Diagnostic Value of HLA-B27 Tests for Ankylosing Spondylitis in Chinese Population: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 AIJin-wei ^1,2 ^# ,  LIUYing ^1,2 ^# , GUANXiang-fei ² , CHENQiong ² , ZHANGWei ² , DENGJin ² ,  PEIBin ^1,2

1. Evidence-based Medicine Center, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;
2. Department of Micro-orthopedic Surgery, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;

Corresponding author：

PEIBin, Email: xyxzyxzx@163.com

Keywords：

HLA-B27; Ankylosing spondylitis; Diagnostic test; Chinese population; Meta-analysis

DOI：

10.7507/1672-2531.20160124

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the diagnostic value of HLA-B27 for ankylosing spondylitis (AS) in Chinese population. Methods We searched PubMed, EMbase, The Cochrane Library (Issue 8, 2015), CNKI, and WanFang data from inception to August 2015, to collect diagnostic studies about HLA-B27 for AS in Chinese population. Two reviewers independently screened literature, extracted data, and assessed the methodological quality of included studies. Then meta-analysis was performed by using Stata12.0 software. Results A total of 16 studies involving 3137 AS and 5617 suspect patients were finally included. The results of meta-analysis showed that the pooled Sen, Spe, +LR, -LR and DOR were 0.91(95%CI 0.89 to 0.93), 0.94(95%CI 0.91 to 0.96), 14.90(95%CI 9.60 to 23.10), 0.09(95%CI 0.08 to 0.12) and 157.00(95%CI 90.00 to 275.00), respectively. The AUC of SROC was 0.98(95%CI 0.93 to 0.97). Conclusions HLA-B27 detection is of great diagnostic value for AS in Chinese population. However, due to the limited quality and quantity of the included studies, more long-term follow-up prospective studies are needed to verify the above conclusion.

Citation： AIJin-wei, LIUYing, GUANXiang-fei, CHENQiong, ZHANGWei, DENGJin, PEIBin. Diagnostic Value of HLA-B27 Tests for Ankylosing Spondylitis in Chinese Population: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(7): 802-808. doi: 10.7507/1672-2531.20160124 Copy

