A Brief Introduction of Recursive Cumulative Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 ZENGZi ¹ ^# ,  TIANXu ¹ ^# , SHUAITing ¹ , YILi-juan ¹ , WANGYan ² ,  SONGGuo-min ³

1. Graduate College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
2. School of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
3. Department of Nursing, Tianjin Hospital, Tianjin 300211, China;

Corresponding author：

SONGGuo-min, Email: songguomin134@163.com

Keywords：

Recursive cumulative meta-analysis; Meta-analysis of individual patient data; Meta-analysis of the published literature; Methodology

DOI：

10.7507/1672-2531.20150240

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Meta-analyses include meta-analysis of the published literature (MPL) and meta-analysis of individual patient data (MIPD). Recursive cumulative meta-analysis is a method used to reorganize the secondary analysis data based on original studies thus to ensure a timely update, in addition, it can also be used to analyze the data from longer followup of existing trials. By using this method, with the each newly included or updated study, the change of pooled effect size in each pooled step can be detected, therefore, the bias/heterogeneity and stability of pooled results can be evaluated. In this article, we briefly introduced the concept of recursive cumulative meta-analysis and an example was used to illustrate this method.

Citation： ZENGZi, TIANXu, SHUAITing, YILi-juan, WANGYan, SONGGuo-min. A Brief Introduction of Recursive Cumulative Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(12): 1475-1478. doi: 10.7507/1672-2531.20150240 Copy

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3.	Dickersin K. The existence of publication bias and risk factors for its occurrence. JAMA, 1990, 263(10):1385-1389.
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5.	Stewart LA, Clarke MJ. Practical methodology of meta-analyses (overviews) using updated individual patient data. Stat Med, 1995, 14(19):2057-2079.
6.	赵景波. 累积meta分析方法及其在临床医学研究中的运用.循证医学, 2002, 2(3):161-167.
7.	Lau J, Antman EM, Jimenez-Silva J, et al. Cumulative meta-analysis of trials of treatments for myocardial infarction. N Engl J Med, 1992, 327(4):248-254.
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9.	Berkey CS, Mosteller F, Lau J, et al. Uncertainty of the time of first significance in random effects cumulative meta-analysis. Control Clin Trials, 1996, 17(5):357-371.
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11.	DerSimonian R, Laird NM. Meta-analysis in clinical trials. Control Clin Trials, 1986, 7(3):177-188.
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14.	Deeks JJ. Issues in the selection of a summary statistic for metaanalysis of clinical trials with binary outcomes. Stat Med, 2002, 21(11):1575-1600.
15.	胡国清, 黄琼峰, 黄镇南, 等. 临床研究中最小临床意义变化值确定方法. 中南大学学报(医学版), 2009, 34(11):1058-1062.
16.	Thorlund K, Engstrøm J, Wetterslev J, et al. Comments on 'Sequential meta-analysis:an efficient decision-making tool' by I van der Tweel and C Bollen. Clin Trials, 2010, 7(6):752-753.
17.	Ioannidis JP, Bassett R, Hughes MD, et al. Predictors and impact of patients lost to follow-up in a long-term trial of early versus deferred antiretroviral treatment. J Acquir Immune Defic Syndr Hum Retrovirol, 1997, 16(1):22-30.

1. Hedges LV, Olkin I. Statistical Methods for Meta Analysis. Academic Press, New York, 1985.
2. Borm GF, Donders AR. Updating meta-analyses leads to larger type I errors than publication bias. J Clin Epidemiol, 2009, 62(8):825-830.
3. Dickersin K. The existence of publication bias and risk factors for its occurrence. JAMA, 1990, 263(10):1385-1389.
4. Ioannidis JP. Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials. JAMA, 1998, 279(4):281-286.
5. Stewart LA, Clarke MJ. Practical methodology of meta-analyses (overviews) using updated individual patient data. Stat Med, 1995, 14(19):2057-2079.
6. 赵景波. 累积meta分析方法及其在临床医学研究中的运用.循证医学, 2002, 2(3):161-167.
7. Lau J, Antman EM, Jimenez-Silva J, et al. Cumulative meta-analysis of trials of treatments for myocardial infarction. N Engl J Med, 1992, 327(4):248-254.
8. Lau J, Schmid CH, Chalmers TC. Cumulative meta-analysis builds evidence for exemplary medical care. J Clin Epidemiol, 1995, 48(1): 45-57.
9. Berkey CS, Mosteller F, Lau J, et al. Uncertainty of the time of first significance in random effects cumulative meta-analysis. Control Clin Trials, 1996, 17(5):357-371.
10. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 1959, 22(4): 719-748.
11. DerSimonian R, Laird NM. Meta-analysis in clinical trials. Control Clin Trials, 1986, 7(3):177-188.
12. Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med, 1997, 127(9):820-826.
13. Kim DH, Rogers JR, Fulchino LA, et al. Bisphosphonates and Risk of Cardiovascular Events:A Meta-Analysis. PLoS One, 2015, 10(4): e0122646.
14. Deeks JJ. Issues in the selection of a summary statistic for metaanalysis of clinical trials with binary outcomes. Stat Med, 2002, 21(11):1575-1600.
15. 胡国清, 黄琼峰, 黄镇南, 等. 临床研究中最小临床意义变化值确定方法. 中南大学学报(医学版), 2009, 34(11):1058-1062.
16. Thorlund K, Engstrøm J, Wetterslev J, et al. Comments on 'Sequential meta-analysis:an efficient decision-making tool' by I van der Tweel and C Bollen. Clin Trials, 2010, 7(6):752-753.
17. Ioannidis JP, Bassett R, Hughes MD, et al. Predictors and impact of patients lost to follow-up in a long-term trial of early versus deferred antiretroviral treatment. J Acquir Immune Defic Syndr Hum Retrovirol, 1997, 16(1):22-30.

Chinese Journal of Evidence-Based Medicine

A Brief Introduction of Recursive Cumulative Meta-analysis

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