Association between SNP BsmI (rs1544410) in Vitamin D Receptor Gene and Coronary Artery Disease: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHAOQiong-rui ¹ , HUANGDong-hui ¹ , HOUXiao-wen ¹ , JIACheng-yong ³ ,  SHIJing-pu ^1,2,4

1. Department of Clinical Epidemiology and Evidence-based Medicine, First Affiliated Hospital, China Medical University, Shenyang 110001, China;
2. Institute of Cardiovascular Diseases, China Medical University, Shenyang 110001, China;
3. Department of Public Health, China Medical University, Shenyang 110001, China;
4. Center of Evidence-Based Medicine of Liaoning Province, China Medical University, Shenyang 110001, China;

Corresponding author：

SHIJing-pu, Email: sjp562013@126.com

Keywords：

Vitamin D Receptor; BsmI (rs1544410); Genetic polymorphisms; Coronary artery disease; Meta-analysis

DOI：

10.7507/1672-2531.20160120

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Objective To evaluate the association between the Single Nucleotide Polymorphism (SNP) BsmI (rs1544410) in the vitamin D receptor gene and the susceptibility of coronary artery disease. Methods Databases including PubMed, Web of Science, CNKI, WanFang Data, VIP and CBM were searched from inception to May, 2016 to collect case-control studies about SNP BsmI (rs1544410) in the vitamin D receptor gene and the susceptibility of coronary artery disease. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Then Meta-analysis was performed by using RevMan 5.3. Results A total of seven studies were included, which involved 2182 patients and 5925 controls. The results of meta-analyses showed that the B allele and BB genotype in rs1544410 was associated with the risk of coronary artery disease (B vs. b:OR=1.36, 95%CI 1.03 to 1.79, P=0.03; BB vs. bb:OR=1.70, 95%CI 1.06 to 2.72, P=0.03; BB+Bb vs. bb:OR=1.52, 95%CI 1.00 to 2.30, P=0.05). Subgroup analysis by age showed that rs1544410 was associated with the risk of coronary artery disease in the age <65(B vs. b:OR=1.65, 95%CI 1.00 to 2.73, P=0.05; BB vs. Bb+ bb:OR=1.79, 95%CI 1.08 to 2.97, P=0.02; BB vs. bb:OR=2.64, 95%CI 1.12 to 6.25, P=0.03). Subgroup analysis by ethnicity showed that rs1544410 was associated with the risk of coronary artery disease in Caucasians (B vs. b:OR=1.47, 95%CI 1.10 to 1.97, P=0.01; BB+Bb vs. bb:OR=1.71, 95%CI 1.09 to 2.68, P=0.02; BB vs. Bb+bb:OR=1.39, 95%CI 1.01 to 1.92, P=0.05; BB vs. bb:OR=1.80, 95%CI 1.10 to 2.95, P=0.03). Subgroup analysis by genotyping methods showed that rs1544410 was associated with the risk of coronary artery disease in the TaqMan (B vs. b:OR=2.18, 95%CI 1.06 to 4.45, P=0.03; BB+Bb vs. bb:OR=3.32, 95%CI 1.06 to 10.40, P=0.04; BB vs. bb:OR=3.31, 95%CI 1.06 to 10.30, P=0.04). Subgroup analysis by diagnostic criteria for cases showed that rs1544410 was associated with the risk of coronary artery disease in the ECG (B vs. b:OR=1.15, 95%CI 1.02 to 1.29, P=0.02; BB+Bb vs. bb:OR=1.22, 95%CI 1.02 to 1.45, P=0.03; BB vs. bb:OR=1.31, 95%CI 1.03 to1.67, P=0.03). Conclusion BsmI (rs1544410) B allele may have a significant association with the high risk of coronary artery disease especially the Caucasians and the ones with age <65.

