Efficacy and Safety Radio-chemotherapy Combined with Thermotherapy for Cervical Cancer: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 YANXiang-yong ¹ ,  LIUWen-chao ¹ , YANZhong-sheng ² , MAJi ¹

1. Department of Clinical Oncology, The Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;
2. Department of Integrative Medicine, Lanzhou Military Region General Hospital, Lanzhou 730050, China;

Corresponding author：

LIUWen-chao, Email: liuch@fmmu.edu.cn

Keywords：

Cervical cancer; Thermotherapy; Radio-chemotherapy; Meta-analysis; Systematic review; Randomized controlled trial

DOI：

10.7507/1672-2531.20140126

Video：

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Objective To systematically review the efficacy and safety of radio-chemotherapy combined with thermotherapy for cervical cancer. Methods Literature about the efficacy and safety of radio-chemotherapy combined with thermotherapy for patients with cervical cancer at mid-term/advanced stage was retrieved from digital databases of The Cochrane Library (Issue 7, 2013), PubMed, EMbase, CBM, VIP, CNKI, and WanFang Data, and from their established dates to July, 2013. Data extraction and quality assessment of included studies were conducted by two reviewers independently. RevMan 5.2 software was then used to perform meta-analysis. Results A total of 9 randomized controlled trials involving 693 patients were included. The results of meta-analysis showed that, compared with the radio-chemotherapy alone group, the radio-chemotherapy combined with thermotherapy group had significant increased 1-year survival rates (OR=3.05, 95%CI 1.70 to 6.68, P=0.005), 2-year survival rates (OR=2.29, 95%CI 1.19 to 4.38, P=0.01), and overall effective rates (OR=3.66, 95%CI 2.31 to 5.81, P < 0.000 01). The incidence of adverse reactions was no statistically significant between the two groups. Conclusion Radio-chemotherapy combined with thermotherapy improves long-term survival rates and short-term curative effects for patients with cervical cancer at mid-term/advanced stage. However, due to the limited quantity and quality of the included studies, more high quality studies with large sample size and long-term follow-up are still needed to verify the above conclusion.

Citation： YANXiang-yong, LIUWen-chao, YANZhong-sheng, MAJi. Efficacy and Safety Radio-chemotherapy Combined with Thermotherapy for Cervical Cancer: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(6): 752-758. doi: 10.7507/1672-2531.20140126 Copy

1.	Shi JF, Canfell K, Lew JB, et al. The burden of cervical cancer in China:Synthesis of the evidence. Int J Cancer, 2011, 130(3):641-652.
2.	杨芸.宫颈癌治疗进展.中外医疗, 2009, 27(9):169.
3.	Wust P, Hildebrandt B, Sreenivasa G, et al. Hyperthermia in combined treatment of cancer. Lancet Oncol, 2002, 3(8):487-497.
4.	高琨, 张彩红, 陈心秋, 等.同步热放化疗治疗中晚期宫颈癌的近期疗效观察.重庆医学, 2013, 42(7):736-738.
5.	石兴源, 周同冲, 林晓丹, 等.深部热疗联合放化疗与单纯放化疗治疗中晚期子宫颈癌的随机对照研究.实用肿瘤杂志, 2012, 27(4):386-390.
6.	李凯新, 张江灵.深部热疗加同步放化疗治疗局部晚期宫颈癌的临床研究.现代肿瘤医学, 2012, 20(3):595-598.
7.	陈文娟, 王捷忠, 潘建基, 等.中晚期巨块型宫颈癌热疗配合同步放化疗的近期疗效观察.中国医药指南, 2012, 10(27):54-55.
8.	许江兰, 王也, 任磊.深部热疗联合顺铂增敏同步放疗治疗中晚期宫颈癌的临床研究.内蒙古医学杂志, 2011, 43(9):1045-1047.
9.	袁春銮, 王忠明, 蒋华. PF方案同步化放疗联合热疗治疗中晚期宫颈癌的临床观察.实用临床医药杂志, 2010, 14(23):139-140.
10.	李绪彤, 张彩霞, 于洪莉.热疗联合放化疗治疗局部晚期子宫颈癌的临床分析.肿瘤研究与临床, 2009, 21(11):734-736.
11.	刘甲炎, 马爱平, 李菲.深部热疗加同步放化疗治疗晚期宫颈癌的近期疗效观察.中国实用医药, 2009, 4(6):132-134.
12.	方绳权, 张洁清, 高琨, 等.深部热疗加同步放化疗治疗Ⅲb期宫颈癌的临床价值.中国实用妇科与产科杂志, 2008, 24(11):827-829.
13.	Symonds P. Chemoradiation:the new gold standard for non-surgical treatment of cervical cance. Clin Oncol (R Coll Radiol), 2002, 14(3):201-202.
14.	丁素银, 李青山.肿瘤热疗的基础及临床研究进展.承德医学院学报, 2010, 27(4):415-419.
15.	Westermann AM, Grosen EA, Katschinski DM, et al. A pilot study of whole body hyperthermia and carboplatin in platinum-resistant ovarian cancer. Eur J Cancer, 2001, 37(9):1111-1117.
16.	Takahashi I, Emi Y, Hasuda S, et al. Clinical application of hyperthermia combined with anticancer drugs for the treatment of solid tumors. Surgery, 2002, 131(suppl1):78-84.
17.	李征, 杨克虎, 米登海, 等.进展期胃癌术后腹腔热灌注化疗有效性和安全性的系统评价.中国循证医学杂志, 2011, 11(12):1402-1408.
18.	李征, 米登海, 杨克虎, 等. NP化疗联合热疗治疗非小细胞肺癌的Meta分析.甘肃医药, 2011, 30(8):451-456.
19.	de Haas-Kock DF, Buijsen J, Pijls-Johannesma M, et al. Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer. Cochrane Database Syst Rev, 2009, (3): CD006269.
20.	Lutgens L, van der Zee J, Pijls-Johannesma M, et al. Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma. Cochrane Database Syst Rev, 2010, (1): CD006377.
21.	Bergs JW, Franken NA, Haveman J, et al. Hyperthermia, cisplatin and radiation trimodality treatment:a promising cancer treatment? A review from preclinical studies to clinical application. Int J Hyperthermia, 2007, 23(4):329-341.

