Influence of Paternal Serum HBV-DNA Load Levels and Pregnant Women's HBsAb on Paternal Vertical Transmission of Hepatitis B Virus_Chinese Journal of Evidence-Based Medicine

Authors：

 CHENShun-ping ¹ ,  ZHANGRong-lian ² , RENKun-hai ²

1. Department of Nursing, Fujian Health College, Fuzhou 350101, China;
2. Department of Healthcare, Fujian Maternal and Children's Health Care Hospital, Fuzhou 350101, China;

Corresponding author：

ZHANGRong-lian, Email: wpxzrl@163.com

Keywords：

Hepatitis B virus; Father to infant vertical transmission; DNA; HBsAb; Case-control study

DOI：

10.7507/1672-2531.20140152

Video：

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Objective To explore the influence of paternal serum HBV-DNA load levels and pregnant women's HBsAb on vertical transmission of hepatitis B virus (HBV) from HBsAg positive fathers to infants in order to provide effective methods for paternal-fetal ventrical transmission of HBV prevention. Methods Using HBsAg and HBV-DNA as indicators to screen pregnant women and their husbands after gained consent, 121 families with HBVM negative or only HBsAb positive and HBV-DNA negative pregnant women, HBsAg positive husbands and their newborns were selected. In this case-control study, according to neonatal cord blood HBV-DNA detection, 23 newborns with cord blood HBV-DNA positive were selected as cases, 98 newborns as controls. Results The positive rate of neonatal cord blood HBV-DNA was 19.0% (23/121); and there was dose-response relationship between paternal serum HBV-DNA load levels and neonatal cord blood HBV-DNA positive (trend χ²=60.108, P=0.000). The analysis of ROC curve showed that paternal serum HBV-DNA load level (10⁶ copies/mL) is a better demarcation point to forecast the occurrence of vertical transmission of HBV from HBsAg positive fathers to infants, because there was a better sensitivity and specificity during forecast; and HBsAb negative pregnant women's were statistically significant (χ²=12.399, P=0.000). There was no significant difference at the positive rate of neonatal cord blood HBV-DNA between the case group and control group when paternal serum HBV-DNA load levels exceed 10⁷ copies/mL (P > 0.05). Conclusion Paternal serum HBV-DNA load levels and HBsAb negative pregnant women are the risk factors of vertical transmission of HBV from HBsAg positive father to infants. Paternal serum HBV-DNA load level (10⁶ copies/mL) is an appropriate index of the occurrence of vertical transmission.

Citation： CHENShun-ping, ZHANGRong-lian, RENKun-hai. Influence of Paternal Serum HBV-DNA Load Levels and Pregnant Women's HBsAb on Paternal Vertical Transmission of Hepatitis B Virus. Chinese Journal of Evidence-Based Medicine, 2014, 14(8): 915-918. doi: 10.7507/1672-2531.20140152 Copy

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19.	张海青.乙型肝炎病毒父婴垂直传播的临床分析.中国优生与遗传杂志, 2010, 18(6): 27, 30.
20.	张国民, 孙校金, 王富珍, 等.中国18～59岁人群乙型病毒性肝炎流行病学特征分析及乙型肝炎疫苗免疫策略探讨.中国疫苗和免疫, 2013, 19(3): 266-270.
21.	陈顺萍, 林翔.重视围生期孕产妇乙肝防治的健康教育.中国妇幼保健, 2012, 18(2): 4355-4357.

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2. 中华人民共和国国家卫生和计划生育委员会. 2012年度全国法定传染病疫情概况. 2013. Available at: http://www.chinapop.gov.cn/zhuzhan/yqxx/201304/b540269c8e5141e6bb2d00ca539bb9f7.shtml.
3. 王建设, 朱启镕, 张鸿飞.中华医学会感染病学分会第八次全国小儿肝病学术会议纪要.中国循证儿科杂志, 2007, 2(3): 238-239.
4. Ali BA, Huang TH, Saleml HH, et al. Expression of hepatitis B virus genes in early embryonic cells originated from hamster ova and human spermatozoa transfected with the complete viral genome. Asian J Androl, 2006, 8(3): 273.
5. 孟庆举, 肖小敏.产前乙型肝炎病毒父婴垂直传播几率的Meta分析.中国优生与遗传杂志, 2008, 16(5): 62-63.
6. 李穗湘.人乙肝免疫球蛋白联合重组乙肝疫苗对乙型肝炎父婴传播控制的临床研究.中国初级卫生保健, 2006, 20(6): 65-66.
7. 杨静, 邵兴兰, 尤世刚.乙肝免疫球蛋白阻断HBV父婴、母婴传播的观察.现代预防医学, 2006, 33(5): 806-813.
8. 练云, 陆晓梅, 崔琰, 等.乙型肝炎病毒父婴垂直传播及预防免疫的临床研究.中国妇幼保健, 2007, 22(7): 4122-4123.
9. 陈红, 李小鸥, 雷艳喆.阻断乙型肝炎病毒父婴传播的研究.中国优生与遗传杂志, 2009, 17(2): 80-81.
10. 张俊明, 李国敏, 洪宝林, 等.预防免疫阻断乙型肝炎父婴传播的临床研究.实用临床医药杂志, 2009, 13(12): 134-135.
11. 张荣莲, 罗颖, 谢婧娴, 等. HBV父婴垂直传播水平与HBV-DNA载量的相关研究.中华流行病学杂志, 2010, 31(5): 159-162.
12. 潘大虎, 翟海燕, 宋农, 等. HBV-DNA的定量检测对乙肝父婴与母婴传播的研究.右江民族医学院学报, 2007, 2(5): 211-212.
13. 高颖, 李峰. HBV父婴传播的分子生物学研究.中国医药指南, 2008, 6(1): 1-2.
14. 卢银平, 曹伟, 洪梅, 等.父亲HBV携带与婴儿HBV感染的关系.中国妇幼保健, 2011, 26(2): 220-221.
15. 王文龙, 唐晓鹏, 丁依玲, 等.妊娠晚期母婴乙型肝炎表面抗体浓度相关性研究.中国感染控制杂志, 2004, 3(2): 106-108.
16. 朱科伦, 朱郇悯, 曾文铤, 等.乙型肝炎病毒经生殖细胞传播的研究.广州医药, 2008, 9(2): 3-5.
17. 夏良斌, 敖良飞, 杨菁, 等.不同方案阻断乙型肝炎病毒父婴垂直传播的初步研究.实用医学杂志, 2010, 26(4): 583-584.
18. 葛晓英, 徐云萍, 蔡东飞, 等.预防免疫阻断乙肝病毒父婴传播效果观察.浙江临床医学, 2006, 8(5): 458-459.
19. 张海青.乙型肝炎病毒父婴垂直传播的临床分析.中国优生与遗传杂志, 2010, 18(6): 27, 30.
20. 张国民, 孙校金, 王富珍, 等.中国18～59岁人群乙型病毒性肝炎流行病学特征分析及乙型肝炎疫苗免疫策略探讨.中国疫苗和免疫, 2013, 19(3): 266-270.
21. 陈顺萍, 林翔.重视围生期孕产妇乙肝防治的健康教育.中国妇幼保健, 2012, 18(2): 4355-4357.

Chinese Journal of Evidence-Based Medicine

Influence of Paternal Serum HBV-DNA Load Levels and Pregnant Women's HBsAb on Paternal Vertical Transmission of Hepatitis B Virus

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