Efficacy of Chinese Medicine for Endometrial Hypoplasia: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 SUNYang ^1,2 , CHENYa-qiong ¹ , HOUHai-yan ¹ , LANXiao-xia ² , LIANGJing ³

1. Obstetric and Gynecologic Department, Armed Police Rear Service Institute Affiliated Hospital, Tianjin 300162, China;
2. Department of Epidemiology and Principle of Statistics, Armed Police Rear Service Institute, Tianjin 300309, China;
3. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;

Corresponding author：

Keywords：

Endometrial hypoplasia; Chinese medicine; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.20150037

Video：

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Objective To systematically review the efficacy of Chinese medicine for endometrial hypoplasia. Methods Databases such as PubMed, EMbase, MEDLINE (Ovid), The Cochrane Library (Issue 8, 2014), CNKI, VIP and WanFang Data were searched for randomized controlled trials (RCTs) and quasi-RCTs concerning the efficacy of Chinese medicine for endometrial hypoplasia up to August 2014. According to the inclusion and exclusion criteria, two reviewers screened literature, extracted data, and assessed methodological quality of included studies. Then meta-analysis was performed using RevMan 5.3 software. Results A total of 5 RCTs and 6 quasi-RCTs involving 914 patients were included. The results of meta-analysis showed that Chinese medicine group was superior to control group in endometrial thickness (MD=0.86, 95%CI 0.35 to 1.37, P=0.000 01), clinical pregnancy rates (RR=2.62, 95%CI 2.02 to 3.38, P<0.000 01), endometrial morphous (RR=1.23, 95%CI 1.06 to 1.42, P=0.005), PI of uterine artery blood flow (MD=-0.54, 95%CI -0.80 to -0.28, P<0.000 1), RI of uterine artery blood flow (MD=-0.12, 95%CI -0.17 to -0.08, P<0.000 1), and estradiol level (MD=96.03, 95%CI 44.32 to 144.74, P=0.003); However, the two groups were alike in progesterone level without significant difference (MD=2.00, 95%CI -0.64 to 4.65, P=0.14). Conclusion Current evidence indicated that, Chinese medicine is beneficial for endometrial hypoplasia. Due to limited quantity and quality of the included studies, the above conclusion still needs to be verified by conducting more high quality studies.

Citation： SUNYang, CHENYa-qiong, HOUHai-yan, LANXiao-xia, LIANGJing. Efficacy of Chinese Medicine for Endometrial Hypoplasia: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2015, 15(2): 215-222. doi: 10.7507/1672-2531.20150037 Copy

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2.	Al-Ghamdi A, Coskun S, Al-Hassan S, et al. The correlation between endometrial thickness and outcome of invitro fertilization and embryo transfer (IVF-ET) outcome. Reprod Biol Endocinol, 2008, 6(37):1-5.
3.	Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[updated March 2011].The Cochrane Collaboration, 2011. Available at:www.cochranehandbook.org.
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5.	王海文, 阮祥燕. 资癸女贞胶囊应用于子宫内膜薄性不育症的临床研究. 首都医科大学学报, 2014, 35(2):248-252.
6.	周茂溪, 冯雪花, 李玉, 等. 血流方对肾虚血瘀型冻融胚胎移植患者子宫内容受性影响. 辽宁中医药大学学报, 2013, 15(10):183-184.
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9.	刘昱磊, 王俊玲, 腾辉. 活血补肾方治疗子宫内膜生长不良性不孕症30例. 陕西中医学院学报, 2011, 34(1):60-61.
10.	陈文英. 温经汤直肠滴入对体外受精-胚胎移植失败患者子宫内膜容受性的影响. 陕西中医, 2013, 34(3):266-268.
11.	冯雪花, 杨楠, 陈晓会, 等. 内膜方对促排卵周期中肾虚型患者子宫内膜容受性的影响. 辽宁中医药大学学报, 2012, 14(10):66-67.
12.	李秀然. 助孕增膜方对促排卵周期子宫内膜容受性的影响. 中医药临床杂志, 2011, 23(7):624-626.
13.	王利红, 赵丽颖, 夏天. 补肾调冲方改善促排卵周期中子宫内膜容受性的临床观察. 天津中医药大学学报, 2011, 30(3):150-152.
14.	徐艳, 王磊, 马兆文. 温阳化瘀颗粒治疗不孕症患者临床疗效观察研究. 中医临床研究, 2011, 3(22):64-66.
15.	刘元文, 盖德美, 孙建欣, 等. 益肾生膜颗粒治疗子宫内膜发育不良性不孕120例. 山东中医杂志, 2012, 31(7):481-483.
16.	田甜, 赵静. 薄型子宫内膜治疗的研究进展. 国际生殖健康/计划生育杂志, 2013, 32(3):214-217.
17.	郭佳, 王丽娜, 李东. 改善子宫内膜血流状态提高体外受精-胚胎移植成功率的中医研究与思考. 中西医结合学报, 2011, 9(12):1301-1306.
18.	罗江霞, 覃爱平, 张海英. 子宫内膜厚度与容受性的研究. 实用妇产科杂志, 2010, 26(8):608-610.
19.	Wang L, Qiao J, Li R, et al. Role of Endometrial blood flow assessment with color Doppler energy in predicting pregnancy outcome of IVF-ET cycles. Reprod Biol Endocrinol, 2010, 8(1):122.
20.	Lilic V, Tubic-Pavlvic A, Radovic-Janosevic D, et al. Assessment of endometrial receptivity by color Doppler and ultrasound imaging. Med Pregl, 2007, 60(5-6):237-240.
21.	Amir W, Micha B, Ariel H, et al. Predicting factors for endometrial thickness during treatment with assisted reproductive technology. Fertil Steril, 2007, 87:799-804.