1. Shi JF, Canfell K, Lew JB, et al. The burden of cervical cancer in China:Synthesis of the evidence. Int J Cancer, 2011, 130(3):641-652.
2. 杨芸.宫颈癌治疗进展.中外医疗, 2009, 27(9):169.
3. Wust P, Hildebrandt B, Sreenivasa G, et al. Hyperthermia in combined treatment of cancer. Lancet Oncol, 2002, 3(8):487-497.
4. 高琨, 张彩红, 陈心秋, 等.同步热放化疗治疗中晚期宫颈癌的近期疗效观察.重庆医学, 2013, 42(7):736-738.
5. 石兴源, 周同冲, 林晓丹, 等.深部热疗联合放化疗与单纯放化疗治疗中晚期子宫颈癌的随机对照研究.实用肿瘤杂志, 2012, 27(4):386-390.
6. 李凯新, 张江灵.深部热疗加同步放化疗治疗局部晚期宫颈癌的临床研究.现代肿瘤医学, 2012, 20(3):595-598.
7. 陈文娟, 王捷忠, 潘建基, 等.中晚期巨块型宫颈癌热疗配合同步放化疗的近期疗效观察.中国医药指南, 2012, 10(27):54-55.
8. 许江兰, 王也, 任磊.深部热疗联合顺铂增敏同步放疗治疗中晚期宫颈癌的临床研究.内蒙古医学杂志, 2011, 43(9):1045-1047.
9. 袁春銮, 王忠明, 蒋华. PF方案同步化放疗联合热疗治疗中晚期宫颈癌的临床观察.实用临床医药杂志, 2010, 14(23):139-140.
10. 李绪彤, 张彩霞, 于洪莉.热疗联合放化疗治疗局部晚期子宫颈癌的临床分析.肿瘤研究与临床, 2009, 21(11):734-736.
11. 刘甲炎, 马爱平, 李菲.深部热疗加同步放化疗治疗晚期宫颈癌的近期疗效观察.中国实用医药, 2009, 4(6):132-134.
12. 方绳权, 张洁清, 高琨, 等.深部热疗加同步放化疗治疗Ⅲb期宫颈癌的临床价值.中国实用妇科与产科杂志, 2008, 24(11):827-829.
13. Symonds P. Chemoradiation:the new gold standard for non-surgical treatment of cervical cance. Clin Oncol (R Coll Radiol), 2002, 14(3):201-202.
14. 丁素银, 李青山.肿瘤热疗的基础及临床研究进展.承德医学院学报, 2010, 27(4):415-419.
15. Westermann AM, Grosen EA, Katschinski DM, et al. A pilot study of whole body hyperthermia and carboplatin in platinum-resistant ovarian cancer. Eur J Cancer, 2001, 37(9):1111-1117.
16. Takahashi I, Emi Y, Hasuda S, et al. Clinical application of hyperthermia combined with anticancer drugs for the treatment of solid tumors. Surgery, 2002, 131(suppl1):78-84.
17. 李征, 杨克虎, 米登海, 等.进展期胃癌术后腹腔热灌注化疗有效性和安全性的系统评价.中国循证医学杂志, 2011, 11(12):1402-1408.
18. 李征, 米登海, 杨克虎, 等. NP化疗联合热疗治疗非小细胞肺癌的Meta分析.甘肃医药, 2011, 30(8):451-456.
19. de Haas-Kock DF, Buijsen J, Pijls-Johannesma M, et al. Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer. Cochrane Database Syst Rev, 2009, (3): CD006269.
20. Lutgens L, van der Zee J, Pijls-Johannesma M, et al. Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma. Cochrane Database Syst Rev, 2010, (1): CD006377.
21. Bergs JW, Franken NA, Haveman J, et al. Hyperthermia, cisplatin and radiation trimodality treatment:a promising cancer treatment? A review from preclinical studies to clinical application. Int J Hyperthermia, 2007, 23(4):329-341.

Chinese Journal of Evidence-Based Medicine

Efficacy and Safety Radio-chemotherapy Combined with Thermotherapy for Cervical Cancer: A Meta-Analysis

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