1.	黎勤云, 李志强.强直性脊柱炎相关HLA-B27的研究进展.中国输血杂志, 2012, 25(11):1138-1140.
2.	Dougados M, Paternotte S, Braun J, et al. ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial spondyloarthritis. Ann Rheum Dis, 2011, 70(2):249-251.
3.	Linden S, Valkenburg H, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum, 1984, 27(4):361-388.
4.	Rachid B, Zorkany B, Youseif E, et al. Early diagnosis and treatment of ankylosing spondylitis in Africa and the Middle East. Clin Rheumatol, 2012, 31(11):1633-1639.
5.	Popa O, Bojinca M, Bojinca V, et al. Distribution of HLA-B27 in Romanian spondyloarthritides patients. Int J Immunopharmacol, 2010, 37(6):513-516.
6.	Acar M, Cora T, Tunc R, et al. HLA-B27 subtypes in Turkish patients with ankylosing spondylitis and healthy controls. Rheumatol Int, 2012, 32(10):3103-3105.
7.	蒋娟, 熊小敏, 张卫云, 等.人白细胞抗原HLA-B27在强直性脊柱炎中的临床意义.生物技术通讯, 2014, 25(3):410-411.
8.	于莉. PCR-SSP法、FCM法及MLCT法检测强直性脊柱炎患者HLA-B27对比分析.风湿病与关节炎, 2014, 10(3):13-15.
9.	艾金伟, 李德胜, 刘羽, 等.国内HLA-B27诊断强直性脊柱炎价值的Meta分析.中国循证医学杂志, 2015, 15(9):1059-1067.
10.	Moher D, Liberati A, Tetzlaff J, et al. Reprint——preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement. Phys Ther, 2009, 89(9):873-880.
11.	尹森林, 刘雪梅, 何林, 等.对系统评价/Meta分析报告规范的系统评价.中国循证医学杂志, 2011, 11(8):971-977.
12.	曾宪涛, Joey S, 田国祥, 等. Meta分析系列之二:Meta分析的软件.中国循证心血管医学杂志, 2012, 4(2):89-91.
13.	徐建业, 林丁, 李伟道, 等.甲胎蛋白诊断原发性肝癌准确性的系统评价.中国循证医学杂志, 2009, 9(5):525-530.
14.	王海军, 李彦彦, 王慧春, 等.双时相18F-FDG PET鉴别肺部良恶性病变准确性的Meta分析.中国循证医学杂志, 2013, 13(11):1326-1332.
15.	张俊, 徐志伟, 李克.诊断性试验Meta分析的效应指标评价.中国循证医学杂志, 2013, 13(7):890-895.
16.	倪吴花, 胡晓霞, 章圣辉, 等.强直性脊柱炎867例HLA-B27的表达及意义.实用医学杂志, 2008, 24(9):1511-1513.
17.	章涛, 方宁, 祁莹, 等.强直性脊柱炎疑似患者HLA-B27检测结果分析.山东医药, 2008, 48(37):83-84.
18.	何进才, 傅新文, 侯智辉, 等. HLA-B27基因检测对强直性脊柱炎诊断的评价.江西医学检验, 2003, 21(4):240-242.
19.	方宁, 章涛, 胡锡阶, 等.外周血T淋巴细胞HLA-B27检测辅助诊断强直性脊柱炎.免疫学杂志, 2009, 25(2):210-213.
20.	邓小军, 谢志雄, 张阳根. HLA-B27抗原检测在诊断AS中的意义.实用医技杂志, 2006, 13(4):505-507.
21.	陈建华, 魏文宁, 喻喜. PCR-SSP法与流式细胞仪检测强直性脊柱炎患者HLA-B27的比较.检验医学与临床, 2007, 4(3):161-162.
22.	吴娟.检测强直性脊柱炎患者人类白细胞抗原B27的Il缶床意义.检验医学与临床, 2013, 10(6):663-665.
23.	胡庆宏, 易诚予, 彭燕, 等.江西地区强直性脊柱炎与HLA-B27基因关联性.中国组织工程研究与临床康复, 2009, 13(46):9183-9186.
24.	蒋娟, 熊小敏, 张卫云, 等.人白细胞抗原HLA-B27在强直性脊柱炎中的临床意义.生物技术通讯, 2014, 25(3):410-411.
25.	林静华, 方琳丽, 陈彦融, 等. HLA-B27抗原检测在强直性脊柱炎诊断中的价值.中国热带医学, 2013, 8(11):1946-1948.
26.	邱金英.流式细胞术检测HLA-B27抗原在强直性脊柱炎诊断中的价值.现代医院, 2009, 9(Suppl):171-173.
27.	刘波, 邱萌.早中期强直性脊柱炎患者两种检测HLA-B27方法比较.中国医药导报, 2011, 8(13):47-48.
28.	罗玲, 严海燕, 罗晓红. HLA-B27/B7抗原检测在诊断强直性脊柱炎中的临床价值.中国实用医药, 2013, 8(4):8-9.
29.	刘永杰, 张小芳, 张运刚, 等. HLA-B27检测对强直性脊柱炎诊断的临床意义.国际检验医学杂志, 2014, 35(10):1285-1286.
30.	谢能轩, 章健, 黄晓超, 等.强直性脊柱炎患者CD3+ T细胞HLA-B27表达水平.临床检验杂志, 2008, 26(4):281.
31.	黄传英.强直性脊柱炎免疫指标检测及临床价值.临床输血与检验, 2006, 8(3):187-189.
32.	Browerton D, Hart F, Nichous N, et al. Ankylosing spondylitis and HLA-B27. Lancet, 1973, 1(8):904-907.
33.	曾宪涛, 何明武.诊断准确性试验Meta分析软件一本通.北京:军事医学科学出版社, 2014:7-8.

