Diagnostic Value of Interferon-γ Release Assay (TB-IGRA) for Tuberculosis in the Tibetan_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHANGLin , LIUPing , LINJing , CHENYue-jie , WUWei-qi ,  ZHOUWei-dong

Department of Clinical Laboratory, AVIC 363 Hospital, Chengdu 610041, China;

Corresponding author：

ZHOUWei-dong, Email: 553586801@qq.com

Keywords：

Interferon-γ; TB-IGRA; Tibetan; Tuberculosis; Diagnostic test

DOI：

10.7507/1672-2531.20150104

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the diagnostic value of interferon-gamma release assay (TB-IGRA) for tuberculosis in the Tibetan. Methods From January 2014 to December 2014, suspected Tibetan tuberculosis patients were enrolled from AVIC 363 Hospital and underwent TB-IGRA test. All patients were also underwent smear test for Mycobacteria. The diagnostic value of TB-IGRA test for Tibetan TB patients was analyzed. Results A total of 77 suspected Tibetan tuberculosis patients were included. According to the diagnostic criteria, of the 77 suspected patients, 50 were diagnosed as TB patients, and 27 were diagnosed as not-TB patients. The sensitivity and specificity of TB-IGRA test was 86% and 81.5%. While the sensitivity and specificity of smear test were 22% and 100%, respectively. Conclusion The TB-IGRA test is superior to smear test, and is the fast and sensitivity test for diagnosing Tibetan TB patients.

Citation： ZHANGLin, LIUPing, LINJing, CHENYue-jie, WUWei-qi, ZHOUWei-dong. Diagnostic Value of Interferon-γ Release Assay (TB-IGRA) for Tuberculosis in the Tibetan. Chinese Journal of Evidence-Based Medicine, 2015, 15(6): 625-627. doi: 10.7507/1672-2531.20150104 Copy

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2.	Tang Y,Zhao M,Wang Y,et al.Non-adherence to anti-tuberculosis treatment among internal migrants with pulmonary tuberculosis in Shenzhen,China:a cross-sectional study.BMC Public Health,2015,15(1):474.
3.	Zeng J,Wu G,Yang W,et al.A serum vitamin d level <25nmol/l pose high tuberculosis risk:a meta-analysis.PLoS One,2015,10(5):e0126014.
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6.	Wang J,Chen R,Tang S,et al.Analysis of IL-6,STAT3 and HSPA1L gene polymorphisms in anti-tuberculosis drug-induced hepatitis in a nested case-control study.PLoS One,2015,10(3):e0118862.
7.	Jang JY,Park IW,Choi BW,et al.The Usefulness of the Tuberculosis Skin Test and the Interferon-gamma Release Assay in the Diagnosis of Latent Tuberculosis Infection in South Korea.Osong Public Health Res Perspect,2014,5(Suppl):S18-23.
8.	Little KM,Pai M,Dowdy DW.Costs and Consequences of Using Interferon-gamma Release Assays for the Diagnosis of Active Tuberculosis in India.PLoS One,2014,10(4):e0124525.
9.	Cekic C,Aslan F,Vatansever S,et al.Latent tuberculosis screening tests and active tuberculosis infection rates in Turkish inflammatory bowel disease patients under anti-tumor necrosis factor therapy.Ann Gastroenterol,2015,28(2):241-246.
10.	Kruczak K,Duplaga M,Sanak M,et al.Comparison of IGRA tests and TST in the diagnosis of latent tuberculosis infection and predicting tuberculosis in risk groups in Krakow,Poland.Scand J Infect Dis,2014,46(9):649-655.
11.	Aichelburg MC,Mandorfer M,Tittes J,et al.The association of smoking with IGRA and TST results in HIV-1-infected subjects.Int J Tuberc Lung Dis,2014,18(6):709-716.
12.	Campbell JR,Krot J,Elwood K,et al.A systematic review on TST and IGRA tests used for diagnosis of LTBI in immigrants.Mol Diagn Ther,2015,19(1):9-24.
13.	Targowski T,Chelstowska S,Plusa T.IGRA as a predictive factor of silent pulmonary changes in individuals following exposure to tuberculosis.Lung,2014,192(6):869-874.
14.	Wong SH,Ip M,Tang W,et al.Performance of interferon-gamma release assay for tuberculosis screening in inflammatory bowel disease patients.Inflamm Bowel Dis,2014,20(11):2067-2072.
15.	Feng Y,Diao N,Shao L,et al.Interferon-gamma release assay performance in pulmonary and extrapulmonary tuberculosis.PLoS One,2012,7(3):e32652.
16.	Zhang M,Wang H,Liao M,et al.Diagnosis of latent tuberculosis infection in bacille Calmette-Guerin vaccinated subjects in China by interferon-gamma ELISpot assay.Int J Tuberc Lung Dis,2010,14(12):1556-1563.
17.	Zhou Q,Chen YQ,Qin SM,et al.Diagnostic accuracy of T-cell interferon-gamma release assays in tuberculous pleurisy:a meta-analysis.Respirology,2011,16(3):473-480.