1. 胡倩, 中医改善子宫内膜研究进展. 内蒙古中医药, 2012, 2:137-138.
2. Al-Ghamdi A, Coskun S, Al-Hassan S, et al. The correlation between endometrial thickness and outcome of invitro fertilization and embryo transfer (IVF-ET) outcome. Reprod Biol Endocinol, 2008, 6(37):1-5.
3. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[updated March 2011].The Cochrane Collaboration, 2011. Available at:www.cochranehandbook.org.
4. 刘艳, 席丽军. 紫河车胶囊用于治疗子宫内膜过薄不孕症的探讨. 中医药信息, 2011, 28(4):118-119.
5. 王海文, 阮祥燕. 资癸女贞胶囊应用于子宫内膜薄性不育症的临床研究. 首都医科大学学报, 2014, 35(2):248-252.
6. 周茂溪, 冯雪花, 李玉, 等. 血流方对肾虚血瘀型冻融胚胎移植患者子宫内容受性影响. 辽宁中医药大学学报, 2013, 15(10):183-184.
7. 马翠霞. 定坤丹对子宫内膜发育不良不孕患者的临床疗效观察. 中医中药, 2013, (1):260-261.
8. 高志云, 高修安, 马文敏, 等. 中药周期疗法对体外受精-胚胎移植失败患者子宫内膜厚度影响的研究. 长春中医药大学学报, 2012, 28(3):417-419.
9. 刘昱磊, 王俊玲, 腾辉. 活血补肾方治疗子宫内膜生长不良性不孕症30例. 陕西中医学院学报, 2011, 34(1):60-61.
10. 陈文英. 温经汤直肠滴入对体外受精-胚胎移植失败患者子宫内膜容受性的影响. 陕西中医, 2013, 34(3):266-268.
11. 冯雪花, 杨楠, 陈晓会, 等. 内膜方对促排卵周期中肾虚型患者子宫内膜容受性的影响. 辽宁中医药大学学报, 2012, 14(10):66-67.
12. 李秀然. 助孕增膜方对促排卵周期子宫内膜容受性的影响. 中医药临床杂志, 2011, 23(7):624-626.
13. 王利红, 赵丽颖, 夏天. 补肾调冲方改善促排卵周期中子宫内膜容受性的临床观察. 天津中医药大学学报, 2011, 30(3):150-152.
14. 徐艳, 王磊, 马兆文. 温阳化瘀颗粒治疗不孕症患者临床疗效观察研究. 中医临床研究, 2011, 3(22):64-66.
15. 刘元文, 盖德美, 孙建欣, 等. 益肾生膜颗粒治疗子宫内膜发育不良性不孕120例. 山东中医杂志, 2012, 31(7):481-483.
16. 田甜, 赵静. 薄型子宫内膜治疗的研究进展. 国际生殖健康/计划生育杂志, 2013, 32(3):214-217.
17. 郭佳, 王丽娜, 李东. 改善子宫内膜血流状态提高体外受精-胚胎移植成功率的中医研究与思考. 中西医结合学报, 2011, 9(12):1301-1306.
18. 罗江霞, 覃爱平, 张海英. 子宫内膜厚度与容受性的研究. 实用妇产科杂志, 2010, 26(8):608-610.
19. Wang L, Qiao J, Li R, et al. Role of Endometrial blood flow assessment with color Doppler energy in predicting pregnancy outcome of IVF-ET cycles. Reprod Biol Endocrinol, 2010, 8(1):122.
20. Lilic V, Tubic-Pavlvic A, Radovic-Janosevic D, et al. Assessment of endometrial receptivity by color Doppler and ultrasound imaging. Med Pregl, 2007, 60(5-6):237-240.
21. Amir W, Micha B, Ariel H, et al. Predicting factors for endometrial thickness during treatment with assisted reproductive technology. Fertil Steril, 2007, 87:799-804.

Chinese Journal of Evidence-Based Medicine

Efficacy of Chinese Medicine for Endometrial Hypoplasia: A Systematic Review

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