Citation： ZHAOQiong-rui, HUANGDong-hui, HOUXiao-wen, JIACheng-yong, SHIJing-pu. Association between SNP BsmI (rs1544410) in Vitamin D Receptor Gene and Coronary Artery Disease: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(7): 771-779. doi: 10.7507/1672-2531.20160120 Copy

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2.	Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med, 2006, 3(11):e442.
3.	Haussler MR, Haussler CA, Jurutka PW, et al. The vitamin D hormone and its nuclear receptor:molecular actions and disease states. J Endocrinol, 1997, 154 Suppl:S57-73.
4.	Dowd DR, MacDonald PN. The 1,25-dihydroxyvitamin D3-independent actions of the vitamin D receptor in skin. J Steroid Biochem Mol Biol, 2010, 121(1-2):317-21.
5.	Fukazawa T, Yabe I, Kikuchi S, et al. Association of vitamin D receptor gene polymorphism with multiple sclerosis in Japanese. J Neurol Sci, 1999, 166(1):47-52.
6.	Raimondi S, Johansson H, Maisonneuve P, et al. Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis, 2009, 30(7):1170-1180.
7.	Ortlepp JR, Lauscher J, Hoffmann R, et al. The vitamin D receptor gene variant is associated with the prevalence of type 2 diabetes mellitus and coronary artery disease. Diabet Med, 2001, 18(10):842-845.
8.	Ortlepp JR, Krantz C, Kimmel M, et al. Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years. Int J Cardiol, 2005, 105(1):90-95.
9.	Pan XM, Li DR, Yang L, et al. No association between vitamin D receptor polymorphisms and coronary artery disease in a Chinese population. DNA Cell Biol, 2009, 28(10):521-525.
10.	Ferrarezi DA, Bellili-Munoz N, Dubois-Laforgue D, et al. Allelic variations of the vitamin D receptor (VDR) gene are associated with increased risk of coronary artery disease in type 2 diabetics:the DIABHYCAR prospective study. Diabetes Metab, 2013, 39(3):263-270.
11.	Santoro D, Buemi M, Gagliostro G, et al. Association of VDR gene polymorphisms with heart disease in chronic kidney disease patients. Clin Biochem, 2015, 48(16-17):1028-1032.
12.	Zmuda JM, Cauley JA, Ferrell RE. Molecular epidemiology of vitamin D receptor gene variants. Epidemiol Rev, 2000, 22(2):203-217.
13.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9):603-605.
14.	Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11):1539-1558.
15.	Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4):1088-1101.
16.	Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109):629-634.
17.	Dixon KM, Mason RS. Vitamin d. Int J Biochem Cell Biol, 2009, 41(5):982-985.
18.	Roy S, Frodsham A, Saha B, et al. Association of vitamin D receptor genotype with leprosy type. J Infect Dis, 1999, 179(1):187-191.
19.	宋琳, 韩睿. 2型糖尿病患者维生素D受体基因多态性与大血管病变的关系. 中华临床医师杂志(电子版), 2013, 7(4):167-8.
20.	Thomas MG, Tebbutt S, Williamson RC. Vitamin D and its metabolites inhibit cell proliferation in human rectal mucosa and a colon cancer cell line. Gut, 1992, 33(12):1660-1663.
21.	Cheon CK, Nam HK, Lee KH, et al. Vitamin D receptor gene polymorphisms and type 1 diabetes mellitus in a Korean population. Pediatr Int, 2015, 57(5):870-874.
22.	Morrison NA, Qi JC, Tokita A, et al. Prediction of bone density from vitamin D receptor alleles. Nature, 1994, 367(6460):284-287.
23.	Qiao G, Kong J, Uskokovic M, et al. Analogs of 1alpha, 25-dihydroxyvitamin D(3) as novel inhibitors of renin biosynthesis. J Steroid Biochem Mol Biol, 2005, 96(1):59-66.
24.	Stathopoulou MG, Dedoussis GV, Trovas G, et al. The role of vitamin D receptor gene polymorphisms in the bone mineral density of Greek postmenopausal women with low calcium intake. J Nutr Biochem, 2011, 22(8):752-757.

