Epidemiological Study on Asymptomatic Hyperuricemia Associated with Cardiovascular Risk Factors between Urban and Rural Areas in Chengdu_Chinese Journal of Evidence-Based Medicine

Authors：

TANG Guohua ¹ ,  LIAO Xiaoyang ² , YUAN Bo ² , ZOU Chuan ² , ZHOU Xinping ² , YAO Ke ³

1. Hearth Examination Center, West China Hospital, Sichuan University, Chengdu 610041, China;2. Department of General Medicine, West China Hospital, Sichuan University, Chengdu 610041, China;3. Department of Health Statistics, School of Public Health, Sichuan University, Chengdu 610041, China;

Corresponding author：

LIAO Xiaoyang, Email: liaoxiaoyang@sohu.com

Keywords：

Hyperuricemia; Cardiovascular risk factor; Urban and rural

DOI：

10.7507/1672-2531.20130141

Video：

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Objective 　To investigate the prevalence of hyperuricemia and the current status as well as differences of cardiovascular risk factors in hyperuricemia patients between urban and rural areas in Chengdu.
Methods 　We randomly sampled 2 032 patients aged from 35 to 70 years age in urban and rural communities, using a questionnaire, physical examination and laboratory tests.
Results 　a) The prevalence of hyperuricemia was 17.77%, which was higher in urban residents (21.38%) than that in rural residents (14.16%). b) The prevalence of hyperuricemia associated with hypercholesterolemia was higher in urban residents (34.10%) than that in rural residents (13.98%); urban women (39.06%) were higher than rural women (16.13%) and urban men (26.97%) were higher than rural men (12.20%). c) The prevalence of hyperuricemia associated with hypertension which was higher in urban residents (58.06%) than that in rural residents (32.64%); urban women (59.38%) were higher than rural women (35.48%) and urban men (56.18%) were higher than rural men (30.49%). d) The prevalence of hyperuricemia associated with impaired glucose tolerance (IGT) in urban women (28.91%) were lower than that in rural women (45.16%).
Conclusion 　Hypercholesterolemia and hypertension are the most commonly seen cardiovascular risk factors accompanied in patients with hyperuricemia in urban areas, which has obviously higher prevalence than in rural areas. IGT is the most commonly seen cardiovascular risk factors accompanied in patients with hyperuricemia among rural women. But in aspects of hyperuricemia associated with impaired fasting glucose (IFG), hypertriglyceridemia, low high-density fetoprotein cholesterol, abdominal obesity and obesity, there is no difference between urban and rural areas.

Citation： TANG Guohua,LIAO Xiaoyang,YUAN Bo,ZOU Chuan,ZHOU Xinping,YAO Ke. Epidemiological Study on Asymptomatic Hyperuricemia Associated with Cardiovascular Risk Factors between Urban and Rural Areas in Chengdu. Chinese Journal of Evidence-Based Medicine, 2013, 13(7): 789-792. doi: 10.7507/1672-2531.20130141 Copy

1.	Chen JH, Chuang SY, Chen HJ, et al. Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis Rheum, 2009, 61(2): 225-232.
2.	中国医师协会心血管内科医师分会, 中国医师协会循证医学专业委员会. 无症状高尿酸血症合并心血管疾病诊治建议中国专家共识. 中国当代医药, 2009, 16(24): 4-8.
3.	中国高血压防治指南修订委员会. 中国高血压防治指南2010. 中华心血管病杂志, 2011, 39(7): 579-616.
4.	Doherty M. New insights into the epidemiology of gout. Rheumatology (Oxford), 2009, 48(Suppl 2): ii2-ii8.
5.	方圻, 陈灏珠, 郁知非, 等. 中国正常人血尿酸调查及其血脂的关系. 中华内科杂志, 1983, 22(7): 434-438.
6.	方卫纲, 黄晓明, 王玉, 等. 高尿酸血症在北京地区1997人中的患病情况及相关因素分析. 中华医学杂志, 2006, 86(25): 1764-1768.
7.	曾瑶池, 黄鑫, 周光宇, 等. 高尿酸血症在长沙市2340名公务员中的患病情况及其相关因素分析. 卫生研究, 2008, (06): 679-681.
8.	Li NF, Wang HM, Yang J, et al. Serum uric acid is associated with metabolic risk factors for cardiovascular disease in the Uygur population. Appl Physiol Nutr Metab, 2009, 34(6): 1032-1039.
9.	吕海燕, 叶小丽. 机关干部超重人群心脑血管危险因素分析和营养教育策略. 肠外与肠内营养, 2010, 17(1): 47-48．.
10.	宋娓, 李长贵. 原发性高尿酸血症与代谢综合征关系的研究进展. 山东医药, 2006, 46(7): 77-78.
11.	Palmer IM, Schutte AE, Huisman HW. Uric acid and the cardiovascular profile of African and Caucasian men. J Hum Hypertens, 2010, 24(10): 639-645.
12.	Tsai WC, Huang YY, Lin CC, et al. Uric acid is an independent predictor of arterial stiffness in hypertensive patients. Heart Vessels, 2009, 24(5): 371-375.
13.	Zhang W, Sun K, Yang Y, et al. Plasma uric acid and hypertension in a Chinese community: prospective study and meta-analysis. Clin Chem, 2009, 55(11): 2026-2034.
14.	Mellen PB, Bleyer AJ, Erlinger TP, et al. Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study. Hypertension, 2006, 48(6): 1037-1042.
15.	Krishnan E, Kwoh CK, Schumacher HR, et al. Hyperuricemia and incidence of hypertension among men without metabolic syndrome. Hypertension, 2007, 49(2): 298-303.
16.	Forman JP, Choi H, Curhan GC. Uric acid and insulin sensitivity and risk of incident hypertension. Arch Intern Med, 2009, 169(2): 155-162.
17.	Dehghan A, van Hoek M, Sijbrands EJ, et al. High serum uric acid as a novel risk factor for type 2 diabetes. Diabeted Care, 2008, 31(2): 361-362.
18.	温晓燕, 路方红, 杨建民, 等. 济南市居民高尿酸血症及影响因素分析.中国公共卫生,2007, 23(12): 1520-1523.
19.	王敬瀚, 苏丽, 王中心, 等. 腰围是代谢综合征最主要的危险成分. 中华高血压杂志, 2007, 11(15): 896-899.

