Effectiveness of Intranasal Lidocaine Spray before Nasogastric Tube Insertion: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LIWei ¹ ,  SUNXiao-ming ²

1. Department of Oncology, the First Hospital of Lanzhou University, Lanzhou 730000, China;
2. Department of Haematology, the First Hospital of Lanzhou University, Lanzhou 730000, China;

Corresponding author：

SUNXiao-ming, Email: liweizlwk@163.com

Keywords：

Lidocaine; Nasogastric tube; Saline; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.20150057

Video：

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Objective To systematically review the efficacy and safety of intranasal lidocaine spray before nasogastric tube insertion. Methods We searched PubMed, EMbase, The Cochrane Library, WanFang Data, VIP, CBM and CNKI databases concerning randomized controlled trial (RCT) of the efficacy and safety of intranasal lidocaine spray before nasogastric tube insertion from their inception to January 2014. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality of included studies. Meta-analysis was then conducted using RevMan 5.2 software. Results Six RCTs involving 384 patients were included. The results of meta-analysis showed that there were no significant differences between the lidocaine group and the saline group in pain and discomfort scores (MD=-25.35, 95%CI -30.37 to -24.33) and first successful insertion rate (RR=1.38, 95%CI 1.21 to 1.57). Conclusion Intranasal lidocaine spray before nasogastric tube insertion could reduce patient pain and discomforts related to the procedure, and improve the first successful insertion rate.

Citation： LIWei, SUNXiao-ming. Effectiveness of Intranasal Lidocaine Spray before Nasogastric Tube Insertion: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(3): 342-345. doi: 10.7507/1672-2531.20150057 Copy

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3.	Spektor M, Kaplan J, Kelley J, et al. Nebulized or sprayed lidocaine as anesthesia for nasogastric intubations. Acad Emerg Med, 2000, 7(4):406-408.
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5.	Cullen L, Taylor D, Taylor S, et al. Nebulized lidocaine decreases the discomfort of nasogastric tube insertion:a randomized, double-blind trial. Ann Emerg Med, 2004, 44(2):131-137.
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7.	Chan CP, Lau FL. Should lidocaine spray be used to ease nasogastric tube insertion? A double-blind, randomised controlled trial. Hong Kong Med J, 2010, 16(4):282-286.
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1. Singer AJ, Konia N. Comparison of topical anesthetics and vasoconstrictors vs lubricants prior to nasogastric intubation:a randomized, controlled trial. Acad Emerg Med, 1999, 6(3):184-190.
2. Nott MR, Hughes JH. Topical anaesthesia for the insertion of nasogastric tubes. Eur J Anaesthesiol, 1995, 12(3):287-290.
3. Spektor M, Kaplan J, Kelley J, et al. Nebulized or sprayed lidocaine as anesthesia for nasogastric intubations. Acad Emerg Med, 2000, 7(4):406-408.
4. Wolfe TR, Fosnocht DE, Linscott MS. Atomized lidocaine as topical anesthesia for nasogastric tube placement:A randomized, double-blind, placebo-controlled trial. Ann Emerg Med, 2000, 35(5):421-425.
5. Cullen L, Taylor D, Taylor S, et al. Nebulized lidocaine decreases the discomfort of nasogastric tube insertion:a randomized, double-blind trial. Ann Emerg Med, 2004, 44(2):131-137.
6. Babl FE, Goldfinch C, Mandrawa C, et al. Does nebulized lidocaine reduce the pain and distress of nasogastric tube insertion in young children? A randomized, double-blind, placebo-controlled trial. Pediatrics, 2009, 123(6):1548-1555.
7. Chan CP, Lau FL. Should lidocaine spray be used to ease nasogastric tube insertion? A double-blind, randomised controlled trial. Hong Kong Med J, 2010, 16(4):282-286.
8. Penrod J, Morse JM, Wilson S. Comforting strategies used during nasogastric tube insertion. J Clin Nurs, 1999, 8(1):31-38.
9. Morse JM, Penrod J, Kassab C, et al. Evaluating the efficiency and effectiveness of approaches to nasogastric tube insertion during trauma care. Am J Crit Care, 2000, 9(5):325-333.
10. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1. 0[updated March 2011]. The Cochrane Collaboration, 2011. Available at:http://www.cochrane.org/handbook.
11. Gjonaj ST, Lowenthal DB, Dozor AJ. Nebulized lidocaine administered to infants and children undergoing flexible bronchoscopy. Chest, 1997, 112(6):1665-1669.
12. Altman DG, Schulz KF, Moher D, 等. 报告随机对照试验的CONSORT声明修订版:说明与详述(一). 中国循证医学杂志, 2005, 5(9):712-714.
13. Altman DG, Schulz KF, Moher D, 等. 报告随机对照试验的CONSORT声明修订版:说明与详述(二). 中国循证医学杂志, 2005, 5(10):786-787.

Chinese Journal of Evidence-Based Medicine

Effectiveness of Intranasal Lidocaine Spray before Nasogastric Tube Insertion: A Meta-analysis

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