Efficacy and Safety of <sup>125</sup>I Seed Interstitial Implantation for Lung Cancer: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 ZENGLin-miao ¹ , YUXiao-lian ² , YUTing-ting ³ , XIAOJian-hong ¹ , SONGBin ¹ ,  PENGJin-yun ¹

1. Mindong Hospital Affiliated to Fujian Medical University, Fu'an 355000, China;
2. Fujian Mindong Health School, Fu'an 355017, China;
3. Fujian Vocational College Of Bioengineering, Fuzhou 350002, China;

Corresponding author：

PENGJin-yun, Email: 569972281@qq.com

Keywords：

¹²⁵I radioactive seed; Implantation; Brachytherapy; Lung cancer; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.20150160

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To systematically evaluate the efficacy and safety of ¹²⁵I seed interstitial implantation for lung cancer. Methods We searched PubMed, The Wiley Online Library, Elsevier, CNKI, VIP and WanFang Data from inception to February 2014 to collect randomized controlled trials (RCTs) of ¹²⁵I seed interstitial implantation in the treatment of lung cancer. Two reviewers independently screened literature, extracted data and assessed the risk bias of included studies, and then meta-analysis was performed by using RevMan 5.1 software. Results A total of 23 RCTs involving 1 492 patients were included. The results of meta-analysis showed that:the effective rate (OR=3.43,95%CI 2.71,4.33,P<0.000 01), 1 year survival rate (OR=2.83, 95%CI 2.03 to 3.95, P<0.000 01) and 2 year survival rate (OR=2.49, 95%CI 1.60 to 3.88, P<0.000 01) in the ¹²⁵I seed interstitial implantation group were higher than those in the control group, but the rate of postoperative complications was higher than that of control group (OR=19.72, 95%CI 11.63 to 33.45, P<0.000 01). In addition, there were no significant differences between both groups in the 3 year survival rate (OR=2.45, 95%CI 0.21 to 28.89, P=0.48) and the adverse reaction rate (OR=0.74, 95%CI 0.52 to 1.05, P=0.09). Conclusion ¹²⁵I seed interstitial implantation is effective in the treatment of lung cancer. It can improve treatment efficiency and short-time survival rate, but may increase the rate of complications such as pneumothorax, seed malposition, bleeding and so on. Due to the limited quality and quantity of included studies, more high quality and larger sample studies are needed to verify the above conclusion.

Citation： ZENGLin-miao, YUXiao-lian, YUTing-ting, XIAOJian-hong, SONGBin, PENGJin-yun. Efficacy and Safety of ¹²⁵I Seed Interstitial Implantation for Lung Cancer: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(8): 957-966. doi: 10.7507/1672-2531.20150160 Copy