1. World Health Organization. The Atlas of Heart Disease and Stroke. Available at:http://www.who.int/cardiovascular_diseases/resources/atlas/en/.
2. Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med, 2006, 3(11):e442.
3. Haussler MR, Haussler CA, Jurutka PW, et al. The vitamin D hormone and its nuclear receptor:molecular actions and disease states. J Endocrinol, 1997, 154 Suppl:S57-73.
4. Dowd DR, MacDonald PN. The 1,25-dihydroxyvitamin D3-independent actions of the vitamin D receptor in skin. J Steroid Biochem Mol Biol, 2010, 121(1-2):317-21.
5. Fukazawa T, Yabe I, Kikuchi S, et al. Association of vitamin D receptor gene polymorphism with multiple sclerosis in Japanese. J Neurol Sci, 1999, 166(1):47-52.
6. Raimondi S, Johansson H, Maisonneuve P, et al. Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis, 2009, 30(7):1170-1180.
7. Ortlepp JR, Lauscher J, Hoffmann R, et al. The vitamin D receptor gene variant is associated with the prevalence of type 2 diabetes mellitus and coronary artery disease. Diabet Med, 2001, 18(10):842-845.
8. Ortlepp JR, Krantz C, Kimmel M, et al. Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years. Int J Cardiol, 2005, 105(1):90-95.
9. Pan XM, Li DR, Yang L, et al. No association between vitamin D receptor polymorphisms and coronary artery disease in a Chinese population. DNA Cell Biol, 2009, 28(10):521-525.
10. Ferrarezi DA, Bellili-Munoz N, Dubois-Laforgue D, et al. Allelic variations of the vitamin D receptor (VDR) gene are associated with increased risk of coronary artery disease in type 2 diabetics:the DIABHYCAR prospective study. Diabetes Metab, 2013, 39(3):263-270.
11. Santoro D, Buemi M, Gagliostro G, et al. Association of VDR gene polymorphisms with heart disease in chronic kidney disease patients. Clin Biochem, 2015, 48(16-17):1028-1032.
12. Zmuda JM, Cauley JA, Ferrell RE. Molecular epidemiology of vitamin D receptor gene variants. Epidemiol Rev, 2000, 22(2):203-217.
13. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9):603-605.
14. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11):1539-1558.
15. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4):1088-1101.
16. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109):629-634.
17. Dixon KM, Mason RS. Vitamin d. Int J Biochem Cell Biol, 2009, 41(5):982-985.
18. Roy S, Frodsham A, Saha B, et al. Association of vitamin D receptor genotype with leprosy type. J Infect Dis, 1999, 179(1):187-191.
19. 宋琳, 韩睿. 2型糖尿病患者维生素D受体基因多态性与大血管病变的关系. 中华临床医师杂志(电子版), 2013, 7(4):167-8.
20. Thomas MG, Tebbutt S, Williamson RC. Vitamin D and its metabolites inhibit cell proliferation in human rectal mucosa and a colon cancer cell line. Gut, 1992, 33(12):1660-1663.
21. Cheon CK, Nam HK, Lee KH, et al. Vitamin D receptor gene polymorphisms and type 1 diabetes mellitus in a Korean population. Pediatr Int, 2015, 57(5):870-874.
22. Morrison NA, Qi JC, Tokita A, et al. Prediction of bone density from vitamin D receptor alleles. Nature, 1994, 367(6460):284-287.
23. Qiao G, Kong J, Uskokovic M, et al. Analogs of 1alpha, 25-dihydroxyvitamin D(3) as novel inhibitors of renin biosynthesis. J Steroid Biochem Mol Biol, 2005, 96(1):59-66.
24. Stathopoulou MG, Dedoussis GV, Trovas G, et al. The role of vitamin D receptor gene polymorphisms in the bone mineral density of Greek postmenopausal women with low calcium intake. J Nutr Biochem, 2011, 22(8):752-757.

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Association between SNP BsmI (rs1544410) in Vitamin D Receptor Gene and Coronary Artery Disease: A Meta-analysis

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