Brucea Javanica Oil Emulsion in Treatment of Malignant Pleural Effusion: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 WEIKong-ping ^1,2 ,  WANGQi-tuan ³ , WANGQi-rong ¹ , WEIKong-yuan ¹ , JINYan-ling ¹ , SUNYu ¹ , SHAOLi-li ¹ , WANGQuan ¹ , TIANJin-hui ¹

1. Evidence-based Medicine Center, Lanzhou University, Lanzhou 730000, China;
2. Second Hospital of Lanzhou University, Lanzhou 730000, China;
3. Department of Pediatrics, Academic Department of Zhejiang Jiuxu Pharmaceutical Co, LTD, Jinhua 321016, China;

Corresponding author：

WANGQi-tuan, Email: zjjxwqt@126.com

Keywords：

Brucea javanica oil emulsion; Malignant pleural effusion; Meta-analysis; Systematic review; Randomized controlled trial

DOI：

10.7507/1672-2531.20140203

Video：

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Objective To systematically review the efficacy and safety of brucea javanica oil emulsion with/without cisplatin in the treatment of malignant pleural effusion (MPE). Methods We electronically search PubMed, The Cochrane Library (Issue 6, 2013), EMbase, CBM, WanFang Data, VIP and CNKI to collect randomized controlled trial about brucea javanica oil emulsion for MPE from the establishment dates to June 2013. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted data, and assessed the methodological quality of included studies. Then meta-analysis was performed using RevMan 5.1 software. Results A total of twenty-five RCTs involving 1 620 patients were included. The results of meta-analysis showed that:compared with using cisplatin alone, brucea javanica oil emulsion plus cisplatin could improve clinical efficiency (RR=1.45, 95%CI 1.34 to 1.57, P < 0.000 01) and patients' quality of life (RR=1.36, 95%CI 1.18 to 1.56, P < 0.000 1), and relieved the incidences of bone marrow depression (OR=0.31, 95%CI 0.22 to 0.42, P < 0.000 01) and digestive tract reaction (OR=0.36, 95%CI 0.24 to 0.54, P < 0.000 01, ) and fever (OR=0.18, 95%CI 0.08 to 0.40, P < 0.000 1). Conclusion Current evidence indicates that brucea javanica oil emulsion could improve chemotherapy effects MPE. However, due to the limited quality of the included studies, more high quality studies with large sample size are needed to verify the conclusion.

Citation： WEIKong-ping, WANGQi-tuan, WANGQi-rong, WEIKong-yuan, JINYan-ling, SUNYu, SHAOLi-li, WANGQuan, TIANJin-hui. Brucea Javanica Oil Emulsion in Treatment of Malignant Pleural Effusion: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(10): 1263-1269. doi: 10.7507/1672-2531.20140203 Copy

