Effectiveness and Safety of Dezocine versus Fentanyl for Postoperative Patient-controlled Intravenous Analgesia: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 ZOUDan ¹ , WUFeng-bo ¹ , LIUYong ²

1. Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China;
2. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Dezocine; Fentanyl; Postoperative patient-controlled intravenous analgesia; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.20140012

Video：

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Objective To systematically evaluate the effectiveness and safety of dezocine versus fentanyl for postoperative patient-controlled intravenous analgesia (PCIA). Methods We electronically searched the specialized trials registered in The Cochrane Library (Issue 2, 2013), the Cochrane anesthesia group, MEDLINE, EMbase, CBM, CNKI, VIP and WanFang Data from inception to February, 2013. Randomized controlled trials (RCTs) on dezocine versus Fentanyl for postoperative PCIA were included. RevMan 5.0 software was used for meta-analysis after critically literature screening, data extracting and assessing of methodological quality independently by two reviewers. Results A total of 15 RCTs involving 1 116 patients were finally included. The results of meta-analysis showed that there was no significant difference in postoperative analgesia and sedation at the hour-points of 2 h, 4 h, 6 h, 8 h, 12 h, 24 h, and 48 h after surgery. As for safety, the incidences of postoperative nausea, vomiting, skin pruritus, respiratory depression and uroschesis in the dezocine group were lower than those in the fentanyl group. Conclusion Compared with fentanyl, dezocine has the same effects of analgesia and sedation for PCIA; its incidence of adverse reactions is lower, so dezocine is safer in clinic.

Citation： ZOUDan, WUFeng-bo, LIUYong. Effectiveness and Safety of Dezocine versus Fentanyl for Postoperative Patient-controlled Intravenous Analgesia: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2014, 14(1): 65-71. doi: 10.7507/1672-2531.20140012 Copy

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5.	刘卫校, 丁华, 万营.地佐辛用于乳腺癌根治术后静脉自控镇痛的临床观察.中国现代医生, 2012, 50(14):93-94.
6.	刘新伟, 郭艳巍.芬太尼与地佐辛对老年骨科病人术后镇痛效果的对比.中国老年学杂志, 2011, 31(22):4465-4466.
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9.	任培才.肠道肿瘤切除手术术后地佐辛静脉自控镇痛的评价.广州医药, 2012, 43(5):24-26.
10.	陶岩, 鄂爽, 陈琦, 等.地佐辛用于颈椎手术术后镇痛的临床研究.中外医疗, 2013, (2):109-111.
11.	王军, 王志萍, 黄东晓.地佐辛与芬太尼患者自控静脉镇痛的比较.实用临床医药杂志, 2011, 15(5):109-110.
12.	王磊. 0.05%的地佐辛用于术后静脉自控镇痛临床观察.吉林医学, 2012, 33(15):3211.
13.	谢国柱, 钱涛, 姜琳.地佐辛用于妇科术后镇痛的临床观察.海南医学, 2011, 22(21):48-50.
14.	叶秀丽.地佐辛与芬太尼用于子宫切除术后镇痛效果的比较.中国医药指南, 2011, 9(25):267-268.
15.	张贵权, 高秀敏.地佐辛用于术后镇痛的临床观察.吉林医学, 2013, 34(3):480-481.
16.	赵森, 吕国义, 孙成亮, 等.地佐辛与芬太尼用于悬雍垂腭咽成形术后镇痛的评价.天津医药, 2012, 40(9):905-907.
17.	师小伟, 熊源长, 刘佩蓉.地佐辛临床镇痛的研究进展.医学综述, 2013, 19(6):1105-1107.
18.	Kaczor A, Matosiuk D. Non-peptide opioid receptor ligands-recent advances. PartII-antagonists. Curr Med Chem, 2002, 9(17):1591-1603.
19.	Gal TJ, DiFazio CA.Ventilatory and analgesic effects of dezocine in human. Anesthesiology, 1984, 61(6):716-722.
20.	Zacny JP, Lichtor JL, De Wit H. Subjective, behavioral, and physiologic responses to intravenous dezocine in healthy volunteers. Anesth Analg, 1992, 74(4):523-530.

1. 徐建国, 吴新民, 罗爱伦, 等.成人术后疼痛处理专家共识.临床麻醉学杂志, 2010, 26(3):190-196.
2. 焦向阳, 贺显建, 薛璋明, 等.地佐辛与芬太尼用于术后静脉镇痛的疗效比较.陕西医学杂志, 2011, 40(10):1365-1367.
3. 金震, 文艳.地佐辛应用于剖宫产术后静脉镇痛临床效果观察.现代医药卫生, 2011, 27(21):3292-3293.
4. 兰群飞, 樊理华, 戴仁锋, 等.地佐辛在静脉自控镇痛的临床观察.海峡药学, 2011, 23(9):97-98.
5. 刘卫校, 丁华, 万营.地佐辛用于乳腺癌根治术后静脉自控镇痛的临床观察.中国现代医生, 2012, 50(14):93-94.
6. 刘新伟, 郭艳巍.芬太尼与地佐辛对老年骨科病人术后镇痛效果的对比.中国老年学杂志, 2011, 31(22):4465-4466.
7. 乔孝武, 徐瑱.地佐辛在妇科全麻手术后PCIA中的疗效观察.中国现代药物应用, 2012, 6(11):77-79.
8. 秦革萍, 马平康, 杜睿, 等.地佐辛用于剖宫产术后镇痛的疗效观察.中国现代药物应用, 2012, 6(13):84-85.
9. 任培才.肠道肿瘤切除手术术后地佐辛静脉自控镇痛的评价.广州医药, 2012, 43(5):24-26.
10. 陶岩, 鄂爽, 陈琦, 等.地佐辛用于颈椎手术术后镇痛的临床研究.中外医疗, 2013, (2):109-111.
11. 王军, 王志萍, 黄东晓.地佐辛与芬太尼患者自控静脉镇痛的比较.实用临床医药杂志, 2011, 15(5):109-110.
12. 王磊. 0.05%的地佐辛用于术后静脉自控镇痛临床观察.吉林医学, 2012, 33(15):3211.
13. 谢国柱, 钱涛, 姜琳.地佐辛用于妇科术后镇痛的临床观察.海南医学, 2011, 22(21):48-50.
14. 叶秀丽.地佐辛与芬太尼用于子宫切除术后镇痛效果的比较.中国医药指南, 2011, 9(25):267-268.
15. 张贵权, 高秀敏.地佐辛用于术后镇痛的临床观察.吉林医学, 2013, 34(3):480-481.
16. 赵森, 吕国义, 孙成亮, 等.地佐辛与芬太尼用于悬雍垂腭咽成形术后镇痛的评价.天津医药, 2012, 40(9):905-907.
17. 师小伟, 熊源长, 刘佩蓉.地佐辛临床镇痛的研究进展.医学综述, 2013, 19(6):1105-1107.
18. Kaczor A, Matosiuk D. Non-peptide opioid receptor ligands-recent advances. PartII-antagonists. Curr Med Chem, 2002, 9(17):1591-1603.
19. Gal TJ, DiFazio CA.Ventilatory and analgesic effects of dezocine in human. Anesthesiology, 1984, 61(6):716-722.
20. Zacny JP, Lichtor JL, De Wit H. Subjective, behavioral, and physiologic responses to intravenous dezocine in healthy volunteers. Anesth Analg, 1992, 74(4):523-530.

Chinese Journal of Evidence-Based Medicine

Effectiveness and Safety of Dezocine versus Fentanyl for Postoperative Patient-controlled Intravenous Analgesia: A Systematic Review

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