1. 黎勤云, 李志强.强直性脊柱炎相关HLA-B27的研究进展.中国输血杂志, 2012, 25(11):1138-1140.
2. Dougados M, Paternotte S, Braun J, et al. ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial spondyloarthritis. Ann Rheum Dis, 2011, 70(2):249-251.
3. Linden S, Valkenburg H, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum, 1984, 27(4):361-388.
4. Rachid B, Zorkany B, Youseif E, et al. Early diagnosis and treatment of ankylosing spondylitis in Africa and the Middle East. Clin Rheumatol, 2012, 31(11):1633-1639.
5. Popa O, Bojinca M, Bojinca V, et al. Distribution of HLA-B27 in Romanian spondyloarthritides patients. Int J Immunopharmacol, 2010, 37(6):513-516.
6. Acar M, Cora T, Tunc R, et al. HLA-B27 subtypes in Turkish patients with ankylosing spondylitis and healthy controls. Rheumatol Int, 2012, 32(10):3103-3105.
7. 蒋娟, 熊小敏, 张卫云, 等.人白细胞抗原HLA-B27在强直性脊柱炎中的临床意义.生物技术通讯, 2014, 25(3):410-411.
8. 于莉. PCR-SSP法、FCM法及MLCT法检测强直性脊柱炎患者HLA-B27对比分析.风湿病与关节炎, 2014, 10(3):13-15.
9. 艾金伟, 李德胜, 刘羽, 等.国内HLA-B27诊断强直性脊柱炎价值的Meta分析.中国循证医学杂志, 2015, 15(9):1059-1067.
10. Moher D, Liberati A, Tetzlaff J, et al. Reprint——preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement. Phys Ther, 2009, 89(9):873-880.
11. 尹森林, 刘雪梅, 何林, 等.对系统评价/Meta分析报告规范的系统评价.中国循证医学杂志, 2011, 11(8):971-977.
12. 曾宪涛, Joey S, 田国祥, 等. Meta分析系列之二:Meta分析的软件.中国循证心血管医学杂志, 2012, 4(2):89-91.
13. 徐建业, 林丁, 李伟道, 等.甲胎蛋白诊断原发性肝癌准确性的系统评价.中国循证医学杂志, 2009, 9(5):525-530.
14. 王海军, 李彦彦, 王慧春, 等.双时相18F-FDG PET鉴别肺部良恶性病变准确性的Meta分析.中国循证医学杂志, 2013, 13(11):1326-1332.
15. 张俊, 徐志伟, 李克.诊断性试验Meta分析的效应指标评价.中国循证医学杂志, 2013, 13(7):890-895.
16. 倪吴花, 胡晓霞, 章圣辉, 等.强直性脊柱炎867例HLA-B27的表达及意义.实用医学杂志, 2008, 24(9):1511-1513.
17. 章涛, 方宁, 祁莹, 等.强直性脊柱炎疑似患者HLA-B27检测结果分析.山东医药, 2008, 48(37):83-84.
18. 何进才, 傅新文, 侯智辉, 等. HLA-B27基因检测对强直性脊柱炎诊断的评价.江西医学检验, 2003, 21(4):240-242.
19. 方宁, 章涛, 胡锡阶, 等.外周血T淋巴细胞HLA-B27检测辅助诊断强直性脊柱炎.免疫学杂志, 2009, 25(2):210-213.
20. 邓小军, 谢志雄, 张阳根. HLA-B27抗原检测在诊断AS中的意义.实用医技杂志, 2006, 13(4):505-507.
21. 陈建华, 魏文宁, 喻喜. PCR-SSP法与流式细胞仪检测强直性脊柱炎患者HLA-B27的比较.检验医学与临床, 2007, 4(3):161-162.
22. 吴娟.检测强直性脊柱炎患者人类白细胞抗原B27的Il缶床意义.检验医学与临床, 2013, 10(6):663-665.
23. 胡庆宏, 易诚予, 彭燕, 等.江西地区强直性脊柱炎与HLA-B27基因关联性.中国组织工程研究与临床康复, 2009, 13(46):9183-9186.
24. 蒋娟, 熊小敏, 张卫云, 等.人白细胞抗原HLA-B27在强直性脊柱炎中的临床意义.生物技术通讯, 2014, 25(3):410-411.
25. 林静华, 方琳丽, 陈彦融, 等. HLA-B27抗原检测在强直性脊柱炎诊断中的价值.中国热带医学, 2013, 8(11):1946-1948.
26. 邱金英.流式细胞术检测HLA-B27抗原在强直性脊柱炎诊断中的价值.现代医院, 2009, 9(Suppl):171-173.
27. 刘波, 邱萌.早中期强直性脊柱炎患者两种检测HLA-B27方法比较.中国医药导报, 2011, 8(13):47-48.
28. 罗玲, 严海燕, 罗晓红. HLA-B27/B7抗原检测在诊断强直性脊柱炎中的临床价值.中国实用医药, 2013, 8(4):8-9.
29. 刘永杰, 张小芳, 张运刚, 等. HLA-B27检测对强直性脊柱炎诊断的临床意义.国际检验医学杂志, 2014, 35(10):1285-1286.
30. 谢能轩, 章健, 黄晓超, 等.强直性脊柱炎患者CD3+ T细胞HLA-B27表达水平.临床检验杂志, 2008, 26(4):281.
31. 黄传英.强直性脊柱炎免疫指标检测及临床价值.临床输血与检验, 2006, 8(3):187-189.
32. Browerton D, Hart F, Nichous N, et al. Ankylosing spondylitis and HLA-B27. Lancet, 1973, 1(8):904-907.
33. 曾宪涛, 何明武.诊断准确性试验Meta分析软件一本通.北京:军事医学科学出版社, 2014:7-8.

Chinese Journal of Evidence-Based Medicine

Diagnostic Value of HLA-B27 Tests for Ankylosing Spondylitis in Chinese Population: A Meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content