Neonatal Resuscitation Technique in Reducing Neonatal Asphyxia Rate and Mortality Rate in China: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 LIHong-bin ¹ , FENGHai-juan ² , CHENJi-hua ¹ , FANHe-lian ¹ , DINGYan ¹ , ZHUJi-hua ¹ , ZHANGXiao-yan ¹

1. Maternal and Child Health Care Family Planning Service Center of Rugao, Rugao 226500, China;
2. The People's Hospital of Rugao, Rugao 226500, China;

Corresponding author：

Keywords：

Resuscitation; Neonatal asphyxia; Systematic Review; Meta-analysis; Mortality rate

DOI：

10.7507/1672-2531.20160218

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the efficacy of promoting neonatal resuscitation technique in treatment of neonatal asphyxia in China. Methods Electronical databases including WanFang Data, CNKI, VIP, Jiangsu Engineering and Technology Literature Information Center, PubMed and The Cochrane Library (Issue 5, 2016) were searched to collect studies of neonatal resuscitation technique in treatment of neonatal asphyxia up to June 1st, 2016. Two reviewers independently screened literature, extracted data and assessed the risk bias of included studies, and then meta-analysis was performed by using RevMan 5.2 software. Results A total of eighteen observational studies were included, involving 28 144 cases of neonatal asphyxia and 32 636 cases of control, 2 148 death cases of neonatal asphyxia and 1 679 cases of controls. The results of meta-analysis showed that neonatal resuscitation technique could reduce newborn suffocation rate compared with the control group in hospital surveys (RR=0.59, 95%CI 0.55 to 0.63, P<0.000 01) and in regional project surveys (RR=0.72, 95%CI 0.69 to 0.75, P<0.000 01). Neonatal resuscitation could also reduce neonatal asphyxia mortality rate in hospital surveys (RR=0.26, 95%CI 0.16 to 0.42, P<0.000 01) and in regional surveys (RR=0.65, 95%CI 0.55 to 0.77, P<0.000 01). Conclusion The existing evidence shows that neonatal resuscitation technology could effectively reduce the incidence of neonatal asphyxia and mortality rate in China. Due to the limitations of the quantity and quality of present studies, we need to carry out prospective multicenter cohort studies to verify the current results.

Citation： LIHong-bin, FENGHai-juan, CHENJi-hua, FANHe-lian, DINGYan, ZHUJi-hua, ZHANGXiao-yan. Neonatal Resuscitation Technique in Reducing Neonatal Asphyxia Rate and Mortality Rate in China: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2016, 16(12): 1454-1464. doi: 10.7507/1672-2531.20160218 Copy

