Association between the Insertion/Deletion Polymorphism of ACE Gene and Athletes' Sport Performance in Power Sports: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 AIJin-wei ^1,2 ^# ,  LIUYing ² ^# , LIDe-sheng ² , LIUYu ² ,  PEIBin ^1,2

1. Evidence-Based Medicine Center, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;
2. Department of Micro-orthopedic Surgery, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;

Corresponding author：

PEIBin, Email: xyxzyxzx@163.com

Keywords：

Peptidyl-dipeptidase A; Polymorphism; Athlete; Power sports; Meta-analysis

DOI：

10.7507/1672-2531.20160043

Video：

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Objective To systematically review the association between the insertion/deletion (I/D) polymorphism of angiotension-converting enzyme (ACE) gene and the athletes' performance in power sports. Methods Databases including PubMed, EMbase, CNKI, CBM, VIP and WanFang Data were searched up to August 1st, 2015 to collect case-control studies about the association between ACE I/D polymorphism and the athletes' performance in power sports. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 26 case-control studies involving 2032 athletes and 10600 controls were included. The results of meta-analysis showed that no significant association was found between ACE I/D polymorphism and the athletes' performance in power sports (DD vs. DI+Ⅱ:OR=1.05, 95%CI 0.81 to 1.36, P=0.70; DD+DI vs. Ⅱ:OR=1.03, 95%CI 0.82 to 1.29, P=0.80; DD vs. Ⅱ:OR=1.04, 95%CI 0.74 to 1.47, P=0.82; DI vs. Ⅱ:OR=0.99, 95%CI 0.81 to 1.22, P=0.96; D vs. I:OR=1.04, 95%CI 0.88 to 1.24, P=0.62). Also, in subgroup analysis by ethnicity, no significant association was found between ACE I/D polymorphism and the performance of athletes of difference races in power sports. Conclusions Current evidence indicates that the ACE I/D polymorphism may not associate with the performance of athletes in power sports. Due to the quality limitations of included studies, more high quality case-control or cohort studies are needed to verify the above conclusions.

Citation： AIJin-wei, LIUYing, LIDe-sheng, LIUYu, PEIBin. Association between the Insertion/Deletion Polymorphism of ACE Gene and Athletes' Sport Performance in Power Sports: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(3): 263-269. doi: 10.7507/1672-2531.20160043 Copy

