Diagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 for Sepsis: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

WU Youping , LI Jinbao ,  DENG Xiaoming

Department of Anesthesiology, Changhai Hospital, The First Affiliated Hospital, The Second Military Medical University, Shanghai 200433, China;

Corresponding author：

DENG Xiaoming, Email: deng_x@yahoo.com

Keywords：

Sepsis; Soluble triggering receptor expressed on myeloid cells-1; Diagnostic test; Systematic review

DOI：

10.7507/1672-2531.20130073

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To evaluate the diagnostic value of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for sepsis.
Methods 　Such databases as The Cochrane Library (Issue 4, 2012), PubMed, EMbase, CBM, CNKI, VIP and WanFang Data were searched to collect the diagnostic tests on sTREM-1 for sepsis published before April 2012. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted the data, and assessed the methodological quality. Then, Meta-Disc software (Version 1.5) was used to conduct analyses, draw the summary receiver operating characteristic (SROC) curve, and calculate the area under curve and Q index.
Results 　A total of 11 studies involving 1 615 patients were included. The value of sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, area under of SROC curve, and Q index were 69%, 71%, 3.7, 0.34, 14.73, 0.875, and 0.805, respectively.
Conclusion 　This meta-analysis shows that sTREM-1 as a single indicator has moderate accuracy for early diagnosing sepsis. It should be combined with other diagnostic indicators to further improve the sensitivity and accuracy in diagnosing sepsis.

Citation： WU Youping,LI Jinbao,DENG Xiaoming. Diagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 for Sepsis: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2013, 13(4): 425-430. doi: 10.7507/1672-2531.20130073 Copy

1. Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med, 2003, 348(16): 1546-1554.

2. Warren HS. Strategies for the treatment of sepsis. N Engl J Med, 1997, 336(13): 952-953.

3. Otero RM, Nguyen HB, Huang DT, et al. Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest, 2006, 130(5): 1579-1595.

4. Adib-Conquy M, Cavaillon JM. Stress molecules in sepsis and systemic inflammatory response syndrome. FEBS Lett, 2007, 581(19): 3723-3733.

5. Jiyong J, Tiancha H, Wei C, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med, 2009, 35(4): 587-595.

6. Summah H, Tao LL, Zhu YG, et al. Pleural fluid soluble triggering receptor expressed on myeloid cells-1 as a marker of bacterial infection: a meta-analysis. BMC Infect Dis, 2011, 11: 280.

7. Soud DEM, Amin OAI, Amin AAI. New era "soluble triggering receptor expressed on myeloid cells-I" as a marker for early detection of infection in trauma patients. Egyptian Journal of Anaesthesia, 2011, 27(4): 267-272.

8. Barati M, Bashar FR, Shahrami R, et al. Soluble triggering receptor expressed on myeloid cells 1 and the diagnosis of sepsis. J Crit Care, 2010, 25(2): 362 e361-366.

9. Kofoed K, Andersen O, Kronborg G, et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care, 2007, 11(2): R38.

10. Latour-Péreza J, Alcalá-López A, García-García MA, et al. Diagnostic accuracy of sTREM-1 to identify infection in critically ill patients with systemic inflammatory response syndrome. Clin Biochem, 2010, 43(9): 720-724.

11. Gibot S, Kolopp-Sarda MN, Bene MC, et al. Plasma level of a triggering receptor expressed on myeloid cells-1: its diagnostic accuracy in patients with suspected sepsis. Ann Intern Med, 2004, 141(1): 9-15.

12. Giamarellos-Bourboulis EJ, Mouktaroudi M, Tsaganos T, et al. Evidence for the participation of soluble triggering receptor expressed on myeloid cells-1 in the systemic inflammatory response syndrome after multiple trauma. J Trauma, 2008, 65(6): 1385-1390.

13. Gamez-Diaz LY, Enriquez LE, Matute JD, et al. Diagnostic Accuracy of HMGB-1, sTREM-1, and CD64 as Markers of Sepsis in Patients Recently Admitted to the Emergency Department. Acad Emerg Med, 2011, 18(8): 807-815.

14. Rivera-Chavez FA, Minei JP. Soluble triggering receptor expressed on myeloid cells-1 is an early marker of infection in the surgical intensive care unit. Surg Infect (Larchmt), 2009, 10(5): 435-439.