1. Song X,Li S,QuCuo M,et al.Association between SNPs in microRNA-machinery genes and tuberculosis susceptibility in Chinese Tibetan population.Mol Biol Rep,2013,40(10):6027-6033.
2. Tang Y,Zhao M,Wang Y,et al.Non-adherence to anti-tuberculosis treatment among internal migrants with pulmonary tuberculosis in Shenzhen,China:a cross-sectional study.BMC Public Health,2015,15(1):474.
3. Zeng J,Wu G,Yang W,et al.A serum vitamin d level <25nmol/l pose high tuberculosis risk:a meta-analysis.PLoS One,2015,10(5):e0126014.
4. Li R,Ruan Y,Sun Q,et al.Effect of a comprehensive programme to provide universal access to care for sputum-smear-positive multidrug-resistant tuberculosis in China:a before- and-after study.Lancet Glob Health,2015,3(4):e217-228.
5. Dong H,Shi L,Zhao X,et al.Genetic diversity of Mycobacterium tuberculosis isolates from Tibetans in Tibet,China.PLoS One,2012,7(3):e33904.
6. Wang J,Chen R,Tang S,et al.Analysis of IL-6,STAT3 and HSPA1L gene polymorphisms in anti-tuberculosis drug-induced hepatitis in a nested case-control study.PLoS One,2015,10(3):e0118862.
7. Jang JY,Park IW,Choi BW,et al.The Usefulness of the Tuberculosis Skin Test and the Interferon-gamma Release Assay in the Diagnosis of Latent Tuberculosis Infection in South Korea.Osong Public Health Res Perspect,2014,5(Suppl):S18-23.
8. Little KM,Pai M,Dowdy DW.Costs and Consequences of Using Interferon-gamma Release Assays for the Diagnosis of Active Tuberculosis in India.PLoS One,2014,10(4):e0124525.
9. Cekic C,Aslan F,Vatansever S,et al.Latent tuberculosis screening tests and active tuberculosis infection rates in Turkish inflammatory bowel disease patients under anti-tumor necrosis factor therapy.Ann Gastroenterol,2015,28(2):241-246.
10. Kruczak K,Duplaga M,Sanak M,et al.Comparison of IGRA tests and TST in the diagnosis of latent tuberculosis infection and predicting tuberculosis in risk groups in Krakow,Poland.Scand J Infect Dis,2014,46(9):649-655.
11. Aichelburg MC,Mandorfer M,Tittes J,et al.The association of smoking with IGRA and TST results in HIV-1-infected subjects.Int J Tuberc Lung Dis,2014,18(6):709-716.
12. Campbell JR,Krot J,Elwood K,et al.A systematic review on TST and IGRA tests used for diagnosis of LTBI in immigrants.Mol Diagn Ther,2015,19(1):9-24.
13. Targowski T,Chelstowska S,Plusa T.IGRA as a predictive factor of silent pulmonary changes in individuals following exposure to tuberculosis.Lung,2014,192(6):869-874.
14. Wong SH,Ip M,Tang W,et al.Performance of interferon-gamma release assay for tuberculosis screening in inflammatory bowel disease patients.Inflamm Bowel Dis,2014,20(11):2067-2072.
15. Feng Y,Diao N,Shao L,et al.Interferon-gamma release assay performance in pulmonary and extrapulmonary tuberculosis.PLoS One,2012,7(3):e32652.
16. Zhang M,Wang H,Liao M,et al.Diagnosis of latent tuberculosis infection in bacille Calmette-Guerin vaccinated subjects in China by interferon-gamma ELISpot assay.Int J Tuberc Lung Dis,2010,14(12):1556-1563.
17. Zhou Q,Chen YQ,Qin SM,et al.Diagnostic accuracy of T-cell interferon-gamma release assays in tuberculous pleurisy:a meta-analysis.Respirology,2011,16(3):473-480.

Chinese Journal of Evidence-Based Medicine

Diagnostic Value of Interferon-γ Release Assay (TB-IGRA) for Tuberculosis in the Tibetan

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