Risk Factors of Epilepsy: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 YANGBo-wen ^1,2 , CHENXin ^1,2 , SUNHao ^1,2 , ZOUSa-feng ³ ,  SHIJing-pu ^1,2

1. Department of Clinical Epidemiology, The First Alienated Hospital, China Medical University, Shenyang 110001, China;
2. Evidence-Based Center of Liaoning Province, Shenyang 110001, China;
3. Dalian Central Hospital Affiliated to Dalian Medical University, Dalian 116001, China;

Corresponding author：

SHIJing-pu, Email: sjp56@yahoo.com

Keywords：

Epilepsy; Risk factor; Case-control study; Meta-analysis

DOI：

10.7507/1672-2531.20140016

Video：

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Objective To explore the main risk factors related to the incidence of epilepsy and the cause of epilepsy, so as to provide basis for decision making on epilepsy prevention. Methods Such databases as PubMed (1980 to 2013.1.2), EMbase (1980 to 2013.1.2) and CNKI (1987 to 2013.1.2) were electronically searched to collect case-control studies on risk factors for epilepsy. Meanwhile, relevant studies were also manually retrieved. Two reviewers independently screened studies according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality. Then, meta-analysis was performed using RevMan 5.2 software. Results 17 studies involving 6 641 participants (including 3 114 cases and 3 527 controls) were included. The results of meta-analysis showed that, family history of epilepsy, traumatic brain injury, febrile seizures, neonatal disease, and risk factors during pregnancy were associated with the incidence of epilepsy, with pooled OR (95%CI) values of 5.11 (3.19, 8.20), 4.14 (3.63, 4.73), 5.10 (2.64, 9.87), 3.33 (1.84, 6.05), and 3.23 (1.80, 5.78), respectively. Conclusion Currently evidence shows that the risk factors influencing the incidence of epilepsy are family history of epilepsy, traumatic brain injury, febrile seizures, neonatal disease, and risk factors during pregnancy.

Citation： YANGBo-wen, CHENXin, SUNHao, ZOUSa-feng, SHIJing-pu. Risk Factors of Epilepsy: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(1): 94-100. doi: 10.7507/1672-2531.20140016 Copy

1.	Annegers J. Epidemiology and genetics of epilepsy. Neurol Clinics, 1994, 12(1):15.
2.	Beghi E, Berg A, Carpio A, et al. Comment on epileptic seizures and epilepsy:definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 2005, 46(10):1698-1699.
3.	李明.癫痫发病危险因素及原发性癫痫遗传流行病学研究.济南:山东大学, 2010.
4.	DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials:an update. Contemp Clin Trials, 2007, 28(2):105-114.
5.	杨春霞, 张思霖.原发性癫痫的病例对照研究.现代预防医学1997, 24(4):397-398.
6.	李明, 车峰远, 薛付忠.癫痫危险因素病例对照研究.中国公共卫生2010, (6):789-790.
7.	杨金升, 吴志英, 郭起棠, 等.西北五省区儿童癫痫流行病学研究.实用儿科临床杂志1990, 2(2):3.
8.	曾军, 洪震, 黄茂盛, 等.人群癫痫危险因素及社会心理因素病例对照研究.中华流行病学杂志, 2003, 24(2):116-118.
9.	吴志英.中国西北癫痫遗传流行病学病例对照研究.兰后卫生, 1994, 15(1):1-2.
10.	Masri A, Badran E, Hamamy H, et al. Etiologies, outcomes, and risk factors for epilepsy in infants:A case-control study. Clin Neurol Neurosurg, 2008, 110(4):352-356.
11.	Asadi-Pooya AA, Hojabri K. Risk factors for childhood epilepsy:a case-control study. Epilepsy Behav, 2005, 6(2):203.
12.	Kannoth S, Unnikrishnan JP, Santhosh Kumar T, et al. Risk factors for epilepsy:A population-based case-control study in Kerala, southern India. Epilepsy Behav, 2009, 16(1):58-63.
13.	Matuja W, Kilonzo G, Mbena P, et al. Risk Factors for Epilepsy in a Rural Area in Tanzania. Neuroepidemiology, 2001, 20(4):242-247.
14.	Ogunniyi A, Osuntokun B, Bademosi O, et al. Risk factors for epilepsy:case-control study in Nigerians. Epilepsia, 1987, 28(3):280.
15.	Attumalil T, Sundaram A, Varghese V, et al. Risk factors of childhood epilepsy in Kerala. Ann Indian Acad Neurol, 2011, 14(4):283.
16.	Daoud A, Batieha A, Bashtawi M, et al. Risk factors for childhood epilepsy:a case-control study from Irbid, Jordan. Seizure, 2003, 12(3):171-174.
17.	Tran DS, Odermatt P, Le Oanh T, et al. Risk factors for epilepsy in rural Lao PDR:a case-control study. Southeast Asian J Trop Med Public Health, 2007, 38(3):537-542.
18.	Kwong KL, Sung WY, Wong SN, et al. Early predictors of medical intractability in childhood epilepsy. Pediatr Neurol, 2003, 29(1):46-52.
19.	Bhalla D, Chea K, Hun C, et al. Population-based study of epilepsy in Cambodia associated factors, measures of impact, stigma, quality of life, knowledge-attitude-practice, and treatment gap. PLoS One, 2012, 7(10):e46296.
20.	Matias-Guiu J, Galiano L, Vioque J, et al. A case-control study to evaluate the association of epilepsy and migraine. Neuroepidemiology, 1992, 11(4-6):313-314.
21.	Sawhney I, Singh A, Kaur P, et al. A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country. J Neurol Sci, 1999, 165(1):31-35.
22.	Scheffer IE, Berkovic SF. Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. Brain, 1997, 120(3):479-490.
23.	龚珂, 王红霞.颅脑损伤并发癫痫的观察与分析.河南实用神经疾病杂志, 2002, 5(5):47.
24.	张美林, 黄斌, 陈阳美.缺血性卒中后癫痫发作危险因素的临床分析.重庆医科大学学报, 2010, 35(4):608-612.
25.	张策.颅脑损伤后预防应用抗癫痫药物疗效Meta分析.中华神经医学杂志, 2011, 10(4):4.
26.	赵永波, 邵丽.颅脑损伤后癫痫.临床神经病学杂志, 2006, 19(5):397-398.
27.	林庆, 主编.实用小儿癫痫病学.第1版.北京:科学技术出版社, 2004:58-113.
28.	李袁华, 周春雷, 赵德明, 等.癫痫持续状态致MODS的发生率及其相关因素分析.中华全科医学, 2008, 6(9):925-926.
29.	秦兵, 廖卫平.癫痫:全球重点防治的神经精神疾病.实用医学杂志, 2012, 28(13):2109-2111.

