Physical Risk Factors for Type 2 Diabetic Kidney Disease: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 CHENXiao-yu ¹ , YANGAi ¹ ,  WUHong-mei ¹ , YANGMing ¹ , LIUGuan-jian ² , DONGBi-rong ¹

1. Center of Geriatrics & Gerontology, West China Hospital, Sichuan University, Chengdu 610041, China;
2. Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

WUHong-mei, Email: drwhm@163.com

Keywords：

Type 2 diabetes mellitus; Diabetic kidney disease; Physical factor; Systematic review

DOI：

10.7507/1672-2531.20140194

Video：

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Objective To systematically review the independent physical risk factors associated with diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus. Methods We searched MEDLINE, EMbase, CBM, CNKI and VIP for all studies about the independent physical risk factors associated with diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus up to December 2012. Two reviewers independently screened studies according to the inclusion and exclusion criteria, extracted data, and assessed the methodological quality of included studies. Then meta-analysis was conducted using RevMan 5.2 software. Results A total of 11 studies involving 12 957 patients with type 2 diabetes were included. Of these 11 studies, 9 were cross-sectional studies, two were cohort studies, and one was case-control study. The results showed that:the main physical factors associated with DKD were:duration of diabetes (OR=1.11, 95%CI 1.05 to 1.18), waist circumference (OR=1.02, 95%CI 1.00 to 1.04), fasting glucose (OR=1.11, 95%CI 1.07 to 1.16), glycosylated hemoglobin (OR=1.20, 95%CI 1.06 to 1.36), systolic blood pressure (OR=1.03, 95%CI 1.02 to 1.05), diastolic blood pressure (OR=2.41, 95%CI 1.15 to 4.64), triglycerides (OR=1.24, 95%CI 1.02 to 1.51), high-density lipoprotein (OR=0.558, 95%CI 0.369 to 0.844), blood uric acid (OR=1.005, 95%CI 1.002 to 1.009), blood urea nitrogen (OR=1.58, 95%CI 1.37 to 1.82), past history of kidney disease (OR=3.26, 95%CI 1.20 to 8.87) and family history of kidney disease (OR=1.83, 95%CI 1.29 to 2.60). Conclusion Current evidence shows that multiple physical factors were associated with the development of type 2 diabetic kidney disease. However, due to the limited quantity and quality of the included studies, more high quality studies are needed to verify the conclusion.

Citation： CHENXiao-yu, YANGAi, WUHong-mei, YANGMing, LIUGuan-jian, DONGBi-rong. Physical Risk Factors for Type 2 Diabetic Kidney Disease: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2014, 14(10): 1201-1205. doi: 10.7507/1672-2531.20140194 Copy