1.	严文跃, 钱晓萍, 刘宝瑞.恶性胸腔积液的治疗进展.现代肿瘤医学, 2009, 17(7):1393-1396.
2.	Am J. Managment of malignant pleural effusions. Respire Crit Care Med, 2000, 162(5):987.
3.	吴一龙.肺癌多学科综合治疗的理论与实践.北京:人民卫生出版社, 2000:277.
4.	孙慨, 魏桂珍, 王亚湘.鸦胆子乳加化疗治疗晚期肺癌疗效观察.中国中西医结合杂志, 1994, 14(2):108.
5.	Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version5. 1. 0[updated March 2011]. The Cochrane Collaboration, 2011. Available at:www.Cochrane-handbook.org.
6.	付相建, 尚志, 杨光华, 等.导管持续引流联合鸦胆子油乳、顺铂治疗恶性胸腔积液的疗效观察.临床军医杂志, 2009, 37(5):818-820.
7.	陈勇.鸦胆子油乳联合顺铂治疗恶性胸腔积液疗效观察.浙江中西医结合杂志, 2011, 21(17):713-714.
8.	王恳, 龙鑫.胸腔内灌注鸦胆子油乳剂与顺铂治疗肺癌导致恶性胸腔积液疗效比较.中国医药, 2010, 5(6):513-514.
9.	吉佑华.顺铂联合鸦胆子油乳腔内治疗30例恶性胸腔积液.肿瘤学杂志, 2009, 15(5):474-475.
10.	高作文, 姜金书, 丁太良, 等.鸭胆子油乳联合顺铂及白细胞介素-Ⅱ治疗肺癌恶性胸腔积液临床观察.中国肿瘤临床与康复, 2013, 20(2):153-154.
11.	尤建良, 薛青, 赵义纯.鸦胆子乳胸腔内注射治疗癌性胸水临床研究.长春中医学院学报, 2001, 17(3):11-12.
12.	吴共国.鸦胆子油乳联合顺铂胸腔内灌注治疗癌性胸水92例疗效观察.医药前沿, 2012, 2(19):211.
13.	王红梅, 廖国清, 刘鹏辉, 等.鸦胆子油乳注射液联合顺铂治疗肺癌胸水70例.中国肿瘤, 2007, 16(12):1035-1036.
14.	骆明莲, 程宏文.鸦胆子油乳联合顺铂治疗恶性胸腔积液临床观察.中国基层医药, 2011, 18(3):293-294.
15.	柳宝, 张丽敏.鸦胆子油乳联合顺铂胸腔内灌注治疗肺癌所致恶性胸腔积液的疗效观察.中国当代医药, 2012, 19(7):48-47.
16.	吴述洪, 芮磊, 洪原城.鸦胆子油乳联合顺铂胸腔注射治疗癌性胸水68例疗效观察.海南医学, 2009, 20(9):14-15.
17.	杨洁, 何琳.鸦胆子油乳联合顺铂腔内注射治疗癌性胸水.河南肿瘤学杂志, 2002, 15(4):281-282.
18.	郭彦伟, 吴建有, 杨河川, 等.鸦胆子油乳联合顺铂腔内注入治疗恶性胸腔积液.肿瘤学杂志, 2004, 10(2):129-130.
19.	宋应健, 王立新, 洪永青, 等.鸦胆子油乳剂联合顺铂治疗恶性胸腔积液的疗效.江苏医药, 2011, 37(21):2527-2528.
20.	莫绍雄, 杨小平, 赵文, 等.鸦胆子油乳剂联合顺铂胸腔灌注治疗癌性胸水疗效观察.浙江中西医结合杂志, 2009, 19(11):683-684.
21.	张昊, 靳端阳, 赵燕.鸦胆子油乳联合顺铂治疗恶性胸腔积液34例.中国中医药现代远程教育, 2013, 11(5):41-42.
22.	杨晓慧, 郝培.鸦胆子油乳联合顺铂治疗恶性胸腔积液疗效观察.山东医药, 2005, 45(16):68-69.
23.	罗俊华.鸦胆子油乳治疗恶性胸腔积液临床疗效回顾性分析.医学理论与实践, 2013, 26(25):609-610.
24.	钱祥夕.鸦胆子油乳胸腔灌注治疗恶性胸腔积液临床观察.山东医药, 2011, 51(28):14.
25.	陈成宏, 李宏斌, 李迎春, 等.鸦胆子油乳注射液联合伽玛刀治疗癌性胸水疗效观察.现代肿瘤医学, 2009, 17(6):1092-1093.
26.	陈上民, 肖震宇.鸦胆子油乳胸腔灌注治疗癌性胸水临床研究.赣南医学院学报, 2005, 25(6):837.
27.	苏忠, 张静, 任兴帅.鸦胆子油乳胸腔灌注治疗恶性胸腔积液30例临床观察.医学信息(中旬刊), 2011, 24(8):3946.
28.	何学军, 崔林.鸦胆子油乳剂与顺铂治疗恶性胸腔积液的疗效比较.肿瘤研究与临床, 2006, 18(11):777-778.
29.	李杨.使用鸦胆子油乳静滴联合腔内注射或顺铂腔内注射治疗胸腔积液的观察.内蒙古中医药, 2010, 29(23):27-28.
30.	李猛, 余少娜.鸦胆子油乳剂联合热疗治疗恶性胸腔积液的临床观察.中华临床医师杂志, 2011, 5(11):3337-3338.
31.	曾普华, 蒋益兰, 蔡美, 等.鸦胆子油乳经胸腔热灌注治疗恶性胸腔积液的临床研究.湖南中医药大学学报, 2011, 31(5):51-53.
32.	邢秋月, 贾晨光, 刘欣燕, 等.鸦胆子油乳注射液治疗晚期非小细胞肺癌疗效观察.河北医药, 2008, 30(7):963-964.
33.	张玲娟, 苏娟, 彭菊聪, 等.白细胞介素-2联合顺铂与顺铂胸腔内注射治疗恶性胸腔积液的有效性和安全性的Meta分析.中国循证医学杂志, 2010, (增刊):132.
34.	刘莉, 赵艳, 孙甜甜, 等.胸腔内注射白细胞介素-2与顺铂治疗恶性胸腔积液有效性和安全性的系统评价.中国循证医学杂志, 2010, (增刊):132-133.

