Health-Related Quality of Life for Disease Population in China based on EQ-5D: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHOUTing ¹ , GUANHai-jing ² , GordonG. LIU ^2,3 ,  MAAi-xia ¹

1. School of International Pharmaceutical Business of China Pharmaceutical University, Nanjing 211198, China;
2. Peking University China Center for Health Economic Research, Beijing 100080, China;
3. Peking University National School of Development, PKU China Center for Health Economic Research, Beijing 100871, China;

Corresponding author：

MAAi-xia, Email: ma86128@sina.com

Keywords：

EQ-5D; Disease population in China; Quality of life; Systematic Review

DOI：

10.7507/1672-2531.20160024

Video：

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Objective To systematically review the health-related quality of life (QOL) based on EQ-5D instrument for disease population in China. Methods We searched databases including PubMed, The Cochrane Library (Issue 5, 2015), EMbase, CNKI, VIP and WanFang Data from inception to August 2015, to identify studies involving healthrelated QOL about different diseases in China. A descriptive analysis was used to analyze health utility by disease and the proportion of patients who having problem in five dimensions, as well as comparing health-related QOL in different diseases. Results A total of 26 studies were included, involving 15 kinds of diseases. The health utility in different studies about the same disease was different. Diabetes ranged from 0.79 to 0.94, liver disease infected by HBV was from 0 to 0.80, hypertension was from 0.78 to 0.93, coronary heart disease was from 0.75 to 0.90, and chronic obstructive pulmonary disease was from 0.64 to 0.73. After ranking the health utility of fifteen kinds of diseases, the utility of kashin-beck disease and rheumatoid arthritis were 0.45 and 0.56, respectively, and the utility of children cerebral palsy was 0.44, which was the lowest. "Pain/discomfort" was the dimension with highest proportion of patients who having problem for most diseases while atrial fibrillation and children cerebral palsy were the "Self-care" and "Usual Activities". Conclusion EQ-5D is widely used in health-related QOL studies among different diseases in China. Many factors including sample source, severity of disease, complication and value set have influence on the measurement results of health utility.

Citation： ZHOUTing, GUANHai-jing, GordonG. LIU, MAAi-xia. Health-Related Quality of Life for Disease Population in China based on EQ-5D: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2016, 16(2): 135-142. doi: 10.7507/1672-2531.20160024 Copy

