• 1. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University;Center for Evidence-Based and Translational Medicine, Wuhan University;Department of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical Medical College of Wuhan University, Wuhan 430071, China;
  • 2. National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China;
  • 3. Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China;
  • 4. Evidence-Based Nursing Center, Nursing School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
  • 5. Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;
ZENGXian-tao, Email: zengxiantao1128@163.com
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Cumulative meta-analysis could help researchers to justify the effectiveness of the intervention and whether the obtained evidence is sufficient. However, the process of the meta-analysis does not adjust the repeated testing of the null hypothesis and neither quantifies the statistical power. The sequential meta-analysis has solved the aforementioned problems and has been widely used in the clinical practice and decision-making. Currently several methods of sequential meta-analysis have been proposed and these methods differ from each other. Of which, the methodology of trial sequential (TSA) is well developed and corresponding performance is relatively easy; the methodology of double-triangular test of Whitehead is lagged than TSA and its performance is relatively difficult; the approach of semi-Bayes refers to the theory of Bayes and it's very difficult to generalize. Our paper aimed to give a brief introduction of the methodology of the sequential meta-analysis.

Citation: WENGHong, WUShan-shan, ZHANGYong-gang, JINYing-hui, CAOYue, ZENGXian-tao. Brief Introduction of Methodology of Sequential Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(10): 1216-1220. doi: 10.7507/1672-2531.20160184 Copy

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