1.	Payne J, Montgomery H. Genetic variation and physical performance. World Rev Nutr Diet, 2004, 93:270-302.
2.	Jones A, Montgomery HE, Woods DR. Human performance:a role for the ACE genotype? Exerc Sport Sci Rev, 2002, 30(4):184-190.
3.	左彦方, 龙爱梅, 黄晓青, 等. 血管紧张素转换酶基因多态性与2型糖尿病肾病相关性的Meta分析. 中国循证医学杂志, 2012, 12(9):1071-1075.
4.	吴晓梅, 时玥, 时景璞. 中国汉族人群脑出血患者血管紧张素转换酶基因插入/缺失多态性的Meta分析. 中国循证医学杂志, 2009, 9(12):1323-1327.
5.	Woods D, Humphries S, Montgomery HE. The ACE I/D Polymorphism and Human Physical Performance. Trends Endocrinol Metab, 2000, 11(10):416-420.
6.	Sessa F, Chetta M, Petito A, et al. Gene polymorphisms and sport attitude in Italian athletes. Genet Test Mol Biomarkers, 2011, 15(4):285-290.
7.	Myerson S, Hemingway H, Budget R, et al. Human angiotensin I-converting enzyme gene and endurance performance. J Appl Physiol, 1999, 87(4):1313-1316.
8.	Costa A, Silva A, Garrido N, et al. Association between ACE D allele and elite short distance swimming. Eur J Appl Physiol, 2009, 106(6):785-790.
9.	Woods D, Hickman M, Jamshidi Y, et al. Elite swimmers and the D allele of the ACE I/D polymorphism. Hum Genet, 2001, 108(3):230-232.
10.	Cieszczyk P, Maciejewska A, Sawczuk M, et al. The angiotensin converting enzyme gene I/D polymorphism in ellite Polish and Lithuanian judo players. Biol Sport, 2010, 27(2):119-122.
11.	Ma F, Yang Y, Li X, et al. The association of sport performance with ACE and ACTN3 genetic polymorphisms:a systematic review and meta-analysis. PLoS One, 2013, 8(1):e54685.
12.	张明军, 叶学球. 中国汉族成年运动员ACE基因多态性与运动能力的Meta分析. 惠州学院学报, 2015, 35(3):109-116.
13.	Moher D, Liberati A, Tetzlaff J, et al. Reprint——preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement. Phys Ther, 2009, 89(9):873-880.
14.	曾宪涛, Joey S, 田国祥, 等. Meta分析系列之二:Meta分析的软件. 中国循证心血管医学杂志, 2012, 4(2):89-91.
15.	徐畅, 刘同族, 曾宪涛. Meta分析系列之十四:Stata实现单核苷酸多态性研究的Meta分析. 中国循证心血管医学杂志, 2013, 5(5):445-448.
16.	王丹, 翟俊霞, 牟振云, 等. Meta分析中的异质性及其处理方法. 中国循证医学杂志, 2009, 9(10):1115-1118.
17.	文进, 李幼平. Meta分析中效应尺度指标的选择. 中国循证医学杂志, 2007, 7(8):606-613.
18.	郑辉烈, 王忠旭, 王增珍. Meta分析中发表偏倚的Begg's检验、Egger's检验及Macaskill's检验的SAS程序实现. 中国循证医学杂志, 2009, 9(8):910-916.
19.	Amir O, Amir R, Yamin C, et al. The ACE deletion allele is associated with Israeli elite endurance athletes. Exp Physiol, 2007, 92(5):881-886.
20.	Nazarov IB, Woods DR, Montgomery HE, et al. The angiotensin converting enzyme I/D polymorphism in Russian athletes. Eur J Hum Genet, 2001, 9(10):797-801.
21.	Papadimitriou ID, Papadopoulos C, Kouvatsi A, et al. The ACE I/D polymorphism in elite Greek track and field athletes. J Sports Med Phys Fitness, 2009, 49(4):459-463.
22.	Ginevičienė V1, Pranculis A, Jakaitienė A, et al. Genetic variation of the human ACE and ACTN3 genes and their association with functional muscle properties in Lithuanian elite athletes. Medicina (Kaunas), 2011, 47(5):284-290.
23.	Scott RA, Irving R, Irwin L, et al. ACTN3 and ACE genotypes in elite jamaican and US sprinters. Med Sci Sport Exerc, 2010, 42(1):107-112.
24.	Ruiz JR, Arteta D, Buxens A, et al. Can we identify a power-oriented polygenic profile? J Appl Physiol, 2010, 108(3):561-566.
25.	Shahmoradi S, Ahmadalipour A, Salehi M. Evaluation of ACE gene I/D polymorphism in Iranian elite athletes. Adv Biomed Res, 2014, 3(1):207-213.
26.	Eynon N, Alves AJ, Yamin C, et al. Is there an ACE ID-ACTN3 R577X polymorphisms interaction that influences sprint performance? Int J Sports Med, 2009, 30(12):888-891.
27.	Drozdovska SB, Dosenko VE, Ahmetov Ⅱ, et al. The association of gene polymorphisms with athlete status in Ukrainians. Biol Sport, 2013, 30(3):163-167.
28.	Grenda A, Leońska-Duniec A, Kaczmarczyk M, et al. Interaction between ACE I/D and ACTN3 R557X polymorphisms in Polish competitive swimmers. J Hum Kinet, 2014, 42(1):127-136.
29.	Wang G, Mikami E, Chiu LL, et al. Association analysis of ACE and ACTN3 in elite Caucasian and East Asian swimmers. Med Sci Sportd Exerc, 2013, 45(5):892-900.
30.	Ash GI, Scott RA, Dawson TA, et al. No Association between ACE Gene Variation and Endurance Athlete Status in Ethiopians. Med Sci Sports Exerc, 2011, 43(4):590-597.
31.	孙小敏, 甄文娟, 王煜, 等. 运动员血管紧张素转换酶基因插入或缺失多态性研究. 中国运动医学杂志, 2004, 23(5):546-547.
32.	赵云, 马力宏. 优秀力量运动员ACE基因I/D多态性与运动能力的关联研究. 中国运动医学杂志, 2000, 19(3):308-310.
33.	余黎霞, 宋磊刚. 武术散打运动员ACE基因I/D多态性研究. 现代预防医学, 2010, 37(5):893-896.
34.	张坤, 江雪, 鲜贵平, 等. 跳远运动员血管紧张素转化酶基因插入/缺失多态性研究. 重庆医学, 2015, 44(1):18-20.
35.	Kikuchi N, Min SK, Ueda D, et al. Higher frequency of the ACTN3 R allele + ACE DD genotype in Japanese elite wrestlers. J Strength Cond Res, 2012, 26(12):3275-3280.
36.	Kim CH, Cho JY, Jeon JY, et al. ACE DD genotype is unfavorable to Korean short-term muscle power athletes. Int J Sports Med, 2010, 31(1):65-71.
37.	Hagberg J, Rankinen T, Loos RJ, et al. Advances in exercise, fitness, and performance genomics in 2010. Med Sci Sports Exer, 2011, 43(5):743-752.
38.	Guth LM, Roth SM. Genetic influence on athletic performance. Curr Opin Pediatr, 2013, 25(6):653-658.
39.	Woods D. Angiotensin-converting enzyme, renin-angiotensin system and human performance. Med Sport Sci, 2009, 54:72-87.
40.	杨若愚, 王予彬, 沈勋章, 等. 杰出爆发力素质与基因多态性研究进展. 中国医药导报, 2014, 11(19):163-168.

