Effectiveness of Green Tea Extracts for Simple Obesity: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 SUNWei-ming ^1,3 , SHANGHong-xia ² , DUANYong-qiang ^2,3 ,  CHENGWei-dong ^3,4

1. Department of Endocrinology, First Hospital of Lanzhou University, Lanzhou 730000, China;
2. School of Basic Medical Sciences, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China;
3. Institute of Combined Traditional Chinese and Western Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China;
4. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China;

Corresponding author：

CHENGWei-dong, Email: chengwd@lzu.edu.cn

Keywords：

Green tea extract; Simple obesity; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.20140164

Video：

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Objective To systematically review the clinical effects of green tea extracts on simple obesity. Methods Systematic retrieval were conducted in PubMed, The Cochrane Library (Issue 8, 2012), CNKI, VIP, CBM, and WanFang Data to collect the randomized controlled trials (RCTs) on green tea extracts in treating patients with simple obesity. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted data, and assessed the methodological quality of the included studies. Meta-analysis was then performed using RevMan 5.0. Results A total of 11 RCTs involving 693 patients were included. Results of meta-analysis displayed that compared with the control group, patients in the green tea extracts group significantly had a obvious decrease of body mass (WMD=-0.32, 95%CI-0.46 to-0.17, P < 0.000 1) as well as body mass index (BMI) (WMD=-0.07, 90%CI-0.09 to-0.05, P < 0.000 01) with significant differences. Conclusion Current evidence shows that, green tea extracts could effectively treat simple obesity.

Citation： SUNWei-ming, SHANGHong-xia, DUANYong-qiang, CHENGWei-dong. Effectiveness of Green Tea Extracts for Simple Obesity: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2014, 14(8): 999-1003. doi: 10.7507/1672-2531.20140164 Copy

1.	Boschmann M, Thielecke F. The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study. J Am Coll Nutr, 2007, 26(4): 389S-395S.
2.	刘俊, 郭毅, 刘晴, 等.超重、肥胖与2型糖尿病相关性的Meta分析.中国循证医学杂志, 2013, 13(2): 190-195.
3.	Lenon GB, Li KX, Chang YH, et al. Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial. Evid Based Complement Alternat Med, 2012, 2012: 435702.
4.	Xi B, Liang Y, He T, et al. Secular trends in the prevalence of general and abdominal obesity among Chinese adults, 1993-2009. Obes Rev, 2012, 13(3): 287-296.
5.	Baskin ML, Ard J, Franklin F, et al. Prevalence of obesity in the United States. Obes Rev, 2005, 6(1): 5-7.
6.	Tucci SA, Boyland EJ, Halford JC. The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents. Diabetes Metab Syndr Obes, 2010, 3: 125-143.
7.	潘雯, 宫建, 郑刚, 等.中国内地减肥手术治疗肥胖型2型糖尿病的Meta分析.中国循证医学杂志, 2013, 13(4): 441-445.
8.	Hasani-Ranjbar S, Nayebi N, Larijani B, et al. A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity. World J Gastroenterol, 2009, 15(25): 3073-3085.
9.	Burke LE, Wang J. Treatment strategies for overweight and obesity. J Nurs Scholarsh, 2011, 43(4): 368-375.
10.	Auvichayapat P, Prapochanung M, Tunkamnerdthai O, et al. Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial. Physiol Behav, 2008, 93(3): 486-491.
11.	李幼平, 主编.循证医学.第1版.北京:高等教育出版社, 2003: 50-66.
12.	Brown AL, Lane J, Holyoak C, et al. Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial. Br J Nutr, 2011, 106(12): 1880-1889.
13.	Brown AL, Lane J, Coverly J, et al. Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br J Nutr, 2009, 101(6): 886-894.
14.	Hursel R, Viechtbauer W, Westerterp-Plantenga MS. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes (Lond), 2009, 33(9): 956-961.
15.	Hsu CH, Tsai TH, Kao YH, et al. Effect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trial. Clin Nutr, 2008, 27(3): 363-370.
16.	Westerterp-Plantenga MS, Lejeune MP, Kovacs EM. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes Res, 2005, 13(7): 1195-1204.
17.	Kovacs EM, Lejeune MP, Nijs I, et al. Effects of green tea on weight maintenance after body-weight loss. Br J Nutr, 2004, 91(3): 431-437.
18.	赵杰, 王恒照, 李婧, 等.肥胖男性饮用绿茶提取物血脂变化检验分析.山西中医, 2011, 27(2): 58-59.
19.	Hill AM, Coates AM, Buckley JD, et al. Can EGCG reduce abdominal fat in obese subjects? J Am Coll Nutr, 2007, 26(4): 396S-402S.
20.	Diepvens K, Kovacs EM, Nijs IM, et al. Effect of green tea on resting energy expenditure and substrate oxidation during weight loss in overweight females. Br J Nutr, 2005, 94(6): 1026-1034.
21.	Suliburska J, Bogdanski P, Szulinska M, et al. Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients. Biol Trace Elem Res, 2012, 149(3): 315-322.