1.	Collins AJ, Foley RN, Herzog C, et al. United States Renal Data System 2011 Annual Data Report:Atlas of chronic kidney disease and end-stage renal disease in the United States. Am J Kidney Dis, 2012, 59(1 Suppl 1):1-420.
2.	Levin A, Rocco M. KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease. Am J Kidney Dis, 2007, 49(2 Suppl 2):S12-154.
3.	Gowdak LH, Arantes RL, Paula FJ, et al. Underuse of American College of Cardiology/American Heart Association Guidelines in hemodialysis patients. Ren Fail, 2007, 29(5):559-565.
4.	Keane WF, Zhang Z, Lyle PA, et al. Risk scores for predicting outcomes in patients with type 2 diabetes and nephropathy:the RENAAL study. Clin J Am Soc Nephrol, 2006, 1(4):761-767.
5.	Stenvinkel P. Chronic kidney disease:a public health priority and harbinger of premature cardiovascular disease. J Intern Med, 2010, 268(5):456-467.
6.	Reutens AT, Atkins RC. Epidemiology of diabetic nephropathy. Contrib Nephrol, 2011, 170:1-7.
7.	Tang SC. Diabetic nephropathy:a global and growing threat. Hong Kong Med J, 2010, 16(4):244-245.
8.	胡仁明.糖尿病肾脏病变的诊断和治疗.中国医学前沿杂志, 2012, 4(3):36-38.
9.	Alberti KG, Zimmet PZ. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Diabet Med, 1998, 15(7):539-553.
10.	Gavin JR, Alberti K, Davidson MB, et al. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 1997, 20:1183-1197.
11.	American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care, 2012, 35(1):64-71.
12.	American Diabetes Association. Standards of medical care in diabetes. Diabetes Care, 2011, 34(1):11-61.
13.	National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease:evaluation, classification and stratification. Am J Kidney Dis, 2002, 39(2 Suppl 1):1-266.
14.	Rocco MV, Berns JS. KDOQI clinical practice guideline for diabetes and CKD:2012 UPDATE. Am J Kidney Dis, 2012, 60(5):850-886.
15.	Gordon G, Rennie D, Meade M, et al. User's Guides to the medical literature:a manual for evidence-based clinical practice, second edition. The McGraw-Hill Co, 2008. Available at:http://www.accp.com/bookstore/ro_02ugmlm.aspx.
16.	Colhoun HM, Lee ET, Bennett PH, et al. Risk factors for renal failure:The WHO multinational study of vascular disease in diabetes. Diabetologia, 2001, 44(Suppl 2):46-53.
17.	李国玲, 李威, 石明. 2型糖尿病并代谢综合征与早期慢性肾脏病的相关性研究.中国医师杂志, 2010, 12(6):835-837.
18.	吴文芳, 曹长春, 万辛, 等. 2型糖尿病合并代谢综合征组分与慢性肾脏病的相关性.中国临床医学, 2009, 16(1):108-111.
19.	叶威巍, 鹿斌, 龚伟, 等. 2型糖尿病和慢性肾脏病的相关性分析.中国临床医学, 2009, 16(4):575-577.
20.	翟莎, 王站建. 2型糖尿病患者腹腔内脏脂肪面积与尿白蛋白排泄量相关性分析.中华医学杂志, 2011, 91(30):2108-2111.
21.	陈凯, 张佳, 卢薇娜, 等. 2型糖尿病患者血尿酸水平和尿白蛋白排泄量的相关性研究.浙江医学, 2011, 33(10):1536-1538.
22.	管乐, 郑少雄. 2型糖尿病肾病危险因素.中华肾脏医学杂志, 2006, 22(1):18.
23.	李青, 潘洁敏, 包玉倩, 等. 2型糖尿病住院患者糖尿病肾脏疾病的发生率及危险因素分析.中国中西医结合肾病杂志, 2011, 12(10):891-894.
24.	邱泉.影响2型糖尿病患者并发糖尿病肾病的因素探讨-以社区为基础的病例对照研究. 2008. Available at:http://f.wanfangdata.com.cn/.
25.	Thomas MC, Weekes AJ, Broadley OJ, et al. The burden of chronic kidney disease in Australian patients with type 2 diabetes (the NEFRON study). Med J Aust, 2006, 185(3):140-144.
26.	Yeo ES, Hwang JY, Park JE, et al. Tumor Necrosis Factor (TNF-α) and C-reactive Protein(CRP) are Positively Associated with the Risk of Chronic Kidney Disease in Patients with Type 2 Diabetes. Yonsei Med J, 2010, 51(4):519-525.