1.	American Academy of Pediatrics. Neonatal resuscitation ProgramTM.[2016-06-29] Available at:http://www2.aap.org/nrp/about.html.
2.	Ersdal HL, Singhal N. Resuscitation in resource-limited settings. Semin Fetal Neonatal Med, 2013, 18(6):373-378.
3.	Lee AC, Cousens S, Wall SN, et al. Neonatal resuscitation and immediate newborn assessment and stimulation for the prevention of neonatal deaths:a systematic review, meta-analysis and Delphi estimation of mortality effect. BMC Public Health, 2011, 11(Suppl 3):S12.
4.	2015AHA心肺复苏及心血管急救指南更新. Available at:http://circ.cmt.com.cn/detail/970133.html.[2016-07-20].
5.	Curran V, Fleet L, White S, et al. A randomized controlled study of manikin simulator fidelity on neonatal resuscitation program learning outcomes. Adv Health Sci Educ Theory Pract, 2015, 20(1):205-218.
6.	Ersdal HL, Vossius C, Bayo E, et al. A one-day "Helping Babies Breathe" course improves simulated performance but not clinical management of neonates. Resuscitation, 2013, 84(10):1422-1427.
7.	Lee M, Brown L, Bender J, et al. A medical simulation-based educational intervention for emergency medicine residents in neonatal resuscitation. Acad Emerg Med, 2012, 19:577-585.
8.	Rubio-Gurung S, Putet G, Touzet S, et al. In situ simulation training for neonatal resuscitation:an RCT. Pediatrics, 2014, 134(3):790-977.
9.	Dempsey E, Pammi M, Ryan AC, et al. Standardised formal resuscitation training programmes for reducing mortality and morbidity in newborn infants. Cochrane Database Syst Rev, 2015, (9):CD009106.
10.	徐韬, 王惠珊, 宫丽敏, 等. 中国新生儿窒息复苏培训项目中期效果评价. 中华围产医学杂志, 2009, 12(6):409-412.
11.	王凌云, 宋志英, 曹玉莲. 实施新生儿复苏项目对降低我院新生儿窒息发生率和死亡率的意义. 中华围产医学杂志, 2013, 16(12):745-746.
12.	李鸿斌, 顾建明, 冯海娟, 等. 复苏技术降低我国新生儿窒息发生率和死亡率的Meta分析. 中国妇幼健康研究, 2015, 26(5):1031-1034.
13.	李鸿斌, 王洁, 吉苏梅, 等. 新生儿复苏项目发展历程、现状与政策趋向. 中国实用护理杂志, 2016, 32(16):1273-1276.
14.	顾建明, 李鸿斌, 陆平, 等. 如皋市民营一级医院新生儿复苏现状分析. 中国妇幼健康研究, 2015, 26(3):539-542.
15.	叶鸿瑁. 再接再厉, 继续深入开展我国的新生儿复苏工作. 中华围产医学杂志, 2016, 19(1):12-13.
16.	刘鸣. 系统评价、Meta分析设计与实施方法. 北京:人民卫生出版社, 2011:72-73.
17.	张洁晶, 顾承萍. 妇幼保健院新生儿复苏管理模式的作用. 中医药管理杂志, 2016, 24(4):150-152.
18.	申巧俐, 曹玉莲, 郭朝得, 等. 新生儿复苏质量控制体系实施效果研究. 中国妇幼卫生杂志, 2015, 6(2):16-19.
19.	谭玮, 丁香平, 周锦龙, 等. 新生儿窒息复苏流程临床应用效果评价. 中国新生儿科杂志, 2013, 28(4):256-258.
20.	覃超强. 新生儿窒息复苏指南应用效果之评价. 中国实用医药, 2012, 7(14):17-18.
21.	尹丽霞, 胡艳丽. 新生儿窒息规范化复苏培训效果分析. 中国妇幼保健, 2008, 23(5):594-595.
22.	候林霞, 何艳君, 张丽清. 新生儿窒息新法复苏术的临床效果观察. 中外医疗, 2013, (16):59-61.
23.	谭春迎, 王海鸥. 新生儿窒息复苏效果评价. 中国妇幼保健, 2010, 25(15):2085-2086.
24.	邓顺周, 林建国, 朱惠清, 等. 不同时期新生儿新法复苏效果对比分析. 中国妇幼保健, 2011, 26(19):2935-2937.
25.	李明珠, 王晓军, 李龙, 等. 新疆新生儿复苏培训项目的实施及效果评价. 中华围产医学杂志, 2013, 16(12):741-744.
26.	王颖, 张万恩, 徐韬, 等. 浙江新生儿复苏项目管理模式探讨及效果评估. 中国妇幼卫生杂志, 2015, 6(4):64-66.
27.	徐韬, 宫丽敏, 王惠珊, 等. 我国4县开展新生儿复苏长效机制试点干预效果评价. 中国儿童保健杂志, 2012, 20(6):504-506.
28.	毛新梅, 高红卫, 李晓强, 等. 基层新生儿复苏技术培训模式的探索及效果评价. 中国妇幼卫生杂志, 2016, 7(2):17-20, 29.
29.	高淑强. 新生儿窒息新法复苏技术推广5年总结. 中国妇幼保健, 2009, 24(2):198-199.
30.	许厚琴, 朱丽萍, 杜莉, 等. 上海市推广新生儿窒息复苏技术对降低围产儿死亡率的效果. 中国妇幼保健, 2012, 27(12):12-14.
31.	陈晖, 李燕, 王静. 农村基层医院开展新生儿窒息复苏培训项目的效果评价. 中外妇儿健康, 2011, 19(5):74-74.
32.	吴迅, 郭小芳, 方文, 等. 基层医疗机构新生儿窒息复苏培训模式的探讨及效果评价.中国儿童保健杂志, 2010, 18(5):422-425.
33.	国家卫生和计划生育委员会统计信息中心. 2016年3月底全国医疗卫生机构数.[2016-07-22] Available at:http://www.moh.gov.cn/mohwsbwstjxxzx/s7967/201607/5dde54faa3dd4efc8cd213e3fd53cebc.shtml.
34.	张悦, 徐韬, 马艺, 等. 我国163所医疗机构新生儿复苏工作现状调查. 中华围产医学杂志, 2013, 16(12):736-740.
35.	罗杰, 冷卫东. 系统评价/Meta分析理论与实践. 北京:军事医学科学出版社, 2013:160-164.
36.	国家卫生和计划生育委员会. 中国卫生和计划生育统计年鉴2014. 北京:中国协和医科大学出版社, 2015:217.
37.	Carlo WA, Goudar SS, Jehan I, et al. Newborn-care training and perinatal mortality in developing countries. N Engl J Med, 2010, 362(7):614-623.
38.	Carlo WA, Goudar SS, Jehan I, et al. for the First Breath Study Group. High mortality rates for very low birth weight infants in developing countries despite training. Pediatrics, 2010, 126(5):1072-1080.
39.	Gill CJ, Phiri-Mazala G, Guerina NG, et al. Effect of training traditional birth attendants on neonatal mortality (Lufwanyama Neonatal Survival Project):randomised controlled study. BMJ, 2011, 342:d346.

