Association between Toll like receptor 2 Gene I/D Polymorphism and Cancer Risk: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 ZENGLing-jun , HELing , LILi , BIYu-ling , WANGLing

Department of Respiratory, First People Hospital of Ziyang City, Ziyang 641300, China;

Corresponding author：

Keywords：

Toll like receptor 2; Cancer; Polymorphism; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20150171

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically evaluate the association between Toll like receptor 2 (TLR2) gene I/D polymorphism and the risk of cancer. Methods We searched PubMed, EMbase, The Cochrane Library (Issue 7, 2015), CBM, CNKI, VIP and WanFang Data to collect case-control studies about the association between TLR2 gene I/D polymorphism and the risk of cancer from inception to July 2015. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was conducted using RevMan 5.3 software. Results A total of 11 case-control studies involving 3 250 cancer patients and 4 332 controls were included. The results of meta-analysis showed that significant association was found between TLR2 gene I/D polymorphism and the risk of cancer (DD+DI vs. Ⅱ:OR=1.60, 95%CI 1.13 to 2.27, P=0.009; DD vs. Ⅱ+DI:OR=1.73, 95%CI 1.13 to 2.66, P=0.01; DD vs. Ⅱ:OR=1.99, 95%CI 1.22 to 3.24, P=0.006; DI vs. Ⅱ:OR=1.52, 95%CI 1.09 to 2.11, P=0.01; D vs. I:OR=1.54, 95%CI 1.14 to 2.09, P=0.005). Conclusion TLR2 gene L/D polymorphism may be associated with cancer risk. Due to the limited quantity and quality of included studies, the conclusion should be verified in further studies.

Citation： ZENGLing-jun, HELing, LILi, BIYu-ling, WANGLing. Association between Toll like receptor 2 Gene I/D Polymorphism and Cancer Risk: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(9): 1024-1029. doi: 10.7507/1672-2531.20150171 Copy

1.	Kutikhin AG. Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk. Hum Immunol, 2011, 72(11):1095-1116.
2.	Etokebe GE, Knezevic J, Petricevic B, et al. Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in case-control study with breast cancer. Genet Test Mol Biomarkers, 2009, 13(6):729-734.
3.	Bodelon C, Madeleine MM, Johnson LG, et al. Genetic variation in the TLR and NF-kappaB pathways and cervical and vulvar cancer risk:a population-based case-control study. Int J Cancer, 2014, 134(2):437-444.
4.	Resler AJ, Malone KE, Johnson LG, et al. Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer:a case-control study. BMC Cancer, 2013, 13:219.
5.	Castro FA, Forsti A, Buch S, et al. TLR-3 polymorphism is an independent prognostic marker for stage Ⅱ colorectal cancer. Eur J Cancer, 2011, 47(8):1203-1210.
6.	Zeljic K, Supic G, Jovic N, et al. Association of TLR2, TLR3, TLR4 and CD14 genes polymorphisms with oral cancer risk and survival. Oral Dis, 2014, 20(4):416-424.
7.	Zeng HM, Pan KF, Zhang Y, et al. Genetic variants of toll-like receptor 2 and 5, helicobacter pylori infection, and risk of gastric cancer and its precursors in a chinese population. Cancer Epidemiol Biomarkers Prev, 2011, 20(12):2594-2602.
8.	Hishida A, Matsuo K, Goto Y, et al. No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese. Gastric Cancer, 2010, 13(4):251-257.
9.	Nischalke HD, Coenen M, Berger C, et al. The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C. Int J Cancer, 2012, 130(6):1470-1475.
10.	Proenca MA, de Oliveira JG, Cadamuro AC, et al. TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer. World J Gastroenterol, 2015, 21(25):7730-7741.
11.	de Oliveira JG, Rossi AF, Nizato DM, et al. Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer. Dig Dis Sci, 2013, 58(4):978-988.
12.	Mandal RK, George GP, Mittal RD. Association of Toll-like receptor (TLR) 2, 3 and 9 genes polymorphism with prostate cancer risk in North Indian population. Mol Biol Rep, 2012, 39(7):7263-7269.
13.	Pandey S, Mittal RD, Srivastava M, et al. Impact of Toll-like receptors[TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervical cancer susceptibility in North Indian women. Gynecol Oncol, 2009, 114(3):501-505.
14.	Castaño-Rodríguez N, Kaakoush NO, Pardo AL, et al. Genetic polymorphisms in the Toll-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer. Hum Immunol, 2014, 75(8):808-815.
15.	Devi KR, Chenkual S, Majumdar G, et al. TLR222 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene:a case-control study from four ethnic groups of North Eastern region of India. Tumour Biol, 2015.
16.	Singh V, Srivastava N, Kapoor R, et al. Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in a case-control study with bladder cancer susceptibility in a North Indian population. Arch Med Res, 2013, 44(1):54-61.
17.	Tahara T, Arisawa T, Wang F, et al. Toll-like receptor 2 -196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer. Cancer Sci, 2007, 98(11):1790-1794.
18.	Theodoropoulos GE, Saridakis V, Karantanos T, et al. Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development. Breast, 2012, 21(4):534-538.
19.	赵真真, 石源源, 刘颂, 等. Toll样受体基因多态性与EBV感染相关胃癌的易感性. 癌变·畸变·突变, 2014, 26(3):171-174, 179.

