• Department of Pharmacy, Beijing Obstetrics Gynecology Hospital Affiliated to Capital Medical University, Beijing 100006, China;
FENGXin, Email: fengxin1115@126.com
Export PDF Favorites Scan Get Citation

Objective To systematically review the efficacy and safety of intravenous calcium infusion for preventing ovarian hyperstimulation syndrome (OHSS). Methods Databases including PubMed, EMbase, The Cochrane Library (Issue 7, 2015), CNKI, Sinomed and WanFang Data were searched from inception to July 2015 to collect randomized controlled trials (RCTs) and non-RCTs about intravenous calcium infusion for OHSS. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of six studies involving 1 061 women were included. The results of meta-analysis showed that intravenous calcium infusion could reduce the incidence of moderate OHSS (RR=0.27, 95% CI 0.11 to 0.65, P=0.003), but not the incidence of severe OHSS (RR=0.77, 95% CI 0.23 to 2.63, P=0.68). In addition, intravenous calcium infusion had a tendency to increase the pregnant rate (RR=1.19, 95% CI 0.94 to 1.50, P=0.15). The subgroup analysis showed that, compared with placebo/no treatment, intravenous calcium infusion reduced the incidence of moderate OHSS, but not the incidence of severe OHSS. There were no statistical differences between intravenous calcium infusion and other positive control (cabergoline and hydroxyethyl starch) in the incidence of OHSS and pregnant rate. No side effect was reported in the studies included. Conclusions Current evidence indicates that intravenous calcium infusion can reduce the incidence of OHSS without influence pregnant outcomes. Due to the quantity and quality limitations of included studies, more high quality case-control or cohort studies are needed to verify the above conclusions.

Citation: WANGAi-hua, LIUXiao-yan, LIUQi, FENGXin. Efficacy and Safety of Intravenous Calcium Infusion for Preventing Ovarian Hyperstimulation Syndrome: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(8): 920-925. doi: 10.7507/1672-2531.20160142 Copy

  • Previous Article

    Effect of Laparoscopy versus Laparotomy on Recurrence for Borderline Ovarian Tumors: A Meta-analysis
  • Next Article

    Efficacy and Safety of Moistened versus Dry Misoprostol for Mid-trimester Pregnancy Termination: A Systematic Review