How to use GRADEpro GDT to Rate the Quality of Evidence in Systematic Reviews of Intervention Studies: An Introduction_Chinese Journal of Evidence-Based Medicine

Authors：

 CHENHao ¹ , WANGYan ² , HUXuan-ming ¹ , ZHOUFang ¹ , ZENGXian-tao ³ ,  GUYi-huang ¹

1. The Second Clinical College, Nanjing University of Chinese Medicine, Nanjing 210023, China;
2. Nanjing Hospital of Red Cross, Nanjing 210023, China;
3. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;

Corresponding author：

GUYi-huang, Email: tcsgc@sina.com

Keywords：

GRADE; GDT; Grading of evidence; Evidence-based medicine; Systematic review; Clinical practice guideline

DOI：

10.7507/1672-2531.20150099

Video：

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GRADEpro GDT-Guideline Development Tool, is an online tool for the integration of important data and process of clinical practice guidelines and diagnostic guidelines. It is a new methodology progress of the GRADE system. This paper introduced how to use GRADEpro GDT to rate the quality of evidence in systematic reviews of intervention studies with an example.

Citation： CHENHao, WANGYan, HUXuan-ming, ZHOUFang, ZENGXian-tao, GUYi-huang. How to use GRADEpro GDT to Rate the Quality of Evidence in Systematic Reviews of Intervention Studies: An Introduction. Chinese Journal of Evidence-Based Medicine, 2015, 15(5): 600-606. doi: 10.7507/1672-2531.20150099 Copy

1.	Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328(7454):1490.
2.	曾宪涛, 田国祥, 牛玉明, 等. GRADEprofiler软件使用简介. 中国循证心血管医学杂志, 2011, 12(3):390-392.
3.	Guyatt GH, Oxman AD, Vist GE, et al. GRADE:an emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 2008, 336(7650):924-926.
4.	Guyatt GH, Oxman AD, Kunz R, et al. What is "quality of evidence" and why is it important to clinicians? BMJ, 2008, 336(7651):995-998.
5.	Guyatt GH, Oxman AD, Kunz R, et al. Going from evidence to recommendations. BMJ, 2008, 336(7652):1049-1051.
6.	Schünemann HJ, Oxman AD, Brozek J, et al. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ, 2008, 336(7653):1106-1110.
7.	Guyatt GH, Oxman AD, Kunz R, et al. Incorporating considerations of resources use into grading recommendations. BMJ, 2008, 336(7654):1170-1173.
8.	Jaeschke R, Guyatt GH, Dellinger P, et al. Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive. BMJ, 2008, 337:a744.
9.	陈耀龙, 杨克虎, 姚亮, 等. GRADE系统方法学进展. 中国循证儿科杂志, 2013, 8(1):64-65.
10.	曾宪涛, 冷卫东, 李胜, 等. 如何正确理解及使用GRADE系统. 中国循证医学杂志, 2011, 11(9):985-990.
11.	陈耀龙, 姚亮, Norris S, 等. GRADE在系统评价中应用的必要性及注意事项. 中国循证医学杂志, 2013, 13(12):1401-1404.
12.	陈耀龙, 姚亮, 杜亮, 等. GRADE在诊断准确性试验系统评价中应用的原理、方法、挑战及发展趋势. 中国循证医学杂志, 2014, 14(11):1402-1406.
13.	姚亮, 陈耀龙, 杜亮, 等. GRADE在诊断准确性试验系统评价中的应用实例解析. 中国循证医学杂志, 2014, 14(11):1407-1412.
14.	Puhan MA, Schünemann HJ, Murad MH, et al. A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis. BMJ, 2014, 24, 349:g5630.
15.	Lorio A, Spencer FA, Falavigna M, et al. Use of GRADE for assessment of evidence about prognosis:rating confidence in estimates of event rates in broad categories of patients. BMJ, 2015, 350:h870.
16.	Guyatt GH, Schünemann HJ, Djulbegovic B, et al. Guideline panels should not GRADE good practice statements. J Clin Epidemiol, 2015, 68(5):597-600.
17.	曾宪涛, 金晶, 向招燕, 等. 思密达与锡类散比较治疗小儿口腔溃疡的Meta分析. 中国循证医学杂志, 2012, 12(3):326-333.
18.	Guyatt GH, Oxman AD, Vist G, et al. GRADE guidelines:4. Rating the quality of evidence-study limitations(risk of bias) and publication bias. J Clin Epidemiol, 2011, 64(4):407-415.
19.	Nolting A, Perleth M, Langer G, et al. GRADE guidelines:5. Rating the quality of evidence:publication bias. J Clin Epidemiol, 2012, 106(9):670-676.
20.	Kulig M, Perleth M, Langer G, et al. GRADE guidelines:6. Rating the quality of evidence:imprecision. J Clin Epidemiol, 2012, 106(9):677-88.
21.	Perleth M, Langer G, Meerpohl JJ, et al. GRADE guidelines:7. Rating the quality of evidence-inconsistency. J Clin Epidemiol, 2012, 106(10):733-744.
22.	Rasch A, Perleth M, Langer G, et al. GRADE guidelines:8. Rating the quality of evidence-indirectness. J Clin Epidemiol, 2012, 106(10):745-753.
23.	Kien C, Gartiehner G, Kaminski-Hartenthaler A, et al. GRADE guidelines:9. Rating up the quality of evidence. J Clin Epidemiol, 2013, 107(3):249-255.

1. Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328(7454):1490.
2. 曾宪涛, 田国祥, 牛玉明, 等. GRADEprofiler软件使用简介. 中国循证心血管医学杂志, 2011, 12(3):390-392.
3. Guyatt GH, Oxman AD, Vist GE, et al. GRADE:an emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 2008, 336(7650):924-926.
4. Guyatt GH, Oxman AD, Kunz R, et al. What is "quality of evidence" and why is it important to clinicians? BMJ, 2008, 336(7651):995-998.
5. Guyatt GH, Oxman AD, Kunz R, et al. Going from evidence to recommendations. BMJ, 2008, 336(7652):1049-1051.
6. Schünemann HJ, Oxman AD, Brozek J, et al. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ, 2008, 336(7653):1106-1110.
7. Guyatt GH, Oxman AD, Kunz R, et al. Incorporating considerations of resources use into grading recommendations. BMJ, 2008, 336(7654):1170-1173.
8. Jaeschke R, Guyatt GH, Dellinger P, et al. Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive. BMJ, 2008, 337:a744.
9. 陈耀龙, 杨克虎, 姚亮, 等. GRADE系统方法学进展. 中国循证儿科杂志, 2013, 8(1):64-65.
10. 曾宪涛, 冷卫东, 李胜, 等. 如何正确理解及使用GRADE系统. 中国循证医学杂志, 2011, 11(9):985-990.
11. 陈耀龙, 姚亮, Norris S, 等. GRADE在系统评价中应用的必要性及注意事项. 中国循证医学杂志, 2013, 13(12):1401-1404.
12. 陈耀龙, 姚亮, 杜亮, 等. GRADE在诊断准确性试验系统评价中应用的原理、方法、挑战及发展趋势. 中国循证医学杂志, 2014, 14(11):1402-1406.
13. 姚亮, 陈耀龙, 杜亮, 等. GRADE在诊断准确性试验系统评价中的应用实例解析. 中国循证医学杂志, 2014, 14(11):1407-1412.
14. Puhan MA, Schünemann HJ, Murad MH, et al. A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis. BMJ, 2014, 24, 349:g5630.
15. Lorio A, Spencer FA, Falavigna M, et al. Use of GRADE for assessment of evidence about prognosis:rating confidence in estimates of event rates in broad categories of patients. BMJ, 2015, 350:h870.
16. Guyatt GH, Schünemann HJ, Djulbegovic B, et al. Guideline panels should not GRADE good practice statements. J Clin Epidemiol, 2015, 68(5):597-600.
17. 曾宪涛, 金晶, 向招燕, 等. 思密达与锡类散比较治疗小儿口腔溃疡的Meta分析. 中国循证医学杂志, 2012, 12(3):326-333.
18. Guyatt GH, Oxman AD, Vist G, et al. GRADE guidelines:4. Rating the quality of evidence-study limitations(risk of bias) and publication bias. J Clin Epidemiol, 2011, 64(4):407-415.
19. Nolting A, Perleth M, Langer G, et al. GRADE guidelines:5. Rating the quality of evidence:publication bias. J Clin Epidemiol, 2012, 106(9):670-676.
20. Kulig M, Perleth M, Langer G, et al. GRADE guidelines:6. Rating the quality of evidence:imprecision. J Clin Epidemiol, 2012, 106(9):677-88.
21. Perleth M, Langer G, Meerpohl JJ, et al. GRADE guidelines:7. Rating the quality of evidence-inconsistency. J Clin Epidemiol, 2012, 106(10):733-744.
22. Rasch A, Perleth M, Langer G, et al. GRADE guidelines:8. Rating the quality of evidence-indirectness. J Clin Epidemiol, 2012, 106(10):745-753.
23. Kien C, Gartiehner G, Kaminski-Hartenthaler A, et al. GRADE guidelines:9. Rating up the quality of evidence. J Clin Epidemiol, 2013, 107(3):249-255.

Chinese Journal of Evidence-Based Medicine

How to use GRADEpro GDT to Rate the Quality of Evidence in Systematic Reviews of Intervention Studies: An Introduction

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