1. Chen JH, Chuang SY, Chen HJ, et al. Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis Rheum, 2009, 61(2): 225-232.
2. 中国医师协会心血管内科医师分会, 中国医师协会循证医学专业委员会. 无症状高尿酸血症合并心血管疾病诊治建议中国专家共识. 中国当代医药, 2009, 16(24): 4-8.
3. 中国高血压防治指南修订委员会. 中国高血压防治指南2010. 中华心血管病杂志, 2011, 39(7): 579-616.
4. Doherty M. New insights into the epidemiology of gout. Rheumatology (Oxford), 2009, 48(Suppl 2): ii2-ii8.
5. 方圻, 陈灏珠, 郁知非, 等. 中国正常人血尿酸调查及其血脂的关系. 中华内科杂志, 1983, 22(7): 434-438.
6. 方卫纲, 黄晓明, 王玉, 等. 高尿酸血症在北京地区1997人中的患病情况及相关因素分析. 中华医学杂志, 2006, 86(25): 1764-1768.
7. 曾瑶池, 黄鑫, 周光宇, 等. 高尿酸血症在长沙市2340名公务员中的患病情况及其相关因素分析. 卫生研究, 2008, (06): 679-681.
8. Li NF, Wang HM, Yang J, et al. Serum uric acid is associated with metabolic risk factors for cardiovascular disease in the Uygur population. Appl Physiol Nutr Metab, 2009, 34(6): 1032-1039.
9. 吕海燕, 叶小丽. 机关干部超重人群心脑血管危险因素分析和营养教育策略. 肠外与肠内营养, 2010, 17(1): 47-48．.
10. 宋娓, 李长贵. 原发性高尿酸血症与代谢综合征关系的研究进展. 山东医药, 2006, 46(7): 77-78.
11. Palmer IM, Schutte AE, Huisman HW. Uric acid and the cardiovascular profile of African and Caucasian men. J Hum Hypertens, 2010, 24(10): 639-645.
12. Tsai WC, Huang YY, Lin CC, et al. Uric acid is an independent predictor of arterial stiffness in hypertensive patients. Heart Vessels, 2009, 24(5): 371-375.
13. Zhang W, Sun K, Yang Y, et al. Plasma uric acid and hypertension in a Chinese community: prospective study and meta-analysis. Clin Chem, 2009, 55(11): 2026-2034.
14. Mellen PB, Bleyer AJ, Erlinger TP, et al. Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study. Hypertension, 2006, 48(6): 1037-1042.
15. Krishnan E, Kwoh CK, Schumacher HR, et al. Hyperuricemia and incidence of hypertension among men without metabolic syndrome. Hypertension, 2007, 49(2): 298-303.
16. Forman JP, Choi H, Curhan GC. Uric acid and insulin sensitivity and risk of incident hypertension. Arch Intern Med, 2009, 169(2): 155-162.
17. Dehghan A, van Hoek M, Sijbrands EJ, et al. High serum uric acid as a novel risk factor for type 2 diabetes. Diabeted Care, 2008, 31(2): 361-362.
18. 温晓燕, 路方红, 杨建民, 等. 济南市居民高尿酸血症及影响因素分析.中国公共卫生,2007, 23(12): 1520-1523.
19. 王敬瀚, 苏丽, 王中心, 等. 腰围是代谢综合征最主要的危险成分. 中华高血压杂志, 2007, 11(15): 896-899.

Chinese Journal of Evidence-Based Medicine

Epidemiological Study on Asymptomatic Hyperuricemia Associated with Cardiovascular Risk Factors between Urban and Rural Areas in Chengdu

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