1. Payne J, Montgomery H. Genetic variation and physical performance. World Rev Nutr Diet, 2004, 93:270-302.
2. Jones A, Montgomery HE, Woods DR. Human performance:a role for the ACE genotype? Exerc Sport Sci Rev, 2002, 30(4):184-190.
3. 左彦方, 龙爱梅, 黄晓青, 等. 血管紧张素转换酶基因多态性与2型糖尿病肾病相关性的Meta分析. 中国循证医学杂志, 2012, 12(9):1071-1075.
4. 吴晓梅, 时玥, 时景璞. 中国汉族人群脑出血患者血管紧张素转换酶基因插入/缺失多态性的Meta分析. 中国循证医学杂志, 2009, 9(12):1323-1327.
5. Woods D, Humphries S, Montgomery HE. The ACE I/D Polymorphism and Human Physical Performance. Trends Endocrinol Metab, 2000, 11(10):416-420.
6. Sessa F, Chetta M, Petito A, et al. Gene polymorphisms and sport attitude in Italian athletes. Genet Test Mol Biomarkers, 2011, 15(4):285-290.
7. Myerson S, Hemingway H, Budget R, et al. Human angiotensin I-converting enzyme gene and endurance performance. J Appl Physiol, 1999, 87(4):1313-1316.
8. Costa A, Silva A, Garrido N, et al. Association between ACE D allele and elite short distance swimming. Eur J Appl Physiol, 2009, 106(6):785-790.
9. Woods D, Hickman M, Jamshidi Y, et al. Elite swimmers and the D allele of the ACE I/D polymorphism. Hum Genet, 2001, 108(3):230-232.
10. Cieszczyk P, Maciejewska A, Sawczuk M, et al. The angiotensin converting enzyme gene I/D polymorphism in ellite Polish and Lithuanian judo players. Biol Sport, 2010, 27(2):119-122.
11. Ma F, Yang Y, Li X, et al. The association of sport performance with ACE and ACTN3 genetic polymorphisms:a systematic review and meta-analysis. PLoS One, 2013, 8(1):e54685.
12. 张明军, 叶学球. 中国汉族成年运动员ACE基因多态性与运动能力的Meta分析. 惠州学院学报, 2015, 35(3):109-116.
13. Moher D, Liberati A, Tetzlaff J, et al. Reprint——preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement. Phys Ther, 2009, 89(9):873-880.
14. 曾宪涛, Joey S, 田国祥, 等. Meta分析系列之二:Meta分析的软件. 中国循证心血管医学杂志, 2012, 4(2):89-91.
15. 徐畅, 刘同族, 曾宪涛. Meta分析系列之十四:Stata实现单核苷酸多态性研究的Meta分析. 中国循证心血管医学杂志, 2013, 5(5):445-448.
16. 王丹, 翟俊霞, 牟振云, 等. Meta分析中的异质性及其处理方法. 中国循证医学杂志, 2009, 9(10):1115-1118.
17. 文进, 李幼平. Meta分析中效应尺度指标的选择. 中国循证医学杂志, 2007, 7(8):606-613.
18. 郑辉烈, 王忠旭, 王增珍. Meta分析中发表偏倚的Begg's检验、Egger's检验及Macaskill's检验的SAS程序实现. 中国循证医学杂志, 2009, 9(8):910-916.
19. Amir O, Amir R, Yamin C, et al. The ACE deletion allele is associated with Israeli elite endurance athletes. Exp Physiol, 2007, 92(5):881-886.
20. Nazarov IB, Woods DR, Montgomery HE, et al. The angiotensin converting enzyme I/D polymorphism in Russian athletes. Eur J Hum Genet, 2001, 9(10):797-801.
21. Papadimitriou ID, Papadopoulos C, Kouvatsi A, et al. The ACE I/D polymorphism in elite Greek track and field athletes. J Sports Med Phys Fitness, 2009, 49(4):459-463.