1.	官海静, 刘国恩. 中国四地城乡居民生命质量的比较分析. 中国卫生经济, 2015, 33(2):5-12.
2.	Rabin R, de Charro F. EQ-5D:a measure of health status from the EuroQol Group. Ann Med, 2001, 33(5):337-343.
3.	Horsman J, Furlong W, Feeny D, et al. The Health Utilities Index (HUI):concepts, measurement properties and applications. Health Qual Life Out, 2003, 1(1):54.
4.	Brazier J, Roberts J, Deverill M. The estimation of a preferencebased measure of health from the SF-36. J Health Econ, 2002, 21(2): 271-292.
5.	Brooks, R. EuroQol:The current state of play. Health Policy, 1996, 37(1), 53-72.
6.	中华人民共和国卫生部. 2013中国卫生统计年鉴. Available at:http://www.nhfpc.gov.cn/htmlfiles/zwgkzt/ptjnj/year2013/index2013.html.
7.	朱银潮. 2型糖尿病患者口服药物治疗模式和生活质量现状的研究. 浙江:浙江大学, 2013.
8.	梁敏红. 北京社区Ⅱ型糖尿病患者生命质量及其影响因素研究. 北京:北京中医药大学, 2014.
9.	罗娅珺, 方芸, 丁选胜. 采用EQ-5D评估2型糖尿病患者的生活质量及影响因素研究. 中国药物经济学, 2009, 4(2):12-18.
10.	唐晓梅, 姚美华, 陈国, 平. 农村糖尿病患者生活质量评价研究. 浙江预防医学, 2015, 27(5):458-461.
11.	韩月蓉, 吴晶, 蔡德鸿, 等. 中国城市口服降糖药物治疗的2型糖尿病患者合并症与生活质量评价. 中华内分泌代谢杂志, 2013, 29(8):656-659.
12.	Chang K. Comorbidities, quality of life and patients' willingness to pay for a cure for type 2 diabetes in Taiwan. Public Health, 2010, 124(5):284-294.
13.	曹洋, 唐迅, 杨莉, 等. 应用EQ-5D量表对北京房山农村中老年人慢性病患者生命质量及影响因素的研究. 中华流行病学杂志, 2014, 33(1):17-22.
14.	李阳, 董朝晖, 孙利华. 高血压社区管理对患者生命质量影响的调查分析. 中国药房, 2014, 25(12):1080-1083.
15.	何敏媚, 范长生, 曾光, 等. 北京市高血压患者用药依从性与生命质量相关分析. 中国初级卫生保健, 2013, 27(3):57-58.
16.	熊琴梅, 周琼琼, 刘勇, 等. 冠心病患者生活质量现状及其相关影响因素分析. 临床心血管病杂志, 2014, 30(1):27-30.
17.	Wang L, Wu Y Q, Tang X, et al. Profile and Correlates of Healthrelated Quality of Life in Chinese Patients with Coronary Heart Disease. Chinese Med J-Peking, 2015, 128(14):1853-1861.
18.	Wu J, Han Y, Xu J, et al. Chronic Stable Angina Is Associated with Lower Health-Related Quality of Life:Evidence from Chinese Patients. PloS One, 2014, 9(5):e97294.
19.	Wu J, Han Y, Zhao FL, et al. Validation and comparison of EuroQoL-5 dimension (EQ-5D) and Short Form-6 dimension (SF-6D) among stable angina patients. Heal Qual Life Out, 2014, 12(1): 156-167.
20.	Wu M, Zhao Q, Chen Y, et al. Quality of life and its association with direct medical costs for COPD in urban China. Heal Qual Life Out, 2015, 13(1):57-62.
21.	Chen J, Wong CKH, McGhee SM, et al. A Comparison between the EQ-5D and the SF-6D in Patients with Chronic Obstructive Pulmonary Disease (COPD). PLoS One, 2014, 9(11):e112389.
22.	Che Y H, You J, Chongsuvivatwong V, et al. Dynamics and liver disease specific aspects of quality of life among patients with chronic liver disease in yunnan, china. Asian Pac J Cancer Prev, 2013, 15(12): 4765-4771.
23.	金辉. 江苏省乙肝母婴阻断相关免疫策略及卫生经济学评价. 南京:东南大学, 2011.
24.	Gao L, Xia L, Pan SQ, et al. Psychometric properties of Chinese language Liverpool Seizure Severity Scale 2.0 (LSSS 2.0) and status and determinants of seizure severity for patients with epilepsy in China. Epilepsy Behav, 2014, 31(1):187-193.
25.	Zhao F, Yue M, Yang H, et al. Validation and comparison of EuroQol and short form 6D in chronic prostatitis patients. Value in Health, 2010, 13(5):649-656.
26.	Lin JC, Yu JH. Assessment of quality of life among Taiwanese patients with visual impairment. J Formos Med Assoc, 2012, 111(10): 572-579.
27.	崔巍. 河北省脑瘫患儿生存质量状况调查与经济负担评价. 吉林: 吉林大学, 2014.
28.	顾杰. 类风湿关节炎疾病效用值测量方法的比较. 上海:复旦大学, 2009.
29.	胡永勤, 王来根, 方杭燕, 等. 欧洲EQ-5D量表用于杭州市余杭区慢性淋巴丝虫病生命质量调查. 中国农村卫生事业管理, 2012, 32(3):274-276.
30.	Wang KL, Wu CH, Huang CC, et al. Complexity of atrial fibrillation patients and management in Chinese ethnicity in routine daily practice:Insights from the RealiseAF Taiwanese cohort. J Cardiol, 2014, 64(3):211-217.
31.	Shi JF, Kang DJ, Qi SZ, et al. Impact of genital warts on health related quality of life in men and women in mainland China:a multicenter hospital-based cross-sectional study. BMC Public Health, 2012, 12(1):153-161.
32.	Farooq U, Guo X, Chuang LH, et al. Measuring health-related quality of life in Kashin-Beck disease using EQ-5D. Qual Life Res, 2011, 20(3):425-429.
33.	Liu GG, Wu H, Li M, et al. Chinese time trade-off values for EQ-5D health states. Value in Health, 2014, 17(5):597-604.
34.	李平, 李泽楷, 邓爱玲. 脑瘫患儿家庭支持的研究进展. 中华护理杂志, 2013, 48(4):365-367.
35.	王权, 李秀霞, 李伦, 等. 硒与大骨节病相关性的Meta分析. 中国循证医学杂志, 2013, 13(12):1421-1430.

