Aminophylline combined with Traditional Chinese Medicine for Asthma: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LISi-yu ¹ , LIRui ¹ , TIANWei-lan ¹ , SHANGHong-cai ² ,  ZHAIHua-qiang ¹

1. Institute of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China;
2. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;

Corresponding author：

ZHAIHua-qiang, Email: zhaihq@bucm.edu.cn

Keywords：

Bronchial asthma; Aminophylline; Traditional Chinese medicine; Systematic review; Meta-analysis; Randomized Controlled Trial

DOI：

10.7507/1672-2531.20150217

Video：

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Objective To systematically review the effects of aminophylline combined with traditional Chinese medicine (TCM) in the treatment of asthma. Methods Databases including The Cochrane Library(Issue 1, 2015), PubMed, EMbase, CNKI, VIP and WanFang Data databases were electronically searched from January 2005 to December 2014 to collect randomized controlled trials (RCTs) about the treatment of bronchial asthma combining aminophylline with TCM. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 10 RCTs involving 820 participants were included. The results of meta-analysis showed that: The total clinical effective rate in the aminophylline plus TCM group was higher than that of the aminophylline alone group (RR=1.22, 95%CI 1.11 to 1.33). The FEV1 in the aminophylline plus TCM group was also higher than that of the aminophylline alone group (MD=0.53, 95%CI 0.33 to 0.73). Conclusion Current evidence shows, the total clinical effective rate of aminophylline combined with TCM for asthma is better than that of aminophylline alone, and its mechanism may be related to the improvement of FEV1. Due to the limited quantity and quality of included studies, the above conclusion needs to be further verified by more high quality studies.

Citation： LISi-yu, LIRui, TIANWei-lan, SHANGHong-cai, ZHAIHua-qiang. Aminophylline combined with Traditional Chinese Medicine for Asthma: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(11): 1322-1326. doi: 10.7507/1672-2531.20150217 Copy

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6.	唐上英. 中西医结合治疗小儿支气管哮喘的疗效研究. 中华实用医药, 2008, 3(35):55-56.
7.	黄家聪. 加用小青龙汤合阳和汤治疗寒性支气管哮喘疗效观察. 广西中医药, 2012, 35(6):30-31.
8.	黄杜宁. 中西医结合治疗支气管哮喘疗效观察. 实用中医药杂志, 2014, 30(4):285-286.
9.	黄和祥. 中西医结合治疗40例支气管哮喘临床疗效观察. 现代诊断与治疗, 2014, 25(8):1735.
10.	沙向红, 朱慧平, 陈怀. 平喘汤配合西药对儿童支气管哮喘急性发作期的临床对照观察. 北京中医药, 2008, 27(2):102-103.
11.	林涛, 邓治平, 杨莹. 中西医结合治疗支气管哮喘急性发作的临床分析. 中国医药指南, 2013, 11(19):671-672.
12.	曹洪波. 中西医结合治疗支气管哮喘临床研究. 河南中医, 2014, 34(3):502-503.
13.	李思深, 邓智武. 中西医结合治疗支气管哮喘70例临床观察. 中医药导报, 2014, 20(6):54-55.
14.	李学明, 陆炜青, 王克俭. 平喘补肾祛瘀煎方配合氨茶碱治疗支气管哮喘临床观察. 内蒙古中医药, 2014, 33(28):61.

1. Masoli M, Fabian D, Holt S, et al. The global burden of asthma: executive summary of GINA Dissemination Committee report. Allergy, 59(5):469-478.
2. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2014:36.
3. 中华医学会呼吸病分会哮喘学组. 支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案). 中华哮喘杂志, 2008, 2(1): 3-13.
4. 钟文昭, 吴一龙, 谷力加. Review Manager (RevMan)--临床医生通向Meta分析的桥梁. 循证医学, 2013, 3(4):234-246.
5. 周棉勇. 中西医结合治疗哮喘疗效分析. 药物与人, 2014, 4(27): 239-240. 图3氨茶碱联合中药组与单用氨茶碱组FEV1比较的Meta分析.
6. 唐上英. 中西医结合治疗小儿支气管哮喘的疗效研究. 中华实用医药, 2008, 3(35):55-56.
7. 黄家聪. 加用小青龙汤合阳和汤治疗寒性支气管哮喘疗效观察. 广西中医药, 2012, 35(6):30-31.
8. 黄杜宁. 中西医结合治疗支气管哮喘疗效观察. 实用中医药杂志, 2014, 30(4):285-286.
9. 黄和祥. 中西医结合治疗40例支气管哮喘临床疗效观察. 现代诊断与治疗, 2014, 25(8):1735.
10. 沙向红, 朱慧平, 陈怀. 平喘汤配合西药对儿童支气管哮喘急性发作期的临床对照观察. 北京中医药, 2008, 27(2):102-103.
11. 林涛, 邓治平, 杨莹. 中西医结合治疗支气管哮喘急性发作的临床分析. 中国医药指南, 2013, 11(19):671-672.
12. 曹洪波. 中西医结合治疗支气管哮喘临床研究. 河南中医, 2014, 34(3):502-503.
13. 李思深, 邓智武. 中西医结合治疗支气管哮喘70例临床观察. 中医药导报, 2014, 20(6):54-55.
14. 李学明, 陆炜青, 王克俭. 平喘补肾祛瘀煎方配合氨茶碱治疗支气管哮喘临床观察. 内蒙古中医药, 2014, 33(28):61.

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Chinese Journal of Evidence-Based Medicine

Aminophylline combined with Traditional Chinese Medicine for Asthma: A Meta-analysis

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