Association between -634G/C Polymorphism in the IL-6 Gene and the Risk of Lung Cancer: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LIGuang-qing ¹ ,  WUZhao-ping ¹ ,  LIXiao-bo ¹ , QIZhan-zhong ¹ , LIShuo ² , LIANGYing-jun ¹ , WUMing-ya ¹ , ZHANGQiong ¹ , YUANJiao ¹ , XIAZhi-qiang ³ , LIDong ¹ , CHENQiu-ling ¹ , WANGXin-ping ¹ , BAIHong-guang ¹

1. Department of Respiratory, the 452nd Military Hospital, Chengdu 610021, China;
2. Department of Nutrition, the 452nd Military Hospital, Chengdu 610021, China;
3. Medical Department, the 452nd Military Hospital, Chengdu 610021, China;

Corresponding author：

WUZhao-ping, Email: wuzhaokjYY@163.com; LIXiao-bo, Email: 739409535@qq.com

Keywords：

Lung cancer; Polymorphism; IL-6; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20150225

Video：

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Objective To systematically review the association between the IL-6 gene -634G/C polymorphism and the risk of lung cancer. Methods Databases including the PubMed, EMbase, CNKI and WanFang Data were searched from inception to October 2015 to collect case-control studies about the correlation between the IL-6 gene -634G/C polymorphism and the risk of lung cancer. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software. Results A total of 12 case-control studies concerning 3 657 lung cancer cases and 4 100 controls from 11 articles were included. The results of meta-analysis showed that there was no significant association between the -634G/C polymorphism and the risk of lung cancer (GG+GC vs. CC: OR=1.11, 95%CI 0.89 to 1.39, P=0.37; GG vs. CC+GC: OR=1.17, 95%CI 0.88 to 1.55, P=0.27; GG vs. CC: OR=1.27, 95%CI 0.93 to 1.72, P=0.13; GC vs. CC: OR=1.12, 95%CI 0.89 to 1.40, P=0.33; G vs. C: OR=1.08, 95%CI 0.89 to 1.30, P=0.43). Conclusion IL-6 gene -634G/C polymorphism may not be a risk factor of lung cancer. Due to the limited quality and quantity of included studies, more high quality studies are needed to verify the above conclusion.

Citation： LIGuang-qing, WUZhao-ping, LIXiao-bo, QIZhan-zhong, LIShuo, LIANGYing-jun, WUMing-ya, ZHANGQiong, YUANJiao, XIAZhi-qiang, LIDong, CHENQiu-ling, WANGXin-ping, BAIHong-guang. Association between -634G/C Polymorphism in the IL-6 Gene and the Risk of Lung Cancer: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(12): 1372-1377. doi: 10.7507/1672-2531.20150225 Copy

1.	Chen J, Liu RY, Yang L, et al. A two-SNP IL-6 promoter haplotype is associated with increased lung cancer risk. J Cancer Res Cli Oncol, 2013, 139(2):231-242.
2.	Kiyohara C, Horiuchi T, Takayama K, et al. Genetic polymorphisms involved in the inflammatory response and lung cancer risk:a casecontrol study in Japan. Cytokine, 2014, 65(1):88-94.
3.	Mostaid MS, Ahmed MU, Islam MS, et al. Lung cancer risk in relation to TP53 codon 47 and codon 72 polymorphism in Bangladeshi population. Tumour Biology, 2014, 35(10):10309-10317. 图 5 IL-6 基因-634G/C 多态性与肺癌相关性的 Meta 分析:GC vs. CC 图 6 IL-6 基因-634G/C 多态性与肺癌相关性的 Meta 分析:G vs. C.
4.	Piao JM, Shin MH, Kim HN, et al. Glutathione-S-transferase (GSTM1, GSTT1) null phenotypes and risk of lung cancer in a Korean population. Asian Pac J Cancer Prev, 2013, 14(12):7165-7169.
5.	Kim HC, Song JS, Lee JC, et al. Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limitedstage small cell lung cancer. Int J Clin Exp Pathol, 2014, 7(10):6743-6751.
6.	Tsuchiya T, Arai J, Matsumoto K, et al. Prognostic Impact of the ABCC11/MRP8 Polymorphism in Adjuvant Oral Chemotherapy with S-1 for Non-Small Cell Lung Cancer. Chemotherapy, 2015, 61(2):77-86.
7.	Lee SY, Choi JE, Jeon HS, et al. A Panel of Genetic Polymorphism for the Prediction of Prognosis in Patients with Early Stage NonSmall Cell Lung Cancer after Surgical Resection. PloS One, 2015, 10(10):e0140216.
8.	Xu X, Hua H, Fan B, et al. EPHX1 rs2234922 polymorphism and lung cancer susceptibility in Asian populations:a meta-analysis. J Thorac Dis, 2015, 7(7):1125-1129.
9.	von Elm E, Moher D, Little J, et al. Reporting genetic association studies:the STREGA statement. Lancet, 2009, 374(9684):98-100.
10.	Bai L, Yu H, Wang H, et al. Genetic single-nucleotide polymorphisms of inflammation-related factors associated with risk of lung cancer. Med Oncol, 2013, 30(1):414.
11.	Bhat IA, Qasim I, Masoodi KZ, et al. Significant impact of IL-6-174G/C but inverse relation with -634 C/G polymorphism in patients with non-small cell lung cancer in Kashmiri population. Immunol Invest, 2015, 44(4):349-360.
12.	Liang J, Liu X, Bi Z, et al. Relationship between gene polymorphisms of two cytokine genes (TNF-alpha and IL-6) and occurring of lung cancers in the ethnic group Han of China. Mol Biol Rep, 2013, 40(2): 1541-1546.
13.	Lim WY, Chen Y, Ali SM, et al. Polymorphisms in inflammatory pathway genes, host factors and lung cancer risk in Chinese female never-smokers. Carcinogenesis, 2011, 32(4):522-529.
14.	Seow A, Ng DP, Choo S, et al. Joint effect of asthma/atopy and an IL-6 gene polymorphism on lung cancer risk among lifetime nonsmoking Chinese women. Carcinogenesis, 2006, 27(6):1240-1244.
15.	Zhang YM, Mao YM, Sun YX. Genetic polymorphisms of IL-6 and IL-10 genes correlate with lung cancer in never-smoking Han population in China. Int J Clin Exp Med, 2015, 8(1):1051-1058.
16.	李君蕊, 肖颖, 付盈菊, 等. 血清白细胞介素6和白细胞介素8水平及其基因多态性与非小细胞肺癌的关系. 中国综合临床, 2015, 31(7):581-584.
17.	刘晓琳, 李岩, 梁婧, 等. 白细胞介素-6基因多态性与肺癌易感关联性的研究. 中国肿瘤临床, 2007, 34(10):562-565.
18.	宿濛, 周宝森. IL-6和IL-1β单核苷酸多态性与非吸烟女性肺癌易感性的关系. 中国肺癌杂志, 2014, 17(8):612-617.

