YANGMing-gen , ZHENGZhou-da , XUZhen-qiang , LINHai-li , ZHUANGZhi-ming , ZHANGChao-xian
  • Department of Urology, Zhangzhou Affiliated Hospital, Fujian Medical University, Zhangzhou 363000, China;
Prostate cancer; Hyperlipoidemia; Risk factor
10.7507/1672-2531.20140072
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Objective To assess whether hyperlipoidemia affects the occurrence and progression of prostate cancer (PCA). Methods A hospital based retrospective study was carried out in Zhangzhou Affiliated Hospital of Fujian Medical University using data from a total of 112 cases of PCA, which underwent radical prostatectomy due to suspected PCA and confirmed by prostate biopsy pathology. Results Of the 112 PCA patients, 64 (57.14%) were PCA with hyperlipoidemia (PCA-H). Compared with PCA patients, the patients of PCA-H patients had younger onset age (65.0±5.0 vs. 67.8±3.7, P=0.001), increased prostate volume (75.0±11.7 mL vs. 54.5±8.5 mL, P < 0.001), increased level of TPSA (61.4±23.3 ng/mL vs. 33.4±14.9 ng/mL, P < 0.001), and Gleason grade (6.9±1.8 vs. 5.0±1.9, P < 0.001), later clinical stage (P < 0.001), shorter survival time (49.8±12.7 months vs. 57.3±6.2 months, P < 0.001) and decreased 5 years of survival rate (51.6% vs. 77.1%, P=0.006). The level of cholesterol, triglyceride and high density lipoprotein was significantly associated with the rejuvenation of onset age, the enlargement of prostate volume, increasing of serum TPSA, the progression of TNM clinical stage, increasing of Gleason grade, shorten of survival time and dropping of 5 years of survival rate (P < 0.05). In multiplefactor regression analysis, only hyperlipoidemia (OR=3.204, P=0.022) and Gleason grade (OR=8.611, P < 0.001) were the independent risk factors of prognosis. Conclusion The situation of PCA with hyperlipoidemia is frequently noted in clinics, and hyperlipoidemia may be one of the risk factors in the processes of PCA growth and progression.

Citation： YANGMing-gen, ZHENGZhou-da, XUZhen-qiang, LINHai-li, ZHUANGZhi-ming, ZHANGChao-xian. Correction between Hyperlipoidemia and Prostate Cancer: A Clinical Study. Chinese Journal of Evidence-Based Medicine, 2014, 14(4): 414-417. doi: 10.7507/1672-2531.20140072 Copy

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