ORMDL3 rs72l6389 Polymorphism and the Susceptibility to Asthma in Chinese Population: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LIULi-hong ¹ , GUOWen-cai ¹ , ZHOUJiang ¹ ,  LIXiao-bo ²

1. Department of Respiratory Medicine, Central Hospital of Bazhong City, Bazhong 636600, China;
2. Department of Respiratory Medicine, 452 nd Military Hospital, Chengdu 610021, China;

Corresponding author：

LIXiao-bo, Email: 739409535@qq.com

Keywords：

ORMDL3; Polymorphism; Asthma; Systematic review; Meta-analysis; Case-control study; Chinese

DOI：

10.7507/1672-2531.20150030

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Objective To systematically review the association between ORMDL3 gene rs7216389 polymorphism and the susceptibility to asthma among Chinese population. Methods Such databases as PubMed, EMbase, The Cochrane Library (Issue 8, 2014), CBM, CNKI, VIP and WanFang Data were systemically searched to collect casecontrol studies published to August 2013. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and evaluated methodological quality of included studies. Meta-analysis was then performed using RevMan 5.2 software. Stata 11.0 software were used for publication bias evaluation. Results A total of 7 case-control studies were included, which involved 1 711 cases and 1 763 controls. The results of meta-analysis showed that, ORMDL3 gene rs7216389 polymorphism was associated with the susceptibility to asthma among Chinese population (OR=0.71, 95%CI 0.62 to 0.81, P<0.000 01). In the subgroup analysis by age, ORMDL3 gene rs7216389 polymorphism was associated with the susceptibility to adult asthma (OR=0.71, 95%CI 0.61 to 0.83, P<0.000 1) and children asthma (OR=0.69, 95%CI 0.52 to 0.90, P=0.006). Conclusion ORMDL3 gene rs7216389 polymorphism is a risk factor of adult and children asthma among Chinese population.

Citation： LIULi-hong, GUOWen-cai, ZHOUJiang, LIXiao-bo. ORMDL3 rs72l6389 Polymorphism and the Susceptibility to Asthma in Chinese Population: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(2): 170-175. doi: 10.7507/1672-2531.20150030 Copy

1.	Ierodiakonou D, Postma DS, Koppelman GH, et al. TGF-beta1 polymorphisms and asthma severity, airway inflammation, and remodeling. J Allergy Clin Immunol, 2013, 131(2):582-585.
2.	Birbian N, Singh J, Jindal SK. Protective role of IL-18-137G/C polymorphism in a North Indian population with asthma:a pilot study. Cytokine, 2013, 61(1):188-193.
3.	Yamaide F, Undarmaa S, Mashimo Y, et al. Association study of matrix metalloproteinase-12 gene polymorphisms and asthma in a Japanese population. Int Arch Allergy Immunol, 2013, 160(3):287-296.
4.	Binia A, Khorasani N, Bhavsar PK, et al. Chromosome 17q21 SNP and severe asthma. J Hum Genet, 2011, 56(1):97-98.
5.	Galanter J, Choudhry S, Eng C, et al. ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am J Respir Crit Care Med, 2008, 177(11):1194-1200.
6.	Kang MJ, Yu HS, Seo JH, et al. GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness. Hum Immunol, 2012, 73(9):954-959.
7.	Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature, 2007, 448(7152):470-473.
8.	Fang Q, Zhao H, Wang A, et al. Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population. BMC Med Genet, 2011, 12:133.
9.	Sy HY, Ko FW, Chu HY, et al. Asthma and bronchodilator responsiveness are associated with polymorphic markers of ARG1, CRHR2 and chromosome 17q21. Pharmacogenet Genomics, 2012, 22(7):517-524.
10.	Yang FF, Huang Y, Li QB, et al. Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population. Genet Mol Res, 2012, 11(4):4646-4653.
11.	丁毅鹏, 何海武, 石慧芳, 等. 海南黎族哮喘ORMDL3基因多态性研究. 海南医学, 2012, 23(11):1-2.
12.	黄汉琮, 曾林祥, 杜哲明. ORMDL3基因多态性与支气管哮喘患者发病及肺功能的相关性研究. 中华结核和呼吸杂志, 2011, 34(10):780-781.
13.	金哲. ORMDL3基因单核苷酸多态性及表达水平与北京地区儿童哮喘关联性研究. 中国人民解放军军事医学科学院, 2010.
14.	阳爱梅. 湖南省哮喘儿童ORMDL3基因多态性分析及与OPN、TGF-βl水平相关性探讨. 中南大学, 2012.
15.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in metaanalyses. Eur J Epidemiol, 2010, 25(9):603-605.
16.	陈甲, 和儒林, 朗莹, 等. 中国人群MTHFR基因C677T多态性与青中年缺血性脑卒中相关性的Meta分析. 中国循证医学杂志, 2014, 14(4):435-442.
17.	刁敏, 柳慧, 林雪梅. 腰硬联合麻醉用于剖宫产有效性及安全性的系统评价. 中国循证医学杂志, 2014, 14(10):1218-1224.
18.	Daley D, Park JE, He JQ, et al. Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes. J Allergy Clin Immunol, 2012, 130(6):1284-1293.
19.	Burkhardt J, Kirsten H, Wolfram G, et al. Differential allelic expression of IL13 and CSF2 genes associated with asthma. Genet Mol Biol, 2012, 35(3):567-574.
20.	Toncheva AA, Suttner K, Michel S, et al. Genetic variants in Protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children. Pediatr Allergy Immunol, 2012, 23(7):636-641.