15. 董裕康, 梁显泉. 可溶性髓细胞触发受体-1在脓毒症诊断及病情判断的价值. 中国急救医学, 2012, 32(2): 115-119.

16. 曾小莉, 张韶岩, 郭晶, 等. 可溶性髓样细胞触发受体1在脓毒症中的表达和临床意义. 中国呼吸与危重监护杂志, 2011, 10(6): 538-542.

17. 黎丽芬. 髓样细胞触发受体1(TREM1)在危重病人脓毒症的诊断价值. 2007.

18. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest, 1992, 101(6): 1644-1655.

19. Whiting P, Rutjes AW, Reitsma JB, et al. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 3: 25.

20. Bowden J, Tierney JF, Copas AJ, et al. Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics. BMC Med Res Methodol, 2011, 11: 41.

21. Moses LE, Shapiro D, Littenberg B. Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations. Stat Med, 1993, 12(14): 1293-1316.

22. Mitaka C. Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response syndrome. Clin Chim Acta, 2005, 351(1-2): 17-29.

23. Kibe S, Adams K, Barlow G. Diagnostic and prognostic biomarkers of sepsis in critical care. J Antimicrob Chemother, 2011, 66(Suppl 2): 33-40.

24. Vouloumanou EK, Plessa E, Karageorgopoulos DE, et al. Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis. Intensive Care Med, 2011, 37(5): 747-762.

25. Uzzan B, Cohen R, Nicolas P, et al. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med, 2006, 34(7): 1996-2003.

26. Tang BM, Eslick GD, Craig JC, et al. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis, 2007, 7(3): 210-217.

27. Colonna M, Facchetti F. TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses. J Infect Dis, 2003, 187(Suppl 2): S397-401.

28. Tessarz AS, Cerwenka A. The TREM-1/DAP12 pathway. Immunol Lett, 2008, 116(2): 111-116.

29. Song F, Khan KS, Dinnes J, et al. Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy. Int J Epidemiol, 2002, 31(1): 88-95.

30. Cavaillon JM. Monocyte TREM-1 membrane expression in non-infectious inflammation. Criti care, 2009, 13(3): 152.

31. Ferat-Osorio E, Wong-Baeza I, Esquivel-Callejas N, et al. Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis. Criti care, 2009, 13(3): R69.

32. Bingold TM, Pullmann B, Sartorius S, et al. Soluble triggering receptor on myeloid cells-1 (sTREM-1) is expressed in the course of non-infectious inflammation after traumatic lung contusion: A prospective cohort study. Criti Care, 2011: R115.

1. Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med, 2003, 348(16): 1546-1554.

2. Warren HS. Strategies for the treatment of sepsis. N Engl J Med, 1997, 336(13): 952-953.

3. Otero RM, Nguyen HB, Huang DT, et al. Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest, 2006, 130(5): 1579-1595.

4. Adib-Conquy M, Cavaillon JM. Stress molecules in sepsis and systemic inflammatory response syndrome. FEBS Lett, 2007, 581(19): 3723-3733.

5. Jiyong J, Tiancha H, Wei C, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med, 2009, 35(4): 587-595.

6. Summah H, Tao LL, Zhu YG, et al. Pleural fluid soluble triggering receptor expressed on myeloid cells-1 as a marker of bacterial infection: a meta-analysis. BMC Infect Dis, 2011, 11: 280.

7. Soud DEM, Amin OAI, Amin AAI. New era "soluble triggering receptor expressed on myeloid cells-I" as a marker for early detection of infection in trauma patients. Egyptian Journal of Anaesthesia, 2011, 27(4): 267-272.

8. Barati M, Bashar FR, Shahrami R, et al. Soluble triggering receptor expressed on myeloid cells 1 and the diagnosis of sepsis. J Crit Care, 2010, 25(2): 362 e361-366.

9. Kofoed K, Andersen O, Kronborg G, et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care, 2007, 11(2): R38.

10. Latour-Péreza J, Alcalá-López A, García-García MA, et al. Diagnostic accuracy of sTREM-1 to identify infection in critically ill patients with systemic inflammatory response syndrome. Clin Biochem, 2010, 43(9): 720-724.

11. Gibot S, Kolopp-Sarda MN, Bene MC, et al. Plasma level of a triggering receptor expressed on myeloid cells-1: its diagnostic accuracy in patients with suspected sepsis. Ann Intern Med, 2004, 141(1): 9-15.