1. Kutikhin AG. Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk. Hum Immunol, 2011, 72(11):1095-1116.
2. Etokebe GE, Knezevic J, Petricevic B, et al. Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in case-control study with breast cancer. Genet Test Mol Biomarkers, 2009, 13(6):729-734.
3. Bodelon C, Madeleine MM, Johnson LG, et al. Genetic variation in the TLR and NF-kappaB pathways and cervical and vulvar cancer risk:a population-based case-control study. Int J Cancer, 2014, 134(2):437-444.
4. Resler AJ, Malone KE, Johnson LG, et al. Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer:a case-control study. BMC Cancer, 2013, 13:219.
5. Castro FA, Forsti A, Buch S, et al. TLR-3 polymorphism is an independent prognostic marker for stage Ⅱ colorectal cancer. Eur J Cancer, 2011, 47(8):1203-1210.
6. Zeljic K, Supic G, Jovic N, et al. Association of TLR2, TLR3, TLR4 and CD14 genes polymorphisms with oral cancer risk and survival. Oral Dis, 2014, 20(4):416-424.
7. Zeng HM, Pan KF, Zhang Y, et al. Genetic variants of toll-like receptor 2 and 5, helicobacter pylori infection, and risk of gastric cancer and its precursors in a chinese population. Cancer Epidemiol Biomarkers Prev, 2011, 20(12):2594-2602.
8. Hishida A, Matsuo K, Goto Y, et al. No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese. Gastric Cancer, 2010, 13(4):251-257.
9. Nischalke HD, Coenen M, Berger C, et al. The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C. Int J Cancer, 2012, 130(6):1470-1475.
10. Proenca MA, de Oliveira JG, Cadamuro AC, et al. TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer. World J Gastroenterol, 2015, 21(25):7730-7741.
11. de Oliveira JG, Rossi AF, Nizato DM, et al. Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer. Dig Dis Sci, 2013, 58(4):978-988.
12. Mandal RK, George GP, Mittal RD. Association of Toll-like receptor (TLR) 2, 3 and 9 genes polymorphism with prostate cancer risk in North Indian population. Mol Biol Rep, 2012, 39(7):7263-7269.
13. Pandey S, Mittal RD, Srivastava M, et al. Impact of Toll-like receptors[TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervical cancer susceptibility in North Indian women. Gynecol Oncol, 2009, 114(3):501-505.
14. Castaño-Rodríguez N, Kaakoush NO, Pardo AL, et al. Genetic polymorphisms in the Toll-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer. Hum Immunol, 2014, 75(8):808-815.
15. Devi KR, Chenkual S, Majumdar G, et al. TLR222 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene:a case-control study from four ethnic groups of North Eastern region of India. Tumour Biol, 2015.
16. Singh V, Srivastava N, Kapoor R, et al. Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in a case-control study with bladder cancer susceptibility in a North Indian population. Arch Med Res, 2013, 44(1):54-61.
17. Tahara T, Arisawa T, Wang F, et al. Toll-like receptor 2 -196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer. Cancer Sci, 2007, 98(11):1790-1794.
18. Theodoropoulos GE, Saridakis V, Karantanos T, et al. Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development. Breast, 2012, 21(4):534-538.
19. 赵真真, 石源源, 刘颂, 等. Toll样受体基因多态性与EBV感染相关胃癌的易感性. 癌变·畸变·突变, 2014, 26(3):171-174, 179.

Previous Article
Pharmacoeconomic Evaluation of Radiofrequency Ablation versus Amiodarone for Atrial Fibrillation
Next Article
Correlation between Cadmium and Alzheimer's Disease:A Meta-analysis

Chinese Journal of Evidence-Based Medicine

Association between Toll like receptor 2 Gene I/D Polymorphism and Cancer Risk: A Meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content