Effectiveness and Safety of China-Made Omeprazole in Treating Acute Non-Variceal Upper Gastrointestinal Bleeding: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LIU Wenping , HUANG Caiyun

Department of Gastroenterology, Zhangzhou Hospital Affiliated to Fujian Medical University, Zhangzhou 363000, China;

Corresponding author：

LIU Wenping, Email: doctorlwp@126.com

Keywords：

China-made omeprazole; Imported omeprazole; Non-variceal upper gastrointestinal bleeding; Effectiveness; Safety; Meta-analysis; Systematic review; Randomized controlled trial

DOI：

10.7507/1672-2531.20130128

Video：

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Objective 　To systematically evaluate the effectiveness and safety of China-made omeprazole in treating acute non-variceal upper gastrointestinal bleeding.
Methods 　Such databases as PubMed, MEDLINE, Springer, The Cochrane Library, CNKI, VIP, CBM and WanFang data were searched to collect the randomized controlled trials (RCTs) about China-made omeprazole in treating acute non-variceal upper gastrointestinal bleeding, and the references of included studies were also retrieved. The retrieval time was from inception to December 2012. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data, and assessed the quality, and then the meta-analysis was conducted by using RevMan 5.1 software.
Results 　A total of 11 RCTs were included. Among all 1 075 patients, 544 were in the treatment group, while the other 531 were in the control group. The results of meta-analysis showed that, there were no significant differences in the total effective rate (OR=0.68, 95%CI 0.35 to 1.33, P=0.26) and safety (RR=1.33, 95%CI 0.45 to 3.91, P=0.96) between the China-made omeprazole and imported omeprazole.
Conclusion 　China-made omeprazole is effective and safe in treating acute non-variceal upper gastrointestinal bleeding in comparison with the imported omeprazole.

Citation： LIU Wenping,HUANG Caiyun. Effectiveness and Safety of China-Made Omeprazole in Treating Acute Non-Variceal Upper Gastrointestinal Bleeding: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2013, 13(6): 723-727. doi: 10.7507/1672-2531.20130128 Copy

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1. British Society of Gastroenterology Endoscopy Committee. Non-vaiceal upper gastrointestinal haemorrhage: guide-lines. Gut, 2002, 51(4): l-6．.
2. Barkun A, Bardou M, marshall JK, et al. Consensus recom-mendations for managing patients with nonvariceal upper-gastrointinal bleeding. Ann Intern Med, 2003, 139(10): 843-857.
3. Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008.
4. 孔庆印, 张春梅, 李仲霞. 国产奥美拉唑注射剂治疗消化性溃疡出血临床疗效观察. 中国临床医药研究杂志, 2007, (169): 7-9.
5. 胡伏莲, 董欣红, 成虹, 等. 国产注射用奥美拉唑治疗非静脉曲张上消化道出血的疗效与安全性. 中国新药杂志, 2005, 14(12): 1469-1471.
6. 袁耀宗, 江石湖, 夏璐, 等. 注射用奥美拉唑钠治疗消化性溃疡出血临床观察. 中国新药杂志, 2005, 14(4): 477-479.
7. 北京国产奥美拉唑针剂研究协作组. 国产奥美拉唑针剂对非静脉曲张破裂出血的临床观察. 中华内科杂志, 1999, 38(7): 478-480.
8. 许慧健, 黄宗清. 国产与进口奥美拉唑治疗消化性溃疡出血的疗效比较. 中国中西医结合消化杂志, 2008, 16(4): 253-254.
9. 徐秋香. 奥美拉唑治疗消化性溃疡出血临床疗效及成本-效果分析. 中国医药指南, 2010, 8(7): 83-84.
10. 王康达. 国产奥美拉唑粉针剂对消化性溃疡并上消化道出血的疗效观察. 苏州大学学报(医学版), 2002, 22(3): 305-306.
11. 宋军平, 王科兵, 冯习坤. 奥美拉唑治疗消化性溃疡出血的经济学探讨. 临床合理用药, 2011, 4(2A): 10-11.
12. 刘光辉, 杨希宁. 国产奥美拉哇和进口洛赛克在消化性溃疡出血中的疗效比较. 中国基层医药, 1999, 6(4): 234.
13. 王威, 刘佳煜, 杨连峰, 等. 国产奥美拉唑钠治疗应激性溃疡并上消化道出血临床疗效. 中国现代药物应用, 2009, 3(1): 106.
14. 张斌, 金瑞, 王贞飙. 国产奥美拉唑治疗非静脉曲张破裂出血58例观察. 中国航天工业医药, 2000, 2(4): 37-38.
15. 《中华内科杂志》编委会,《中华消化内镜》编委会. 急性非静脉曲张性上消化道出血诊治指南. 中华内科杂志, 2009, 48(10): 891-894.
16. 万里程. 奥美拉唑治疗急性非静脉曲张性上消化道出血70例临床分析. 亚太传统医学, 2011, 7(2): 80-83.
17. 刘泓. 奥美拉唑治疗老年上消化道出血临床观察. 临床消化病杂志, 2012, 24(5): 268-272.
18. 吴木生, 张庆年, 吴瑗, 等. 奥美拉唑注射液治疗消化性溃疡上消化道出血62例疗效分析. 职业与健康, 2009, 25(20): 2236-2237.
19. 江学富. 奥美拉唑用于急性非静脉曲张性上消化道出血的临床诊治分析. 当代医学, 2012, 18(22): 137-138.

Chinese Journal of Evidence-Based Medicine

Effectiveness and Safety of China-Made Omeprazole in Treating Acute Non-Variceal Upper Gastrointestinal Bleeding: A Meta-Analysis

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