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2.	Ettinger DS, Akerley W, Borghaei H, et al. Non-small cell lung cancer. J Natl Compr Canc Netw, 2012, 10(10):1236-1271.
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4.	Ettinger DS, Akerley W, Borghaei H, et al. Non-small cell lung cancer, version 2.2013. J Natl Compr Canc Netw, 2013, 11(6):645-653.
5.	Solano-Reina S, De Granda-Orive Ji, Jiménez-Ruiz CA. Smoking cessation:an essential component in the treatment of lung cancer patients. Arch Bronconeumol, 2011, 47(9):477.
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7.	王忠敏, 黄钢, 陈克敏, 等. 放射性粒子组织间植入治疗技术指南的建议. 介入放射学杂志, 2009, 18(9):641-644.
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12.	郭国华. ¹²⁵I放射性粒子肺内插植联合吉西他滨+顺铂支气管动脉灌注化疗治疗中晚期非小细胞肺癌临床疗效观察. 中国现代医生, 2012, 50(32):152-153.
13.	郭志远, 崔建岭, 付吕平, 等. ¹²⁵I放射性粒子组织间植入联合化疗治疗非小细胞肺癌的研究. 河北医药, 2011, 33(8):1134-1137.
14.	贺克武, 高斌, 秦汉林, 等. ¹²⁵I粒子组织间植入联合支气管动脉灌注化疗治疗肺癌的疗效观察. 介入放射学杂志, 2012, 21(7):554-558.
15.	林锋, 冉鹏, 肖家荣, 等. 术中植入放射性¹²⁵I粒子治疗肺癌效果分析. 广东医学, 2010, 31(1):104-106.
16.	陆相杨, 王启飞. ¹²⁵I粒子姑息治疗ⅢB期非小细胞肺癌的近期疗效观察. 宁夏医科大学学报, 2011, 33(6):551-553.
17.	骆红蕾, 喻晓娟, 李进, 等. ¹²⁵I粒子植入联合化疗治疗同期放化疗后局部复发的Ⅲ期非小细胞肺癌. 中华核医学与分子影像杂志, 2013, 33(3):195-198.
18.	钟辉. CT引导下¹²⁵I粒子植入治疗肺癌的价值探讨. 健康必读(下旬刊), 2011, 5:129.
19.	时沛. ¹²⁵I粒子植入联合NP方案化疗治疗晚期非小细胞肺癌的临床研究. 中国误诊学杂志, 2010, 10(1):39-40.
20.	宋爱国, 刘增良, 杨秀贞, 等. 放射性¹²⁵I粒子植入治疗局部晚期肺癌的近期疗效. 河北医药, 2012, 34(6):844-845.
21.	晏欣珺, 郑长福, 严厚君, 等. ¹²⁵I粒子植入联合GP方案治疗局部晚期非小细胞肺癌33例疗效评价. 肿瘤学杂志, 2013, 19(5):408-410.
22.	杨树法, 樊喜文, 张国庆, 等. 放射性¹²⁵I粒子植入联合化疗治疗不可手术的局部晚期非小细胞肺癌的疗效和安全性. 中华肿瘤杂志, 2010, 32(8):626-629.
23.	赵书元. ¹²⁵I粒子植入联合支气管动脉灌注化疗治疗中晚期肺癌的临床研究. 中国医药指南, 2013, 11(25):87-88.
24.	郑琳, 郭晨阳, 黎海亮. 吉西他滨、顺铂双路径用药联合¹²⁵I粒子植入治疗Ⅲ期非小细胞肺癌的临床对照研究. 中华放射学杂志, 2011, 45(4):379-382.
25.	李俊升, 李建华, 王昕, 等. ¹²⁵I放射性粒子术中组织间植入治疗Ⅲa期非小细胞肺癌的近期临床研究. 内蒙古医学杂志, 2005, 37(4):303-304.
26.	杜学明, 许建辉, 郎建华, 等. ¹²⁵I粒子联合化疗治疗非小细胞肺癌. 肿瘤, 2007, 27(5):406-408.
27.	李玉亮, 王永正, 张福君, 等. CT引导下经皮穿刺植入¹²⁵I粒子治疗老年中心型肺癌近期疗效分析. 中华肿瘤防治杂志, 2007, 14(23):1818-1820.
28.	刘春香, 刘涛, 李德杰, 等. 经支气管动脉化疗药物灌注术联合¹²⁵I粒子植入治疗老年中心型肺癌近期疗效分析. 中华肿瘤防治杂志, 2007, 14(12):951-952.
29.	田立景, 田秀荣. ¹²⁵I粒子内放疗联合化疗治疗中晚期肺癌52例疗效分析. 中国肿瘤临床, 2008, 35(2):82-84.
30.	王馨, 吴炜新, 王卫星, 等. ¹²⁵I粒子肿瘤内植入联合吉西他滨治疗周围性非小细胞肺癌. 介入放射学杂志, 2008, 17(3):194-196.
31.	赵化云. 中医药联合¹²⁵I植入对老年中晚期非小细胞肺癌生存质量的临床观察. 河南中医学院, 2008.
32.	张青平, 赵志勇, 林武华, 等. CT导向下¹²⁵I粒子组织间植入治疗局部晚期非小细胞肺癌临床研究(附56例报告). 肿瘤预防与治疗, 2009, 22(4):392-394.
33.	胡永进, 杜学明, 吴春娃, 等. ¹²⁵I粒子植入联合化疗对小细胞肺癌生存期的影响. 武警后勤学院学报(医学版), 2013, 22(7):602-605.
34.	裘海燕, 许飞, 张伟, 等. ¹²⁵I粒子植入联合化疗治疗晚期非小细胞肺癌的近期疗效. 南昌大学学报(医学版), 2013, 53(2):78-80, 96.
35.	胡晓宇. 不可手术胰腺癌¹²⁵I植入治疗的系统评价. 新疆医科大学, 2010.
36.	Goldberg SN, Gazelle GS, Mueller PR. Thermal ablation therapy for focal malignancy:a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR Am J Roentgenol, 2000, 174(2):323-331.
37.	Lecchi M, Fossati P, Elisei F, et al. Current concepts on imaging in radiotherapy. Eur J Nucl Med Mol imaging, 2008, 35(4):821-837.
38.	罗开元. 实用组织间植入内放射治疗恶性肿瘤学. 北京:人民卫生出版社, 2008:39, 77.
39.	魏巍, 沈啸洪, 孙慧慧, 等. 放射性¹²⁵I粒子植入治疗非小细胞肺癌近期疗效的多因素分析. 中华内科杂志, 2012, 51(12):978-981.

