Correlation of CK19 Expression and Clinical Significance in Oral Squamous Cell Carcinoma: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHANGJian ¹ ,  HUANXiao-feng ¹ , ZHANGPing ² , GUOLi-chuan ³

1. Department of Stomatology, Wuxi No.;
2. Hospital, Nanjing Medical University, Wuxi 214102, China;
3. School of Biotechnology, Jiangnan University, Wuxi 214122, China;
1. Jiangsu Qitian Gene Bio-Sci & Tech Co Ltd., Wuxi 214135, China;

Corresponding author：

HUANXiao-feng, Email: zorain@126.com

Keywords：

Oral squamous cell carcinoma; CK19; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20150190

Video：

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Objective To systematically review the correlation between the expression of cytokeratin 19 (CK19) and oral squamous cell carcinoma (OSCC). Methods PubMed, EMbase, CJFD, CBM, CNKI, VIP, WanFang Data and The Cochrane Library (Issue 1, 2015) were electronically searched from inception to January 1st 2015 to collect case-control studies about the correlation between CK19 expression and clinical pathogenic features in OSCC. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 11 studies were included, involving 612 OSCC cases and 564 normal controls. The results of meta-analysis showed that:The expression levels of CK19 were significantly different between the OSCC group and the control group, between OSCC groups with and without lymph node metastasis, between the high differentiation group and the middle/poor differentiation group, and between the clinical stage I group and the clinical stages Ⅱ to Ⅲ group (all P values≤0.05). However, there were no significant differences in expression levels of CK19 between the male OSCC group and the female OSCC group, and between the carcinoma size T₁/T₂ group and the T₃/T₄ group (all P values >0.05). Conclusion Current evidence shows that, CK19 expression may be associated with the occurrence, development and transfer of OSCC, and may be positively corrected with tumor malignance. It may be an indicator of poor prognosis and can be considered as a molecular marker of OSCC.

Citation： ZHANGJian, HUANXiao-feng, ZHANGPing, GUOLi-chuan. Correlation of CK19 Expression and Clinical Significance in Oral Squamous Cell Carcinoma: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(10): 1142-1147. doi: 10.7507/1672-2531.20150190 Copy

1.	Sano D, Myers JN. Metastasis of squamous cell carcinoma of the oral tongue. Cancer Metastasis Rev, 2007, 26 (3-4):645-662.
2.	Moll R, Franke WW, Schiller DL, et al. The catalog of human ctokeratins:patterns of expression in normal epithelia, tumors and cultured cells. Cell, 1982, 31(1):11-24.
3.	Crowe DL, Milo GE, Schuler CF. Keratin 19 downregulation by oral squamous cell carcinoma lines increases invasive potential. J Dent Res, 1999, 78(6):1256-1263.
4.	Wells GA, Shea B, O'connell D, et al. The Newcasde-0ttawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 3rd Syrnposium on Systematic Reviews:Beyond the Basics, 2000.
5.	储德强, 颜雨春. CK17和CK19在口腔鳞状细胞癌组织中的表达及意义. 安徽医科大学学报, 2011, 46(7):675-677.
6.	钟来平, 张志愿, 胡永杰, 等. 口腔鳞癌组织CK19蛋白质与mRNA水平的关系及其临床意义. 中国口腔颌面外科杂志, 2007, 5(3):170-175.
7.	彭为, 黎春晖, 聂敏海, 等. 细胞角蛋白19和抑癌基因PTEN在口腔鳞癌中的表达研究. 泸州医学院学报, 2012, 35(1):14-17.
8.	和晓坡, 尚德志, 魏玉云, 等. 细胞角蛋白CK13和CK19在口腔鳞癌中的表达及意义. 社区医学杂志, 2006, 4(7):4-7.
9.	聂敏海, 钟利, 曾光明, 等. 细胞角蛋白CK19在口腔黏膜癌变过程中的变化. 中华口腔医学杂志, 2002, 37(3):187-189.
10.	张齐梅, 聂敏海. OSCC患者病变组织和血清中CK19的表达研究. 泸州医学院学报, 2010, 33(3):238-241.
11.	Xu XC, Lee JS, Lippman SM, et al. Increased expression of cytokeratins CK8 and CK19 is associated with head and neck carcinogenesis. Cancer Epidemiol Biomarkers Prev, 1995, 4(8):871-876.
12.	Babiker AY, Rahmani AH, Abdalaziz MS, et al. Expressional analysis of p16 and cytokeratin19 protein in the genesis of oral squamous cell carcinoma patients. Int J Clin Exp Med, 2014, 7(6):1524-1530.
13.	Fillies T, Jogschies M, Kleinheinz J, et al. Cytokeratin alteration in oral leukoplakiaand oral squamous cell carcinoma. Oncol Rep, 2007, 18(3):639-643.
14.	Coltrera MD, Zarbo RJ, Sakr WA, et al. Suprabasal Expression of PCNA, p53, and CK19 in Alcohol-fixed, Embedded Tissue. AJP October, 1992, 141(4):817-824.
15.	Vora H, Shah N, Patel D, et al. Prognostic Significance of Biomarkers in Squamous Cell Carcinoma of the Tongue:Multivariate Analysis. J Surg Oncol, 2003, 82(1):34-50.
16.	Lindberg K, Rheinwald JG. Suprabasal 40 kd keratin (K19) expression as an immunohistologic marker of premalignancy in oral epithelium. Am J Pathol, 1989, 134(1):89-98.
17.	Ogden GR. Evidence for field change in oral cancel based on cytokeratin expression. Br J Cancer, 1993, 67(6):1324-1330.
18.	Morgan PK. Intermediate filaments in oral neoplasia. I. Oral cancer and epithelial dysphsia. Eur J Cancer B Oral Oncol, 1994, 30B(3):160-166.
19.	Copper MP, Braakhuis BJ, Vries Nd, et al. A panel of biomarkers of carcinogenesis of the upper aerodigestive tract as potential intermediate endpoints in chemoprevention trails. Cancer, 1993, 71(3):825-830.
20.	Ram PVV, Nirmala NR, Kotian MS, et al. Immunohistochemical evaluation of expression of cytokeratin 19 in different histological grades of leukoplakia and oral squamous cell carcinoma. India J Dent Res, 2005, 16(1):6-11.
21.	Hamakawa H, Bao Y, Takarada M, et al. Cytokeratin expression in squamous cell carcinoma of the lung and oral cavity:an immunohistochemical study with possible clinical relevance. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1998, 85(4):438-443.