22. Ginevičienė V1, Pranculis A, Jakaitienė A, et al. Genetic variation of the human ACE and ACTN3 genes and their association with functional muscle properties in Lithuanian elite athletes. Medicina (Kaunas), 2011, 47(5):284-290.
23. Scott RA, Irving R, Irwin L, et al. ACTN3 and ACE genotypes in elite jamaican and US sprinters. Med Sci Sport Exerc, 2010, 42(1):107-112.
24. Ruiz JR, Arteta D, Buxens A, et al. Can we identify a power-oriented polygenic profile? J Appl Physiol, 2010, 108(3):561-566.
25. Shahmoradi S, Ahmadalipour A, Salehi M. Evaluation of ACE gene I/D polymorphism in Iranian elite athletes. Adv Biomed Res, 2014, 3(1):207-213.
26. Eynon N, Alves AJ, Yamin C, et al. Is there an ACE ID-ACTN3 R577X polymorphisms interaction that influences sprint performance? Int J Sports Med, 2009, 30(12):888-891.
27. Drozdovska SB, Dosenko VE, Ahmetov Ⅱ, et al. The association of gene polymorphisms with athlete status in Ukrainians. Biol Sport, 2013, 30(3):163-167.
28. Grenda A, Leońska-Duniec A, Kaczmarczyk M, et al. Interaction between ACE I/D and ACTN3 R557X polymorphisms in Polish competitive swimmers. J Hum Kinet, 2014, 42(1):127-136.
29. Wang G, Mikami E, Chiu LL, et al. Association analysis of ACE and ACTN3 in elite Caucasian and East Asian swimmers. Med Sci Sportd Exerc, 2013, 45(5):892-900.
30. Ash GI, Scott RA, Dawson TA, et al. No Association between ACE Gene Variation and Endurance Athlete Status in Ethiopians. Med Sci Sports Exerc, 2011, 43(4):590-597.
31. 孙小敏, 甄文娟, 王煜, 等. 运动员血管紧张素转换酶基因插入或缺失多态性研究. 中国运动医学杂志, 2004, 23(5):546-547.
32. 赵云, 马力宏. 优秀力量运动员ACE基因I/D多态性与运动能力的关联研究. 中国运动医学杂志, 2000, 19(3):308-310.
33. 余黎霞, 宋磊刚. 武术散打运动员ACE基因I/D多态性研究. 现代预防医学, 2010, 37(5):893-896.
34. 张坤, 江雪, 鲜贵平, 等. 跳远运动员血管紧张素转化酶基因插入/缺失多态性研究. 重庆医学, 2015, 44(1):18-20.
35. Kikuchi N, Min SK, Ueda D, et al. Higher frequency of the ACTN3 R allele + ACE DD genotype in Japanese elite wrestlers. J Strength Cond Res, 2012, 26(12):3275-3280.
36. Kim CH, Cho JY, Jeon JY, et al. ACE DD genotype is unfavorable to Korean short-term muscle power athletes. Int J Sports Med, 2010, 31(1):65-71.
37. Hagberg J, Rankinen T, Loos RJ, et al. Advances in exercise, fitness, and performance genomics in 2010. Med Sci Sports Exer, 2011, 43(5):743-752.
38. Guth LM, Roth SM. Genetic influence on athletic performance. Curr Opin Pediatr, 2013, 25(6):653-658.
39. Woods D. Angiotensin-converting enzyme, renin-angiotensin system and human performance. Med Sport Sci, 2009, 54:72-87.
40. 杨若愚, 王予彬, 沈勋章, 等. 杰出爆发力素质与基因多态性研究进展. 中国医药导报, 2014, 11(19):163-168.

Chinese Journal of Evidence-Based Medicine

Association between the Insertion/Deletion Polymorphism of ACE Gene and Athletes' Sport Performance in Power Sports: A Meta-analysis

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