1. American Academy of Pediatrics. Neonatal resuscitation ProgramTM.[2016-06-29] Available at:http://www2.aap.org/nrp/about.html.
2. Ersdal HL, Singhal N. Resuscitation in resource-limited settings. Semin Fetal Neonatal Med, 2013, 18(6):373-378.
3. Lee AC, Cousens S, Wall SN, et al. Neonatal resuscitation and immediate newborn assessment and stimulation for the prevention of neonatal deaths:a systematic review, meta-analysis and Delphi estimation of mortality effect. BMC Public Health, 2011, 11(Suppl 3):S12.
4. 2015AHA心肺复苏及心血管急救指南更新. Available at:http://circ.cmt.com.cn/detail/970133.html.[2016-07-20].
5. Curran V, Fleet L, White S, et al. A randomized controlled study of manikin simulator fidelity on neonatal resuscitation program learning outcomes. Adv Health Sci Educ Theory Pract, 2015, 20(1):205-218.
6. Ersdal HL, Vossius C, Bayo E, et al. A one-day "Helping Babies Breathe" course improves simulated performance but not clinical management of neonates. Resuscitation, 2013, 84(10):1422-1427.
7. Lee M, Brown L, Bender J, et al. A medical simulation-based educational intervention for emergency medicine residents in neonatal resuscitation. Acad Emerg Med, 2012, 19:577-585.
8. Rubio-Gurung S, Putet G, Touzet S, et al. In situ simulation training for neonatal resuscitation:an RCT. Pediatrics, 2014, 134(3):790-977.
9. Dempsey E, Pammi M, Ryan AC, et al. Standardised formal resuscitation training programmes for reducing mortality and morbidity in newborn infants. Cochrane Database Syst Rev, 2015, (9):CD009106.
10. 徐韬, 王惠珊, 宫丽敏, 等. 中国新生儿窒息复苏培训项目中期效果评价. 中华围产医学杂志, 2009, 12(6):409-412.
11. 王凌云, 宋志英, 曹玉莲. 实施新生儿复苏项目对降低我院新生儿窒息发生率和死亡率的意义. 中华围产医学杂志, 2013, 16(12):745-746.
12. 李鸿斌, 顾建明, 冯海娟, 等. 复苏技术降低我国新生儿窒息发生率和死亡率的Meta分析. 中国妇幼健康研究, 2015, 26(5):1031-1034.
13. 李鸿斌, 王洁, 吉苏梅, 等. 新生儿复苏项目发展历程、现状与政策趋向. 中国实用护理杂志, 2016, 32(16):1273-1276.
14. 顾建明, 李鸿斌, 陆平, 等. 如皋市民营一级医院新生儿复苏现状分析. 中国妇幼健康研究, 2015, 26(3):539-542.
15. 叶鸿瑁. 再接再厉, 继续深入开展我国的新生儿复苏工作. 中华围产医学杂志, 2016, 19(1):12-13.
16. 刘鸣. 系统评价、Meta分析设计与实施方法. 北京:人民卫生出版社, 2011:72-73.
17. 张洁晶, 顾承萍. 妇幼保健院新生儿复苏管理模式的作用. 中医药管理杂志, 2016, 24(4):150-152.
18. 申巧俐, 曹玉莲, 郭朝得, 等. 新生儿复苏质量控制体系实施效果研究. 中国妇幼卫生杂志, 2015, 6(2):16-19.
