How to Conduct Dose-response Meta-analysis:Method of Adjustment of Non-randomized Error_Chinese Journal of Evidence-Based Medicine

Authors：

 XUChang ^1,2 ^# ,  ZHANGChao ¹ ^# , KWONGJoey S. W ³ , YUANRui-xia ⁴ , WENGHong ^5,6 ,  NIUYu-ming ^1,7

1. Center for Evidence-based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China;
2. Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;
3. Clinical Research and Evaluation Unit, Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China;
4. Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University and Global Health Institute, Wuhan University, Wuhan 430071, China;
5. Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430071, China;
6. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;
7. Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China;

Corresponding author：

NIUYu-ming, Email: niuyuming@yeah.net

Keywords：

Dose-response relationship; Meta-analysis; Non-randomized error; Bias

DOI：

10.7507/1672-2531.20160075

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

As a valid method in systematic review, dose-response meta-analysis is widely used in investigating the relationship between independent variable and dependent variable, and which usually based on observational studies. With large sample size, observational studies can provide a reasonable amount of statistical power for meta-analysis. However, due to the design defects of observational studies, they tend to introduce many kinds of biases, which may influence the final results that make them deviation from the truth. Given the dead zone of methodology, there is no any bias adjusting method in dose-response meta-analysis. In this article, we will introduce some bias adjusting methods from other observational-study-based meta-analysis and make them suit for dose-response meta-analysis, and then compare the advantages and disadvantages of these methods.

Citation： XUChang, ZHANGChao, KWONGJoey S. W, YUANRui-xia, WENGHong, NIUYu-ming. How to Conduct Dose-response Meta-analysis:Method of Adjustment of Non-randomized Error. Chinese Journal of Evidence-Based Medicine, 2016, 16(4): 488-491. doi: 10.7507/1672-2531.20160075 Copy

1.	Sedgwick P. Bias in observational study designs:case-control studies. BMJ, 2015, 350:h560.
2.	Sedgwick P. Bias in observational study designs:prospective cohort studies. BMJ, 2014, 349:g7731.
3.	Rota M, Bellocco R, Scotti L, et al. Random-effects meta-regression models for studying nonlinear dose-response relationship, with an application to alcohol and esophageal squamous cell carcinoma. Stat Med, 2010, 29(26):2679-2687.
4.	Ioannidis JPA. Commentary:Adjusting for bias:a user's guide to performing plastic surgery on meta-analyses of observational studies. Int J Epidemiol, 2011, 40(3):777-779.
5.	Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[Updated March 2011]. Available at:http://www.cochrane-handbook.org.
6.	Thompson S, Ekelund U, Jebb S, et al. A proposed method of bias adjustment for meta-analyses of published observational studies. Int J Epidemiol, 2011, 40(3):765-777.
7.	罗杰, 冷卫东, 主编. 系统评价/Meta分析理论与实践. 第1版. 北京:军事医学科学出版社, 2013:127-133.
8.	Zeng X, Zhang Y, Kwong JSW, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline:a systematic review. J Evid-Based Med, 2015, 8(1):2-10.
9.	Wells GA, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2011. Available at:http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm.
10.	徐畅, 张永刚, 韩芳芳, 等. 剂量反应Meta分析的方法学简介. 中国循证医学杂志, 2015, 15(10):1236-1240.
11.	盛骤, 谢式千, 潘承毅, 编著. 概率论与数理统计. 第4版. 北京:高等教育出版社, 2008:149-177.
12.	Greenland S, O'rourke K. On the bias produced by quality scores in meta-analysis, and a hierarchical view of proposed solutions. Biostatistics, 2001, 2(4):463-471.

1. Sedgwick P. Bias in observational study designs:case-control studies. BMJ, 2015, 350:h560.
2. Sedgwick P. Bias in observational study designs:prospective cohort studies. BMJ, 2014, 349:g7731.
3. Rota M, Bellocco R, Scotti L, et al. Random-effects meta-regression models for studying nonlinear dose-response relationship, with an application to alcohol and esophageal squamous cell carcinoma. Stat Med, 2010, 29(26):2679-2687.
4. Ioannidis JPA. Commentary:Adjusting for bias:a user's guide to performing plastic surgery on meta-analyses of observational studies. Int J Epidemiol, 2011, 40(3):777-779.
5. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[Updated March 2011]. Available at:http://www.cochrane-handbook.org.
6. Thompson S, Ekelund U, Jebb S, et al. A proposed method of bias adjustment for meta-analyses of published observational studies. Int J Epidemiol, 2011, 40(3):765-777.
7. 罗杰, 冷卫东, 主编. 系统评价/Meta分析理论与实践. 第1版. 北京:军事医学科学出版社, 2013:127-133.
8. Zeng X, Zhang Y, Kwong JSW, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline:a systematic review. J Evid-Based Med, 2015, 8(1):2-10.
9. Wells GA, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2011. Available at:http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm.
10. 徐畅, 张永刚, 韩芳芳, 等. 剂量反应Meta分析的方法学简介. 中国循证医学杂志, 2015, 15(10):1236-1240.
11. 盛骤, 谢式千, 潘承毅, 编著. 概率论与数理统计. 第4版. 北京:高等教育出版社, 2008:149-177.
12. Greenland S, O'rourke K. On the bias produced by quality scores in meta-analysis, and a hierarchical view of proposed solutions. Biostatistics, 2001, 2(4):463-471.

Previous Article
Examples Interpretation of WHO Guidelines
Next Article
A Brief Introduction of Jadad Algorithm of Interpreting Discordant Meta-analyses

Chinese Journal of Evidence-Based Medicine

How to Conduct Dose-response Meta-analysis:Method of Adjustment of Non-randomized Error

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content