1. Collins AJ, Foley RN, Herzog C, et al. United States Renal Data System 2011 Annual Data Report:Atlas of chronic kidney disease and end-stage renal disease in the United States. Am J Kidney Dis, 2012, 59(1 Suppl 1):1-420.
2. Levin A, Rocco M. KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease. Am J Kidney Dis, 2007, 49(2 Suppl 2):S12-154.
3. Gowdak LH, Arantes RL, Paula FJ, et al. Underuse of American College of Cardiology/American Heart Association Guidelines in hemodialysis patients. Ren Fail, 2007, 29(5):559-565.
4. Keane WF, Zhang Z, Lyle PA, et al. Risk scores for predicting outcomes in patients with type 2 diabetes and nephropathy:the RENAAL study. Clin J Am Soc Nephrol, 2006, 1(4):761-767.
5. Stenvinkel P. Chronic kidney disease:a public health priority and harbinger of premature cardiovascular disease. J Intern Med, 2010, 268(5):456-467.
6. Reutens AT, Atkins RC. Epidemiology of diabetic nephropathy. Contrib Nephrol, 2011, 170:1-7.
7. Tang SC. Diabetic nephropathy:a global and growing threat. Hong Kong Med J, 2010, 16(4):244-245.
8. 胡仁明.糖尿病肾脏病变的诊断和治疗.中国医学前沿杂志, 2012, 4(3):36-38.
9. Alberti KG, Zimmet PZ. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Diabet Med, 1998, 15(7):539-553.
10. Gavin JR, Alberti K, Davidson MB, et al. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 1997, 20:1183-1197.
11. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care, 2012, 35(1):64-71.
12. American Diabetes Association. Standards of medical care in diabetes. Diabetes Care, 2011, 34(1):11-61.
13. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease:evaluation, classification and stratification. Am J Kidney Dis, 2002, 39(2 Suppl 1):1-266.
14. Rocco MV, Berns JS. KDOQI clinical practice guideline for diabetes and CKD:2012 UPDATE. Am J Kidney Dis, 2012, 60(5):850-886.
15. Gordon G, Rennie D, Meade M, et al. User's Guides to the medical literature:a manual for evidence-based clinical practice, second edition. The McGraw-Hill Co, 2008. Available at:http://www.accp.com/bookstore/ro_02ugmlm.aspx.
16. Colhoun HM, Lee ET, Bennett PH, et al. Risk factors for renal failure:The WHO multinational study of vascular disease in diabetes. Diabetologia, 2001, 44(Suppl 2):46-53.
17. 李国玲, 李威, 石明. 2型糖尿病并代谢综合征与早期慢性肾脏病的相关性研究.中国医师杂志, 2010, 12(6):835-837.
18. 吴文芳, 曹长春, 万辛, 等. 2型糖尿病合并代谢综合征组分与慢性肾脏病的相关性.中国临床医学, 2009, 16(1):108-111.
19. 叶威巍, 鹿斌, 龚伟, 等. 2型糖尿病和慢性肾脏病的相关性分析.中国临床医学, 2009, 16(4):575-577.
20. 翟莎, 王站建. 2型糖尿病患者腹腔内脏脂肪面积与尿白蛋白排泄量相关性分析.中华医学杂志, 2011, 91(30):2108-2111.
21. 陈凯, 张佳, 卢薇娜, 等. 2型糖尿病患者血尿酸水平和尿白蛋白排泄量的相关性研究.浙江医学, 2011, 33(10):1536-1538.
22. 管乐, 郑少雄. 2型糖尿病肾病危险因素.中华肾脏医学杂志, 2006, 22(1):18.
23. 李青, 潘洁敏, 包玉倩, 等. 2型糖尿病住院患者糖尿病肾脏疾病的发生率及危险因素分析.中国中西医结合肾病杂志, 2011, 12(10):891-894.
24. 邱泉.影响2型糖尿病患者并发糖尿病肾病的因素探讨-以社区为基础的病例对照研究. 2008. Available at:http://f.wanfangdata.com.cn/.
25. Thomas MC, Weekes AJ, Broadley OJ, et al. The burden of chronic kidney disease in Australian patients with type 2 diabetes (the NEFRON study). Med J Aust, 2006, 185(3):140-144.
26. Yeo ES, Hwang JY, Park JE, et al. Tumor Necrosis Factor (TNF-α) and C-reactive Protein(CRP) are Positively Associated with the Risk of Chronic Kidney Disease in Patients with Type 2 Diabetes. Yonsei Med J, 2010, 51(4):519-525.

Chinese Journal of Evidence-Based Medicine

Physical Risk Factors for Type 2 Diabetic Kidney Disease: A Systematic Review

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