, 董海原, 等. 活动性类风湿关节炎患者生活质量及影响因素分析. 中华风湿病学杂志, 2009, 13(7): 447-450.
29.	李计香, 张莉芸, 袁建花, 等. 类风湿关节炎、强直性脊柱炎和健康对照组生活质量的比较及其与疾病活动的研究. 中国医疗前沿(下半月), 2010, 5(3): 5-7.
30.	王秀茹, 苏茵, 安媛, 等. 全国多中心类风湿关节炎患者门诊用药费用的调查. 中华风湿病学杂志, 2010, 14(6): 368-372.
31.	李宁秀, 刘朝杰, 李俊, 等. 四川省城乡居民SF-36评价参考值. 华西医科大学学报, 2001, 32: 43-47.
32.	杨克虎. 系统评价指导手册. 北京: 人民卫生出版社, 2010.
33.	Wong JB, Ramey DR, Singh G. Long-term morbidity, mortality, and economics of rheumatoid arthritis. Arthritis Rheum, 2001, 44(12): 2746-2749.

1. Alamanos Y, Voulgari PV, Drosos AA. Incidence and Prevalence of rheumatoid arthritis, Based on the 1987 American College of Rheumatology Criteria: A Systematic Review. Seminars in Arthritis and Rheumatism, 2006; 36: 182-188.
2. 胡善联. 疾病负担的研究. 卫生经济学研究, 2005, 5: 22-27.
3. Burton W, Morrison A, Maclean R, et al. Systematic review of studies of productivity loss due to rheumatoid arthritis. Occupational Medicine, 2006, 56: 18-27.
4. Cooper NJ. Economic burden of rheumatoid arthritis: a systematic review. Rheumatology, 2000, 39: 28-33.
5. Boonen A. Socioeconomic consequences of ankylosing spondylitis. Clin Exp Rheumatol, 2002, 20 (28): 23-6.
6. Chorus AMJ, Miedema HS, Boonen A, et al. Quality of life and work in patients with rheumatoid arthritis and ankylosing spondylitis of working age. Ann Rheum Dis, 2003, 62: 1178-84.
7. Critchley JA, Capewell S. Mortality risk reduction associated with smoking cessation in patients with coronary heart disease: a systematic review. JAMA, 2003, 290(1): 86-97.
8. The Cochrane Collaboration. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6, 2006.
9. Rostom A, Dubé C, Cranney A, et al. Celiac Disease. Evidence Reports/Technology Assessments, No. 104. Rockville (MD): Agency for Healthcare Research and Quality (US), 2004.
10. Sutton AJ, Abrams KR, Jones DR, et al. Methods for Meta-analysis in medical research. Chichester, England: JohnWiley & Sons, Ltd, 2000.
11. 张凤山, 任潞雪. 我国北方高寒林区风湿病的流行病学调查. 哈尔滨医科大学学报, 1991, 25(1): 25-27.
12. 叶冬青, 倪进发, 郑惠玲, 等. 安徽省淮南市潘集区类风湿性关节炎的流行病学调查. 安徽医科大学学报, 1993, (01): 34-36.
13. 王晓光, 严碧玉. “风湿四病”与虚证发病相关性的流行病学调查. 新中医, 1993, 25(5): 15-17.
14. 张乃峥, K Couo. 关于某些风湿性疾病在中国流行情况的调查. 中华内科杂志, 1995, 34(2): 79-83.
15. 曾庆馀, 黄小弼. 汕头地区风湿病流行病学调查十年小结. 汕头大学医学院学报, 1997. 10(2): 59-62.
16. 薛昭平, 曹华, 丁志勇. 市郊“风湿四病”流行病学调查及地理气候相关性分析. 上海预防医学, 1998, 10(7): 328-329.
17. 张鸿逵, 刘振帆, 苏厚恒. 对山东省农村地区类风湿关节炎与强直性脊柱炎流行病学的调查. 中华风湿病学杂志, 1998, 2(2): 85-87.
18. 万晓芳, 周端求. 湖南省湘乡市风湿四病流行病学抽样调查报告. 中国全科医学, 2000, 3(1): 53-55.
19. 戴生明, 韩星海, 施冶青, 等. 上海市杨浦区常见风湿性疾病的流行病学调查. 现代康复, 2001, (01): 42-43, 51.
20. 白人骁. 我国"风湿四病"流行病学抽样调查. 首届国际中西医结合风湿病学术会议. 2004.
21. 史方. 上海市关节炎疾病负担评价. 上海: 复旦大学, 2005.
22. 叶志中. 深圳市风湿病流行病学调查. 中国误诊学杂志, 2006, 6(4): 786-787.
23. 臧长海. 太原地区常见风湿病流行病学研究. 中国药物与临床, 2007. 7(8): 597-602.
24. 陈勇, 陈志伟, 黄华, 等. SF-36量表用于类风湿关节炎患者生命质量的研究. 苏州大学学报(医学版), 2005, (03): 443-455, 450.
25. 杨帆, 兰光华. 类风湿性关节炎患者病情与生活质量的相关研究. 中国民康医学(上半月), 2006, 18(13): 536-538.
26. 胡绍先, 萧文泽, 孔芳, 等. 三种常见风湿性疾病患者生活质量分析. 中华物理医学与康复杂志, 2007, 29(10): 688-691.
27. 高翌娟. 类风湿性关节炎患者生命质量及相关因素分析. 临床医学, 2009, 29(9): 28-30.
28. 牛红青, 李小峰, 董海原, 等. 活动性类风湿关节炎患者生活质量及影响因素分析. 中华风湿病学杂志, 2009, 13(7): 447-450.
29. 李计香, 张莉芸, 袁建花, 等. 类风湿关节炎、强直性脊柱炎和健康对照组生活质量的比较及其与疾病活动的研究. 中国医疗前沿(下半月), 2010, 5(3): 5-7.
30. 王秀茹, 苏茵, 安媛, 等. 全国多中心类风湿关节炎患者门诊用药费用的调查. 中华风湿病学杂志, 2010, 14(6): 368-372.
31. 李宁秀, 刘朝杰, 李俊, 等. 四川省城乡居民SF-36评价参考值. 华西医科大学学报, 2001, 32: 43-47.
32. 杨克虎. 系统评价指导手册. 北京: 人民卫生出版社, 2010.
33. Wong JB, Ramey DR, Singh G. Long-term morbidity, mortality, and economics of rheumatoid arthritis. Arthritis Rheum, 2001, 44(12): 2746-2749.

Chinese Journal of Evidence-Based Medicine

Disease Burden and Quality of Life of Rheumatoid Arthritis in China: A Systematic Review

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