Association between LIG4 Gene T9I Polymorphism and Cancer Susceptibility: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LIGuang-qing , LIXiao-bo ,  WUZhao-ping , QIZhan-zhong , WANGXin-ping , WUMing-ya , CHENQiu-ling , LIDong

Department of Respiratory Medicine, 452^nd Military Hospital, Chengdu 610041, China;

Corresponding author：

WUZhao-ping, Email: 1350907099@qq.com

Keywords：

LIG4; Polymorphism; Cancer; Systematic review; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20140213

Video：

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Objective To systematically review the association between LIG4 gene T9I polymorphism and cancer susceptibility. Methods Such databases as PubMed, EMbase, The Cochrane Library (Issue 10, 2013), CBM, CNKI, VIP and WanFang Data were electronically searched to collect case-control studies published up to Oct. 2013 on the association between LIG4 gene T9I polymorphism and cancer susceptibility. According to inclusion and exclusion criteria, two reviewers independently screened literature, extracted data, and assessed methodological quality of included studies. Then meta-analysis was performed using RevMan 5.0 software. Results A total of 11 case-control studies were included, which involved 5 016 cancer cases and 4 860 controls. The results of meta-analysis showed that, no significant association was found between LIG4 gene T9I polymorphism and the risk of cancer in the total analysis (TT+CT vs. CC:OR=0.96, 95%CI 0.80 to 1.15, P=0.63; TT vs. CT+CC:OR=1.10, 95%CI 0.78 to 1.56, P=0.59; TT vs. CC:OR=1.10, 95%CI 0.73 to 1.64, P=0.65; CT vs. CC:OR=0.94, 95%CI 0.80 to 1.11, P=0.48; T vs. C:OR=0.97, 95%CI 0.82 to 1.15, P=0.75). In the subgroup analysis, significant association was found in Caucasians (TT+CT vs. CC:OR=0.87, 95%CI 0.77 to 0.98, P=0.02) but not in Asians. Conclusion LIG4 gene T9I polymorphism could be associated with cancer susceptibility in Caucasians.

Citation： LIGuang-qing, LIXiao-bo, WUZhao-ping, QIZhan-zhong, WANGXin-ping, WUMing-ya, CHENQiu-ling, LIDong. Association between LIG4 Gene T9I Polymorphism and Cancer Susceptibility: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(11): 1311-1317. doi: 10.7507/1672-2531.20140213 Copy

1.	Larsen SC, Angquist L, Ahluwalia TS, et al. Interaction between genetic predisposition to obesity and dietary calcium in relation to subsequent change in body weight and waist circumference. Am J Clin Nutr, 2014, 99(4):957-965.
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5.	Tan X, Chen M. Association between Catechol-O-methyltransferase rs4680(G>A) polymorphism and lung cancer risk. Diagn Pathol, 2014, 9(1):192.
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16.	Wu X, Gu J, Grossman HB, et al. Bladder cancer predisposition:a multigenic approach to DNA-repair and cell-cycle-control genes. Am J Hum Genet, 2006, 78(3):464-479.
17.	Hill DA, Wang SS, Cerhan JR, et al. Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. Blood, 2006, 108(9):3161-3167.
18.	Zhao P, Zou P, Zhao L, et al. Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility. BMC Cancer, 2013, 13:234.
19.	Fu YP, Yu JC, Cheng TC, et al. Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes:a multigenic study on cancer susceptibility. Cancer Res, 2003, 63(10):2440-2446.
20.	Tseng RC, Hsieh FJ, Shih CM, et al. Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes:a multiple genotype-phenotype study. Cancer, 2009, 115(13):2939-2948.
21.	Li D, Suzuki H, Liu B, et al. DNA repair gene polymorphisms and risk of pancreatic cancer. Clin Cancer Res, 2009, 15(2):740-746.
22.	Garcia-Closas M, Egan KM, Newcomb PA, et al. Polymorphisms in DNA double-strand break repair genes and risk of breast cancer:two population-based studies in USA and Poland, and meta-analyses. Hum Genet, 2006, 119(4):376-388.
23.	Andreae J, Varon R, Sperling K, et al. Polymorphisms in the DNA ligase IV gene might influence the risk of acute lymphoblastic leukemia in children. Leukemia, 2007, 21(10):2226-2227.
24.	Salagovic J, Klimcakova L, Ilencikova D, et al. Association of follicular lymphoma risk with BRCA2 N372H polymorphism in Slovak population. Med Oncol, 2012, 29(2):1173-1178.
25.	Werbrouck J, De Ruyck K, Duprez F, et al. Single-nucleotide polymorphisms in DNA double-strand break repair genes:association with head and neck cancer and interaction with tobacco use and alcohol consumption. Mutat Res, 2008, 656(1-2):74-81.
26.	Gomes BC, Silva SN, Azevedo AP, et al. The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk. Oncol Rep, 2010, 24(4):1079-1085.
27.	von Elm E, Moher D, Little J, et al. Reporting genetic association studies:the STREGA statement. Lancet, 2009, 374(9684):98-100.