12. Giamarellos-Bourboulis EJ, Mouktaroudi M, Tsaganos T, et al. Evidence for the participation of soluble triggering receptor expressed on myeloid cells-1 in the systemic inflammatory response syndrome after multiple trauma. J Trauma, 2008, 65(6): 1385-1390.

13. Gamez-Diaz LY, Enriquez LE, Matute JD, et al. Diagnostic Accuracy of HMGB-1, sTREM-1, and CD64 as Markers of Sepsis in Patients Recently Admitted to the Emergency Department. Acad Emerg Med, 2011, 18(8): 807-815.

14. Rivera-Chavez FA, Minei JP. Soluble triggering receptor expressed on myeloid cells-1 is an early marker of infection in the surgical intensive care unit. Surg Infect (Larchmt), 2009, 10(5): 435-439.

15. 董裕康, 梁显泉. 可溶性髓细胞触发受体-1在脓毒症诊断及病情判断的价值. 中国急救医学, 2012, 32(2): 115-119.

16. 曾小莉, 张韶岩, 郭晶, 等. 可溶性髓样细胞触发受体1在脓毒症中的表达和临床意义. 中国呼吸与危重监护杂志, 2011, 10(6): 538-542.

17. 黎丽芬. 髓样细胞触发受体1(TREM1)在危重病人脓毒症的诊断价值. 2007.

18. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest, 1992, 101(6): 1644-1655.

19. Whiting P, Rutjes AW, Reitsma JB, et al. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 3: 25.

20. Bowden J, Tierney JF, Copas AJ, et al. Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics. BMC Med Res Methodol, 2011, 11: 41.

21. Moses LE, Shapiro D, Littenberg B. Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations. Stat Med, 1993, 12(14): 1293-1316.

22. Mitaka C. Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response syndrome. Clin Chim Acta, 2005, 351(1-2): 17-29.

23. Kibe S, Adams K, Barlow G. Diagnostic and prognostic biomarkers of sepsis in critical care. J Antimicrob Chemother, 2011, 66(Suppl 2): 33-40.

24. Vouloumanou EK, Plessa E, Karageorgopoulos DE, et al. Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis. Intensive Care Med, 2011, 37(5): 747-762.

25. Uzzan B, Cohen R, Nicolas P, et al. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med, 2006, 34(7): 1996-2003.

26. Tang BM, Eslick GD, Craig JC, et al. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis, 2007, 7(3): 210-217.

27. Colonna M, Facchetti F. TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses. J Infect Dis, 2003, 187(Suppl 2): S397-401.

28. Tessarz AS, Cerwenka A. The TREM-1/DAP12 pathway. Immunol Lett, 2008, 116(2): 111-116.

29. Song F, Khan KS, Dinnes J, et al. Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy. Int J Epidemiol, 2002, 31(1): 88-95.

30. Cavaillon JM. Monocyte TREM-1 membrane expression in non-infectious inflammation. Criti care, 2009, 13(3): 152.

31. Ferat-Osorio E, Wong-Baeza I, Esquivel-Callejas N, et al. Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis. Criti care, 2009, 13(3): R69.

32. Bingold TM, Pullmann B, Sartorius S, et al. Soluble triggering receptor on myeloid cells-1 (sTREM-1) is expressed in the course of non-infectious inflammation after traumatic lung contusion: A prospective cohort study. Criti Care, 2011: R115.

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Diagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 for Sepsis: A Systematic Review