1. Sano D, Myers JN. Metastasis of squamous cell carcinoma of the oral tongue. Cancer Metastasis Rev, 2007, 26 (3-4):645-662.
2. Moll R, Franke WW, Schiller DL, et al. The catalog of human ctokeratins:patterns of expression in normal epithelia, tumors and cultured cells. Cell, 1982, 31(1):11-24.
3. Crowe DL, Milo GE, Schuler CF. Keratin 19 downregulation by oral squamous cell carcinoma lines increases invasive potential. J Dent Res, 1999, 78(6):1256-1263.
4. Wells GA, Shea B, O'connell D, et al. The Newcasde-0ttawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 3rd Syrnposium on Systematic Reviews:Beyond the Basics, 2000.
5. 储德强, 颜雨春. CK17和CK19在口腔鳞状细胞癌组织中的表达及意义. 安徽医科大学学报, 2011, 46(7):675-677.
6. 钟来平, 张志愿, 胡永杰, 等. 口腔鳞癌组织CK19蛋白质与mRNA水平的关系及其临床意义. 中国口腔颌面外科杂志, 2007, 5(3):170-175.
7. 彭为, 黎春晖, 聂敏海, 等. 细胞角蛋白19和抑癌基因PTEN在口腔鳞癌中的表达研究. 泸州医学院学报, 2012, 35(1):14-17.
8. 和晓坡, 尚德志, 魏玉云, 等. 细胞角蛋白CK13和CK19在口腔鳞癌中的表达及意义. 社区医学杂志, 2006, 4(7):4-7.
9. 聂敏海, 钟利, 曾光明, 等. 细胞角蛋白CK19在口腔黏膜癌变过程中的变化. 中华口腔医学杂志, 2002, 37(3):187-189.
10. 张齐梅, 聂敏海. OSCC患者病变组织和血清中CK19的表达研究. 泸州医学院学报, 2010, 33(3):238-241.
11. Xu XC, Lee JS, Lippman SM, et al. Increased expression of cytokeratins CK8 and CK19 is associated with head and neck carcinogenesis. Cancer Epidemiol Biomarkers Prev, 1995, 4(8):871-876.
12. Babiker AY, Rahmani AH, Abdalaziz MS, et al. Expressional analysis of p16 and cytokeratin19 protein in the genesis of oral squamous cell carcinoma patients. Int J Clin Exp Med, 2014, 7(6):1524-1530.
13. Fillies T, Jogschies M, Kleinheinz J, et al. Cytokeratin alteration in oral leukoplakiaand oral squamous cell carcinoma. Oncol Rep, 2007, 18(3):639-643.
14. Coltrera MD, Zarbo RJ, Sakr WA, et al. Suprabasal Expression of PCNA, p53, and CK19 in Alcohol-fixed, Embedded Tissue. AJP October, 1992, 141(4):817-824.
15. Vora H, Shah N, Patel D, et al. Prognostic Significance of Biomarkers in Squamous Cell Carcinoma of the Tongue:Multivariate Analysis. J Surg Oncol, 2003, 82(1):34-50.
16. Lindberg K, Rheinwald JG. Suprabasal 40 kd keratin (K19) expression as an immunohistologic marker of premalignancy in oral epithelium. Am J Pathol, 1989, 134(1):89-98.
17. Ogden GR. Evidence for field change in oral cancel based on cytokeratin expression. Br J Cancer, 1993, 67(6):1324-1330.
18. Morgan PK. Intermediate filaments in oral neoplasia. I. Oral cancer and epithelial dysphsia. Eur J Cancer B Oral Oncol, 1994, 30B(3):160-166.
19. Copper MP, Braakhuis BJ, Vries Nd, et al. A panel of biomarkers of carcinogenesis of the upper aerodigestive tract as potential intermediate endpoints in chemoprevention trails. Cancer, 1993, 71(3):825-830.
20. Ram PVV, Nirmala NR, Kotian MS, et al. Immunohistochemical evaluation of expression of cytokeratin 19 in different histological grades of leukoplakia and oral squamous cell carcinoma. India J Dent Res, 2005, 16(1):6-11.
21. Hamakawa H, Bao Y, Takarada M, et al. Cytokeratin expression in squamous cell carcinoma of the lung and oral cavity:an immunohistochemical study with possible clinical relevance. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1998, 85(4):438-443.

Chinese Journal of Evidence-Based Medicine

Correlation of CK19 Expression and Clinical Significance in Oral Squamous Cell Carcinoma: A Meta-analysis

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