1. 官海静, 刘国恩. 中国四地城乡居民生命质量的比较分析. 中国卫生经济, 2015, 33(2):5-12.
2. Rabin R, de Charro F. EQ-5D:a measure of health status from the EuroQol Group. Ann Med, 2001, 33(5):337-343.
3. Horsman J, Furlong W, Feeny D, et al. The Health Utilities Index (HUI):concepts, measurement properties and applications. Health Qual Life Out, 2003, 1(1):54.
4. Brazier J, Roberts J, Deverill M. The estimation of a preferencebased measure of health from the SF-36. J Health Econ, 2002, 21(2): 271-292.
5. Brooks, R. EuroQol:The current state of play. Health Policy, 1996, 37(1), 53-72.
6. 中华人民共和国卫生部. 2013中国卫生统计年鉴. Available at:http://www.nhfpc.gov.cn/htmlfiles/zwgkzt/ptjnj/year2013/index2013.html.
7. 朱银潮. 2型糖尿病患者口服药物治疗模式和生活质量现状的研究. 浙江:浙江大学, 2013.
8. 梁敏红. 北京社区Ⅱ型糖尿病患者生命质量及其影响因素研究. 北京:北京中医药大学, 2014.
9. 罗娅珺, 方芸, 丁选胜. 采用EQ-5D评估2型糖尿病患者的生活质量及影响因素研究. 中国药物经济学, 2009, 4(2):12-18.
10. 唐晓梅, 姚美华, 陈国, 平. 农村糖尿病患者生活质量评价研究. 浙江预防医学, 2015, 27(5):458-461.
11. 韩月蓉, 吴晶, 蔡德鸿, 等. 中国城市口服降糖药物治疗的2型糖尿病患者合并症与生活质量评价. 中华内分泌代谢杂志, 2013, 29(8):656-659.
12. Chang K. Comorbidities, quality of life and patients' willingness to pay for a cure for type 2 diabetes in Taiwan. Public Health, 2010, 124(5):284-294.
13. 曹洋, 唐迅, 杨莉, 等. 应用EQ-5D量表对北京房山农村中老年人慢性病患者生命质量及影响因素的研究. 中华流行病学杂志, 2014, 33(1):17-22.
14. 李阳, 董朝晖, 孙利华. 高血压社区管理对患者生命质量影响的调查分析. 中国药房, 2014, 25(12):1080-1083.
15. 何敏媚, 范长生, 曾光, 等. 北京市高血压患者用药依从性与生命质量相关分析. 中国初级卫生保健, 2013, 27(3):57-58.
16. 熊琴梅, 周琼琼, 刘勇, 等. 冠心病患者生活质量现状及其相关影响因素分析. 临床心血管病杂志, 2014, 30(1):27-30.
17. Wang L, Wu Y Q, Tang X, et al. Profile and Correlates of Healthrelated Quality of Life in Chinese Patients with Coronary Heart Disease. Chinese Med J-Peking, 2015, 128(14):1853-1861.
18. Wu J, Han Y, Xu J, et al. Chronic Stable Angina Is Associated with Lower Health-Related Quality of Life:Evidence from Chinese Patients. PloS One, 2014, 9(5):e97294.
19. Wu J, Han Y, Zhao FL, et al. Validation and comparison of EuroQoL-5 dimension (EQ-5D) and Short Form-6 dimension (SF-6D) among stable angina patients. Heal Qual Life Out, 2014, 12(1): 156-167.
20. Wu M, Zhao Q, Chen Y, et al. Quality of life and its association with direct medical costs for COPD in urban China. Heal Qual Life Out, 2015, 13(1):57-62.
