Risk Factors of Early Onset Coronary Heart Disease in Tibetan Residents: A Cross-sectional Study_Chinese Journal of Evidence-Based Medicine

Authors：

 LIHong-wei ¹ , ZHOUYao ¹ , WANGHai-yan ¹ , YANGShu-juan ²

1. Department of Cardiology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu 610041, China;
2. Education & Research Department of Child and Adolescent, West China School of Public Health, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Tibetan; Early onset coronary heart disease; Risk factor; Cross-sectional study

DOI：

10.7507/1672-2531.20140111

Video：

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Objective To explore and discuss the risk factors of early onset coronary heart disease in Tibetan residents. Methods We selected Tibetan residents with coronary heart disease who were hospitalized in the Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region between January 2011 and May 2013, and then divided them into two groups by age (early onset and late onset coronary heart disease groups). Univariate analysis was performed between two groups by gender, family history, smoking, drinking, hypertension, diabetes, levels of blood lipid, respectively. The factors with significant differences were extracted for logistic regression. Data analysis was performed using SPSS 16.0 software. Results A total of 64 Tibetan residents with coronary heart disease were included, of which, 22 cases were in the early onset groups and 42 cases the late onset group. The results of univariate analysis showed that, significant differences were found in gender, family history, and levels of HDL-C and LDL-C (all P < 0.05). Besides, the results of logistic regression showed that, family history (OR=3.374, P < 0.05), high triglycerides level (OR=2.369, P < 0.05), low HDL-C level (OR=0.014, P < 0.05) and high level of LDL-C (OR=3.008, P < 0.05) were independent risk factors of early onset coronary heart disease in Tibetan residents. Conclusion Positive family history, high triglycerides level, low HDL-C level and high level of LDL-C are independent risk factors of early onset coronary heart disease in Tibetan residents.

Citation： LIHong-wei, ZHOUYao, WANGHai-yan, YANGShu-juan. Risk Factors of Early Onset Coronary Heart Disease in Tibetan Residents: A Cross-sectional Study. Chinese Journal of Evidence-Based Medicine, 2014, 14(6): 662-664. doi: 10.7507/1672-2531.20140111 Copy

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4.	中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南(2007).中华心血管病杂志, 2007, 35(5):390-409.
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7.	孙建琦, 章锡林, 胡剑平.不同性别早发冠心病患者危险因素及冠脉造影病变特点分析.安徽医学, 2011, 32(2):213-214.
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11.	刘晓宁, 黄晓江, 宋燕, 等. G蛋白β3亚单位基因和α-内收蛋白基因多态性与早发冠心病的相关性研究.中华心血管病杂志, 2004, 32(8):708-711.
12.	Lamm G, Auer J, Weber T, et al. Cardiovascular risk factor profiles and angiography results in young patients. Acta Med Austriaca, 2003, 30(3):72-75.
13.	Hauser ER, Mooser V, Crossman AD, et al. Design of the genetics of early onset cardiovascular disease (GENECARD) study. Am Heart J, 2003, 145(4):602-613.
14.	刘志远, 李纲, 李玉东, 等.早发冠心病患者冠状动脉病变特点及危险因素的临床研究.中国心血管病研究, 2008, 6(9):657-659.
15.	王立军, 黄浙勇.早发冠心病患者危险因素与冠状动脉病变的性别差异.疑难病杂志, 2006, 5(5):328-330.
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18.	Radak D, Babic S, Peric M, et al. Distribution of risk factors in patients with premature coronary, supra-aortic branches and peripheral atherosclerotic disease. Med Princ Pract, 2012, 21(3):228-233.
19.	李玲, 杨天和, 李菊.男性早发冠心病急性心肌梗死的临床研究.重庆医学, 2009, 38(18):2339-2341.
20.	Hochner-Celnikier D, Manor O, Gotzman O, et al. Cender gap in coronary artery disease:Comparison of the extent, severity and risk factors in men and women aged 45-65 years. Cardiology, 2002, 97(1):18-23.

1. Serena T, Arne W. Implementation of guidelines to screen relatives of patients with premature coronary heart disease in a hospital setting. Am J Cardiol, 2002, 90(11):1211-1214.
2. 中国高血压防治指南修订委员会.中国高血压防治指南2010.中华高血压杂志, 2011, 19(8):701-743.
3. World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Geneva, World Health Org, 1999.
4. 中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南(2007).中华心血管病杂志, 2007, 35(5):390-409.
5. 于扬, 李建平, 霍勇.早发冠心病危险因素和冠状动脉病变特点的研究.中国介入心脏病学杂志, 2007, 15(5):270-273.
6. 王秀英, 王绍红, 张克峰.老年冠心病再发心脏事件的危险因素分析.心血管康复医学杂志, 2000, 9(2):22-23.
7. 孙建琦, 章锡林, 胡剑平.不同性别早发冠心病患者危险因素及冠脉造影病变特点分析.安徽医学, 2011, 32(2):213-214.
8. 陈忠, 马根生, 黄峻.不同性别早发冠心病患者代谢综合征特征分析.中华全科医师杂志, 2006, 5(5):300-302.
9. Taylor AJ, Bindeman J, Bhattarai S, et al. Subclinical calcified atherosclerosis in men and its association with a family history of premature coronary heart disease in first-and second-degree relatives. Prev Cardiol, 2004, 7(4):163-167.
10. Nassar BA, Nanji AA, Ransom TP, et al. Role of the fractalkine receptor CX3CRl polymorphisms V2491 and T280Ma8 risk facton for early-onset coronary artery disease in patients with no classic risk factors. Seand J Clin lab Invest, 2008, 68(4):286-291.
11. 刘晓宁, 黄晓江, 宋燕, 等. G蛋白β3亚单位基因和α-内收蛋白基因多态性与早发冠心病的相关性研究.中华心血管病杂志, 2004, 32(8):708-711.
12. Lamm G, Auer J, Weber T, et al. Cardiovascular risk factor profiles and angiography results in young patients. Acta Med Austriaca, 2003, 30(3):72-75.
13. Hauser ER, Mooser V, Crossman AD, et al. Design of the genetics of early onset cardiovascular disease (GENECARD) study. Am Heart J, 2003, 145(4):602-613.
14. 刘志远, 李纲, 李玉东, 等.早发冠心病患者冠状动脉病变特点及危险因素的临床研究.中国心血管病研究, 2008, 6(9):657-659.
15. 王立军, 黄浙勇.早发冠心病患者危险因素与冠状动脉病变的性别差异.疑难病杂志, 2006, 5(5):328-330.
16. Carr MC, Brunzell JD. Abdominal obesity and dyslipidemia in the metabolic syndrome:Importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrino Metab, 2004, 89(6):2601-2607.
17. Angeja BG, Kermgard S, Chen MS, et al. The smokers paradox:insights from the angiographic substudies of the YMI trials. J Thromb Thrombolysis, 2002, 13(3):133-139.
18. Radak D, Babic S, Peric M, et al. Distribution of risk factors in patients with premature coronary, supra-aortic branches and peripheral atherosclerotic disease. Med Princ Pract, 2012, 21(3):228-233.
19. 李玲, 杨天和, 李菊.男性早发冠心病急性心肌梗死的临床研究.重庆医学, 2009, 38(18):2339-2341.
20. Hochner-Celnikier D, Manor O, Gotzman O, et al. Cender gap in coronary artery disease:Comparison of the extent, severity and risk factors in men and women aged 45-65 years. Cardiology, 2002, 97(1):18-23.

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Risk Factors of Early Onset Coronary Heart Disease in Tibetan Residents: A Cross-sectional Study

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