1. Torres M, Carvalho A, Riera R. Non-invasive positive pressure ventilation for prevention of complications after pulmonary resection in lung cancer patients. Cochrane Database Syst Rev, DOI:10.1002/14651858.CD010355.
2. Ettinger DS, Akerley W, Borghaei H, et al. Non-small cell lung cancer. J Natl Compr Canc Netw, 2012, 10(10):1236-1271.
3. 过为, 李健华, 王峰, 等. 奈达铂联合化疗治疗晚期非小细胞肺癌疗效和安全性的Meta分析. 中国循证医学杂志, 2013, 13(1):47-54.
4. Ettinger DS, Akerley W, Borghaei H, et al. Non-small cell lung cancer, version 2.2013. J Natl Compr Canc Netw, 2013, 11(6):645-653.
5. Solano-Reina S, De Granda-Orive Ji, Jiménez-Ruiz CA. Smoking cessation:an essential component in the treatment of lung cancer patients. Arch Bronconeumol, 2011, 47(9):477.
6. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin, 2009, 59(4):225-249.
7. 王忠敏, 黄钢, 陈克敏, 等. 放射性粒子组织间植入治疗技术指南的建议. 介入放射学杂志, 2009, 18(9):641-644.
8. Martínez-Monge R, Pagola M, Vivas I, et al. CT-guided permanent brachytherapy for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC). Lung Cancer, 2008, 61(2):209-213.
9. 晏欣珺, 郑长福, 严厚君, 等. ¹²⁵I粒子植入联合GP方案治疗局部晚期非小细胞肺癌33例疗效评价. 肿瘤学杂志, 2013, 19(5):408-410.
10. Higgins J, Green S. Cochrane Handbook for Systematic Review of interventions Version 5.1.0[updated March 2011]. The Cochrane Collaboration, 2011. Available at:www.cochranehand-book.org.
11. 丛云峰. 放射性¹²⁵I粒子植入治疗中晚期肺癌恶性管腔狭窄32例临床效果探讨. 中外健康文摘, 2013, 10(5):102.
12. 郭国华. ¹²⁵I放射性粒子肺内插植联合吉西他滨+顺铂支气管动脉灌注化疗治疗中晚期非小细胞肺癌临床疗效观察. 中国现代医生, 2012, 50(32):152-153.
13. 郭志远, 崔建岭, 付吕平, 等. ¹²⁵I放射性粒子组织间植入联合化疗治疗非小细胞肺癌的研究. 河北医药, 2011, 33(8):1134-1137.
14. 贺克武, 高斌, 秦汉林, 等. ¹²⁵I粒子组织间植入联合支气管动脉灌注化疗治疗肺癌的疗效观察. 介入放射学杂志, 2012, 21(7):554-558.
15. 林锋, 冉鹏, 肖家荣, 等. 术中植入放射性¹²⁵I粒子治疗肺癌效果分析. 广东医学, 2010, 31(1):104-106.
16. 陆相杨, 王启飞. ¹²⁵I粒子姑息治疗ⅢB期非小细胞肺癌的近期疗效观察. 宁夏医科大学学报, 2011, 33(6):551-553.
17. 骆红蕾, 喻晓娟, 李进, 等. ¹²⁵I粒子植入联合化疗治疗同期放化疗后局部复发的Ⅲ期非小细胞肺癌. 中华核医学与分子影像杂志, 2013, 33(3):195-198.
18. 钟辉. CT引导下¹²⁵I粒子植入治疗肺癌的价值探讨. 健康必读(下旬刊), 2011, 5:129.
19. 时沛. ¹²⁵I粒子植入联合NP方案化疗治疗晚期非小细胞肺癌的临床研究. 中国误诊学杂志, 2010, 10(1):39-40.
20. 宋爱国, 刘增良, 杨秀贞, 等. 放射性¹²⁵I粒子植入治疗局部晚期肺癌的近期疗效. 河北医药, 2012, 34(6):844-845.