1. Chen J, Liu RY, Yang L, et al. A two-SNP IL-6 promoter haplotype is associated with increased lung cancer risk. J Cancer Res Cli Oncol, 2013, 139(2):231-242.
2. Kiyohara C, Horiuchi T, Takayama K, et al. Genetic polymorphisms involved in the inflammatory response and lung cancer risk:a casecontrol study in Japan. Cytokine, 2014, 65(1):88-94.
3. Mostaid MS, Ahmed MU, Islam MS, et al. Lung cancer risk in relation to TP53 codon 47 and codon 72 polymorphism in Bangladeshi population. Tumour Biology, 2014, 35(10):10309-10317. 图 5 IL-6 基因-634G/C 多态性与肺癌相关性的 Meta 分析:GC vs. CC 图 6 IL-6 基因-634G/C 多态性与肺癌相关性的 Meta 分析:G vs. C.
4. Piao JM, Shin MH, Kim HN, et al. Glutathione-S-transferase (GSTM1, GSTT1) null phenotypes and risk of lung cancer in a Korean population. Asian Pac J Cancer Prev, 2013, 14(12):7165-7169.
5. Kim HC, Song JS, Lee JC, et al. Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limitedstage small cell lung cancer. Int J Clin Exp Pathol, 2014, 7(10):6743-6751.
6. Tsuchiya T, Arai J, Matsumoto K, et al. Prognostic Impact of the ABCC11/MRP8 Polymorphism in Adjuvant Oral Chemotherapy with S-1 for Non-Small Cell Lung Cancer. Chemotherapy, 2015, 61(2):77-86.
7. Lee SY, Choi JE, Jeon HS, et al. A Panel of Genetic Polymorphism for the Prediction of Prognosis in Patients with Early Stage NonSmall Cell Lung Cancer after Surgical Resection. PloS One, 2015, 10(10):e0140216.
8. Xu X, Hua H, Fan B, et al. EPHX1 rs2234922 polymorphism and lung cancer susceptibility in Asian populations:a meta-analysis. J Thorac Dis, 2015, 7(7):1125-1129.
9. von Elm E, Moher D, Little J, et al. Reporting genetic association studies:the STREGA statement. Lancet, 2009, 374(9684):98-100.
10. Bai L, Yu H, Wang H, et al. Genetic single-nucleotide polymorphisms of inflammation-related factors associated with risk of lung cancer. Med Oncol, 2013, 30(1):414.
11. Bhat IA, Qasim I, Masoodi KZ, et al. Significant impact of IL-6-174G/C but inverse relation with -634 C/G polymorphism in patients with non-small cell lung cancer in Kashmiri population. Immunol Invest, 2015, 44(4):349-360.
12. Liang J, Liu X, Bi Z, et al. Relationship between gene polymorphisms of two cytokine genes (TNF-alpha and IL-6) and occurring of lung cancers in the ethnic group Han of China. Mol Biol Rep, 2013, 40(2): 1541-1546.
13. Lim WY, Chen Y, Ali SM, et al. Polymorphisms in inflammatory pathway genes, host factors and lung cancer risk in Chinese female never-smokers. Carcinogenesis, 2011, 32(4):522-529.
14. Seow A, Ng DP, Choo S, et al. Joint effect of asthma/atopy and an IL-6 gene polymorphism on lung cancer risk among lifetime nonsmoking Chinese women. Carcinogenesis, 2006, 27(6):1240-1244.
15. Zhang YM, Mao YM, Sun YX. Genetic polymorphisms of IL-6 and IL-10 genes correlate with lung cancer in never-smoking Han population in China. Int J Clin Exp Med, 2015, 8(1):1051-1058.
16. 李君蕊, 肖颖, 付盈菊, 等. 血清白细胞介素6和白细胞介素8水平及其基因多态性与非小细胞肺癌的关系. 中国综合临床, 2015, 31(7):581-584.
17. 刘晓琳, 李岩, 梁婧, 等. 白细胞介素-6基因多态性与肺癌易感关联性的研究. 中国肿瘤临床, 2007, 34(10):562-565.
18. 宿濛, 周宝森. IL-6和IL-1β单核苷酸多态性与非吸烟女性肺癌易感性的关系. 中国肺癌杂志, 2014, 17(8):612-617.

Chinese Journal of Evidence-Based Medicine

Association between -634G/C Polymorphism in the IL-6 Gene and the Risk of Lung Cancer: A Meta-analysis

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