1. Larsen SC, Angquist L, Ahluwalia TS, et al. Interaction between genetic predisposition to obesity and dietary calcium in relation to subsequent change in body weight and waist circumference. Am J Clin Nutr, 2014, 99(4):957-965.
2. Han F, Tan Y, Cui W, et al. Novel insights into etiologies of leukemia:a HuGE review and meta-analysis of CYP1A1 polymorphisms and leukemia risk. Am J Epidemiol, 2013, 178(4):493-507.
3. Coleman MP. Cancer survival in the developing world. Lancet Oncol, 2010, 11(2):110-111.
4. Yu LX, Zhou NN, Liu LY, et al. Adiponectin Receptor 1(ADIPOR1) rs1342387 Polymorphism and Risk of Cancer:a Meta-analysis. Asian Pac J Cancer Prev, 2014, 15(18):7515-7520.
5. Tan X, Chen M. Association between Catechol-O-methyltransferase rs4680(G>A) polymorphism and lung cancer risk. Diagn Pathol, 2014, 9(1):192.
6. Zhu K, Jiang B, Hu R, et al. The CXCL12 G801A Polymorphism Is Associated with Cancer Risk:A Meta-Analysis. PLoS One, 2014, 9(9):e108953.
7. Lee YH, Song GG. Vitamin Dreceptor FokI, BsmI, ApaI, and TaqI polymorphisms and the susceptibility to breast cancer:a meta-analysis. Neoplasma, 2014, 61(5):607-616.
8. Dai ZJ, Shao YP, Ma XB, et al. Association of the three common SNPs of cyclooxygenase-2 gene (rs20417, rs689466, and rs5275) with the susceptibility of breast cancer:an updated meta-analysis involving 34, 590 subjects. Dis Markers, 2014, 2014:484729.
9. Li W, Yang F, Gui Y, et al. DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma:A meta-analysis. Oncol Lett, 2014, 8(4):1725-1730.
10. Xiang YZ, Jiang SB, Zhao J, et al. Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1beta gene and prostate cancer:a systematic review and meta-analysis. Genet Mol Res, 2014, 13(3):6582-6592.
11. Xu JJ, Zou LY, Yang L, et al. Common polymorphisms in the HIF-1alpha gene confer susceptibility to digestive cancer:a meta-analysis. Genet Mol Res, 2014, 13(3):6228-6238.
12. He H, He G, Wang T, et al. Methylenetetrahydrofolate reductase gene polymorphisms contribute to acute myeloid leukemia and chronic myeloid leukemia susceptibilities:Evidence from meta-analyses. Cancer Epidemiol, 2014, 38(5):471-478.
13. Yang YM, Zhang TT, Yuan L, et al. The association between the C677T polymorphism in MTHFR gene and the risk of thyroid cancer:a meta-analysis. Eur Rev Med Pharmacol Sci, 2014, 18(15):2097-2101.
14. Wu X, Wang ZF, Xu Y, et al. Association between three eNOS polymorphisms and cancer risk:a meta-analysis. Asian Pac J Cancer Prev, 2014, 15(13):5317-5324.
15. Wang HG, Wu QY, Zhou H, et al. The MDM2 SNP309T>G polymorphism increases bladder cancer risk among Caucasians:a meta-analysis. Asian Pac J Cancer Prev, 2014, 15(13):5277-5281.
16. Wu X, Gu J, Grossman HB, et al. Bladder cancer predisposition:a multigenic approach to DNA-repair and cell-cycle-control genes. Am J Hum Genet, 2006, 78(3):464-479.
17. Hill DA, Wang SS, Cerhan JR, et al. Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. Blood, 2006, 108(9):3161-3167.
18. Zhao P, Zou P, Zhao L, et al. Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility. BMC Cancer, 2013, 13:234.
19. Fu YP, Yu JC, Cheng TC, et al. Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes:a multigenic study on cancer susceptibility. Cancer Res, 2003, 63(10):2440-2446.
20. Tseng RC, Hsieh FJ, Shih CM, et al. Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes:a multiple genotype-phenotype study. Cancer, 2009, 115(13):2939-2948.
21. Li D, Suzuki H, Liu B, et al. DNA repair gene polymorphisms and risk of pancreatic cancer. Clin Cancer Res, 2009, 15(2):740-746.
22. Garcia-Closas M, Egan KM, Newcomb PA, et al. Polymorphisms in DNA double-strand break repair genes and risk of breast cancer:two population-based studies in USA and Poland, and meta-analyses. Hum Genet, 2006, 119(4):376-388.
23. Andreae J, Varon R, Sperling K, et al. Polymorphisms in the DNA ligase IV gene might influence the risk of acute lymphoblastic leukemia in children. Leukemia, 2007, 21(10):2226-2227.
24. Salagovic J, Klimcakova L, Ilencikova D, et al. Association of follicular lymphoma risk with BRCA2 N372H polymorphism in Slovak population. Med Oncol, 2012, 29(2):1173-1178.
25. Werbrouck J, De Ruyck K, Duprez F, et al. Single-nucleotide polymorphisms in DNA double-strand break repair genes:association with head and neck cancer and interaction with tobacco use and alcohol consumption. Mutat Res, 2008, 656(1-2):74-81.
26. Gomes BC, Silva SN, Azevedo AP, et al. The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk. Oncol Rep, 2010, 24(4):1079-1085.
27. von Elm E, Moher D, Little J, et al. Reporting genetic association studies:the STREGA statement. Lancet, 2009, 374(9684):98-100.

Chinese Journal of Evidence-Based Medicine

Association between LIG4 Gene T9I Polymorphism and Cancer Susceptibility: A Meta-Analysis

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