Association between ADAM33 Gene Polymorphisms and Susceptibility to Asthma in Chinese Han Population: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 ABUDOJILILIJulaiti , TUERXUNAYIAierken , HUXin , HUANGYi ,  QIMENGULIWushouer

Department of Respiratory Medicine, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;

Corresponding author：

QIMENGULIWushouer, Email: qimenw@hotmail.com

Keywords：

Asthma; ADAM33; Polymorphism; Systematic review; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20160012

Video：

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Objective To systematically review the association between ADAM33 (a disintegrin and metalloproteinase domain33) T2 (rs2280090), S2 (rs528557), and V4 (rs2787094) polymorphisms and asthma in Chinese Han population. Methods We electronically searched databases including PubMed, Web of Science, CNKI, WanFang Data and VIP from inception to December 2014, to collect case-control studies about the association between ADAM33 polymorphisms and asthma in Chinese Han population. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using Stata 12.1 software. Results A total of 8 case-control studies including 1651 asthma patients and 1639 controls were included. The results of meta-analysis showed that: ADAM33 T2 polymorphism was associated with decreased risk of asthma (AA+AG vs. GG: OR=0.316, 95%CI 0.151 to 0.659, P=0.002), and the S2 polymorphism was associated with increased risk of asthma (GG+GC vs. CC: OR=1.271, 95%CI 1.023 to 1.578, P=0.030). However, no significant association was found between asthma risk and V4 polymorphism (GG+GC vs. CC: OR=1.561, 95%CI 0.638 to 3.823, P=0.330). Subgroup analysis by age indicated that the T2 polymorphism was associated with decreased risk of asthma in both adults and children, the S2 polymorphism was only associated with increased risk of asthma in adults, however, no significant association was found between asthma and the ADAM33 V4 polymorphism in both adults and children subgroups. Conclusion Current evidence shows that the ADAM33 T2 and S2 polymorphisms are associated with risk of asthma in Chinese Han population. Due to the limited quantity and quality of the studies, the above conclusion still need to be verified by further more high-quality studies.

Citation： ABUDOJILILIJulaiti, TUERXUNAYIAierken, HUXin, HUANGYi, QIMENGULIWushouer. Association between ADAM33 Gene Polymorphisms and Susceptibility to Asthma in Chinese Han Population: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(1): 54-59. doi: 10.7507/1672-2531.20160012 Copy

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4.	Howard TD, Postma DS, Jongepier H, et al. Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol, 2003, 112(0091-6749): 717-722.
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9.	Shapiro SD, Owen CA. ADAM-33 Surfaces as an Asthma Gene. N Engl J Med, 2002, 347(12): 936-938.
10.	Jie Z, Hu Z, Bai C, et al. ADAM33 gene polymorphisms associate with asthma susceptibility and severity in East China han population. J Asthma, 2011, 48(10): 979-985.
11.	Qu S, Sun D, Wang Y, et al. Association of ADAM33 polymorphisms with childhood asthma in a northern Chinese population. Exp Mol Pathol, 2011, 91(3): 775-779.
12.	迟翔宇, 王来城, 王静, 等. ADAM33基因位点单核苷酸多态性与山东地区支气管哮喘患者的相关性. 中华结核和呼吸杂志, 2011, 34(5): 386-387.
13.	Chi X, Wang L, Wang J, et al. Association of ADAM33 gene polymorphisms with asthma in a Chinese population. Clin Respir J, 2013, 7(1): 16-20.
14.	Su D, Zhang X, Sui H, et al. Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. BMC Med Genet, 2008, 9: 82.
15.	余宏川, 李延琪, 王立军, 等. 陕西关中地区汉族支气管哮喘患儿解整合素-金属蛋白酶33基因S2位点的多态性 . 实用儿科临床杂志, 2011, 26(9): 650-652.
16.	谢衬梨, 赵一菊, 廖政邦, 等. 慢性阻塞性肺疾病和支气管哮喘患者中ADAM33基因功能多态性及与吸烟的交互作用. 广东医学, 2013, 34(22): 3402-3406.
17.	李宏彬, 徐光翠, 桂立辉, 等. TGF-1和ADAM33基因交互作用与儿童哮喘易感性及严重程度相关性. 中国免疫学杂志, 2012, 28(7): 640-644.

1. Ferreira MA, Matheson MC, Duffy DL, et al. Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. Lancet, 2011, 378(9795): 1006-1014.
2. Wan YI, Shrine NR, Soler Artigas M, et al. Genome-wide association study to identify genetic determinants of severe asthma. Thorax, 2012, 67(9): 762-768.
3. Sharma N, Tripathi P, Awasthi S, et al. Role of ADAM33 gene and associated single nucleotide polymorphisms in asthma. Allergy & Rhinology, 2011, 2(2): e63-70.
4. Howard TD, Postma DS, Jongepier H, et al. Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol, 2003, 112(0091-6749): 717-722.
5. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
6. 李陈, 况九龙. 支气管哮喘气道重构的研究进展. 江西医学院学报, 2009, 49(12): 132-133, 137.
7. 袁方, 张建华. 解整合素-金属蛋白酶33与支气管哮喘. 临床儿科杂志, 2009, 27(12): 1187-1189.
8. Arima M, Fukuda T. Prostaglandin D(2) and T(H)2 inflammation in the pathogenesis of bronchial asthma. Korean J Intern Med, 2011, 26(1): 8-18.
9. Shapiro SD, Owen CA. ADAM-33 Surfaces as an Asthma Gene. N Engl J Med, 2002, 347(12): 936-938.
10. Jie Z, Hu Z, Bai C, et al. ADAM33 gene polymorphisms associate with asthma susceptibility and severity in East China han population. J Asthma, 2011, 48(10): 979-985.
11. Qu S, Sun D, Wang Y, et al. Association of ADAM33 polymorphisms with childhood asthma in a northern Chinese population. Exp Mol Pathol, 2011, 91(3): 775-779.
12. 迟翔宇, 王来城, 王静, 等. ADAM33基因位点单核苷酸多态性与山东地区支气管哮喘患者的相关性. 中华结核和呼吸杂志, 2011, 34(5): 386-387.
13. Chi X, Wang L, Wang J, et al. Association of ADAM33 gene polymorphisms with asthma in a Chinese population. Clin Respir J, 2013, 7(1): 16-20.
14. Su D, Zhang X, Sui H, et al. Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. BMC Med Genet, 2008, 9: 82.
15. 余宏川, 李延琪, 王立军, 等. 陕西关中地区汉族支气管哮喘患儿解整合素-金属蛋白酶33基因S2位点的多态性 . 实用儿科临床杂志, 2011, 26(9): 650-652.
16. 谢衬梨, 赵一菊, 廖政邦, 等. 慢性阻塞性肺疾病和支气管哮喘患者中ADAM33基因功能多态性及与吸烟的交互作用. 广东医学, 2013, 34(22): 3402-3406.
17. 李宏彬, 徐光翠, 桂立辉, 等. TGF-1和ADAM33基因交互作用与儿童哮喘易感性及严重程度相关性. 中国免疫学杂志, 2012, 28(7): 640-644.

Chinese Journal of Evidence-Based Medicine

Association between ADAM33 Gene Polymorphisms and Susceptibility to Asthma in Chinese Han Population: A Meta-analysis

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