21. 晏欣珺, 郑长福, 严厚君, 等. ¹²⁵I粒子植入联合GP方案治疗局部晚期非小细胞肺癌33例疗效评价. 肿瘤学杂志, 2013, 19(5):408-410.
22. 杨树法, 樊喜文, 张国庆, 等. 放射性¹²⁵I粒子植入联合化疗治疗不可手术的局部晚期非小细胞肺癌的疗效和安全性. 中华肿瘤杂志, 2010, 32(8):626-629.
23. 赵书元. ¹²⁵I粒子植入联合支气管动脉灌注化疗治疗中晚期肺癌的临床研究. 中国医药指南, 2013, 11(25):87-88.
24. 郑琳, 郭晨阳, 黎海亮. 吉西他滨、顺铂双路径用药联合¹²⁵I粒子植入治疗Ⅲ期非小细胞肺癌的临床对照研究. 中华放射学杂志, 2011, 45(4):379-382.
25. 李俊升, 李建华, 王昕, 等. ¹²⁵I放射性粒子术中组织间植入治疗Ⅲa期非小细胞肺癌的近期临床研究. 内蒙古医学杂志, 2005, 37(4):303-304.
26. 杜学明, 许建辉, 郎建华, 等. ¹²⁵I粒子联合化疗治疗非小细胞肺癌. 肿瘤, 2007, 27(5):406-408.
27. 李玉亮, 王永正, 张福君, 等. CT引导下经皮穿刺植入¹²⁵I粒子治疗老年中心型肺癌近期疗效分析. 中华肿瘤防治杂志, 2007, 14(23):1818-1820.
28. 刘春香, 刘涛, 李德杰, 等. 经支气管动脉化疗药物灌注术联合¹²⁵I粒子植入治疗老年中心型肺癌近期疗效分析. 中华肿瘤防治杂志, 2007, 14(12):951-952.
29. 田立景, 田秀荣. ¹²⁵I粒子内放疗联合化疗治疗中晚期肺癌52例疗效分析. 中国肿瘤临床, 2008, 35(2):82-84.
30. 王馨, 吴炜新, 王卫星, 等. ¹²⁵I粒子肿瘤内植入联合吉西他滨治疗周围性非小细胞肺癌. 介入放射学杂志, 2008, 17(3):194-196.
31. 赵化云. 中医药联合¹²⁵I植入对老年中晚期非小细胞肺癌生存质量的临床观察. 河南中医学院, 2008.
32. 张青平, 赵志勇, 林武华, 等. CT导向下¹²⁵I粒子组织间植入治疗局部晚期非小细胞肺癌临床研究(附56例报告). 肿瘤预防与治疗, 2009, 22(4):392-394.
33. 胡永进, 杜学明, 吴春娃, 等. ¹²⁵I粒子植入联合化疗对小细胞肺癌生存期的影响. 武警后勤学院学报(医学版), 2013, 22(7):602-605.
34. 裘海燕, 许飞, 张伟, 等. ¹²⁵I粒子植入联合化疗治疗晚期非小细胞肺癌的近期疗效. 南昌大学学报(医学版), 2013, 53(2):78-80, 96.
35. 胡晓宇. 不可手术胰腺癌¹²⁵I植入治疗的系统评价. 新疆医科大学, 2010.
36. Goldberg SN, Gazelle GS, Mueller PR. Thermal ablation therapy for focal malignancy:a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR Am J Roentgenol, 2000, 174(2):323-331.
37. Lecchi M, Fossati P, Elisei F, et al. Current concepts on imaging in radiotherapy. Eur J Nucl Med Mol imaging, 2008, 35(4):821-837.
38. 罗开元. 实用组织间植入内放射治疗恶性肿瘤学. 北京:人民卫生出版社, 2008:39, 77.
39. 魏巍, 沈啸洪, 孙慧慧, 等. 放射性¹²⁵I粒子植入治疗非小细胞肺癌近期疗效的多因素分析. 中华内科杂志, 2012, 51(12):978-981.

Chinese Journal of Evidence-Based Medicine

Efficacy and Safety of ¹²⁵I Seed Interstitial Implantation for Lung Cancer: A Meta-analysis

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Chinese Journal of Evidence-Based Medicine

Efficacy and Safety of 125I Seed Interstitial Implantation for Lung Cancer: A Meta-analysis

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Efficacy and Safety of ¹²⁵I Seed Interstitial Implantation for Lung Cancer: A Meta-analysis