1. Ierodiakonou D, Postma DS, Koppelman GH, et al. TGF-beta1 polymorphisms and asthma severity, airway inflammation, and remodeling. J Allergy Clin Immunol, 2013, 131(2):582-585.
2. Birbian N, Singh J, Jindal SK. Protective role of IL-18-137G/C polymorphism in a North Indian population with asthma:a pilot study. Cytokine, 2013, 61(1):188-193.
3. Yamaide F, Undarmaa S, Mashimo Y, et al. Association study of matrix metalloproteinase-12 gene polymorphisms and asthma in a Japanese population. Int Arch Allergy Immunol, 2013, 160(3):287-296.
4. Binia A, Khorasani N, Bhavsar PK, et al. Chromosome 17q21 SNP and severe asthma. J Hum Genet, 2011, 56(1):97-98.
5. Galanter J, Choudhry S, Eng C, et al. ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am J Respir Crit Care Med, 2008, 177(11):1194-1200.
6. Kang MJ, Yu HS, Seo JH, et al. GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness. Hum Immunol, 2012, 73(9):954-959.
7. Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature, 2007, 448(7152):470-473.
8. Fang Q, Zhao H, Wang A, et al. Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population. BMC Med Genet, 2011, 12:133.
9. Sy HY, Ko FW, Chu HY, et al. Asthma and bronchodilator responsiveness are associated with polymorphic markers of ARG1, CRHR2 and chromosome 17q21. Pharmacogenet Genomics, 2012, 22(7):517-524.
10. Yang FF, Huang Y, Li QB, et al. Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population. Genet Mol Res, 2012, 11(4):4646-4653.
11. 丁毅鹏, 何海武, 石慧芳, 等. 海南黎族哮喘ORMDL3基因多态性研究. 海南医学, 2012, 23(11):1-2.
12. 黄汉琮, 曾林祥, 杜哲明. ORMDL3基因多态性与支气管哮喘患者发病及肺功能的相关性研究. 中华结核和呼吸杂志, 2011, 34(10):780-781.
13. 金哲. ORMDL3基因单核苷酸多态性及表达水平与北京地区儿童哮喘关联性研究. 中国人民解放军军事医学科学院, 2010.
14. 阳爱梅. 湖南省哮喘儿童ORMDL3基因多态性分析及与OPN、TGF-βl水平相关性探讨. 中南大学, 2012.
15. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in metaanalyses. Eur J Epidemiol, 2010, 25(9):603-605.
16. 陈甲, 和儒林, 朗莹, 等. 中国人群MTHFR基因C677T多态性与青中年缺血性脑卒中相关性的Meta分析. 中国循证医学杂志, 2014, 14(4):435-442.
17. 刁敏, 柳慧, 林雪梅. 腰硬联合麻醉用于剖宫产有效性及安全性的系统评价. 中国循证医学杂志, 2014, 14(10):1218-1224.
18. Daley D, Park JE, He JQ, et al. Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes. J Allergy Clin Immunol, 2012, 130(6):1284-1293.
19. Burkhardt J, Kirsten H, Wolfram G, et al. Differential allelic expression of IL13 and CSF2 genes associated with asthma. Genet Mol Biol, 2012, 35(3):567-574.
20. Toncheva AA, Suttner K, Michel S, et al. Genetic variants in Protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children. Pediatr Allergy Immunol, 2012, 23(7):636-641.

Chinese Journal of Evidence-Based Medicine

ORMDL3 rs72l6389 Polymorphism and the Susceptibility to Asthma in Chinese Population: A Meta-analysis

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