1. Boschmann M, Thielecke F. The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study. J Am Coll Nutr, 2007, 26(4): 389S-395S.
2. 刘俊, 郭毅, 刘晴, 等.超重、肥胖与2型糖尿病相关性的Meta分析.中国循证医学杂志, 2013, 13(2): 190-195.
3. Lenon GB, Li KX, Chang YH, et al. Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial. Evid Based Complement Alternat Med, 2012, 2012: 435702.
4. Xi B, Liang Y, He T, et al. Secular trends in the prevalence of general and abdominal obesity among Chinese adults, 1993-2009. Obes Rev, 2012, 13(3): 287-296.
5. Baskin ML, Ard J, Franklin F, et al. Prevalence of obesity in the United States. Obes Rev, 2005, 6(1): 5-7.
6. Tucci SA, Boyland EJ, Halford JC. The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents. Diabetes Metab Syndr Obes, 2010, 3: 125-143.
7. 潘雯, 宫建, 郑刚, 等.中国内地减肥手术治疗肥胖型2型糖尿病的Meta分析.中国循证医学杂志, 2013, 13(4): 441-445.
8. Hasani-Ranjbar S, Nayebi N, Larijani B, et al. A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity. World J Gastroenterol, 2009, 15(25): 3073-3085.
9. Burke LE, Wang J. Treatment strategies for overweight and obesity. J Nurs Scholarsh, 2011, 43(4): 368-375.
10. Auvichayapat P, Prapochanung M, Tunkamnerdthai O, et al. Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial. Physiol Behav, 2008, 93(3): 486-491.
11. 李幼平, 主编.循证医学.第1版.北京:高等教育出版社, 2003: 50-66.
12. Brown AL, Lane J, Holyoak C, et al. Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial. Br J Nutr, 2011, 106(12): 1880-1889.
13. Brown AL, Lane J, Coverly J, et al. Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br J Nutr, 2009, 101(6): 886-894.
14. Hursel R, Viechtbauer W, Westerterp-Plantenga MS. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes (Lond), 2009, 33(9): 956-961.
15. Hsu CH, Tsai TH, Kao YH, et al. Effect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trial. Clin Nutr, 2008, 27(3): 363-370.
16. Westerterp-Plantenga MS, Lejeune MP, Kovacs EM. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes Res, 2005, 13(7): 1195-1204.
17. Kovacs EM, Lejeune MP, Nijs I, et al. Effects of green tea on weight maintenance after body-weight loss. Br J Nutr, 2004, 91(3): 431-437.
18. 赵杰, 王恒照, 李婧, 等.肥胖男性饮用绿茶提取物血脂变化检验分析.山西中医, 2011, 27(2): 58-59.
19. Hill AM, Coates AM, Buckley JD, et al. Can EGCG reduce abdominal fat in obese subjects? J Am Coll Nutr, 2007, 26(4): 396S-402S.
20. Diepvens K, Kovacs EM, Nijs IM, et al. Effect of green tea on resting energy expenditure and substrate oxidation during weight loss in overweight females. Br J Nutr, 2005, 94(6): 1026-1034.
21. Suliburska J, Bogdanski P, Szulinska M, et al. Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients. Biol Trace Elem Res, 2012, 149(3): 315-322.

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