• 1. Department of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;
  • 2. Clinical Laboratory, People's Hospital of Jiangsu Province, Nanjing 210029, China;
  • 3. Department of Kidney transplantation, 309 Hospital of PLA, Beijing 100000, China;
  • 4. Department of Urology, General Hospital of Nanjing Military Region, Nanjing 210000, China;
XUECheng, Email: chengxia1568@126.com
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Objective To systematically review the efficacy and safety of laparoscopic versus open nephrectomy in the treatment of autosomal dominant polycystic kidney disease (ADPKD). Methods We searched databases including MEDLINE, EMbase, The Cochrane Library (Issue 1, 2015), Web of Science, CBM and WanFang Data to collect relevant clinical studies comparing the efficacy and safety of laparoscopic versus open nephrectomy for ADPKD from inception to Jan, 2015. Two reviewers independently screened literature, extracted data and assessed the risk bias of included studies. Then, RevMan 5.4 software was used for meta-analysis. Results A total of six retrospective cohort studies involving 182 patients were included. The results of the meta-analysis showed that:compared with the open nephrectomy group, the average hospitalization time was shorter (MD=-4.38 days, 95%CI -5.93 to -2.83, P=0.000 01) and the blood transfusion risk was lower (OR=0.25, 95%CI 0.10 to 0.62, P=0.003) in the laparoscopic nephrectomy group. However, there was no significant difference between two groups in the incidence of overall complications (OR=0.51, 95%CI 0.24 to 1.06, P=0.07). Conclusion The application of laparoscopic nephrectomy for ADPKD can reduce the hospitalization time and blood transfusion risk when compared with the open nephrectomy, but the two operations have similar overall complication rate. Due to the limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion.

Citation: ZHOUChen-chen, YANGMing, WANGWu-tao, GUXiang-chen, YANGBo, YILu-jiang, LIUZhi-jia, FUDian, YUFei, XUECheng. Efficacy and Safety of Laparoscopic Nephrectomy versus Open Nephrectomy for Autosomal Dominant Polycystic Kidney Disease: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(8): 930-937. doi: 10.7507/1672-2531.20150156 Copy

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