As a valid method in systematic review, dose-response meta-analysis is widely used in investigating the relationship between independent variable and dependent variable, and which usually based on observational studies. With large sample size, observational studies can provide a reasonable amount of statistical power for meta-analysis. However, due to the design defects of observational studies, they tend to introduce many kinds of biases, which may influence the final results that make them deviation from the truth. Given the dead zone of methodology, there is no any bias adjusting method in dose-response meta-analysis. In this article, we will introduce some bias adjusting methods from other observational-study-based meta-analysis and make them suit for dose-response meta-analysis, and then compare the advantages and disadvantages of these methods.
Citation：
XUChang, ZHANGChao, KWONGJoey S. W, YUANRui-xia, WENGHong, NIUYu-ming. How to Conduct Dose-response Meta-analysis:Method of Adjustment of Non-randomized Error. Chinese Journal of Evidence-Based Medicine, 2016, 16(4): 488-491. doi: 10.7507/1672-2531.20160075
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Copyright © the editorial department of Chinese Journal of Evidence-Based Medicine of West China Medical Publisher. All rights reserved
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- 1. Sedgwick P. Bias in observational study designs:case-control studies. BMJ, 2015, 350:h560.
- 2. Sedgwick P. Bias in observational study designs:prospective cohort studies. BMJ, 2014, 349:g7731.
- 3. Rota M, Bellocco R, Scotti L, et al. Random-effects meta-regression models for studying nonlinear dose-response relationship, with an application to alcohol and esophageal squamous cell carcinoma. Stat Med, 2010, 29(26):2679-2687.
- 4. Ioannidis JPA. Commentary:Adjusting for bias:a user's guide to performing plastic surgery on meta-analyses of observational studies. Int J Epidemiol, 2011, 40(3):777-779.
- 5. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[Updated March 2011]. Available at:http://www.cochrane-handbook.org.
- 6. Thompson S, Ekelund U, Jebb S, et al. A proposed method of bias adjustment for meta-analyses of published observational studies. Int J Epidemiol, 2011, 40(3):765-777.
- 7. 罗杰, 冷卫东, 主编. 系统评价/Meta分析理论与实践. 第1版. 北京:军事医学科学出版社, 2013:127-133.
- 8. Zeng X, Zhang Y, Kwong JSW, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline:a systematic review. J Evid-Based Med, 2015, 8(1):2-10.
- 9. Wells GA, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2011. Available at:http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm.
- 10. 徐畅, 张永刚, 韩芳芳, 等. 剂量反应Meta分析的方法学简介. 中国循证医学杂志, 2015, 15(10):1236-1240.
- 11. 盛骤, 谢式千, 潘承毅, 编著. 概率论与数理统计. 第4版. 北京:高等教育出版社, 2008:149-177.
- 12. Greenland S, O'rourke K. On the bias produced by quality scores in meta-analysis, and a hierarchical view of proposed solutions. Biostatistics, 2001, 2(4):463-471.
