Association between 936C/T Polymorphism in VEGF Gene and Preeclampsia Risk: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 HEYi ¹ , HEZi-qi ² , LIUJu-fang ¹ , YuanRui-xia ³ , ZUOHong-xia ³ ,  WENGHong ⁴

1. Department of Obstetrics, Xianning Central Hospital & Tongji Xianning Hospital, Xianning 437100, China;
2. Department of Urology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;
3. Center for Evidence-based Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China;
4. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;

Corresponding author：

WENGHong, Email: wengh92@163.com

Keywords：

Preeclampsia; Gene; Polymorphism; VEGF; Meta-analysis

DOI：

10.7507/1672-2531.20150107

Video：

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Objective To systematically evaluate the association between 936C/T polymorphism in vascular endothelial growth factor (VEGF) gene and the risk of preeclampsia (PE). Methods Such databases as PubMed, EMbase, The Cochrane Library (Issue 11, 2014), CBM, CNKI, VIP, and WanFang Data were searched up to November 2014, to collect case-control studies of the association between 936C/T polymorphism in VEGF gene and the risk of PE. Two reveiwers independently screened studies according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias of included studies. And then, meta-analysis was conducted using RevMan 5.3 software. Results A total of nine case-control studies involving 904 PE patients and 1 113 controls were included. The results of meta-analysis showed that, significant association was found between VEGF gene 936C/T polymorphism and the risk of PE in the total analysis (T vs. C:OR=1.61, 95%CI 1.17 to 2.22, P=0.003; TT vs. CC:OR=2.65, 95%CI 1.37 to 5.11, P=0.004; CT vs. CC:OR=1.55, 95%CI 1.09 to 2.22, P=0.02; TT+CT vs. CC:OR=1.68, 95%CI 1.15 to 2.45, P=0.007; TT vs. CT+CC:OR=2.19, 95%CI 1.31 to 3.68, P=0.003). In the subgroup analysis, significant association of the polymorphism was found in Asians but not in Caucasians. Conclusion VEGF gene 936C/T polymorphism may be associated with PE risk in Asians. Due to limited quantity and quality of the included studies, the conclusion should be assessed in further studies.

Citation： HEYi, HEZi-qi, LIUJu-fang, YuanRui-xia, ZUOHong-xia, WENGHong. Association between 936C/T Polymorphism in VEGF Gene and Preeclampsia Risk: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(6): 639-645. doi: 10.7507/1672-2531.20150107 Copy

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2.	Ghulmiyyah L,Sibai B.Maternal mortality from preeclampsia/eclampsia.Semin Perinatol,2012,36(1):56-59.
3.	Eiland E,Nzerue C,Faulkner M.Preeclampsia 2012.J Pregnancy,2012,2012:586578.
4.	Odibo AO,Rada CC,Cahill AG,et al.First-trimester serum soluble fms-like tyrosine kinase-1,free vascular endothelial growth factor,placental growth factor and uterine artery Doppler in preeclampsia.J Perinatol,2013,33(9):670-674.
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8.	曾宪涛,Joey S.W.Kwong,田国祥,等.Meta分析系列之二:Meta分析的软件.中国循证心血管医学杂志,2012,4(2):89-91.
9.	Papazoglou D,Galazios G,Koukourakis MI,et al.Vascular endothelial growth factor gene polymorphisms and pre-eclampsia.Mol Hum Reprod,2004,10(5):321-324.
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11.	Kim YJ,Park BH,Park H,et al.No association of the genetic polymorphisms of endothelial nitric oxide synthase,dimethylarginine dimethylaminohydrolase,and vascular endothelial growth factor with preeclampsia in Korean populations.Twin Res Hum Genet,2008,11(1):77-83.
12.	黄余良,刘珏.VEGF基因多态性与子痫前期易感性的研究.中国妇幼保健,2009,24(19):2712-2714.
13.	陈宝丽,王燕云,李桂荣,等.血管内皮生长因子基因多态性与重度子痫前期易感性.中国妇幼保健,2011,26(32):5052-5055.
14.	Cunha VM,Grecco RL,Paschoini MC,et al.[Genetic polymorphisms of vascular endothelial growth factor in pre-eclampsia].Rev Bras Ginecol Obstet,2011,33(7):158-163.
15.	Andraweera PH,Dekker GA,Dissanayake VH,et al.Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri-Lanka.J Matern Fetal Neonatal Med,2013,26(5):532-536.
16.	Chedraui P,Solis EJ,Bocci G,et al.Feto-placental nitric oxide,asymmetric dimethylarginine and vascular endothelial growth factor (VEGF) levels and VEGF gene polymorphisms in severe preeclampsia.J Matern Fetal Neonatal Med,2013,26(3):226-232.
17.	张竑卉,何云,张彩媚.血管内皮生长因子单核苷酸多态性与子痫前期易感性的相关研究.现代医学,2014,42(4),353-357.
18.	Toi M,Matsumoto T,Bando H.Vascular endothelial growth factor:its prognostic,predictive,and therapeutic implications.Lancet Oncol,2001,2(11):667-673.
19.	Ferrara N.Vascular endothelial growth factor:basic science and clinical progress.Endocr Rev,2004,25(4):581-611.
20.	Leng WD,He MN,Chen QL,et al.Vascular endothelial growth factor (VEGF) gene polymorphisms and risk of head and neck cancer:a meta-analysis involving 2,444 individuals.Mol Biol Rep,2013,40(10):5987-5992.
21.	毛敏,杨勇,曾宪涛,等.牙周病与冠心病发病相关性:一项基于37个病例-对照研究的Meta分析.中国循证心血管医学杂志,2012,4(5):403-407.
22.	曾宪涛,田国祥,张超,等.Meta分析系列之十五:Meta分析的进展与思考.中国循证心血管医学杂志,2013,5(6):561-563.