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1.	Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med, 2003, 348(16): 1546-1554.
2.	Warren HS. Strategies for the treatment of sepsis. N Engl J Med, 1997, 336(13): 952-953.
3.	Otero RM, Nguyen HB, Huang DT, et al. Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest, 2006, 130(5): 1579-1595.
4.	Adib-Conquy M, Cavaillon JM. Stress molecules in sepsis and systemic inflammatory response syndrome. FEBS Lett, 2007, 581(19): 3723-3733.
5.	Jiyong J, Tiancha H, Wei C, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med, 2009, 35(4): 587-595.
6.	Summah H, Tao LL, Zhu YG, et al. Pleural fluid soluble triggering receptor expressed on myeloid cells-1 as a marker of bacterial infection: a meta-analysis. BMC Infect Dis, 2011, 11: 280.
7.	Soud DEM, Amin OAI, Amin AAI. New era "soluble triggering receptor expressed on myeloid cells-I" as a marker for early detection of infection in trauma patients. Egyptian Journal of Anaesthesia, 2011, 27(4): 267-272.
8.	Barati M, Bashar FR, Shahrami R, et al. Soluble triggering receptor expressed on myeloid cells 1 and the diagnosis of sepsis. J Crit Care, 2010, 25(2): 362 e361-366.
9.	Kofoed K, Andersen O, Kronborg G, et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care, 2007, 11(2): R38.
10.	Latour-Péreza J, Alcalá-López A, García-García MA, et al. Diagnostic accuracy of sTREM-1 to identify infection in critically ill patients with systemic inflammatory response syndrome. Clin Biochem, 2010, 43(9): 720-724.
11.	Gibot S, Kolopp-Sarda MN, Bene MC, et al. Plasma level of a triggering receptor expressed on myeloid cells-1: its diagnostic accuracy in patients with suspected sepsis. Ann Intern Med, 2004, 141(1): 9-15.
12.	Giamarellos-Bourboulis EJ, Mouktaroudi M, Tsaganos T, et al. Evidence for the participation of soluble triggering receptor expressed on myeloid cells-1 in the systemic inflammatory response syndrome after multiple trauma. J Trauma, 2008, 65(6): 1385-1390.
13.	Gamez-Diaz LY, Enriquez LE, Matute JD, et al. Diagnostic Accuracy of HMGB-1, sTREM-1, and CD64 as Markers of Sepsis in Patients Recently Admitted to the Emergency Department. Acad Emerg Med, 2011, 18(8): 807-815.
14.	Rivera-Chavez FA, Minei JP. Soluble triggering receptor expressed on myeloid cells-1 is an early marker of infection in the surgical intensive care unit. Surg Infect (Larchmt), 2009, 10(5): 435-439.
15.	董裕康, 梁显泉. 可溶性髓细胞触发受体-1在脓毒症诊断及病情判断的价值. 中国急救医学, 2012, 32(2): 115-119.
16.	曾小莉, 张韶岩, 郭晶, 等. 可溶性髓样细胞触发受体1在脓毒症中的表达和临床意义. 中国呼吸与危重监护杂志, 2011, 10(6): 538-542.
17.	黎丽芬. 髓样细胞触发受体1(TREM1)在危重病人脓毒症的诊断价值. 2007.
18.	Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest, 1992, 101(6): 1644-1655.
19.	Whiting P, Rutjes AW, Reitsma JB, et al. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 3: 25.
20.	Bowden J, Tierney JF, Copas AJ, et al. Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics. BMC Med Res Methodol, 2011, 11: 41.
21.	Moses LE, Shapiro D, Littenberg B. Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations. Stat Med, 1993, 12(14): 1293-1316.
22.	Mitaka C. Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response syndrome. Clin Chim Acta, 2005, 351(1-2): 17-29.
23.	Kibe S, Adams K, Barlow G. Diagnostic and prognostic biomarkers of sepsis in critical care. J Antimicrob Chemother, 2011, 66(Suppl 2): 33-40.
24.	Vouloumanou EK, Plessa E, Karageorgopoulos DE, et al. Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis. Intensive Care Med, 2011, 37(5): 747-762.
25.	Uzzan B, Cohen R, Nicolas P, et al. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med, 2006, 34(7): 1996-2003.
26.	Tang BM, Eslick GD, Craig JC, et al. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis, 2007, 7(3): 210-217.
27.	Colonna M, Facchetti F. TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses. J Infect Dis, 2003, 187(Suppl 2): S397-401.
28.	Tessarz AS, Cerwenka A. The TREM-1/DAP12 pathway. Immunol Lett, 2008, 116(2): 111-116.
29.	Song F, Khan KS, Dinnes J, et al. Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy. Int J Epidemiol, 2002, 31(1): 88-95.
30.	Cavaillon JM. Monocyte TREM-1 membrane expression in non-infectious inflammation. Criti care, 2009, 13(3): 152.
31.	Ferat-Osorio E, Wong-Baeza I, Esquivel-Callejas N, et al. Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis. Criti care, 2009, 13(3): R69.
32.	Bingold TM, Pullmann B, Sartorius S, et al. Soluble triggering receptor on myeloid cells-1 (sTREM-1) is expressed in the course of non-infectious inflammation after traumatic lung contusion: A prospective cohort study. Criti Care, 2011: R115.