1. 严文跃, 钱晓萍, 刘宝瑞.恶性胸腔积液的治疗进展.现代肿瘤医学, 2009, 17(7):1393-1396.
2. Am J. Managment of malignant pleural effusions. Respire Crit Care Med, 2000, 162(5):987.
3. 吴一龙.肺癌多学科综合治疗的理论与实践.北京:人民卫生出版社, 2000:277.
4. 孙慨, 魏桂珍, 王亚湘.鸦胆子乳加化疗治疗晚期肺癌疗效观察.中国中西医结合杂志, 1994, 14(2):108.
5. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version5. 1. 0[updated March 2011]. The Cochrane Collaboration, 2011. Available at:www.Cochrane-handbook.org.
6. 付相建, 尚志, 杨光华, 等.导管持续引流联合鸦胆子油乳、顺铂治疗恶性胸腔积液的疗效观察.临床军医杂志, 2009, 37(5):818-820.
7. 陈勇.鸦胆子油乳联合顺铂治疗恶性胸腔积液疗效观察.浙江中西医结合杂志, 2011, 21(17):713-714.
8. 王恳, 龙鑫.胸腔内灌注鸦胆子油乳剂与顺铂治疗肺癌导致恶性胸腔积液疗效比较.中国医药, 2010, 5(6):513-514.
9. 吉佑华.顺铂联合鸦胆子油乳腔内治疗30例恶性胸腔积液.肿瘤学杂志, 2009, 15(5):474-475.
10. 高作文, 姜金书, 丁太良, 等.鸭胆子油乳联合顺铂及白细胞介素-Ⅱ治疗肺癌恶性胸腔积液临床观察.中国肿瘤临床与康复, 2013, 20(2):153-154.
11. 尤建良, 薛青, 赵义纯.鸦胆子乳胸腔内注射治疗癌性胸水临床研究.长春中医学院学报, 2001, 17(3):11-12.
12. 吴共国.鸦胆子油乳联合顺铂胸腔内灌注治疗癌性胸水92例疗效观察.医药前沿, 2012, 2(19):211.
13. 王红梅, 廖国清, 刘鹏辉, 等.鸦胆子油乳注射液联合顺铂治疗肺癌胸水70例.中国肿瘤, 2007, 16(12):1035-1036.
14. 骆明莲, 程宏文.鸦胆子油乳联合顺铂治疗恶性胸腔积液临床观察.中国基层医药, 2011, 18(3):293-294.
15. 柳宝, 张丽敏.鸦胆子油乳联合顺铂胸腔内灌注治疗肺癌所致恶性胸腔积液的疗效观察.中国当代医药, 2012, 19(7):48-47.
16. 吴述洪, 芮磊, 洪原城.鸦胆子油乳联合顺铂胸腔注射治疗癌性胸水68例疗效观察.海南医学, 2009, 20(9):14-15.
17. 杨洁, 何琳.鸦胆子油乳联合顺铂腔内注射治疗癌性胸水.河南肿瘤学杂志, 2002, 15(4):281-282.
18. 郭彦伟, 吴建有, 杨河川, 等.鸦胆子油乳联合顺铂腔内注入治疗恶性胸腔积液.肿瘤学杂志, 2004, 10(2):129-130.
