Application of the Trial Sequential Analysis Software for Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 WENGHong ^1,2,3 , LISheng ^1,2,3 , ZENGXian-Tao ^1,2,3 , WUShan-Shan ⁴ , LIUng ^2,5 ,  WANGXing-Huan ^1,2,3

1. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;
2. Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430071, China;
3. Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;
4. National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China;
5. Department of Epidemiology, School of Public Health, Wuhan University, Wuhan 430071, China;

Corresponding author：

WANGXing-Huan, Email: wangxinghuan@whu.edu.cn

Keywords：

Systematic review; Meta-analysis; Trial sequential analysis; Sample size

DOI：

10.7507/1672-2531.20160093

Video：

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Abstract Full text Figures/Tables Video References Cited by

The robustness of results of statistical analysis would be altered on the condition of repeated update of traditional meta-analysis and cumulative meta-analysis. In addition, the cumulative meta-analysis lacks estimation of the sample size. While trail sequential analysis (TSA), which introduces group sequential analysis in meta-analysis, can adjust the random error and ultimately estimate the required sample size of the systematic review or meta-analysis. TSA is performed in TSA software. In the present study, we aimed to introduce how to use the TSA software for performing meta-analysis.

Citation： WENGHong, LISheng, ZENGXian-Tao, WUShan-Shan, LIUng, WANGXing-Huan. Application of the Trial Sequential Analysis Software for Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(5): 604-611. doi: 10.7507/1672-2531.20160093 Copy

1.	罗杰, 冷卫东. 系统评价/Meta分析理论与实践. 北京:军事医学科学出版社, 2013.
2.	曾宪涛, 邝心颖, 孙燕, 等. 什么是循证医学? 湖北医药学院学报, 2013, 32(1): 1-5.
3.	曾宪涛, 冷卫东, 郭毅, 等. Meta分析系列之一: Meta分析的类型. 中国循证心血管医学杂志, 2012, 4(1): 3-5.
4.	Pogue JM, Yusuf S. Cumulating Evidence from Randomized Trials: Utilizing Sequential Monitoring Boundaries for Cumulative Meta-Analysis. Control Clin Trials, 1997, 18(6): 580-593.
5.	Pogue J, Yusuf S. Overcoming the limitations of current meta-analysis of randomised controlled trials. Lancet, 1998, 351(9095): 47-52.
6.	Thorlund K, Devereaux PJ, Wetterslev J, et al. Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?. Int J Epidemiol, 2009, 38(1): 276-286.
7.	Wetterslev J, Thorlund K, Brok J, et al. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol, 2008, 61(1): 64-75.
8.	Brok J, Thorlund K, Gluud C, et al. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol, 2008, 61(8): 763-769.
9.	Brok J, Thorlund K, Wetterslev J, et al. Apparently conclusive meta-analyses may be inconclusive——Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Int J Epidemiol, 2009, 38(1): 287-298.
10.	Trikalinos TA, Churchill R, Ferri M, et al. Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time. J Clin Epidemiol, 2004, 57(11): 1124-1130.
11.	王权, 田金徽, 李伦, 等. 试验序贯分析简介. 中国循证医学杂志, 2013, 13(10): 1265-1268.
12.	夏芸, 孙瑛, 刘兆兰, 等. 系统综述或Meta分析的样本量估算——试验序贯分析. 现代中医临床, 2013, 20(5): 31-33.
13.	王欢, 胡厚祥. 试验序贯性分析在随机对照试验Meta分析中的运用. 重庆医学, 2015, 44(21): 2996-2999.
14.	王权, 田金徽, 李伦, 等. 试验序贯分析与Meta分析所需样本量的估算. 兰州大学学报:医学版, 2015, 41(4): 76-80.
15.	Thorlund K, Engstrøm J, Wetterslev J, et al. User manual for trial sequential analysis (TSA). Copenhagen Trial Unit. [Accessed 2011] Available at: http://wwwctudk/tsa/files/tsa_manualpdf.
16.	Li S, Kwong JSW, Zeng XT, et al. Plasmakinetic resection technology for the treatment of benign prostatic hyperplasia: evidence from a systematic review and meta-analysis. Sci Rep, 2015, 5: 12002.
17.	曾宪涛, 李胜, 雷晋, 等. Review Manager 5软件在诊断准确性试验的Meta分析中的应用. 湖北医药学院学报, 2013, 32(1): 6-16.

1. 罗杰, 冷卫东. 系统评价/Meta分析理论与实践. 北京:军事医学科学出版社, 2013.
2. 曾宪涛, 邝心颖, 孙燕, 等. 什么是循证医学? 湖北医药学院学报, 2013, 32(1): 1-5.
3. 曾宪涛, 冷卫东, 郭毅, 等. Meta分析系列之一: Meta分析的类型. 中国循证心血管医学杂志, 2012, 4(1): 3-5.
4. Pogue JM, Yusuf S. Cumulating Evidence from Randomized Trials: Utilizing Sequential Monitoring Boundaries for Cumulative Meta-Analysis. Control Clin Trials, 1997, 18(6): 580-593.
5. Pogue J, Yusuf S. Overcoming the limitations of current meta-analysis of randomised controlled trials. Lancet, 1998, 351(9095): 47-52.
6. Thorlund K, Devereaux PJ, Wetterslev J, et al. Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?. Int J Epidemiol, 2009, 38(1): 276-286.
7. Wetterslev J, Thorlund K, Brok J, et al. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol, 2008, 61(1): 64-75.
8. Brok J, Thorlund K, Gluud C, et al. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol, 2008, 61(8): 763-769.
9. Brok J, Thorlund K, Wetterslev J, et al. Apparently conclusive meta-analyses may be inconclusive——Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Int J Epidemiol, 2009, 38(1): 287-298.
10. Trikalinos TA, Churchill R, Ferri M, et al. Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time. J Clin Epidemiol, 2004, 57(11): 1124-1130.
11. 王权, 田金徽, 李伦, 等. 试验序贯分析简介. 中国循证医学杂志, 2013, 13(10): 1265-1268.
12. 夏芸, 孙瑛, 刘兆兰, 等. 系统综述或Meta分析的样本量估算——试验序贯分析. 现代中医临床, 2013, 20(5): 31-33.
13. 王欢, 胡厚祥. 试验序贯性分析在随机对照试验Meta分析中的运用. 重庆医学, 2015, 44(21): 2996-2999.
14. 王权, 田金徽, 李伦, 等. 试验序贯分析与Meta分析所需样本量的估算. 兰州大学学报:医学版, 2015, 41(4): 76-80.
15. Thorlund K, Engstrøm J, Wetterslev J, et al. User manual for trial sequential analysis (TSA). Copenhagen Trial Unit. [Accessed 2011] Available at: http://wwwctudk/tsa/files/tsa_manualpdf.
16. Li S, Kwong JSW, Zeng XT, et al. Plasmakinetic resection technology for the treatment of benign prostatic hyperplasia: evidence from a systematic review and meta-analysis. Sci Rep, 2015, 5: 12002.
17. 曾宪涛, 李胜, 雷晋, 等. Review Manager 5软件在诊断准确性试验的Meta分析中的应用. 湖北医药学院学报, 2013, 32(1): 6-16.

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