21. Chen J, Wong CKH, McGhee SM, et al. A Comparison between the EQ-5D and the SF-6D in Patients with Chronic Obstructive Pulmonary Disease (COPD). PLoS One, 2014, 9(11):e112389.
22. Che Y H, You J, Chongsuvivatwong V, et al. Dynamics and liver disease specific aspects of quality of life among patients with chronic liver disease in yunnan, china. Asian Pac J Cancer Prev, 2013, 15(12): 4765-4771.
23. 金辉. 江苏省乙肝母婴阻断相关免疫策略及卫生经济学评价. 南京:东南大学, 2011.
24. Gao L, Xia L, Pan SQ, et al. Psychometric properties of Chinese language Liverpool Seizure Severity Scale 2.0 (LSSS 2.0) and status and determinants of seizure severity for patients with epilepsy in China. Epilepsy Behav, 2014, 31(1):187-193.
25. Zhao F, Yue M, Yang H, et al. Validation and comparison of EuroQol and short form 6D in chronic prostatitis patients. Value in Health, 2010, 13(5):649-656.
26. Lin JC, Yu JH. Assessment of quality of life among Taiwanese patients with visual impairment. J Formos Med Assoc, 2012, 111(10): 572-579.
27. 崔巍. 河北省脑瘫患儿生存质量状况调查与经济负担评价. 吉林: 吉林大学, 2014.
28. 顾杰. 类风湿关节炎疾病效用值测量方法的比较. 上海:复旦大学, 2009.
29. 胡永勤, 王来根, 方杭燕, 等. 欧洲EQ-5D量表用于杭州市余杭区慢性淋巴丝虫病生命质量调查. 中国农村卫生事业管理, 2012, 32(3):274-276.
30. Wang KL, Wu CH, Huang CC, et al. Complexity of atrial fibrillation patients and management in Chinese ethnicity in routine daily practice:Insights from the RealiseAF Taiwanese cohort. J Cardiol, 2014, 64(3):211-217.
31. Shi JF, Kang DJ, Qi SZ, et al. Impact of genital warts on health related quality of life in men and women in mainland China:a multicenter hospital-based cross-sectional study. BMC Public Health, 2012, 12(1):153-161.
32. Farooq U, Guo X, Chuang LH, et al. Measuring health-related quality of life in Kashin-Beck disease using EQ-5D. Qual Life Res, 2011, 20(3):425-429.
33. Liu GG, Wu H, Li M, et al. Chinese time trade-off values for EQ-5D health states. Value in Health, 2014, 17(5):597-604.
34. 李平, 李泽楷, 邓爱玲. 脑瘫患儿家庭支持的研究进展. 中华护理杂志, 2013, 48(4):365-367.
35. 王权, 李秀霞, 李伦, 等. 硒与大骨节病相关性的Meta分析. 中国循证医学杂志, 2013, 13(12):1421-1430.

Chinese Journal of Evidence-Based Medicine

Health-Related Quality of Life for Disease Population in China based on EQ-5D: A Systematic Review

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