1. Annegers J. Epidemiology and genetics of epilepsy. Neurol Clinics, 1994, 12(1):15.
2. Beghi E, Berg A, Carpio A, et al. Comment on epileptic seizures and epilepsy:definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 2005, 46(10):1698-1699.
3. 李明.癫痫发病危险因素及原发性癫痫遗传流行病学研究.济南:山东大学, 2010.
4. DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials:an update. Contemp Clin Trials, 2007, 28(2):105-114.
5. 杨春霞, 张思霖.原发性癫痫的病例对照研究.现代预防医学1997, 24(4):397-398.
6. 李明, 车峰远, 薛付忠.癫痫危险因素病例对照研究.中国公共卫生2010, (6):789-790.
7. 杨金升, 吴志英, 郭起棠, 等.西北五省区儿童癫痫流行病学研究.实用儿科临床杂志1990, 2(2):3.
8. 曾军, 洪震, 黄茂盛, 等.人群癫痫危险因素及社会心理因素病例对照研究.中华流行病学杂志, 2003, 24(2):116-118.
9. 吴志英.中国西北癫痫遗传流行病学病例对照研究.兰后卫生, 1994, 15(1):1-2.
10. Masri A, Badran E, Hamamy H, et al. Etiologies, outcomes, and risk factors for epilepsy in infants:A case-control study. Clin Neurol Neurosurg, 2008, 110(4):352-356.
11. Asadi-Pooya AA, Hojabri K. Risk factors for childhood epilepsy:a case-control study. Epilepsy Behav, 2005, 6(2):203.
12. Kannoth S, Unnikrishnan JP, Santhosh Kumar T, et al. Risk factors for epilepsy:A population-based case-control study in Kerala, southern India. Epilepsy Behav, 2009, 16(1):58-63.
13. Matuja W, Kilonzo G, Mbena P, et al. Risk Factors for Epilepsy in a Rural Area in Tanzania. Neuroepidemiology, 2001, 20(4):242-247.
14. Ogunniyi A, Osuntokun B, Bademosi O, et al. Risk factors for epilepsy:case-control study in Nigerians. Epilepsia, 1987, 28(3):280.
15. Attumalil T, Sundaram A, Varghese V, et al. Risk factors of childhood epilepsy in Kerala. Ann Indian Acad Neurol, 2011, 14(4):283.
16. Daoud A, Batieha A, Bashtawi M, et al. Risk factors for childhood epilepsy:a case-control study from Irbid, Jordan. Seizure, 2003, 12(3):171-174.
17. Tran DS, Odermatt P, Le Oanh T, et al. Risk factors for epilepsy in rural Lao PDR:a case-control study. Southeast Asian J Trop Med Public Health, 2007, 38(3):537-542.
18. Kwong KL, Sung WY, Wong SN, et al. Early predictors of medical intractability in childhood epilepsy. Pediatr Neurol, 2003, 29(1):46-52.
19. Bhalla D, Chea K, Hun C, et al. Population-based study of epilepsy in Cambodia associated factors, measures of impact, stigma, quality of life, knowledge-attitude-practice, and treatment gap. PLoS One, 2012, 7(10):e46296.
20. Matias-Guiu J, Galiano L, Vioque J, et al. A case-control study to evaluate the association of epilepsy and migraine. Neuroepidemiology, 1992, 11(4-6):313-314.
21. Sawhney I, Singh A, Kaur P, et al. A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country. J Neurol Sci, 1999, 165(1):31-35.
22. Scheffer IE, Berkovic SF. Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. Brain, 1997, 120(3):479-490.
23. 龚珂, 王红霞.颅脑损伤并发癫痫的观察与分析.河南实用神经疾病杂志, 2002, 5(5):47.
24. 张美林, 黄斌, 陈阳美.缺血性卒中后癫痫发作危险因素的临床分析.重庆医科大学学报, 2010, 35(4):608-612.
25. 张策.颅脑损伤后预防应用抗癫痫药物疗效Meta分析.中华神经医学杂志, 2011, 10(4):4.
26. 赵永波, 邵丽.颅脑损伤后癫痫.临床神经病学杂志, 2006, 19(5):397-398.
27. 林庆, 主编.实用小儿癫痫病学.第1版.北京:科学技术出版社, 2004:58-113.
28. 李袁华, 周春雷, 赵德明, 等.癫痫持续状态致MODS的发生率及其相关因素分析.中华全科医学, 2008, 6(9):925-926.
29. 秦兵, 廖卫平.癫痫:全球重点防治的神经精神疾病.实用医学杂志, 2012, 28(13):2109-2111.

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