1. Roberts JM,Cooper DW.Pathogenesis and genetics of pre-eclampsia.Lancet,2001,357(9249):53-56.
2. Ghulmiyyah L,Sibai B.Maternal mortality from preeclampsia/eclampsia.Semin Perinatol,2012,36(1):56-59.
3. Eiland E,Nzerue C,Faulkner M.Preeclampsia 2012.J Pregnancy,2012,2012:586578.
4. Odibo AO,Rada CC,Cahill AG,et al.First-trimester serum soluble fms-like tyrosine kinase-1,free vascular endothelial growth factor,placental growth factor and uterine artery Doppler in preeclampsia.J Perinatol,2013,33(9):670-674.
5. 曾宪涛,李胜,马钻,等.Meta分析系列之八:Meta分析的报告规范.中国循证心血管医学杂志,2012,4(6):500-503.
6. 曾宪涛,刘慧,陈曦,等.Meta分析系列之四:观察性研究的质量评价工具.中国循证心血管医学杂志,2012,4(4):297-299.
7. Stroup DF,Berlin JA,Morton SC,et al.Meta-analysis of observational studies in epidemiology:a proposal for reporting.Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group.JAMA,2000,283(15):2008-2012.
8. 曾宪涛,Joey S.W.Kwong,田国祥,等.Meta分析系列之二:Meta分析的软件.中国循证心血管医学杂志,2012,4(2):89-91.
9. Papazoglou D,Galazios G,Koukourakis MI,et al.Vascular endothelial growth factor gene polymorphisms and pre-eclampsia.Mol Hum Reprod,2004,10(5):321-324.
10. Shim J,Jun JK,Jung B,et al.Vascular endothelial growth factor gene+936 C/T polymorphism is associated with preeclampsia in Korean women.American Journal of Obstetrics and Gynecology,2007,197(3):271.
11. Kim YJ,Park BH,Park H,et al.No association of the genetic polymorphisms of endothelial nitric oxide synthase,dimethylarginine dimethylaminohydrolase,and vascular endothelial growth factor with preeclampsia in Korean populations.Twin Res Hum Genet,2008,11(1):77-83.
12. 黄余良,刘珏.VEGF基因多态性与子痫前期易感性的研究.中国妇幼保健,2009,24(19):2712-2714.
13. 陈宝丽,王燕云,李桂荣,等.血管内皮生长因子基因多态性与重度子痫前期易感性.中国妇幼保健,2011,26(32):5052-5055.
14. Cunha VM,Grecco RL,Paschoini MC,et al.[Genetic polymorphisms of vascular endothelial growth factor in pre-eclampsia].Rev Bras Ginecol Obstet,2011,33(7):158-163.
15. Andraweera PH,Dekker GA,Dissanayake VH,et al.Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri-Lanka.J Matern Fetal Neonatal Med,2013,26(5):532-536.
16. Chedraui P,Solis EJ,Bocci G,et al.Feto-placental nitric oxide,asymmetric dimethylarginine and vascular endothelial growth factor (VEGF) levels and VEGF gene polymorphisms in severe preeclampsia.J Matern Fetal Neonatal Med,2013,26(3):226-232.
17. 张竑卉,何云,张彩媚.血管内皮生长因子单核苷酸多态性与子痫前期易感性的相关研究.现代医学,2014,42(4),353-357.
18. Toi M,Matsumoto T,Bando H.Vascular endothelial growth factor:its prognostic,predictive,and therapeutic implications.Lancet Oncol,2001,2(11):667-673.
19. Ferrara N.Vascular endothelial growth factor:basic science and clinical progress.Endocr Rev,2004,25(4):581-611.
20. Leng WD,He MN,Chen QL,et al.Vascular endothelial growth factor (VEGF) gene polymorphisms and risk of head and neck cancer:a meta-analysis involving 2,444 individuals.Mol Biol Rep,2013,40(10):5987-5992.
21. 毛敏,杨勇,曾宪涛,等.牙周病与冠心病发病相关性:一项基于37个病例-对照研究的Meta分析.中国循证心血管医学杂志,2012,4(5):403-407.
22. 曾宪涛,田国祥,张超,等.Meta分析系列之十五:Meta分析的进展与思考.中国循证心血管医学杂志,2013,5(6):561-563.

Chinese Journal of Evidence-Based Medicine

Association between 936C/T Polymorphism in VEGF Gene and Preeclampsia Risk: A Meta-Analysis

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