19. 谭玮, 丁香平, 周锦龙, 等. 新生儿窒息复苏流程临床应用效果评价. 中国新生儿科杂志, 2013, 28(4):256-258.
20. 覃超强. 新生儿窒息复苏指南应用效果之评价. 中国实用医药, 2012, 7(14):17-18.
21. 尹丽霞, 胡艳丽. 新生儿窒息规范化复苏培训效果分析. 中国妇幼保健, 2008, 23(5):594-595.
22. 候林霞, 何艳君, 张丽清. 新生儿窒息新法复苏术的临床效果观察. 中外医疗, 2013, (16):59-61.
23. 谭春迎, 王海鸥. 新生儿窒息复苏效果评价. 中国妇幼保健, 2010, 25(15):2085-2086.
24. 邓顺周, 林建国, 朱惠清, 等. 不同时期新生儿新法复苏效果对比分析. 中国妇幼保健, 2011, 26(19):2935-2937.
25. 李明珠, 王晓军, 李龙, 等. 新疆新生儿复苏培训项目的实施及效果评价. 中华围产医学杂志, 2013, 16(12):741-744.
26. 王颖, 张万恩, 徐韬, 等. 浙江新生儿复苏项目管理模式探讨及效果评估. 中国妇幼卫生杂志, 2015, 6(4):64-66.
27. 徐韬, 宫丽敏, 王惠珊, 等. 我国4县开展新生儿复苏长效机制试点干预效果评价. 中国儿童保健杂志, 2012, 20(6):504-506.
28. 毛新梅, 高红卫, 李晓强, 等. 基层新生儿复苏技术培训模式的探索及效果评价. 中国妇幼卫生杂志, 2016, 7(2):17-20, 29.
29. 高淑强. 新生儿窒息新法复苏技术推广5年总结. 中国妇幼保健, 2009, 24(2):198-199.
30. 许厚琴, 朱丽萍, 杜莉, 等. 上海市推广新生儿窒息复苏技术对降低围产儿死亡率的效果. 中国妇幼保健, 2012, 27(12):12-14.
31. 陈晖, 李燕, 王静. 农村基层医院开展新生儿窒息复苏培训项目的效果评价. 中外妇儿健康, 2011, 19(5):74-74.
32. 吴迅, 郭小芳, 方文, 等. 基层医疗机构新生儿窒息复苏培训模式的探讨及效果评价.中国儿童保健杂志, 2010, 18(5):422-425.
33. 国家卫生和计划生育委员会统计信息中心. 2016年3月底全国医疗卫生机构数.[2016-07-22] Available at:http://www.moh.gov.cn/mohwsbwstjxxzx/s7967/201607/5dde54faa3dd4efc8cd213e3fd53cebc.shtml.
34. 张悦, 徐韬, 马艺, 等. 我国163所医疗机构新生儿复苏工作现状调查. 中华围产医学杂志, 2013, 16(12):736-740.
35. 罗杰, 冷卫东. 系统评价/Meta分析理论与实践. 北京:军事医学科学出版社, 2013:160-164.
36. 国家卫生和计划生育委员会. 中国卫生和计划生育统计年鉴2014. 北京:中国协和医科大学出版社, 2015:217.
37. Carlo WA, Goudar SS, Jehan I, et al. Newborn-care training and perinatal mortality in developing countries. N Engl J Med, 2010, 362(7):614-623.
38. Carlo WA, Goudar SS, Jehan I, et al. for the First Breath Study Group. High mortality rates for very low birth weight infants in developing countries despite training. Pediatrics, 2010, 126(5):1072-1080.
39. Gill CJ, Phiri-Mazala G, Guerina NG, et al. Effect of training traditional birth attendants on neonatal mortality (Lufwanyama Neonatal Survival Project):randomised controlled study. BMJ, 2011, 342:d346.

Chinese Journal of Evidence-Based Medicine

Neonatal Resuscitation Technique in Reducing Neonatal Asphyxia Rate and Mortality Rate in China: A Systematic Review

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content