19. 宋应健, 王立新, 洪永青, 等.鸦胆子油乳剂联合顺铂治疗恶性胸腔积液的疗效.江苏医药, 2011, 37(21):2527-2528.
20. 莫绍雄, 杨小平, 赵文, 等.鸦胆子油乳剂联合顺铂胸腔灌注治疗癌性胸水疗效观察.浙江中西医结合杂志, 2009, 19(11):683-684.
21. 张昊, 靳端阳, 赵燕.鸦胆子油乳联合顺铂治疗恶性胸腔积液34例.中国中医药现代远程教育, 2013, 11(5):41-42.
22. 杨晓慧, 郝培.鸦胆子油乳联合顺铂治疗恶性胸腔积液疗效观察.山东医药, 2005, 45(16):68-69.
23. 罗俊华.鸦胆子油乳治疗恶性胸腔积液临床疗效回顾性分析.医学理论与实践, 2013, 26(25):609-610.
24. 钱祥夕.鸦胆子油乳胸腔灌注治疗恶性胸腔积液临床观察.山东医药, 2011, 51(28):14.
25. 陈成宏, 李宏斌, 李迎春, 等.鸦胆子油乳注射液联合伽玛刀治疗癌性胸水疗效观察.现代肿瘤医学, 2009, 17(6):1092-1093.
26. 陈上民, 肖震宇.鸦胆子油乳胸腔灌注治疗癌性胸水临床研究.赣南医学院学报, 2005, 25(6):837.
27. 苏忠, 张静, 任兴帅.鸦胆子油乳胸腔灌注治疗恶性胸腔积液30例临床观察.医学信息(中旬刊), 2011, 24(8):3946.
28. 何学军, 崔林.鸦胆子油乳剂与顺铂治疗恶性胸腔积液的疗效比较.肿瘤研究与临床, 2006, 18(11):777-778.
29. 李杨.使用鸦胆子油乳静滴联合腔内注射或顺铂腔内注射治疗胸腔积液的观察.内蒙古中医药, 2010, 29(23):27-28.
30. 李猛, 余少娜.鸦胆子油乳剂联合热疗治疗恶性胸腔积液的临床观察.中华临床医师杂志, 2011, 5(11):3337-3338.
31. 曾普华, 蒋益兰, 蔡美, 等.鸦胆子油乳经胸腔热灌注治疗恶性胸腔积液的临床研究.湖南中医药大学学报, 2011, 31(5):51-53.
32. 邢秋月, 贾晨光, 刘欣燕, 等.鸦胆子油乳注射液治疗晚期非小细胞肺癌疗效观察.河北医药, 2008, 30(7):963-964.
33. 张玲娟, 苏娟, 彭菊聪, 等.白细胞介素-2联合顺铂与顺铂胸腔内注射治疗恶性胸腔积液的有效性和安全性的Meta分析.中国循证医学杂志, 2010, (增刊):132.
34. 刘莉, 赵艳, 孙甜甜, 等.胸腔内注射白细胞介素-2与顺铂治疗恶性胸腔积液有效性和安全性的系统评价.中国循证医学杂志, 2010, (增刊):132-133.

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Chinese Journal of Evidence-Based Medicine

Brucea Javanica Oil Emulsion in Treatment of Malignant Pleural Effusion: A Meta-Analysis

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